Danshi Li

发表

Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311).

David S. Taylor, Hong Shen, M. Poss, 2015, Journal of medicinal chemistry.

Recommendations to Enhance Pediatric Cardiovascular Drug Development: Report of a Multi‐Stakeholder Think Tank

N. Stockbridge, B. McCrindle, J. Newburger, 2018, Journal of the American Heart Association.

Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice.

S. Nattel, J. Tardif, Khai Le Quang, 2011, Cardiovascular research.

Single-Dose Pharmacokinetics of Milvexian in Participants with Mild or Moderate Hepatic Impairment Compared with Healthy Participants

A. Bello, Liping Zhang, Zhaoqing Wang, 2022, Clinical Pharmacokinetics.

Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent.

P. Lam, Hong Shen, A. Mathur, 2014, Bioorganic & medicinal chemistry letters.

A multi-national trial of a direct oral anticoagulant in children with cardiac disease: Design and rationale of the Safety of ApiXaban On Pediatric Heart disease On the preventioN of Embolism (SAXOPHONE) study.

J. Newburger, P. Monagle, R. M. Payne, 2019, American heart journal.

Rationale and design of the AXIOMATIC-SSP phase II trial: Antithrombotic treatment with factor XIa inhibition to Optimize Management of Acute Thromboembolic events for Secondary Stroke Prevention.

G. Hankey, H. Lutsep, S. Kasner, 2022, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

Deciphering the pecking order of HCN4 expression in the developing heart: lessons from chicken.

Long-Sheng Song, Danshi Li, 2011, Heart rhythm.

Discovery of a potent and novel motilin agonist.

R. Stoffel, Huabin Sun, R. Seethala, 2004, Journal of medicinal chemistry.

Single-Dose Pharmacokinetics of Milvexian in Participants with Normal Renal Function and Participants with Moderate or Severe Renal Impairment

A. Bello, Liping Zhang, Zhaoqing Wang, 2022, Clinical Pharmacokinetics.

First‐in‐human study of milvexian, an oral, direct, small molecule factor XIa inhibitor

M. Cerra, D. Seiffert, J. Luettgen, 2021, Clinical and translational science.

A Randomized, Double-Blind, Phase 3 Trial of Dapagliflozin Add-on to Saxagliptin plus Metformin in Type 2 Diabetes

C. Mathieu, N. Iqbal, B. Hirshberg, 2015 .

A Multi-National Trial of a Direct Oral Anticoagulant in Childrenwith Cardiac Disease: Design and Rationale of the SAXOPHONEStudy

J. Newburger, P. Monagle, R. M. Payne, 2019 .

Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers.

Huabin Sun, Christine S. Huang, M. Conder, 2010, Bioorganic & medicinal chemistry letters.

Consequences of Atrial Tachycardia-Induced Remodeling Depend on the Preexisting Atrial Substrate

S. Nattel, K. Shinagawa, T. Leung, 2002, Circulation.

PREVAPIX-ALL: Apixaban Compared to Standard of Care for Prevention of Venous Thrombosis in Paediatric Acute Lymphoblastic Leukaemia (ALL)—Rationale and Design

J. Newburger, S. O’Brien, V. Rodriguez, 2019, Thrombosis and Haemostasis.

Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.

L. Mueller, K. Kish, H. Klei, 2016, Journal of medicinal chemistry.

Evolution of the atrial fibrillation substrate in experimental congestive heart failure: angiotensin-dependent and -independent pathways.

S. Nattel, É. Thorin, N. Thorin-Trescases, 2003, Cardiovascular research.

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

A. Good, H. Klei, A. Cocuzza, 2014, Journal of medicinal chemistry.

Dihydropyrazolopyrimidines containing benzimidazoles as K(V)1.5 potassium channel antagonists.

Huabin Sun, T. Huynh, Wayne Vaccaro, 2009, Bioorganic & medicinal chemistry letters.

The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.

