H. Karlström

发表

Neurobiology of Disease Alzheimer's Disease: Presenilin 2-sparing ␥-secretase Inhibition Is a Tolerable A␤ Peptide-lowering Strategy

U. Lendahl, B. de Strooper, L. Serneels, 2022 .

Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.

B. Winblad, Susanne Frykman, Jenny Frånberg, 2011, Biochemical and biophysical research communications.

Mutations in Nicastrin Protein Differentially Affect Amyloid β-Peptide Production and Notch Protein Processing*

B. Winblad, L. Tjernberg, R. Bhat, 2011, The Journal of Biological Chemistry.

Functional Domains in Presenilin 1

U. Lendahl, S. Gandy, P. Mathews, 2004, Journal of Biological Chemistry.

Co‐expressed presenilin 1 NTF and CTF form functional γ‐secretase complexes in cells devoid of full‐length protein

B. Winblad, U. Lendahl, S. Gandy, 2004, Journal of neurochemistry.

Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGFβ expression

B. Winblad, M. Viitanen, C. Graff, 2018, Journal of cellular and molecular medicine.

A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling

U. Lendahl, G. Chapman, J. Lundkvist, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Novel Cysteine-Sparing Hypomorphic NOTCH3 A1604T Mutation Observed in a Family With Migraine and White Matter Lesions

U. Lendahl, F. Del Gaudio, ShaoBo Jin, 2021, Neurology: Genetics.

Presenilin dependence of phospholipase C and protein kinase C signaling

B. Winblad, E. Benedikz, R. Cowburn, 2007, Journal of neurochemistry.

APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.

B. Winblad, L. Lannfelt, D. Religa, 2003, Experimental cell research.

A Sensitive and Quantitative Assay for Measuring Cleavage of Presenilin Substrates*

U. Lendahl, J. Lundkvist, J. Näslund, 2002, The Journal of Biological Chemistry.

Mice carrying a R142C Notch 3 knock–in mutation do not develop a CADASIL‐like phenotype

M. Viitanen, U. Lendahl, C. Spenger, 2005, Genesis.

The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression

U. Lendahl, C. Betsholtz, F. Del Gaudio, 2021, Disease Models & Mechanisms.

Mapping of nrdA and nrdB in Escherichia coli K-12

J. Fuchs, H. Karlström, J. A. Fuchs, 1976, Journal of bacteriology.

γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing

K. Blennow, B. Winblad, H. Zetterberg, 2021, Journal of cellular and molecular medicine.

Notch receptor cleavage depends on but is not directly executed by presenilins

U. Lendahl, T. Honjo, T. Mizutani, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Generalized potential of adult neural stem cells.

U. Lendahl, J. Frisén, E. Nilsson, 2000, Science.

Generation and phenotypic characterization of a galanin overexpressing mouse

T. Hökfelt, U. Lendahl, E. Theodorsson, 2005, Neuroscience.

Inability of Escherichia coli B to incorporate added deoxycytidine, deoxyandenosine, and deoxyguanosine into DNA.

H. Karlström, H. Olle Karlstrom, 1970, European journal of biochemistry.

Defective gene product in dnaF mutant of Escherichia coli.

P. Reichard, J. Fuchs, H. Warner, 1972, Nature: New biology.

γ-secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ42/Aβ40 ratio

L. Tjernberg, M. Ankarcrona, Camilla A Hansson Petersen, 2011, Journal of cellular and molecular medicine.

Studies on the γ-Secretase Complex and Processing of the Alzheimer ’ s Disease-associated Amyloid Precursor Protein

B. Winblad, U. Lendahl, L. Lannfelt, 2004 .

Year : 2010 gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes

B. Winblad, L. Tjernberg, Susanne Frykman, 2011 .

γ-Secretase Dependent Production of Intracellular Domains Is Reduced in Adult Compared to Embryonic Rat Brain Membranes

B. Winblad, L. Tjernberg, Susanne Frykman, 2010, PloS one.

Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration–motor neuron disease

P. Schofield, P. Sachdev, M. Barcikowska, 2010, Annals of neurology.

Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model

U. Lendahl, F. Del Gaudio, ShaoBo Jin, 2022, EMBO molecular medicine.

Molecular Chaperone BRICHOS Inhibits CADASIL-Mutated NOTCH3 Aggregation In Vitro

H. Karlström, Gefei Chen, H. Biverstål, 2022, Frontiers in Molecular Biosciences.

Role of NOTCH3 Mutations in the Cerebral Small Vessel Disease Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy.

U. Lendahl, H. Karlström, Kirsten G. Coupland, 2018, Stroke.

Mitofusin‐2 knockdown increases ER–mitochondria contact and decreases amyloid β‐peptide production

M. Ankarcrona, P. Pizzo, R. Filadi, 2016, Journal of cellular and molecular medicine.

Multimodal characterization of the murine neurovascular niche using a novel microvascular isolation protocol

U. Lendahl, C. Betsholtz, F. Del Gaudio, 2021, bioRxiv.

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations

L. Tjernberg, I. Nilsson, J. Lundkvist, 2014, FEBS open bio.

Specificity of presenilin‐1‐ and presenilin‐2‐dependent γ‐secretases towards substrate processing

Claudia Marinangeli, B. Tasiaux, P. Kienlen-Campard, 2017, Journal of cellular and molecular medicine.

Second Generation γ-Secretase Modulators Exhibit Different Modulation of Notch β and Aβ Production*

K. Blennow, H. Zetterberg, E. Portelius, 2012, The Journal of Biological Chemistry.

A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature.

U. Lendahl, C. Betsholtz, Hao Li, 2023, Cell reports methods.

The Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating γ-Secretase Complex Assembly and Dictating the Amyloid β Peptide (Aβ) Profile without Affecting Notch Processing*

B. Winblad, J. Lundkvist, J. Näslund, 2010, The Journal of Biological Chemistry.

Biochemical studies of poly-T variants in the Alzheimer's disease associated TOMM40 gene.

C. Graff, M. Ankarcrona, C. Pinho, 2012, Journal of Alzheimer's disease : JAD.

Visualizing Active Enzyme Complexes Using a Photoreactive Inhibitor for Proximity Ligation – Application on γ-Secretase

B. Winblad, L. Tjernberg, Sophia Schedin‐Weiss, 2013, PloS one.

The Prefrontal Cortex : Response Selection or Maintenance Within Working Memory ?

U. Lendahl, J. Frisén, J. Wilbertz, 2022 .

A mutant of Escherichia coli defective in ribonucleosidediphosphate reductase. 2. Characterization of the enzymatic defect.

J. Fuchs, H. Karlström, 1973, European journal of biochemistry.