R. Elliott

发表

Piperidine-derived gamma-secretase modulators.

I. Hussain, Alan Naylor, Beverley Smith, 2010, Bioorganic & medicinal chemistry letters.

Evaluation of basic, heterocyclic ring systems as templates for use as potassium competitive acid blockers (pCABs).

E. Demont, A. Naylor, M. Bamford, 2009, Bioorganic & medicinal chemistry letters.

In vitro and in vivo characterization of 3-[2-[6-(2-tert-butoxyethoxy)pyridin-3-yl]-1H-imidazol-4-yl]benzonitrile hydrochloride salt, a potent and selective NPY5 receptor antagonist.

T. Maurer, D. Hargrove, C. Mack, 2003, Journal of medicinal chemistry.

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR.

C. Eigenbrot, Ivana Yen, S. Sideris, 2016, ACS medicinal chemistry letters.

Structure-activity relationship studies on 2-heteroaryl-4-arylimidazoles NPY5 receptor antagonists.

T. Maurer, C. Mack, Robert M. Oliver, 2003, Bioorganic & medicinal chemistry letters.

A samarium(II) iodide promoted tandem radical cyclization. The total synthesis of (.+-.)-hypnophilin and the formal synthesis of (.+-.)-coriolin

D. Curran, R. Elliott, T. Fevig, 1988 .

The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man.

Hung‐Yuan Cheng, Stephen A. Smith, I. Stansfield, 2002, Bioorganic & medicinal chemistry letters.

Novel 3-deoxy-3-descladinosyl-6-O-methyl erythromycin a analogues. Synthesis and in vitro activity

J. Plattner, R. Flamm, D. Chu, 1997 .

BASE INDUCED REACTION OF AN AZETIDIN-2-ONE: FORMATION OF A NOVEL [1,4]-DIAZEPINEDIONE

D. Dhanak, R. Haltiwanger, D. M. Hickey, 2001 .

Cascade palladium-catalyzed direct intramolecular arylation/alkene isomerization sequences: synthesis of indoles and benzofurans.

M. Willis, R. Elliott, P. L. Nichols, 2010, Angewandte Chemie.

Total synthesis of (-)-specionin

B. Kim, D. Curran, R. Elliott, 1987 .

Regiocontrol in opening of 2H-cyclopenta[b]furanones with organocopper reagents

D. Curran, M. Chen, R. Elliott, 1986 .

Synthesis of t-Butylsilicon Compounds by the Wurtz-Fitting Reaction1

C. Chappelow, R. Elliott, J. T. Goodwin, 1962 .

The α-effect in cyclic secondary amines: new scaffolds for iminium ion accelerated transformations

J. Platts, J. Brazier, N. Tomkinson, 2009 .

A Short, Efficient Synthesis of the Novel Cholinergic Channel Activator, ABT 418, from L-Proline

D. Garvey, N. Lin, Yun He, 1995 .

Ligands for brain cholinergic channel receptors: synthesis and in vitro characterization of novel isoxazoles and isothiazoles as bioisosteric replacements for the pyridine ring in nicotine.

D. Anderson, D. Garvey, N. Lin, 1994, Journal of medicinal chemistry.

The α-effect in iminium ion catalysis

J. Platts, N. Tomkinson, R. Elliott, 2006 .

Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase.

Eliot Sugarman, Zhengrong Zhao, Wei Song, 2012, Journal of medicinal chemistry.

Novel 2-(2'-furo[3,2-b]pyridinyl) pyrrolidines : Potent neuronal nicotinic acetylcholine receptor ligands

D. Donnelly-roberts, S. Arneric, T. Kuntzweiler, 1997 .

A general synthetic approach to optically active iridoid aglycones : The total syntheses of β-ethyl descarbomethoxyverbenalol, ethyl catalpol, and (-)-specionin

B. Kim, D. Curran, R. Elliott, 1988 .

Cycloadditions of cephalosporins. The formation of [4+2] adducts with 5-membered heterocycles

A. Takle, J. Tyler, N. Nicholson, 1994 .

Cycloadditions of Cephalosporins. A Comprehensive Study of the Reaction of Cephalosporin Triflates with Olefins, Acetylenes, and Dienes To Form [2 + 2] and [4 + 2] Adducts

M. J. Pearson, C. Richardson, R. Haltiwanger, 1997 .

The Phenylation and Methylation of Alkoxychlorosilanes1

C. Chappelow, R. Elliott, J. T. Goodwin, 1960 .

Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme.

