O. Okazaki

发表

Placental transfer and milk secretion of gadodiamide injection in rats.

H. Hakusui, H. Nomura, O. Okazaki, 1996, Arzneimittel-Forschung.

Effect of ion suppression on judgment of enzyme inhibition and avoidance of error by utilizing a stable isotope-labeled probe substrate: example of CYP3A4 inhibition with [13C4,15N] labeled midazolam as a substrate.

N. Okudaira, K. Sudo, O. Okazaki, 2007, Drug metabolism and pharmacokinetics.

A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding

Osamu Okazaki, Daisuke Nakai, Ryo Atsumi, 2009, Drug Metabolism and Disposition.

In vitro evaluation of the potential for drug-induced toxicity based on (35)S-labeled glutathione adduct formation and daily dose.

A. Kurihara, Y. Miyaji, O. Okazaki, 2012, Bioanalysis.

Glutathione S-transferase pi trapping method for generation and characterization of drug-protein adducts in human liver microsomes using liquid chromatography-tandem mass spectrometry.

Hideo Yukinaga, T. Izumi, H. Iwabuchi, 2012, Journal of pharmaceutical and biomedical analysis.

glutathione adduct formation and daily dose

A. Kurihara, Y. Miyaji, O. Okazaki, 2012 .

In Vitro Metabolism of Rivoglitazone, a Novel Peroxisome Proliferator-Activated Receptor γ Agonist, in Rat, Monkey, and Human Liver Microsomes and Freshly Isolated Hepatocytes

M. Uchiyama, T. Izumi, H. Iwabuchi, 2011, Drug Metabolism and Disposition.

Microsoft Word-87912151-file00

M. Uchiyama, H. Iwabuchi, O. Okazaki, 2011 .

Covalent Binding and Tissue Distribution/Retention Assessment of Drugs Associated with Idiosyncratic Drug Toxicity

H. Masumoto, Hideo Yukinaga, H. Takakusa, 2008, Drug Metabolism And Disposition.

Prediction of Fluoroquinolone‐Induced Elevation in Serum Creatinine Levels: A Case of Drug–Endogenous Substance Interaction Involving the Inhibition of Renal Secretion

H. Kusuhara, Y. Sugiyama, Katsuhisa Inoue, 2011, Clinical pharmacology and therapeutics.

Investigation of the effect of mutations of rat albumin on the binding affinity to the alpha(4)beta(1) integrin antagonist, 4-[1-[3-chloro-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidine-2-yl]methoxybenzoic acid (D01-4582), using recombinant rat albumins.

Y. Sugiyama, O. Okazaki, Takashi Ito, 2010, Molecular pharmaceutics.

Analytical method for the determination of disaccharides derived from keratan, heparan, and dermatan sulfates in human serum and plasma by high-performance liquid chromatography/turbo ionspray ionization tandem mass spectrometry.

S. Tomatsu, A. Montaño, O. Okazaki, 2007, Analytical biochemistry.

Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs

N. Farid, A. Kurihara, K. Hagihara, 2009, Xenobiotica; the fate of foreign compounds in biological systems.

Superiority of a new gradient system utilizing a critical threshold for the adsorption capacity of polypeptides to column packing when compared with a standard gradient system for the simultaneous and quantitative analysis of polypeptides.

H. Masumoto, K. Sudo, O. Okazaki, 2008, Biomedical chromatography : BMC.

Pharmacokinetics, Metabolism, and Disposition of Rivoglitazone, a Novel Peroxisome Proliferator-Activated Receptor γ Agonist, in Rats and Monkeys

M. Uchiyama, T. Izumi, K. Abe, 2011, Drug Metabolism and Disposition.

Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice

T. Izumi, Chiho Ono, R. Atsumi, 2009, Archives of Toxicology.

Effects of DU-6859 a , a New Quinolone Antimicrobial , on Theophylline Metabolism in In Vitro and In Vivo Studies

Y. Niki, O. Okazaki, Kenichi Itokawa, 1998 .

Effects of DU-6859a, a New Quinolone Antimicrobial, on Theophylline Metabolism in In Vitro and In Vivo Studies

Y. Niki, O. Okazaki, Kenichi Itokawa, 1998, Antimicrobial Agents and Chemotherapy.

Effects of pantoprazole on xenobiotic metabolizing enzymes in rat liver microsomes: a comparison with other proton pump inhibitors.

