J. Jiráček

发表

Effects of hyperhomocysteinemia and betaine-homocysteine S-methyltransferase inhibition on hepatocyte metabolites and the proteome.

Z. Demianová, I. Selicharová, Marek Kořínek, 2013, Biochimica et biophysica acta.

Structural and Functional Study of the GlnB22-Insulin Mutant Responsible for Maturity-Onset Diabetes of the Young

A. Brzozowski, V. Veverka, L. Maletínská, 2014, PloS one.

Efficient synthesis of phosphonodepsipeptides derived from norleucine

J. Pícha, M. Buděšínský, V. Vaněk, 2009 .

Structural Integrity of the B24 Site in Human Insulin Is Important for Hormone Functionality*

A. Brzozowski, J. Turkenburg, V. Veverka, 2013, The Journal of Biological Chemistry.

Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues

A. Brzozowski, J. Turkenburg, C. J. Watson, 2010, Proceedings of the National Academy of Sciences.

A radioligand binding assay for the insulin-like growth factor 2 receptor

J. Radosavljević, K. Nováková, L. Žáková, 2020, PloS one.

Radiolabeled hormones in insulin research, a minireview.

L. Žáková, J. Jiráček, A. Marek, 2020, Journal of labelled compounds & radiopharmaceuticals.

Converting Insulin-like Growth Factors 1 and 2 into High-Affinity Ligands for Insulin Receptor Isoform A by the Introduction of an Evolutionarily Divergent Mutation.

A. Brzozowski, J. Radosavljević, M. Fábry, 2018, Biochemistry.

Insulin-Insulin-like Growth Factors Hybrids as Molecular Probes of Hormone:Receptor Binding Specificity.

A. Brzozowski, V. Vaněk, L. Žáková, 2016, Biochemistry.

Cross-Linking/Mass Spectrometry Uncovers Details of Insulin-Like Growth Factor Interaction With Insect Insulin Binding Protein Imp-L2

A. Brzozowski, J. Radosavljević, P. Pompach, 2019, Front. Endocrinol..

Mapping the peptide and protein immune response in the larvae of the fleshfly Sarcophaga bullata

M. Mackova, Z. Voburka, J. Cvačka, 2008, Journal of peptide science : an official publication of the European Peptide Society.

Optimized syntheses of Fmoc azido amino acids for the preparation of azidopeptides

J. Pícha, M. Buděšínský, J. Jiráček, 2017, Journal of peptide science : an official publication of the European Peptide Society.

Insulin and Insulin-like Growth Factor II Differentially Regulate Endocytic Sorting and Stability of Insulin Receptor Isoform A*

A. Brzozowski, R. Iozzo, A. Belfiore, 2012, The Journal of Biological Chemistry.

Synthesis and Evaluation of a Library of Trifunctional Scaffold-Derived Compounds as Modulators of the Insulin Receptor.

J. Pícha, M. Buděšínský, V. Vaněk, 2016, ACS combinatorial science.

Phosphinic Peptide Libraries for Proteolytic Enzymes

V. Dive, A. Yiotakis, J. Jiráček, 1999 .

Insulin Analogues with Altered Insulin Receptor Isoform Binding Specificities and Enhanced Aggregation Stabilities.

J. Pícha, L. Žáková, I. Selicharová, 2021, Journal of medicinal chemistry.

Phosphinic acid compounds in biochemistry, biology and medicine.

J. Jiráček, M. Collinsová, 2000, Current medicinal chemistry.

Acid-Stable Ester Linkers for the Solid-Phase Synthesis of Immobilized Peptides.

J. Pícha, M. Buděšínský, J. Jiráček, 2020, ChemPlusChem.

Effect of a novel selective and potent phosphinic peptide inhibitor of endopeptidase 3.4.24.16 on neurotensin‐induced analgesia and neuronal inactivation

B. Roques, F. Checler, B. Vincent, 1997, British journal of pharmacology.

Changes in the proteomes of the hemocytes and fat bodies of the flesh fly Sarcophaga bullata larvae after infection by Escherichia coli

M. Sanda, I. Selicharová, J. Jiráček, 2010, Proteome Science.

Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats.