P. Portoghese, N. Marks, M. Berg, 1985, Journal of medicinal chemistry.

Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification.

Jackie S. Scott, Alan Wise, A. Muir, 2007, Bioorganic & medicinal chemistry letters.

2-(Aryloxymethyl) azacyclic analogues as novel nicotinic acetylcholine receptor (nAChR) ligands

S. Arneric, J. Sullivan, D. Garvey, 1996 .

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.

Siew K. Yeap, M. Ultsch, C. Eigenbrot, 2022, Journal of medicinal chemistry.

Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.

Siew K. Yeap, C. Eigenbrot, Ivana Yen, 2016, Journal of medicinal chemistry.

Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.

Belen Dominguez-Fernandez, C. Eigenbrot, Ivana Yen, 2015, Journal of medicinal chemistry.

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.

R. McPherson, L. Tong, E. Marr, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and anthelmintic activity of a series of pyrazino[2,1-a][2]benzazepine derivatives.

R. Elliott, B. Manger, R. A. Webster, 1989, Journal of medicinal chemistry.

Cycloadditions of cephalosporins. A general synthesis of novel 2,3-fused cyclobutane and cyclobutene cephems

A. Takle, J. Tyler, R. Elliott, 1993 .

Synthesis of Some Cephem Spiroacetal-Lactones

G. Burton, R. Elliott, J. Bateson, 1994 .

Anhydrolide macrolides. 1. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbamate erythromycin A analogues.

R. Henry, J. Plattner, R. Flamm, 1998, Journal of Medicinal Chemistry.

Anhydrolide macrolides. 2. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbazate erythromycin A analogues.

J. Plattner, R. Flamm, P. Ewing, 1998, Journal of Medicinal Chemistry.

The preparation of 2-(heterocyclyl)thikno[3,2-b]pyridine derivatives

R. Elliott, P. O'hanlon, N. H. Rogers, 1987 .

Structure-activity relationships in a series of NPY Y5 antagonists: 3-amido-9-ethylcarbazoles, core-modified analogues and amide isosteres.

C. Mack, Robert M. Oliver, R. Hank, 2003, Bioorganic & medicinal chemistry letters.

Functional Characterization of the Novel Neuronal Nicotinic Acetylcholine Receptor Ligand GTS-21 In Vitro and In Vivo

W. J. Jackson, D. Donnelly-roberts, S. Arneric, 1997, Pharmacology Biochemistry and Behavior.

Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists.

A. Naylor, A. Takle, J. Witherington, 2006, Bioorganic & medicinal chemistry letters.

Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles.

A. K. Forrest, BinQing Wei, M. Ultsch, 2017, ACS medicinal chemistry letters.

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).

Hoai An Le Thi, E. Gancia, BinQing Wei, 2021, ACS medicinal chemistry letters.

Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity.

A. Kalgutkar, T. Maurer, D. Scott, 2010, Bioorganic & medicinal chemistry letters.

Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs).

E. Demont, A. Naylor, A. Takle, 2009, Bioorganic & medicinal chemistry letters.

Piperidine-Derived γ-Secretase Modulators.

I. Hussain, Alan Naylor, Beverley Smith, 2010 .

Phosphonoethylphenylalanine derivatives as novel antagonists of non-NMDA ionotropic glutamate receptors

R. Patch, J. Ferkany, D. L. Bednar, 1992 .

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).

Hoai An Le Thi, E. Gancia, Weiru Wang, 2021, ACS medicinal chemistry letters.