R. K. Hom

发表

Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents.

H. Sham, N. Yao, T. Yednock, 2010, Bioorganic & medicinal chemistry letters.

Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.

R. Neitz, H. Sham, N. Yao, 2011, Bioorganic & medicinal chemistry letters.

Determination of the absolute configuration of the nonsteroidal contraceptive agent centchroman by X-ray crystallography on its N-methyl iodide salt

Scott R. Wilson, J. Katzenellenbogen, I. Dwivedy, 1996 .

Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.

G. Tóth, R. Neitz, H. Sham, 2010, Bioorganic & medicinal chemistry letters.

Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.

G. Tóth, H. Sham, N. Yao, 2011, Bioorganic & medicinal chemistry letters.

Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.

H. Sham, T. Yednock, M. Bova, 2009, Bioorganic & medicinal chemistry letters.

Heterodimeric Bis(amino thiol) Complexes of Oxorhenium(V) That Mimic the Structure of Steroid Hormones. Synthesis and Stereochemical Issues.

J. Katzenellenbogen, D. Chi, R. K. Hom, 1996, The Journal of organic chemistry.

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.

R. Motter, D. Kholodenko, H. Sham, 2010, Bioorganic & medicinal chemistry letters.

Stereoselective elaboration of side chain residues in cyclopropane-containing dipeptide isosteres

S. Martin, R. K. Hom, 1999 .

A facile synthesis of multigram quantity of ethyl 3-ethylmorpholine-3-carboxylate

H. Sham, L. Latimer, D. Quincy, 2011 .

Technetium-99m-labeled receptor-specific small-molecule radiopharmaceuticals: recent developments and encouraging results.

J. Katzenellenbogen, R. K. Hom, 1997, Nuclear medicine and biology.

Design of Substrate-Based Inhibitors of Human β-Secretase

Eugene D. Thorsett, E. Thorsett, S. Sinha, 2002 .

Synthesis of enantiomerically pure vinylcyclopropanes by SN2′ allylic carboxylate displacements

M. Dwyer, S. Martin, R. K. Hom, 1999 .

Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain

Kent Fitzgerald, Paul Beroza, Lee Latimer, 2013, ChemMedChem.

Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.

P. Beroza, R. Motter, R. Neitz, 2013, Bioorganic & medicinal chemistry letters.

Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.

Paul Beroza, Zhao Ren, Dean R Artis, 2013, Bioorganic & medicinal chemistry letters.

Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.

John-Michael Sauer, Zhao Ren, Dean R Artis, 2011, Bioorganic & medicinal chemistry letters.

Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitor

R. Motter, D. Kholodenko, H. Sham, 2013, Journal of medicinal chemistry.

Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.

P. Beroza, Jiangli Yan, H. Sham, 2013, Bioorganic & medicinal chemistry letters.

Design and synthesis of statine-based cell-permeable peptidomimetic inhibitors of human beta-secretase.

Eugene D. Thorsett, E. Thorsett, S. Sinha, 2003, Journal of medicinal chemistry.

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.

G. Tóth, H. Sham, N. Yao, 2010, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Hydroxyethylene-Based Peptidomimetic Inhibitors of Human β-Secretase

Joseph B. Moon, Eugene D. Thorsett, E. Thorsett, 2004 .

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.

R. Neitz, M. Adler, H. Sham, 2012, Bioorganic & medicinal chemistry letters.

Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase.

Joseph B. Moon, Michel Maillard, Alfredo G. Tomasselli, 2007, Journal of medicinal chemistry.

Design of substrate-based inhibitors of human beta-secretase.

E. Thorsett, S. Sinha, John P. Anderson, 2002, Journal of medicinal chemistry.

Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase.

E. Thorsett, N. Jewett, J. Tung, 2004, Journal of medicinal chemistry.

N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase.

H. Sham, M. Bova, J. Sauer, 2009, Bioorganic & medicinal chemistry letters.

R. Motter, D. Kholodenko, H. Sham, 2013, Journal of medicinal chemistry.

Correction: Label Free Fragment Screening Using Surface Plasmon Resonance as a Tool for Fragment Finding – Analyzing Parkin, a Difficult CNS Target

P. Beroza, K. Regnström, Jiangli Yan, 2013, PLoS ONE.

Label Free Fragment Screening Using Surface Plasmon Resonance as a Tool for Fragment Finding – Analyzing Parkin, a Difficult CNS Target

P. Beroza, K. Regnström, Jiangli Yan, 2013, PloS one.

Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents.

John-Michael Sauer, Gergely Toth, G. Tóth, 2009, Bioorganic & medicinal chemistry letters.

Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain

P. Beroza, R. Motter, R. Neitz, 2013, ChemMedChem.