J. Straková, R. Rozen, W. Kruger, 2010, Nutrition research.

Analysis and characterization of phosphinic pseudopeptides by capillary zone electrophoresis

V. Kašička, T. Garrow, D. Koval, 2002, Electrophoresis.

A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding

M. Hubálek, J. Pícha, M. Buděšínský, 2018, The Journal of Biological Chemistry.

Dietary intake of S -( α -carboxybutyl)- DL -homocysteine induces hyperhomocysteinemia in rats

J. Straková, S. Gupta, R. Rozen, 2010 .

Separation of semisynthetic insulin analogues by capillary electrophoresis

M. Machová, T. Barth, V. Kašička, 1993 .

From venom peptides to a potential diabetes treatment

L. Žáková, J. Jiráček, 2019, eLife.

The use of Fmoc‐Lys(Pac)‐OH and penicillin G acylase in the preparation of novel semisynthetic insulin analogs

J. Ježek, A. Brzozowski, M. Sanda, 2007, Journal of peptide science : an official publication of the European Peptide Society.

How insulin engages its primary binding site on the insulin receptor

Andrzej M. Brzozowski, Colin W. Ward, Christopher J. Watson, 2013, Nature.

Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity.

L. Kazdová, M. Buděšínský, M. Sanda, 2008, Biochemistry.

Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice.

J. Straková, T. Garrow, J. Jiráček, 2006, The Journal of nutrition.

S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors.

G. Salvesen, M. Poręba, C. Klein, 2012, Biochimie.

Characterization of insulin crystalline form in isolated β-cell secretory granules

A. Brzozowski, J. Moravcová, J. Nováček, 2022, Open Biology.

Semisynthetic insulin analogues modified in positions B24, B25 and B29.

T. Barth, V. Kašička, K. Ubik, 1994, Biological chemistry Hoppe-Seyler.

S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase.

M. Buděšínský, I. Rosenberg, T. Garrow, 2006, Journal of medicinal chemistry.

Unusual activity pattern of leucine aminopeptidase inhibitors based on phosphorus containing derivatives of methionine and norleucine

J. Pícha, M. Buděšínský, A. Mucha, 2011, Journal of enzyme inhibition and medicinal chemistry.

Synthesis of α-carboxyphosphinopeptides derived from norleucine

J. Pícha, M. Buděšínský, M. Sanda, 2010, Amino Acids.

Synthesis of methionine- and norleucine-derived phosphinopeptides

J. Pícha, M. Buděšínský, M. Sanda, 2008 .

A CuAAC–Hydrazone–CuAAC Trifunctional Scaffold for the Solid-Phase Synthesis of Trimodal Compounds: Possibilities and Limitations

J. Pícha, M. Buděšínský, V. Vaněk, 2015, Molecules.

Development of the First Potent and Selective Inhibitor of the Zinc Endopeptidase Neurolysin Using a Systematic Approach Based on Combinatorial Chemistry of Phosphinic Peptides*

F. Checler, B. Vincent, V. Dive, 1996, The Journal of Biological Chemistry.

Determination of pKa values of diastereomers of phosphinic pseudopeptides by CZE

V. Kašička, D. Koval, J. Jiráček, 2006, Electrophoresis.

The development of a new class of inhibitors for betaine-homocysteine S-methyltransferase.

J. Pícha, M. Buděšínský, T. Garrow, 2013, European journal of medicinal chemistry.

Protection of the Hydroxyphosphinyl Function of Phosphinic Dipeptides by Adamantyl. Application to the Solid-Phase Synthesis of Phosphinic Peptides.

V. Dive, S. Vassiliou, A. Yiotakis, 1996, The Journal of organic chemistry.

A new colorimetric assay for methionyl aminopeptidases: examination of the binding of a new class of pseudopeptide analog inhibitors.

S. Mitra, R. Holz, L. Žáková, 2006, Analytical biochemistry.

Synthesis of norleucine-derived phosphonopeptides

J. Pícha, M. Buděšínský, M. Sanda, 2008 .

Combining combinatorial chemistry and affinity chromatography: highly selective inhibitors of human betaine: homocysteine S-methyltransferase.

V. Dive, T. Garrow, A. Yiotakis, 2003, Chemistry & biology.

RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites.

P Corvol, P Cuniasse, A Yiotakis, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Development of Highly Potent and Selective Phosphinic Peptide Inhibitors of Zinc Endopeptidase 24-15 Using Combinatorial Chemistry (*)

F. Checler, V. Dive, A. Nicolaou, 1995, The Journal of Biological Chemistry.

Multipodal insulin mimetics built on adamantane or proline scaffolds.

