Kyriakos E Kypreos

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HDL biogenesis and functions: role of HDL quality and quantity in atherosclerosis.

Elisavet H. Fotiadou, Eirini M. Tsompanidi, Maria S. Brinkmeier, 2010, Atherosclerosis.

High density lipoprotein in atherosclerosis and coronary heart disease: Where do we stand today?

Kyriakos E Kypreos, E. Zvintzou, Dimitra Sotiria Karampela, 2021, Vascular pharmacology.

HDL and type 2 diabetes: the chicken or the egg?

Kyriakos E Kypreos, E. Zvintzou, E. Xepapadaki, 2021, Diabetologia.

Pleiotropic effects of apolipoprotein A-Ⅱ on high-density lipoprotein functionality, adipose tissue metabolic activity and plasma glucose homeostasis.

C. Kalogeropoulou, Kyriakos E Kypreos, E. Zvintzou, 2019, Journal of biomedical research.

Impact of apolipoprotein A1- or lecithin:cholesterol acyltransferase-deficiency on white adipose tissue metabolic activity and glucose homeostasis in mice.

G. Maulucci, C. Constantinou, S. Sasson, 2019, Biochimica et biophysica acta. Molecular basis of disease.

Pleiotropic effects of apolipoprotein C3 on HDL functionality and adipose tissue metabolic activity[S]

C. Constantinou, A. Kontush, A. Tselepis, 2017, Journal of Lipid Research.

Distinct Roles of Apolipoproteins A1 and E in the Modulation of High-Density Lipoprotein Composition and Function.

C. Kalogeropoulou, G. Sakellaropoulos, C. Constantinou, 2016, Biochemistry.

Association of the CETP Taq1B and LIPG Thr111Ile Polymorphisms with Glycated Hemoglobin and Blood Lipids in Newly Diagnosed Hyperlipidemic Patients.

A. Goulas, A. Hatzitolios, C. Savopoulos, 2016, Canadian journal of diabetes.

Scavenger Receptor Class B Type I Regulates Plasma Apolipoprotein E Levels and Dietary Lipid Deposition to the Liver.

G. Sakellaropoulos, C. Constantinou, D. Papachristou, 2015, Biochemistry.

Lack of LCAT reduces the LPS-neutralizing capacity of HDL and enhances LPS-induced inflammation in mice.

J. Berbée, A. Spyridonidis, Kyriakos E Kypreos, 2015, Biochimica et biophysica acta.

Effects of bariatric surgery on HDL structure and functionality: results from a prospective trial.

D. Gantz, G. Sakellaropoulos, G. Skroubis, 2014, Journal of clinical lipidology.

HDL particle functionality as a primary pharmacological target for HDL-based therapies.

L. Rallidis, Kyriakos E Kypreos, Spyridon Gkizas, 2013, Biochemical pharmacology.

Perturbations in the HDL metabolic pathway predispose to the development of osteoarthritis in mice following long-term exposure to western-type diet.

I. Lilis, I. Triantaphyllidou, D. Papachristou, 2013, Osteoarthritis and cartilage.

Pharmacodynamic and pharmacokinetic analysis of apoE4 [L261A, W264A, F265A, L268A, V269A], a recombinant apolipoprotein E variant with improved biological properties.

V. Zannis, Kyriakos E Kypreos, A. Lampropoulou, 2012, Biochemical pharmacology.

Testosterone and cardiovascular disease: an old idea with modern clinical implications.

A. Traish, Kyriakos E Kypreos, 2011, Atherosclerosis.

Androgen deficiency and atherosclerosis: The lipid link.

A. Traish, Kyriakos E Kypreos, R. Abdou, 2009, Vascular pharmacology.

Analysis of the structure and function relationship of human apolipoprotein E in vivo, using adenovirus‐mediated gene transfer

B. Teusink, L. Havekes, V. Zannis, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Probing the pathways of chylomicron and HDL metabolism using adenovirus-mediated gene transfer

D. Kardassis, V. Zannis, H. Kan, 2004, Current opinion in lipidology.

SR-BI mediates cholesterol efflux via its interactions with lipid-bound ApoE. Structural mutations in SR-BI diminish cholesterol efflux.

M. Krieger, T. Nieland, V. Zannis, 2005, Biochemistry.

LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice s⃞

V. Zannis, Kyriakos E Kypreos, 2006, Journal of Lipid Research.

Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT.

V. Zannis, Kyriakos E Kypreos, 2007, The Biochemical journal.

ABCA1 promotes the de novo biogenesis of apolipoprotein CIII-containing HDL particles in vivo and modulates the severity of apolipoprotein CIII-induced hypertriglyceridemia.

