Anja Bastian

发表

Cell non-autonomous interactions during non-immune stromal progression in the breast tumor microenvironment

G. Atwal, N. Sadagopan, Qing Gao, 2019, bioRxiv.

Identification of novel drugs to target dormant micrometastases

L. Bourguignon, P. Hauser, M. Ihnat, 2015, BMC Cancer.

Abstract 5682: Design and preclinical evaluation of single agents with combination chemotherapy potential.

M. Ihnat, J. Thorpe, E. Hamel, 2013 .

Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.

M. Ihnat, E. Hamel, A. Gangjee, 2017, Bioorganic & medicinal chemistry.

Synthesis and biological activity of 5-chloro-N⁴-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.

M. Ihnat, J. Thorpe, Sudhir Raghavan, 2013, Bioorganic & medicinal chemistry.

A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model

N. Smith, D. Saunders, R. Towner, 2015, BMC Cancer.

Targeting dormant micrometastases: rationale, evidence to date and clinical implications

M. Ihnat, R. Hurst, L. Bailey-Downs, 2016, Therapeutic advances in medical oncology.

A Small Molecule with Anticancer and Antimetastatic Activities Induces Rapid Mitochondrial-Associated Necrosis in Breast Cancer

M. Ihnat, J. Thorpe, A. Gangjee, 2015, The Journal of Pharmacology and Experimental Therapeutics.

A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer

M. Ihnat, J. Thorpe, A. Gangjee, 2015 .

The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.

M. Ihnat, J. Thorpe, E. Hamel, 2014, Bioorganic & medicinal chemistry.

AG488 as a therapy against gliomas.

M. Lerner, N. Smith, Jadith Ziegler, 2017, Oncotarget.

Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential.

M. Ihnat, J. Thorpe, E. Hamel, 2014, ACS medicinal chemistry letters.

AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization.

M. Ihnat, A. Gangjee, K. Humphries, 2017, Cancer letters.

Development and Characterization of a Preclinical Model of Breast Cancer Lung Micrometastatic to Macrometastatic Progression

P. Hauser, M. Ihnat, R. Hurst, 2014, PloS one.

The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.

M. Ihnat, E. Hamel, S. Mooberry, 2015, Bioorganic & medicinal chemistry.

Interleukin 6 Function in the Skin and Isolated Keratinocytes Is Modulated by Hyperglycemia

R. Gallucci, Anja Bastian, L. Luckett-Chastain, 2019, Journal of immunology research.

Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.

M. Ihnat, A. Gangjee, Nilesh Zaware, 2017, Bioorganic & medicinal chemistry letters.

Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.

M. Ihnat, E. Hamel, A. Gangjee, 2017, Bioorganic & medicinal chemistry.

AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization.

M. Ihnat, A. Gangjee, Nilesh Zaware, 2017, Cancer letters.

Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.

M. Ihnat, A. Gangjee, Nilesh Zaware, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of 5-chloro-N⁴-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.

M. Ihnat, J. Thorpe, Sudhir Raghavan, 2013, Bioorganic & medicinal chemistry.