R. Pohl, P. Hobza, M. Lepšík, 2020, Bioorganic chemistry.

Tri-Orthogonal Scaffolds for the Solid-Phase Synthesis of Peptides

J. Pícha, M. Buděšínský, B. Fabre, 2018, European Journal of Organic Chemistry.

The Development of a Versatile Trifunctional Scaffold for Biological Applications

M. Lepšík, J. Pícha, M. Buděšínský, 2015 .

Physicochemical characterization of phosphinic pseudopeptides by capillary zone electrophoresis in highly acidic background electrolytes

V. Kašička, D. Koval, J. Jiráček, 2003, Electrophoresis.

Separation of diastereomers of phosphinic pseudopeptides by capillary zone electrophoresis and reverse phase high‐performance liquid chromatography

V. Kašička, D. Koval, J. Jiráček, 2003 .

Betaine-homocysteine methyltransferase: zinc in a distorted barrel.

J. C. Evans, M. Ludwig, D. Huddler, 2002, Structure.

Simplified syntheses of the water-soluble chiral shift reagents Sm-(R)-pdta and Sm-(S)-pdta

J. Pícha, M. Buděšínský, V. Vaněk, 2013 .

Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase.

J. Brynda, M. Kožíšek, M. Buděšínský, 2009, Journal of medicinal chemistry.

Specific potassium ion interactions facilitate homocysteine binding to betaine‐homocysteine S‐methyltransferase

P. Jungwirth, Kazuhiro Yamada, T. Garrow, 2014, Proteins.

Quantification of homocysteine-related metabolites and the role of betaine-homocysteine S-methyltransferase in HepG2 cells.

I. Selicharová, Marek Kořínek, Jana Mládková, 2013, Biomedical chromatography : BMC.

Double-headed sulfur-linked amino acids as first inhibitors for betaine-homocysteine S-methyltransferase 2.

Z. Demianová, M. Buděšínský, T. Garrow, 2012, Journal of medicinal chemistry.

Evaluation of carrier ampholyte‐based capillary electrophoresis for separation of peptides and peptide mimetics

Jean-Marc Busnel, V. Kašička, G. Peltre, 2008, Electrophoresis.

Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis.

J. C. Evans, M. Ludwig, T. Garrow, 2004, Biochemistry.

Analysis and characterization of phosphinic pseudopeptides by capillary zone electrophoresis

V. Kašička, T. Garrow, D. Koval, 2002, Electrophoresis.

Gene expression responses in larvae of the fleshfly Sarcophaga bullata after immune stimulation.

M. Kubista, R. Sindelka, J. Kindl, 2009, Folia biologica.

Activation of murine RNase L by isopolar 2'-phosphonate analogues of 2',5' oligoadenylates.

M. Buděšínský, I. Rosenberg, M. Masojídková, 2006, Journal of medicinal chemistry.

Examination of the role of endopeptidase 3.4.24.15 in Aβ secretion by human transfected cells

M. Goedert, F. Checler, B. Vincent, 1997, British journal of pharmacology.

Inhibitors of Nα-acetyl-l-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency

J. Pícha, J. Slaninová, M. Buděšínský, 2010, Amino Acids.

Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs

L. Žáková, J. Jiráček, 2017, Front. Endocrinol..

Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules

A. Brzozowski, J. Turkenburg, P. Jungwirth, 2017, The Journal of Biological Chemistry.

Two-dimensional electrophoretic comparison of metastatic and non-metastatic human breast tumors using in vitro cultured epithelial cells derived from the cancer tissues

E. Matoušková, J. Vydra, M. Sanda, 2008, BMC Cancer.

2‐DE analysis of a new human cell line EM‐G3 derived from breast cancer progenitor cells and comparison with normal mammary epithelial cells

E. Matoušková, K. Ubik, J. Vydra, 2007, Proteomics.

Rational steering of insulin binding specificity by intra-chain chemical crosslinking

A. Brzozowski, J. Turkenburg, V. Veverka, 2016, Scientific Reports.

Mono-N-acyl-2,6-diaminopimelic acid derivatives: analysis by electromigration and spectroscopic methods and examination of enzyme inhibitory activity.

D. Gillner, J. Pícha, I. Mikšík, 2014, Analytical biochemistry.

2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: comparison with parental cell line MDA-MB-231.

V. Vetvicka, S. Ohri, M. Fusek, 2008, Oncology reports.

The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels

A. Brzozowski, J. Turkenburg, P. Šácha, 2020, Open Biology.

Can Arginine Inhibit Insulin Aggregation? A Combined Protein Crystallography, Capillary Electrophoresis, and Molecular Simulation Study.

A. Brzozowski, P. Jungwirth, E. Duboué-Dijon, 2018, The journal of physical chemistry. B.

Pressure assisted partial filling affinity capillary electrophoresis employed for determination of binding constants of human insulin hexamer complexes with serotonin, dopamine, arginine, and phenol.