H. Hakusui, O. Okazaki, N. Masubuchi, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Markers of Electrophilic Stress Caused by Chemically Reactive Metabolites in Human Hepatocytes

H. Masumoto, H. Takakusa, K. Sudo, 2008, Drug Metabolism and Disposition.

Estimation of the interindividual variability of cytochrome 2D6 activity from urinary metabolic ratios in the literature.

Y. Sugiyama, Motohiro Kato, O. Okazaki, 2010, Drug metabolism and pharmacokinetics.

An evaluation of the CYP1A induction potential of pantoprazole in primary rat hepatocytes: a comparison with other proton pump inhibitors.

O. Okazaki, N. Masubuchi, 1997, Chemico-biological interactions.

Quantitative assessment of reactive metabolite formation using 35S-labeled glutathione.

H. Masumoto, H. Takakusa, K. Sudo, 2009, Drug metabolism and pharmacokinetics.

Enantioselective disposition of ofloxacin in humans

H. Hakusui, M. Nakashima, O. Okazaki, 1991, Antimicrobial Agents and Chemotherapy.

IN VITRO METABOLISM OF THE CALMODULIN ANTAGONIST DY-9760e (3-[2-[4-(3-CHLORO-2-METHYLPHENYL)-1-PIPERAZINYL]ETHYL]-5,6-DIMETHOXY-1-(4-IMIDAZOLYLMETHYL)-1H-INDAZOLE DIHYDROCHLORIDE 3.5 HYDRATE) BY HUMAN LIVER MICROSOMES: INVOLVEMENT OF CYTOCHROMES P450 IN ATYPICAL KINETICS AND POTENTIAL DRUG INTERACTI

H. Yokoyama, K. Sudo, O. Okazaki, 2005, Drug Metabolism and Disposition.

Metabolism of irinotecan to SN-38 in a tissue-isolated tumor model.

H. Hakusui, R. Atsumi, O. Okazaki, 1995, Biological & pharmaceutical bulletin.

Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model

H. Saji, T. Izumi, R. Atsumi, 2011, Archives of Toxicology.

Identification of Valproic Acid Glucuronide Hydrolase As a Key Enzyme for the Interaction of Valproic Acid with Carbapenem Antibiotics

N. Kobayashi, Eiko Suzuki, D. Nakai, 2010, Drug Metabolism and Disposition.

Biotransformation of Prasugrel, a Novel Thienopyridine Antiplatelet Agent, to the Pharmacologically Active Metabolite

Hiroyuki Kobayashi, N. Farid, A. Kurihara, 2010, Drug Metabolism and Disposition.

Pharmacokinetics and stability of caldiamide sodium in rats.

H. Hakusui, O. Okazaki, T. Kurata, 1996, Arzneimittel-Forschung.

Effects of proton pump inhibitors on thyroid hormone metabolism in rats: a comparison of UDP-glucuronyltransferase induction.

H. Hakusui, O. Okazaki, N. Masubuchi, 1997, Biochemical pharmacology.

Evidence for specific base catalysis in N-dealkylation reactions catalyzed by cytochrome P450 and chloroperoxidase. Differences in rates of deprotonation of aminium radicals as an explanation for high kinetic hydrogen isotope effects observed with peroxidases.

F. Guengerich, O. Okazaki, 1993, The Journal of biological chemistry.

Radical cation intermediates in N-dealkylation reactions.

