L. Adam

发表

Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311).

David S. Taylor, Hong Shen, M. Poss, 2015, Journal of medicinal chemistry.

Discovery of hydroxyl 1,2-diphenylethanamine analogs as potent cholesterol ester transfer protein inhibitors.

David S. Taylor, P. Sleph, M. Salvati, 2016, Bioorganic & medicinal chemistry letters.

Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) which Demonstrate HDL-C Increase In Vivo.

David S. Taylor, K. Behnia, E. Liu, 2020, Journal of medicinal chemistry.

2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis.

David S. Taylor, David S Nirschl, C. Weigelt, 2008, Bioorganic & medicinal chemistry letters.

NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.

Stephen R. Johnson, David S. Taylor, K. Constantine, 2006, Journal of medicinal chemistry.

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor.

David S. Taylor, P. Sleph, L. Abell, 2018, ACS medicinal chemistry letters.

Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor.

David S. Taylor, P. Sleph, M. Salvati, 2019, ACS medicinal chemistry letters.

Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors.

David S. Nirschl, David S. Taylor, David S Nirschl, 2014, Bioorganic & medicinal chemistry letters.

Discovery of a Phenylpyrazole Amide ROCK Inhibitor as a Tool Molecule for in vivo Studies.

David S. Taylor, J. Sack, Chunhong Yan, 2020, Bioorganic & medicinal chemistry letters.

Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model

J. Seidman, L. Leinwand, N. Hübner, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Development of a Chemiluminescent ELISA Method for the Detection of Total Anti-Adeno Associated Virus Serotype 9 (AAV9) Antibodies.

Yan J. Zhang, U. Kavita, P. Levesque, 2018, Human gene therapy methods.

Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.

J. Macor, J. Krupinski, A. Watson, 2004, Bioorganic & Medicinal Chemistry Letters.

The discovery of novel, potent and selective PDE5 inhibitors.

J. Macor, J. Krupinski, A. Watson, 2001, Bioorganic & medicinal chemistry letters.

Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.

S. Chong, J. Macor, J. Krupinski, 2001, Journal of medicinal chemistry.

Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.

Andrew Henwood, Jian Wang, S. Chong, 2003, Journal of medicinal chemistry.

Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors.

David S. Nirschl, David S. Taylor, David S Nirschl, 2012, Bioorganic & medicinal chemistry letters.

Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors.

David S. Nirschl, David S. Taylor, David S Nirschl, 2012, Journal of medicinal chemistry.

Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).

David S. Taylor, R. Parker, R. Stoffel, 2007, Bioorganic & medicinal chemistry letters.

Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species.

M. Salvati, Christine S. Huang, M. Hageman, 2018, Journal of pharmaceutical sciences.

Plasma biomarkers associated with adverse outcomes in patients with calcific aortic stenosis

Jason W. Moore, M. Hyman, J. Maranville, 2021, European journal of heart failure.

Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase.

David S. Taylor, Brandon L. Parkhurst, E. Liu, 2019, Bioorganic & medicinal chemistry letters.

Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors.

David S. Taylor, Michael A. Galella, Hong Shen, 2018, Bioorganic & medicinal chemistry letters.

Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.

David S. Taylor, Michael A. Galella, L. Abell, 2018, ACS medicinal chemistry letters.

Benzothiazole-based compounds as potent endothelial lipase inhibitors.

David S. Taylor, R. Wexler, Xiaohong Yin, 2019, Bioorganic & medicinal chemistry letters.

Design and SAR of selective T-type calcium channel antagonists containing a biaryl sulfonamide core.

Daniel L Cheney, William R Ewing, Stephen Swartz, 2008, Bioorganic & medicinal chemistry letters.

Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors.

Yan Zou, R. Wexler, J. Muckelbauer, 2023, Bioorganic & medicinal chemistry letters.

Identification of 5H-Chromeno[3,4-c]pyridine and 6H-Isochromeno[3,4-c]pyridine Derivatives as Potent and Selective Dual ROCK Inhibitors.

R. Wexler, J. Muckelbauer, Zilun Hu, 2020, Bioorganic & medicinal chemistry letters.

HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin

Y. Blat, D. Harden, D. Connors, 2023, SLAS discovery : advancing life sciences R & D.