J. Hubbs

发表

Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease

W. Xia, J. Dumin, K. Pojasek, 2012, International journal of Alzheimer's disease.

Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor.

C. Kenific, Melissa Chenard, A. Kral, 2014, ACS medicinal chemistry letters.

Ni(II) bis(oxazoline)-catalyzed enantioselective syn aldol reactions of N-propionylthiazolidinethiones in the presence of silyl triflates.

Davidr . Evans, C. W. Downey, J. Hubbs, 2003, Journal of the American Chemical Society.

The development of a Selectfluor®-mediated oxidative Mannich reaction

Matthew H Daniels, J. Hubbs, 2011 .

Purine derivatives as potent gamma-secretase modulators.

C. Kenific, A. Szewczak, J. Crispino, 2010, Bioorganic & medicinal chemistry letters.

Derives du benzothiophene

Karin M. Otte, Thomas A. Miller, J. Methot, 2006 .

Total synthesis of (+/-)-isoschizogamine.

C. Heathcock, J. Hubbs, 1999, Organic letters.

Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors

A. Aguzzi, K. Frauenknecht, M. Detmar, 2018, Nature Communications.

A second-generation synthesis of the C1-C28 portion of the altohyrtins (spongistatins).

C. Heathcock, J. Hubbs, 2003, Journal of the American Chemical Society.

Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models

J. Dumin, T. McKee, B. Tate, 2013, Alzheimer's Research & Therapy.

Optimization of a natural product-based class of γ-secretase modulators.

W. Xia, S. Creaser, T. McKee, 2012, Journal of medicinal chemistry.

Itch suppression in mice and dogs by modulation of spinal alpha 2 and alpha 3GABA(A) receptors

A. Aguzzi, K. Frauenknecht, M. Detmar, 2018 .

Multigram synthesis of the C29-C51 subunit and completion of the total synthesis of altohyrtin C (spongistatin 2).

C. Hayes, M. McLaughlin, C. Heathcock, 2003, Journal of the American Chemical Society.

Minimization of drug-drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators.

J. Dumin, T. McKee, B. Tate, 2015, Bioorganic & medicinal chemistry letters.

Discovery and Development of the Natural Product Derivative SPI-1865 as a Gamma Secretase Modulator for Alzheimer’s Disease: Part I

W. Austin, Nathan O Fuller, J. Hubbs, 2016 .

Multikilogram-Scale Production of Cycloartenol Triterpenoid Glycosides as Synthetic Intermediates for a γ-Secretase Modulator

J. Kovács, M. Findeis, S. Creaser, 2014 .

Optimization of a Kilogram-Scale Synthesis of a Potent Cycloartenol Triterpenoid-Derived γ-Secretase Modulator

W. Austin, Nathan O Fuller, J. Hubbs, 2014 .

SAR investigations on a novel class of gamma-secretase modulators based on a unique scaffold

M. Findeis, S. Creaser, T. McKee, 2013 .

Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside.

M. Findeis, W. Xia, S. Creaser, 2012, ACS medicinal chemistry letters.

Fluorinated piperidine acetic acids as gamma-secretase modulators.

C. Kenific, A. Szewczak, J. Crispino, 2010, Bioorganic & medicinal chemistry letters.

High-Content Small Molecule Screen Identifies a Novel Compound That Restores AP-4-Dependent Protein Trafficking in Neuronal Models of AP-4-Associated Hereditary Spastic Paraplegia

Wardiya Afshar Saber, M. Sahin, Dosh Whye, 2023, Research square.

Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors

A. Aguzzi, K. Frauenknecht, M. Detmar, 2018, Nature Communications.

ALDH5A1-deficient iPSC-derived excitatory and inhibitory neurons display cell type specific alterations

E. Buttermore, J. Roullet, Xutong Shi, 2023, Neurobiology of Disease.