F. Guengerich, T. Macdonald, Y. Seto, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

Mechanistic study of inhibition of levofloxacin absorption by aluminum hydroxide

M. Tanaka, H. Hakusui, O. Okazaki, 1993, Antimicrobial Agents and Chemotherapy.

Metabolism of the calmodulin antagonist DY-9760e in animals and humans

H. Iwata, M. Tanaka, K. Sudo, 2005, Xenobiotica; the fate of foreign compounds in biological systems.

High-performance liquid chromatographic determination of (S)-(-)-ofloxacin and its metabolites in serum and urine using a solid-phase clean-up.

H. Hakusui, O. Okazaki, H. Aoki, 1991, Journal of chromatography.

Possible effect of pigment on the pharmacokinetics of ofloxacin and its excretion in hair.

O. Okazaki, T. Uematsu, N. Miyazawa, 1992, Journal of pharmaceutical sciences.

Ethylene Glycol Monomethyl Ether–Induced Toxicity Is Mediated through the Inhibition of Flavoprotein Dehydrogenase Enzyme Family

Osamu Okazaki, Lining Guo, Naoki Kiyosawa, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

H. Hakusui, O. Okazaki, H. Tachizawa, 1992, Xenobiotica; the fate of foreign compounds in biological systems.

Stereoselective metabolic disposition of enantiomers of ofloxacin in rats.

O. Okazaki, H. Tachizawa, T. Kurata, 1989, Xenobiotica; the fate of foreign compounds in biological systems.

Inhibition mechanism of carbapenem antibiotics on acylpeptide hydrolase, a key enzyme in the interaction with valproic acid

N. Kobayashi, T. Izumi, Eiko Suzuki, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

Identification of Valproic Acid Glucuronide Hydrolase As a Key Enzyme for the Interaction of Valproic Acid with Carbapenem Antibiotics

N. Kobayashi, Eiko Suzuki, D. Nakai, 2010, Drug Metabolism And Disposition.

Phase I Study of Levofloxacin, (S)-(-)-Ofloxacin.

M. Nakashima, H. Hakusui, M. Kanamaru, 1992 .

Isolation and identification of metabolites of ofloxacin in rats, dogs and monkeys.

K. Sudo, O. Okazaki, M. Tsumura, 1986, Xenobiotica; the fate of foreign compounds in biological systems.

Stereoselective glucuronidation of ofloxacin in rat liver microsomes.

H. Hakusui, O. Okazaki, H. Tachizawa, 1991, Drug metabolism and disposition: the biological fate of chemicals.

Effects of antacids, ferrous sulfate, and ranitidine on absorption of DR-3355 in humans

H. Hakusui, O. Sakai, J. Shimada, 1992, Antimicrobial Agents and Chemotherapy.

Effects ofAntacids, Ferrous Sulfate, andRanitidine on Absorption ofDR-3355 inHumans

O. Sakai, O. Okazaki, K. Shiba, 1992 .

The Pharmacokinetics of DR-3355 (I) : Absorption, Distribution and Excretion after a Single Oral Administration to Rats

H. Hakusui, O. Okazaki, H. Tachizawa, 1991 .

Human Pharmacokinetic Prediction of UDP-Glucuronosyltransferase Substrates with an Animal Scale-Up Approach

Osamu Okazaki, Atsushi Kurihara, N. Suzuki, 2011, Drug Metabolism and Disposition.

Interpretations of cytochrome P450 mechanisms from kinetic studies.

F. Guengerich, O. Okazaki, L. Bell, 1995, Biochimie.

Highly frequent anti‐idiotype antibody in cynomolgus monkeys developed against mouse‐derived regions of anti‐Fas antibody humanized by complementarity determining region grafting

A. Kurihara, W. Takasaki, Y. Yoshigae, 2009, British journal of pharmacology.

Phase I Study of DQ‐2556, a New Parenteral 3‐Quaternary Ammonium Cephalosporin Antibiotic

M. Nakashima, H. Hakusui, M. Kanamaru, 1993, Journal of clinical pharmacology.

A Possible Mechanism for the Differences in Efficiency and Variability of Active Metabolite Formation from Thienopyridine Antiplatelet Agents, Prasugrel and Clopidogrel

Osamu Okazaki, Toshihiko Ikeda, Atsushi Kurihara, 2009, Drug Metabolism and Disposition.

