M. Iwao

发表

Synthetic Approach to Telomerase Inhibitor Dictyodendrin B: Synthesis of the Pyrrolo[2,3-c]carbazole Core

S. Hirao, Y. Sugiyama, M. Iwao, 2009, Bioscience, biotechnology, and biochemistry.

Synthesis of 7‐Substituted Indolines via Directed Lithiation of 1‐(tert‐Butoxycarbonyl)Indoline: 7‐Indolinecarboxaldehyde

M. Iwao, T. Kuraishi, 2003 .

Directed C-7 lithiation of 1-(2,2-diethylbutanoyl)indoles

M. Iwao, T. Fukuda, Ryoichi Maeda, 1999 .

Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: unique effects of the axial chirality on the selectivity of protein kinases inhibition.

L. Meijer, O. Lozach, N. Loaëc, 2013, Journal of medicinal chemistry.

Lamellarin alkaloids: Isolation, synthesis, and biological activity.

M. Iwao, F. Ishibashi, T. Fukuda, 2020, The Alkaloids. Chemistry and biology.

Modular synthesis of lamellarins via regioselective assembly of 3,4,5-differentially arylated pyrrole-2-carboxylates.

M. Iwao, T. Fukuda, Masashi Komatsubara, 2014, The Journal of organic chemistry.

Design and Synthesis of Lamellarin D Analogues Targeting Topoisomerase I

T. Ohta, M. Iwao, F. Ishibashi, 2010 .

Total Syntheses of Lamellarin D and H. The First Synthesis of Lamellarin‐Class Marine Alkaloids.

M. Iwao, F. Ishibashi, Y. Miyazaki, 1997 .

Synthesis and Biological Activity of Lamellarin Alkaloids: An Overview

M. Iwao, F. Ishibashi, T. Fukuda, 2011 .

Synthesis, structure-activity relationships, and mechanism of action of anti-HIV-1 lamellarin α 20-sulfate analogues.

N. Yamamoto, Y. Kubo, Hironori Sato, 2011, Bioorganic & medicinal chemistry.

Total synthesis of lamellarins D, L, and N

Naotaka Fujikawa, T. Ohta, Tomohiro Yamaguchi, 2006 .

Synthesis and structure-activity relationship study of lamellarin derivatives.

T. Oda, M. Iwao, F. Ishibashi, 2002, Journal of natural products.

Determination of sulphur heterocycles in selected synfuels

Milton L. Lee, R. Pratap, R. Castle, 1984 .

Determination of sulfur heterocycles in coal liquids and shale oils

Milton L. Lee, R. Castle, M. Iwao, 1981 .

Mesogenic polysiloxane stationary phase for high-resolution gas chromatography of isomeric polycyclic aromatic compounds

Milton L. Lee, R. Pratap, R. Castle, 1982 .

Total synthesis of the marine natural products lukianols A and B

J. Tanaka, M. Iwao, F. Ishibashi, 2013 .

Assignment of the 1H- and 13C-NMR spectra of phenanthro[1,2-b]thiophene through the concerted application of two-dimensional NMR spectroscopic techniques

Milton L. Lee, G. Martin, M. R. Willcott, 1983 .

Combined application of auto-correlated (COSY) and homonuclear J-resolved two-dimensional nmr spectra for the assignment of congested, non-first order spectra of polycyclic aromatic systems: assignment of the 1H-nmr spectrum of benzo[2,3]phenanthro[4,5-bcd]thiophene and an investigation of long rang

Milton L. Lee, R. Gampe, G. Martin, 1984 .

Methodology for the efficient synthesis of 3,4-differentially substituted indoles. Fluoride ion-induced elimination-addition reaction of 1-triisopropylsilylgramine methiodides

M. Iwao, Osamu Motoi, 1995 .

SYNTHESIS OF BOTH ENANTIOMERS OF PROTOBERBERINES VIA LATERALLY LITHIATED (S)-4-ISOPROPYL-2-(o-TOLYL)OXAZOLINES

M. Iwao, T. Fukuda, 2007 .

Synthesis of (±)-sesbanine via directed metalation of tertiary nicotinamides

M. Iwao, T. Kuraishi, 1983 .

The facile synthesis of some N-heleroarylacetic esters

M. Iwao, T. Kuraishi, 1978 .

Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure-activity relationships.

