S. Cochrane

发表

Observation of the Unbiased Conformers of Putative DNA-Scaffold Ribosugars

B. G. Davis, C. Calabrese, E. Cocinero, 2020, ACS central science.

Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design

M. Bibb, C. Robinson, E. Carpenter, 2018, Cell.

Insights into the Mechanism of Action of the Two-Peptide Lantibiotic Lacticin 3147.

J. Vederas, P. Mercier, R. McKay, 2017, Journal of the American Chemical Society.

Biochemical, Structural, and Genetic Characterization of Tridecaptin A1, an Antagonist of Campylobacter jejuni

J. Vederas, L. McMullen, Zedu Huang, 2014, Chembiochem : a European journal of chemical biology.

Synthesis of Tridecaptin-Antibiotic Conjugates with in Vivo Activity against Gram-Negative Bacteria.

J. Vederas, Min Wu, Sisi He, 2015, Journal of medicinal chemistry.

Total Synthesis and Stereochemical Assignment of the Antimicrobial Lipopeptide Cerexin A1.

J. Vederas, S. Cochrane, Richard R Surgenor, 2015, Organic letters.

The tridecaptins: non-ribosomal peptides that selectively target Gram-negative bacteria†

S. Cochrane, Samantha J Bann, Ross D Ballantine, 2021, RSC medicinal chemistry.

Total Synthesis of the Brevicidine and Laterocidine Family of Lipopeptide Antibiotics

N. Martin, Y. Li, S. Cochrane, 2021 .

Antimicrobial lipopeptide tridecaptin A1 selectively binds to Gram-negative lipid II

J. Vederas, P. Mercier, J. Z. Acedo, 2016, Proceedings of the National Academy of Sciences.

Unacylated tridecaptin A₁ acts as an effective sensitiser of Gram-negative bacteria to other antibiotics.

J. Vederas, S. Cochrane, 2014, International journal of antimicrobial agents.

Solid supported chemical syntheses of both components of the lantibiotic lacticin 3147.

J. Vederas, Wei Liu, A. Chan, 2011, Journal of the American Chemical Society.

Undecaprenol kinase: Function, mechanism and substrate specificity of a potential antibiotic target.

M. Caffrey, C. M. Ives, S. Cochrane, 2020, European journal of medicinal chemistry.

Lipopeptides from Bacillus and Paenibacillus spp.: A Gold Mine of Antibiotic Candidates

J. Vederas, S. Cochrane, 2016, Medicinal research reviews.

Investigation of the ring-closing metathesis of peptides in water.

J. Vederas, Zedu Huang, S. Cochrane, 2013, Organic & biomolecular chemistry.

Molecular cloning and characterization of drimenol synthase from valerian plant (Valeriana officinalis)

D. Ro, J. Vederas, S. Cochrane, 2014, FEBS letters.

From plant to probe: semi-synthesis of labelled undecaprenol analogues allows rapid access to probes for antibiotic targets.

M. Caffrey, C. Boland, S. Fetics, 2020, Chemical communications.

Synthesis and Structure − Activity Relationship Studies of N ‐ Terminal Analogues of the Antimicrobial Peptide Tridecaptin A 1

J. Vederas, G. Armstrong, G. Mulvey, 2014 .

Dissecting the Binding Interactions of Teixobactin with the Bacterial Cell‐Wall Precursor Lipid II

J. Vederas, R. Payne, Antoine Henninot, 2019, Chembiochem : a European journal of chemical biology.

Binding Studies Reveal Phospholipid Specificity and Its Role in the Calcium-Dependent Mechanism of Action of Daptomycin

T. Wood, Ioli Kotsogianni, S. Cochrane, 2021, ACS infectious diseases.

Breaking down the cell wall: Strategies for antibiotic discovery targeting bacterial transpeptidases.

Christopher T. Lohans, S. Cochrane, 2020, European journal of medicinal chemistry.

Synthesis and structure–activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine

Karol Al Ayed, S. Cochrane, N. Martin, 2022, RSC medicinal chemistry.

Studies on tridecaptin B(1), a lipopeptide with activity against multidrug resistant Gram-negative bacteria.

J. Vederas, Christopher T. Lohans, S. Cochrane, 2015, Organic & biomolecular chemistry.

Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy

M. van der Stelt, Zheng Zhong, Charlotte M J Wesseling, 2022, Chemical science.

Key Residues in Octyl‐Tridecaptin A1 Analogues Linked to Stable Secondary Structures in the Membrane

J. Vederas, S. Cochrane, B. Findlay, 2014, Chembiochem : a European journal of chemical biology.

Rational design of new cyclic analogues of the antimicrobial lipopeptide tridecaptin A1† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8cc05790g

S. Cochrane, Yong-Xin Li, Ross D Ballantine, 2018, Chemical Communications.

A Chemical-Intervention Strategy To Circumvent Peptide Hydrolysis by d-Stereoselective Peptidases

P. Qian, Yong-Xin Li, S. Cochrane, 2019, Journal of medicinal chemistry.

PP IX-225 TRIDECAPTIN A 1 SELECTIVELY BINDS TO GRAM-NEGATIVE LIPID II

J. Vederas, P. Dorrestein, J. Correia, 2017 .

Optimizations of lipid II synthesis: an essential glycolipid precursor in bacterial cell wall synthesis and a validated antibiotic target

S. Cochrane, Milandip Karak, Brad R. Baker, 2024, Beilstein journal of organic chemistry.

Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9md00031c

S. Tokajian, Elie Nassour, S. Cochrane, 2019, MedChemComm.

Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity

Barbara R. Terlouw, J. Willemse, G. V. van Wezel, 2024, ACS chemical biology.