Mechanism of action of 2, 3-butanedione 2-monoxime on contraction of frog skeletal muscle fibres

H. Higuchi, S. Kurihara, M. Konishi, 1988, Journal of Muscle Research & Cell Motility.

Interaction of angiotensin II type 1 receptor blockers with P-gp substrates in Caco-2 cells and hMDR1-expressing membranes.

E. Kamiyama, T. Mikkaichi, D. Nakai, 2010, Life sciences.

Identification of cytochrome P450 3A4 modification site with reactive metabolite using linear ion trap-Fourier transform mass spectrometry.

H. Masumoto, Hideo Yukinaga, Z. Tozuka, 2007, Chemical research in toxicology.

Human Carboxymethylenebutenolidase as a Bioactivating Hydrolase of Olmesartan Medoxomil in Liver and Intestine

Mitsunori Kato, T. Izumi, A. Kurihara, 2010, The Journal of Biological Chemistry.

Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite

Osamu Okazaki, Toshihiko Ikeda, Tomoko Ishizuka, 2010, Drug Metabolism and Disposition.

Distribution of KAI-9803, a Novel δ-Protein Kinase C Inhibitor, after Intravenous Administration to Rats

A. Kurihara, Y. Miyaji, Leon Chen, 2011, Drug Metabolism and Disposition.

Pharmacokinetics and disposition of recombinant human osteoprotegerin (rhOPG) after intravenous administration in female fischer rats

E. Kamiyama, A. Kurihara, Y. Miyaji, 2009, Xenobiotica; the fate of foreign compounds in biological systems.

Novel Comb-Shaped PEG Modification Enhances the Osteoclastic Inhibitory Effect and Bone Delivery of Osteoprotegerin After Intravenous Administration in Ovariectomized Rats

A. Kurihara, K. Higaki, K. Ogawara, 2012, Pharmaceutical Research.

Analytical method for determination of disaccharides derived from keratan sulfates in human serum and plasma by high-performance liquid chromatography/turbo-ionspray ionization tandem mass spectrometry.

S. Tomatsu, O. Okazaki, T. Oguma, 2007, Biomedical chromatography : BMC.

N-nitroso-N-methylvinylamine: reaction of the epoxide with guanyl and adenyl moieties to yield adducts derived from both parts of the molecule.

F. Guengerich, M. Persmark, O. Okazaki, 1993, Chemical Research in Toxicology.

Pharmacokinetics, Tissue Distribution, and Excretion of Sitafloxacin, a New Fluoroquinolone Antibiotic, in Rats, Dogs, and Monkeys

Makoto Tanaka, Masaya Tachibana, O. Okazaki, 2004, Arzneimittelforschung.

An evaluation of the cytochrome P450 induction potential of pantoprazole in primary human hepatocytes.

A. Li, O. Okazaki, N. Masubuchi, 1998, Chemico-biological interactions.

Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide

Osamu Okazaki, Atsushi Kurihara, Kengo Watanabe, 2010, Drug Metabolism and Disposition.

Mechanisms of formation of 1,N6-ethenoadenine, 3,N4-ethenocytosine, 1,N2-ethenoguanine and N2,3-ethenoguanine DNA adducts from substituted oxiranes.

W. Humphreys, F. Guengerich, V. M. Raney, 1994, IARC scientific publications.

Pharmacokinetics of SN-38 [(+)-(4S)-4,11-diethyl-4,9-dihydroxy-1H- pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione], an active metabolite of irinotecan, after a single intravenous dosing of 14C-SN-38 to rats.

H. Hakusui, R. Atsumi, O. Okazaki, 1995, Biological & pharmaceutical bulletin.

Lack of effect of ofloxacin on theophylline pharmacokinetics in rats.

O. Okazaki, H. Tachizawa, K. Miyazaki, 1987, Chemotherapy.

In Vitro Evaluation of Drug Interaction Caused by Enzyme Inhibition —HAB Protocol—

Hiroyuki Kobayashi, Satoshi Kobayashi, E. Kashiyama, 2001 .