C. Bailly, F. Gago, E. Marco, 2005, Journal of medicinal chemistry.

Synthesis and Biological Activity of Lamellarin Alkaloids: An Overview

M. Iwao, F. Ishibashi, T. Fukuda, 2011 .

GENERATION AND DIELS–ALDER REACTION OF 1-SILOXY-3-ARYLISOBENZOFURANS FROM 3-ARYLPHTHALIDES

M. Iwao, T. Kuraishi, H. Inoue, 1984 .

Synthesis of bostrycoidin via directed lithiation of tertiary nicotinamide

M. Iwao, T. Kuraishi, S. Furukawa, 1987 .

Design and synthesis of lamellarin D analogues targeting topoisomerase I.

Fumito Ishibashi, Masatomo Iwao, T. Ohta, 2009, The Journal of organic chemistry.

Synthesis of Both Enantiomers of Protoberberines via Laterally Lithiated (S)-4-Isopropyl-2-(o-tolyl)-oxazolines.

M. Iwao, T. Fukuda, 2008 .

Short and flexible route to 3,4-diarylpyrrole marine alkaloids: syntheses of permethyl storniamide A, ningalin B, and lamellarin G trimethyl ether

Naotaka Fujikawa, M. Iwao, F. Ishibashi, 2003 .

Directed lithiation of chlorobenzenes. Regioselectivity and application to a short synthesis of benzocyclobutenes

M. Iwao, 1990 .

Synthesis of 3,4,5-trisubstituted indoles via iterative directed lithiation of 1-(triisopropylsilyl)gramines

M. Iwao, T. Fukuda, H. Akashima, 2005 .

Anticancer Alkaloid Lamellarins Inhibit Protein Kinases

Poonsakdi Ploypradith, Olivier Lozach, Laurent Meijer, 2008, Marine drugs.

Asymmetric synthesis of 3-substituted 8-hydroxy-3,4-dihydroisocoumarins from (S)-4-isopropyl-2-(2-methoxy-6-methylphenyl)oxazoline

M. Iwao, T. Fukuda, Katsuya Uchida, 2007 .

Synthesis of 3-substituted 8-hydroxy-3,4-dihydroisocoumarins via successive lateral and ortho-lithiations of 4,4-dimethyl-2-(o-tolyl)oxazoline

M. Iwao, T. Fukuda, N. Tahara, 2004 .

The first total synthesis of veiutamine, a new type of pyrroloiminoquinone marine alkaloid

M. Iwao, T. Fukuda, Yoshihiro Moro-oka, 1999 .

A concise total synthesis of (±)-cis-and (±)-trans-clavicipitic acids by combinational use of directed lithiation and flouride ion-induced elimination-addition reaction of 1-(triisopropylsilyl)gramine derivatives

M. Iwao, F. Ishibashi, 1997 .

New synthetic approach to pyrroloiminoquinone marine alkaloids. Total synthesis of makaluvamines A, D, I, and K

M. Iwao, F. Ishibashi, T. Fukuda, 1998 .

Isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds as hypoglycemic agents.

S. Onogi, H Shinkai, S Onogi, 1998, Journal of medicinal chemistry.

Divergent Synthesis of Lamellarin α 13-Sulfate, 20-Sulfate, and 13,20-Disulfate

Masatomo Iwao, T. Ohta, Tsutomu Fukuda, 2010 .

A formal total synthesis of the telomerase inhibitor dictyodendrin B

M. Iwao, F. Ishibashi, Shotaro Hirao, 2010 .

A GENERAL METHOD FOR THE SYNTHESIS OF N-UNSUBSTITUTED 3,4-DIARYLPYRROLE-2,5-DICARBOXYLATES

Masatomo Iwao, Tsutomu Fukuda, Yukie Hayashida, 2009 .