Qi Gao, Huabin Sun, Hong Shi, 2014, Journal of medicinal chemistry.

Differential Alterations of Receptor Densities of Three Muscarinic Acetylcholine Receptor Subtypes and Current Densities of the Corre-sponding K+ Channels in Canine Atria with Atrial Fibrillation Induced by Experimental Congestive Heart Failure

Hui-zhen Wang, S. Nattel, Zhiguo Wang, 2004, Cellular Physiology and Biochemistry.

Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure.

S. Nattel, J. Tardif, Yanfen Shi, 2002, Cardiovascular research.

Method for Simultaneous Epicardial and Endocardial Mapping of In Vivo Canine Heart: Application to Atrial Conduction Properties and Arrhythmia Mechanisms

Pierre L. Page, S Nattel, M Courtemanche, 2001, Journal of cardiovascular electrophysiology.

Effects of Angiotensin-Converting Enzyme Inhibition on the Development of the Atrial Fibrillation Substrate in Dogs With Ventricular Tachypacing–Induced Congestive Heart Failure

S. Nattel, Zhiguo Wang, K. Shinagawa, 2001, Circulation.

Potential Ionic Mechanism for Repolarization Differences Between Canine Right and Left Atrium

S Nattel, S. Nattel, J. Kneller, 2001, Circulation research.

Cardiac ion channels in atrial fibrillation: Disease-related changes and relevance to drug therapy

S. Nattel, L. Yue, Danshi Li, 2000 .

Ionic Remodeling in the Heart: Pathophysiological Significance and New Therapeutic Opportunities for Atrial Fibrillation

S. Nattel, Danshi Li, 2000, Circulation research.

Design, synthesis and evaluation of phenethylaminoheterocycles as K(v)1.5 inhibitors.

Huabin Sun, M. Conder, J. Lloyd, 2014, Bioorganic & medicinal chemistry letters.

Epicardial and endocardial ST potential mapping in ischaemia

Danshi Li, 1997 .

Randomized, Double-Blind, Phase 3 Trial of Triple Therapy With Dapagliflozin Add-on to Saxagliptin Plus Metformin in Type 2 Diabetes

C. Mathieu, N. Iqbal, B. Hirshberg, 2015, Diabetes Care.

Ionic Remodeling of Cardiac Purkinje Cells by Congestive Heart Failure

S Nattel, S. Nattel, D Li, 2001, Circulation.

and Stanley Nattel Ionic Remodeling of Cardiac Purkinje Cells by Congestive Heart Failure

S. Nattel, D. Chartier, W. Han, 2001 .

Position 5.46 of the Serotonin 5-HT2A Receptor Contributes to a Species-Dependent Variation for the 5-HT2C Agonist (R)-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one: Impact on Selectivity and Toxicological Evaluation

P. Levesque, J. Robl, K. Rossi, 2009, Molecular Pharmacology.

Pharmacological elimination of motion artifacts during optical imaging of cardiac tissues: is blebbistatin the answer?

S. Nattel, Danshi Li, 2007, Heart rhythm.

Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort.

S Nattel, S Fareh, S. Nattel, 1999, Circulation.

Effects of experimental heart failure on atrial cellular and ionic electrophysiology.

S Nattel, A Shrier, S. Nattel, 2000, Circulation.

Remodeling of atrial dimensions and emptying function in canine models of atrial fibrillation.

A. Ducharme, S. Nattel, J. Tardif, 2001, Cardiovascular research.

Contrasting efficacy of dofetilide in differing experimental models of atrial fibrillation.

S. Nattel, A. Bénardeau, D. Li, 2000, Circulation.

Design, synthesis and evaluation of phenethylaminoheterocycles as K(v)1.5 inhibitors.

Huabin Sun, M. Conder, J. Lloyd, 2014, Bioorganic & medicinal chemistry letters.

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

A. Good, H. Klei, A. Cocuzza, 2014, Journal of medicinal chemistry.