J. Pontillo

发表

Efficient synthesis of bicyclic oxazolino- and thiazolino[3,2-c]pyrimidine-5,7-diones and its application to the synthesis of GnRH antagonists.

Chen Chen, J. Pontillo, 2005, Bioorganic & medicinal chemistry letters.

Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity.

Zhiqian Guo, Chen Chen, Martin W Rowbottom, 2008, Bioorganic & medicinal chemistry letters.

Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines.

Beth A. Fleck, M. Joppa, B. Dyck, 2005, Bioorganic & medicinal chemistry letters.

Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor.

Zhiqian Guo, Chen Chen, J. Saunders, 2008, Journal of medicinal chemistry.

Synthetic approach to potential precursors of sclerophytin A

M. Jung, J. Pontillo, 2003 .

Synthetic approach to analogues of the original structure of sclerophytin A.

M. Jung, J. Pontillo, 2002, The Journal of organic chemistry.

A remarkable multiple rearrangement process in the bromination of endo-3-bromo-4-methylcamphor: Intermediates for triterpenoid synthesis

C. G. Ferguson, J. Pontillo, T. Money, 1996 .

Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers.

Zhiqian Guo, Chen Chen, J. Saunders, 2005, Bioorganic & medicinal chemistry letters.

Substituted chromones and quinolones as potent melanin-concentrating hormone receptor 1 antagonists.

B. Dyck, Junko Tamiya, C. Heise, 2006, Bioorganic & medicinal chemistry letters.

4-{(2R)-[3-Aminopropionylamido]-3-(2,4-dichlorophenyl)propionyl}-1-{2-[(2-thienyl)ethylaminomethyl]phenyl}piperazine as a potent and selective melanocortin-4 receptor antagonist--design, synthesis, and characterization.

Beth A. Fleck, Joe A. Tran, A. Foster, 2004, Journal of medicinal chemistry.

Structure-activity relationships of piperazinebenzylamines as potent and selective agonists of the human melanocortin-4 receptor.

Beth A. Fleck, Joe A. Tran, A. Foster, 2004, Bioorganic & medicinal chemistry letters.

Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor.

Zhiqian Guo, Chen Chen, R. Struthers, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2.

Troy D. Vickers, C. Heise, M. Kiankarimi, 2006, Bioorganic & medicinal chemistry letters.

A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists.

Zhiqian Guo, Chen Chen, J. Saunders, 2005, Bioorganic & medicinal chemistry letters.

Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor.

Beth A. Fleck, Joe A. Tran, A. Foster, 2006, Bioorganic & medicinal chemistry letters.

Structure-activity relationship studies on a series of cyclohexylpiperazines bearing a phanylacetamide as ligands of the human melanocortin-4 receptor.

Beth A. Fleck, Joe A. Tran, A. Foster, 2005, Bioorganic & medicinal chemistry letters.

Structure-activity relationship of a series of cyclohexylpiperidines bearing an amide side chain as antagonists of the human melanocortin-4 receptor.

Beth A. Fleck, Joe A. Tran, A. Foster, 2005, Bioorganic & medicinal chemistry letters.

Identification of agonists and antagonists of the human melanocortin-4 receptor from piperazinebenzylamines.

Beth A. Fleck, Joe A. Tran, A. Foster, 2005, Bioorganic & medicinal chemistry letters.

Piperazinebenzylamines as potent and selective antagonists of the human melanocortin-4 receptor.

Beth A. Fleck, Joe A. Tran, A. Foster, 2004, Bioorganic & medicinal chemistry letters.

Optimization of piperazinebenzylamines with a N-(1-methoxy-2-propyl) side chain as potent and selective antagonists of the human melanocortin-4 receptor.

Beth A. Fleck, Joe A. Tran, A. Foster, 2005, Bioorganic & medicinal chemistry letters.

A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice.

S. Hoare, Beth A. Fleck, M. Joppa, 2005, Bioorganic & medicinal chemistry letters.

Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor.

Beth A. Fleck, Joe A. Tran, A. Foster, 2006, Bioorganic & medicinal chemistry letters.

LBSAT142 Discovery And Characterization Of A Potent And Orally Bioavailable Parathyroid Hormone Receptor Type-1 (PTHR1) Antagonist For The Treatment Of Hypercalcemia

S. Betz, Beth A. Fleck, P. Arroyo, 2022, Journal of the Endocrine Society.

Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with improved pharmaceutical characteristics.

Beth A. Fleck, T. Ewing, Yinghong Gao, 2008, Bioorganic & Medicinal Chemistry Letters.

Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).

Yinghong Gao, Beth A. Fleck, Dongpei Wu, 2008, Bioorganic & medicinal chemistry letters.