Palladium-catalyzed cross-coupling of N-benzenesulfonyl-3,4-dibromopyrrole and its application to the total syntheses of lamellarins O, P, Q, and R

Masatomo Iwao, Tsutomu Fukuda, Ei-ichi Sudo, 2008 .

The first total synthesis of lamellarin α 20-sulfate, a selective inhibitor of HIV-1 integrase

Tomohiro Yamaguchi, M. Iwao, F. Ishibashi, 2006 .

Short and Flexible Route to 3,4-Diarylpyrrole Marine Alkaloids: Syntheses of Permethyl Storniamide A (I), Ningalin B (II), and Lamellarin G Trimethyl Ether (III).

Naotaka Fujikawa, M. Iwao, F. Ishibashi, 2003 .

Total Syntheses of Lamellarin D and H. The First Synthesis of Lamellarin-Class Marine Alkaloids

M. Iwao, F. Ishibashi, Y. Miyazaki, 1997 .

Synthesis and thermolysis of N-heteroarylacetylazides and α-oximino-α-(N-heteroaryl)acetylazides

M. Iwao, T. Kuraishi, 1979 .

A novel naphthoquinone synthesis via tandem directed lithiations

M. Iwao, T. Kuraishi, 1985 .

New routes to the pyrrolo[2,1-a]isoquinoline system.

M. Iwao, T. Kuraishi, 1980 .

The oxidation of s-triazolo[4,3-b]pyridazines with selenium dioxide

M. Iwao, T. Kuraishi, 1976 .

Synthesis of Non-Steroidal Estrogen Receptor Antagonists R1128 A, B, C, and D via an Oxazoline-Promoted Iterative ortho-Lithiation Strategy

M. Iwao, T. Fukuda, Koichiro Fukushima, 2012 .

Optional ortho and lateral lithiations of 4,4-dimethyl-2-(o-tolyl)oxazolines

M. Iwao, T. Fukuda, N. Tahara, 2002 .

Directed Lithiation of Chlorobenzenes. Regioselectivity and Application to a Short Synthesis of Benzocyclobutenes.

M. Iwao, 1990 .

Remarkable effect of water in a regioselective lithiation of 5-(tert-butoxycarbonyl)-7-methoxy-1-methyl-1,3,4,5-tetrahydropyrrolo[4,3,2-de]quinoline

M. Iwao, T. Fukuda, Yoshihiro Moro-oka, 2000 .

Synthesis of 3,4,5‐Trisubstituted Indoles via Iterative Directed Lithiation of 1‐(Triisopropylsilyl)gramines.

M. Iwao, T. Fukuda, H. Akashima, 2005 .

A formal synthesis of optically active clavicipitic acids, unusual azepinoindole-type ergot alkaloids

M. Iwao, T. Fukuda, H. Shinohara, 1999 .

Directed lithiation of 1-triisopropylsilylgramine: a short access to 3,4-disubstituted indoles

M. Iwao, 1993 .

Directed lithiation of 1-(tert-butoxycarbonyl)indolines. A convenient route to 7-substituted indolines

M. Iwao, T. Kuraishi, 1992 .

Concise synthesis and in vitro anticancer activity of benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-ones (BBPIs), topoisomerase I inhibitors based on the marine alkaloid lamellarin.

Shijiao Zha, M. Iwao, F. Ishibashi, 2021, Bioscience, biotechnology, and biochemistry.

Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.

H. To, M. Fujimoto, Fumiyasu Okazaki, 2019, Bioorganic & medicinal chemistry.

Selective C-3 and C-2 lithiation of 1-(2,2-diethylbutanoyl)indole

M. Iwao, T. Fukuda, Yuka Mine, 2001 .

Asymmetric synthesis of 3-substituted 3,4-dihydroisocoumarins via stereoselective addition of laterally lithiated chiral 2-(o-tolyl)oxazolines to aldehydes followed by diastereomer-selective lactonization

M. Iwao, T. Fukuda, Yuji Kurosaki, 2005 .

Synthesis of chiral primary 1-ferrocenylalkylamines via highly diastereoselective addition of organolithium compounds to ferrocenecarboxaldehyde imine derived from (S)-2-methoxy-1-phenylethylamine

M. Iwao, T. Fukuda, Akihiro Takehara, 2000 .

Palladium-catalyzed asymmetric allylic alkylation using iminophosphine ligands derived from chiral primary 1-ferrocenylalkylamines

M. Iwao, T. Fukuda, Akihiro Takehara, 2001 .

Synthesis of 3-Substituted 8-Hydroxy-3,4-dihydroisocoumarins via Successive Lateral and ortho-Lithiations of 4,4-Dimethyl-2-(o-totyl)oxazoline.

