E. Schneider

发表

Macromolecular prodrug that provides the irinotecan (CPT-11) active-metabolite SN-38 with ultralong half-life, low C(max), and low glucuronide formation.

D. Santi, G. Ashley, Eric L Schneider, 2014, Journal of medicinal chemistry.

Interference with heme binding to histidine-rich protein-2 as an antimalarial strategy.

I. Gluzman, D. Goldberg, M. Marletta, 2002, Chemistry & biology.

Mutational Tail Loss Is an Evolutionary Mechanism for Liberating Marapsins and Other Type I Serine Proteases from Transmembrane Anchors*

C. Craik, D. Kirchhofer, Eric L Schneider, 2013, The Journal of Biological Chemistry.

Attenuation of the Reaction of Michael Acceptors with Biologically Important Nucleophiles.

D. Santi, G. Ashley, Shaun D. Fontaine, 2021, Bioconjugate chemistry.

Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates

R. Reid, D. Santi, G. Ashley, 2012, Proceedings of the National Academy of Sciences.

IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus.

C. Craik, J. Dvorak, J. McKerrow, 2011, International journal for parasitology.

Positional scanning synthetic combinatorial libraries for substrate profiling.

C. Craik, Eric L Schneider, E. Schneider, 2009, Methods in molecular biology.

Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates

C. Craik, S. Kanse, G. Løset, 2017, Thrombosis and Haemostasis.

Half-life extension of the HIV-fusion inhibitor peptide TRI-1144 using a novel linker technology.

D. Santi, G. Ashley, B. Malcolm, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Primary deuterium kinetic isotope effects prolong drug release and polymer biodegradation in a drug delivery system

S. Pfaff, D. Santi, G. Ashley, 2018, Journal of controlled release : official journal of the Controlled Release Society.

Heme binding to the histidine-rich protein II from Plasmodium falciparum.

M. Marletta, Eric L Schneider, E. Schneider, 2005, Biochemistry.

High‐throughput, aseptic production of injectable Tetra‐PEG hydrogel microspheres for delivery of releasable covalently bound drugs

D. Santi, G. Ashley, Jeff Henise, 2020, Engineering Reports.

IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus.

M. Bogyo, C. Craik, J. Dvorak, 2007, International journal for parasitology.

A Novel Entamoeba histolytica Cysteine Proteinase, EhCP4, Is Key for Invasive Amebiasis and a Therapeutic Target*

P. Dorrestein, C. Craik, S. Boyd, 2010, The Journal of Biological Chemistry.

β-Eliminative releasable linkers adapted for bioconjugation of macromolecules to phenols.

R. Reid, D. Santi, G. Ashley, 2013, Bioconjugate chemistry.

SmCL3, a Gastrodermal Cysteine Protease of the Human Blood Fluke Schistosoma mansoni

Patricia C. Babbitt, Jan Dvořák, Conor R. Caffrey, 2009, PLoS neglected tropical diseases.

The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti

Petr Horák, Jan Dvořák, Charles S. Craik, 2009, International journal for parasitology.

A long-acting C-natriuretic peptide for achondroplasia

R. Reid, D. Santi, G. Ashley, 2022, Proceedings of the National Academy of Sciences of the United States of America.

The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.

P. Nelson, C. Craik, L. True, 2014, Cancer discovery.

Title : The Androgen-Regulated Protease TMPRSS 2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis

P. Nelson, C. Craik, L. True, 2014 .

A reverse binding motif that contributes to specific protease inhibition by antibodies.

Aida Baharuddin, C. Craik, M. Ward, 2012, Journal of molecular biology.

Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides

C. Craik, M. T. Miranda, A. Tanaka, 2010, Parasites & Vectors.

Tumor detection by imaging proteolytic activity.

C. Craik, B. Hann, J. Marks, 2010, Cancer research.

Subcutaneously Administered Self-Cleaving Hydrogel-Octreotide Conjugates Provide Very Long-Acting Octreotide.

R. Reid, D. Santi, G. Ashley, 2016, Bioconjugate chemistry.

Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition.

C. Craik, Charles S Craik, Eric L Schneider, 2008, Journal of molecular biology.

Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake.

S. Pfaff, R. Reid, D. Santi, 2016, Bioconjugate chemistry.

In Vitro-In Vivo Correlation for the Degradation of Tetra-PEG Hydrogel Microspheres with Tunable β-Eliminative Crosslink Cleavage Rates

Donghui Wang, B. Hann, S. Pfaff, 2019, International Journal of Polymer Science.

A Hydrogel-Microsphere Drug Delivery System That Supports Once-Monthly Administration of a GLP-1 Receptor Agonist.

S. Pfaff, N. Vrang, R. Reid, 2017, ACS chemical biology.

Hydrogel Drug Delivery System Using Self-Cleaving Covalent Linkers for Once-a-Week Administration of Exenatide.

R. Reid, D. Santi, G. Ashley, 2016, Bioconjugate chemistry.

A once-monthly GLP-1 receptor agonist for treatment of diabetic cats.

D. Santi, G. Ashley, D. Parkes, 2019, Domestic animal endocrinology.

Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin

C. Craik, W. Bode, O. Schilling, 2018, Scientific Reports.