V. Kašička, Veronika Šolínová, L. Žáková, 2019, Analytica chimica acta.

Characterization of viral insulins reveals white adipose tissue-specific effects in mice

C. Kahn, R. Friedline, Emrah Altindis, 2020, Molecular metabolism.

Characterization of Viral Insulins Reveals White Adipose Tissue Specific Effects in Mice

C. Kahn, R. Friedline, Emrah Altindis, 2020, bioRxiv.

Preparation and characterization of two LysB29 specifically labelled fluorescent derivatives of human insulin

T. Barth, J. Barthová, Alice Ciencialová, 2004, Journal of peptide science : an official publication of the European Peptide Society.

Contribution of endopeptidase 3.4.24.15 to central neurotensin inactivation.

B. Roques, F. Checler, B. Vincent, 1997, European journal of pharmacology.

Probing Tripodal Peptide Scaffolds as Insulin and IGF-1 Receptor Ligands

J. Pícha, B. Fabre, L. Žáková, 2018, European Journal of Organic Chemistry.

Shortened insulin analogues: marked changes in biological activity resulting from replacement of TyrB26 and N-methylation of peptide bonds in the C-terminus of the B-chain.

Š. Zórad, T. Barth, J. Barthová, 2004, Biochemistry.

Targeting the insulin receptor with hormone and peptide dimers

M. Lepšík, B. Fabre, I. Selicharová, 2022, Journal of peptide science : an official publication of the European Peptide Society.

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses

P. Hobza, J. Radosavljević, M. Lepšík, 2019, The Journal of Biological Chemistry.

Insulin-like Growth Factor 1 Analogs Clicked in the C Domain: Chemical Synthesis and Biological Activities.

A. Brzozowski, J. Pícha, M. Buděšínský, 2017, Journal of medicinal chemistry.

Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain*

Zdeněk Tošner, V. Veverka, P. Srb, 2016, The Journal of Biological Chemistry.

Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex

A. Brzozowski, J. Turkenburg, C. J. Watson, 2014, Acta crystallographica. Section D, Biological crystallography.

Insight into the Structural and Biological Relevance of the T/R Transition of the N-Terminus of the B-Chain in Human Insulin

A. Brzozowski, J. Turkenburg, V. Veverka, 2014, Biochemistry.

Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2

A. Brzozowski, Jakub Kaminský, L. Žáková, 2023, bioRxiv.

Recombinant Insulin-Like Growth Factor 1 Dimers: Receptor Binding Affinities and Activation Abilities

Jakub Kaminský, I. Selicharová, J. Jiráček, 2023, International Journal of Peptide Research and Therapeutics.

Side reactions during photochemical cleavage of an α‐methyl‐6‐nitroveratryl‐based photolabile linker

M. Nováková, V. Kašička, J. Jiráček, 2000, Journal of peptide science : an official publication of the European Peptide Society.

Non-equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface*

A. Cooper, A. Brzozowski, J. Turkenburg, 2011, The Journal of Biological Chemistry.

A radioligand receptor binding assay for measuring of insulin secreted by MIN6 cells after stimulation with glucose, arginine, ornithine, dopamine, and serotonin

L. Žáková, I. Selicharová, J. Jiráček, 2021, Analytical and Bioanalytical Chemistry.

Modulation of the antagonistic properties of an insulin mimetic peptide by disulfide bridge modifications

J. Pícha, M. Buděšínský, L. Žáková, 2023, Journal of peptide science : an official publication of the European Peptide Society.

Chiral analysis of -alanyl-d,l-tyrosine and its derivatives and estimation of binding constants of their complexes with 2-hydroxypropyl-β-cyclodextrin by capillary electrophoresisS.

V. Kašička, P. Sázelová, Veronika Šolínová, 2022, Journal of Separation Science.

Application of Capillary and Free-Flow Zone Electrophoresis for Analysis and Purification of Antimicrobial β-Alanyl-Tyrosine from Hemolymph of Fleshfly Neobellieria bullata

V. Kašička, P. Sázelová, Veronika Šolínová, 2021, Molecules.

Side reactions during photochemical cleavage of an α‐methyl‐6‐nitroveratryl‐based photolabile linker

M. Nováková, V. Kašička, J. Jiráček, 2000 .

A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression

R. DiMarchi, Emrah Altindis, L. Žáková, 2024, Molecular metabolism.

Functional stapled fragments of human preptin of minimised length.

Jakub Kaminský, J. Pícha, M. Buděšínský, 2022, Organic & biomolecular chemistry.

An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin.

Veverka, A. Brzozowski, J. Turkenburg, 2014 .