M. Iwao, T. Fukuda, N. Tahara, 2004 .

Optional Synthesis of 2- or 5-Substituted 3-Bromopyrroles via Bromine-Lithium Exchange of N-Benzenesulfonyl-2,4-dibromopyrrole

M. Iwao, T. Fukuda, 2012 .

Directed ortho metallation of tertiary aromatic amides

V. Snieckus, K. K. Mahalanabis, M. Iwao, 1983 .

Directed metalation of tertiary benzamides. Ortho N-aryl amination and synthesis of acridones

V. Snieckus, M. Iwao, J. Reed, 1982 .

Enantioselective synthesis of planar chiral azaferrocenes via chiral ligand-mediated ring- and lateral-lithiations

M. Iwao, T. Fukuda, Kengo Imazato, 2003 .

Utilization of Sulfide, Sulfoxide, and Sulfone Groups as Regiochemical Control Elements in the Diels–Alder Reaction of Naphthoquinones

M. Iwao, T. Kuraishi, 1987 .

Capillary Column Gas Chromatographic Resolution of Isomeric Polycyclic Aromatic Sulfur Heterocycles in a Coal Liquid

S. Wise, Milton L. Lee, R. Pratap, 1982 .

Infection of XC Cells by MLVs and Ebola Virus Is Endosome-Dependent but Acidification-Independent

H. Hayashi, T. Matsuyama, N. Yamamoto, 2011, PloS one.

Microbial mutagenicity of 3- and 4-ring polycyclic aromatic sulfur heterocycles.

M. Lee, R. Castle, M. Iwao, 1983, Mutation research.

Synthesis and evaluation of azalamellarin N and its A-ring-modified analogues as non-covalent inhibitors of the EGFR T790M/L858R mutant.

Y. Uehara, K. Yamashita, M. Iwao, 2021, Bioorganic & medicinal chemistry.

Design, synthesis, and evaluation of A-ring-modified lamellarin N analogues as noncovalent inhibitors of the EGFR T790M/L858R mutant.

Y. Uehara, M. Iwao, F. Ishibashi, 2017, Bioorganic & medicinal chemistry.

Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor

A. Tomida, S. Dan, H. Seimiya, 2021, Cancer science.

Unique Mode of Antiviral Action of a Marine Alkaloid against Ebola Virus and SARS-CoV-2

H. Hayashi, Y. Kubo, Hironori Sato, 2022, Viruses.

Ortho-metalated aryl tert-butyl sulfones. Comparison with other directing groups and new methodology for polysubstituted aromatics

H. Perrier, V. Snieckus, K. K. Mahalanabis, 1989 .

Direct C‐3 Lithiation of 1‐(Triisopropylsilyl)indole.

M. Iwao, T. Fukuda, Mai Matsuzono, 2002 .

Synthesis of phenanthro[b]thiophenes

Milton L. Lee, R. Castle, M. Iwao, 1980 .

A regiospecific synthesis of carbazoles via consecutive palladium-catalyzed cross-coupling and aryne-mediated cyclization

M. Iwao, M. Watanabe, S. Furukawa, 1993 .

Synthesis of benzo[3,2]phenanthro[4,5‐bcd]thiophene and chryseno[4,5‐bcd]thiophene

Milton L. Lee, R. Castle, M. Iwao, 1981 .

An efficient synthesis of phthalides by Diels-Alder reaction of sulfur-substituted furanones with silyloxydienes: A formal synthesis of mycophenolic acid.

M. Tsukazaki, M. Iwao, S. Furukawa, 1989 .