Pharmacokinetics and disposition of CS-8958, a long-acting prodrug of the novel neuraminidase inhibitor laninamivir in rats

N. Kobayashi, H. Takakusa, O. Okazaki, 2010, Xenobiotica; the fate of foreign compounds in biological systems.

CS-8958, a Prodrug of the Novel Neuraminidase Inhibitor R-125489, Demonstrates a Favorable Long-Retention Profile in the Mouse Respiratory Tract

H. Takakusa, S. Miura, O. Okazaki, 2009, Antimicrobial Agents and Chemotherapy.

Metabolism of Ticlopidine in Rats: Identification of the Main Biliary Metabolite as a Glutathione Conjugate of Ticlopidine S-Oxide

R. Atsumi, K. Sudo, O. Okazaki, 2009, Drug Metabolism and Disposition.

Effects of organic solvents on the time-dependent inhibition of CYP3A4 by diazepam

N. Kobayashi, N. Okudaira, O. Okazaki, 2010, Xenobiotica; the fate of foreign compounds in biological systems.

Combination of GSH Trapping and Time-Dependent Inhibition Assays as a Predictive Method of Drugs Generating Highly Reactive Metabolites

Kazuhito Shiosakai, T. Izumi, H. Takakusa, 2011, Drug Metabolism and Disposition.

Development of a pretreatment method for amyloid beta-protein analysis based on the effect of acetic acid on the dissolution of plasma polypeptides.

H. Masumoto, K. Sudo, O. Okazaki, 2008, Biomedical chromatography : BMC.

Mechanistic StudyofInhibition ofLevofloxacin Absorption byAluminumHydroxide

Makoto Tanaka, O. Okazaki, Y. Ohshima, 1993 .

Enantioselective Disposition ofOfloxacin inHumans

O. Okazaki, Kita-kasai J-Chome, 1991 .

Culture Period-Dependent Change of Function and Expression of ATP-Binding Cassette Transporters in Caco-2 Cells

E. Kamiyama, D. Nakai, S. Miura, 2009, Drug Metabolism and Disposition.

Promising toxicological biomarkers for the diagnosis of liver injury types: Bile acid metabolic profiles and oxidative stress marker as screening tools in drug development.

T. Nishiya, O. Okazaki, N. Masubuchi, 2016, Chemico-biological interactions.

Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel

N. Farid, A. Kurihara, K. Hagihara, 2009, Xenobiotica; the fate of foreign compounds in biological systems.

Risk Assessment for Drug-Drug Interaction Caused by Metabolism-Based Inhibition of CYP3A Using Automated in Vitro Assay Systems and Its Application in the Early Drug Discovery Process

N. Okudaira, K. Sudo, O. Okazaki, 2007, Drug Metabolism and Disposition.

Mechanisms of cytochrome P450 1A2-mediated formation of N-hydroxy arylamines and heterocyclic amines and their reaction with guanyl residues.

W. Humphreys, F. Guengerich, F. Kadlubar, 1995, Princess Takamatsu symposia.

Novel Comb-Shaped PEG Modification Enhances the Osteoclastic Inhibitory Effect and Bone Delivery of Osteoprotegerin After Intravenous Administration in Ovariectomized Rats

T. Izumi, A. Kurihara, K. Higaki, 2012, Pharmaceutical Research.

PEGylation of osteoprotegerin/osteoclastogenesis inhibitory factor (OPG/OCIF) results in decreased uptake into rats and human liver

S. Mochizuki, F. Okada, Yukie Suzuki, 2010, The Journal of pharmacy and pharmacology.

Studies on the Mechanism of Pharmacokinetic Interaction of Aluminum hydroxide, an Antacid, with New Quinolones in Rats

O. Okazaki, H. Tachizawa, T. Kurata, 1988 .

Metabolism of ticlopidine in rats: Identification of the main biliary metabolite as a GSH conjugate of ticlopidine S-oxide

R. Atsumi, K. Sudo, O. Okazaki, 2009 .