Kyriakos E Kypreos, 2008, Biochemistry.

The Hepatic Clearance of VLDL in the Absence of the Three Major ApoE- Recognizing Re ceptors is Dependent on LPL

L. Havekes, P. Rensen, K. W. Dijk, 2006 .

Apolipoprotein A-1 regulates osteoblast and lipoblast precursor cells in mice

D. Deligianni, C. Kontoyannis, H. Blair, 2016, Laboratory Investigation.

Nitroglycerine limits infarct size through S-nitrosation of cyclophilin D: a novel mechanism for an old drug

A. Papapetropoulos, A. Daiber, I. Andreadou, 2018, Cardiovascular research.

Deficiency in apolipoprotein E has a protective effect on diet‐induced nonalcoholic fatty liver disease in mice

I. Giopanou, D. Papachristou, Kyriakos E Kypreos, 2011, The FEBS journal.

Strain-specific Differences in the Effects of Lymphocytes on the Development of Insulin Resistance and Obesity in Mice.

P. Tsakanikas, N. Kostomitsopoulos, K. Karalis, 2018, Comparative medicine.

ApoA1 Deficiency Reshapes the Phenotypic and Molecular Characteristics of Bone Marrow Adipocytes in Mice

H. Blair, D. Papachristou, D. Nikitovic, 2022, International journal of molecular sciences.

Adverse Drug Reactions in Relation to Clozapine Plasma Levels: A Systematic Review

P. Gourzis, M. Skokou, Kyriakos E Kypreos, 2022, Pharmaceuticals.

Apolipoprotein A-I Modulates Processes Associated with Diet-Induced Nonalcoholic Fatty Liver Disease in Mice

I. Triantaphyllidou, D. Papachristou, Kassiani Liopeta, 2012, Molecular medicine.

ANGPTL3 and Apolipoprotein C-III as Novel Lipid-Lowering Targets

T. Filippatos, I. Akoumianakis, Kyriakos E Kypreos, 2021, Current Atherosclerosis Reports.

Mechanisms of obesity and related pathologies

Kyriakos E Kypreos, 2009, The FEBS journal.

Generation of a Recombinant Apolipoprotein E Variant with Improved Biological Functions

K. V. van Dijk, L. Havekes, V. Zannis, 2005, Journal of Biological Chemistry.

Benefits of a fixed-dose combination of standardized P. mume extract with choline on adipose tissue mitochondrial metabolic activity and pancreatic β-islet secretory capacity in mice

G. Panayiotakopoulos, D. Papachristou, Kyriakos E Kypreos, 2022, Phytomedicine Plus.

Discrete roles of apoA‐I and apoE in the biogenesis of HDL species: Lessons learned from gene transfer studies in different mouse models

K. Drosatos, V. Zannis, G. Koukos, 2008, Annals of medicine.

8 Lipoproteins and atherogenesis

D. Kardassis, V. Zannis, E. Zanni, 2004 .

4 The hepatic uptake of VLDL in lrp - ldlr -/- vldlr -/- mice is regulated by LPL activity and involves proteoglycans and SR-BI

J. Romijn, T. J. Berkel, L. Havekes, 2008 .

Lecithin/cholesterol acyltransferase modulates diet-induced hepatic deposition of triglycerides in mice.

D. Papachristou, Kyriakos E Kypreos, E. Karavia, 2013, The Journal of nutritional biochemistry.

Isoform and tissue dependent impact of apolipoprotein E on adipose tissue metabolic activation: The role of apolipoprotein A1.

C. Kalogeropoulou, C. Constantinou, Kyriakos E Kypreos, 2020, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Biophysical properties of apolipoprotein E4 variants: implications in molecular mechanisms of correction of hypertriglyceridemia.

D. Gantz, D. Atkinson, V. Zannis, 2008, Biochemistry.

Adenovirus mediated expression “in vivo” of the chemokine receptor CXCR1

K. Rajarathnam, M. R. Tandang-Silvas, D. Shumate, 2009, Journal of Structural and Functional Genomics.

The low density lipoprotein receptor modulates the effects of hypogonadism on diet-induced obesity and related metabolic perturbations

A. Traish, C. Constantinou, P. Voshol, 2014, Journal of Lipid Research.

Western-type diet differentially modulates osteoblast, osteoclast, and lipoblast differentiation and activation in a background of APOE deficiency

H. Blair, G. Tzanakakis, D. Papachristou, 2018, Laboratory Investigation.

Recommendations for lipid modification in patients with ischemic stroke or transient ischemic attack: A clinical guide by the Hellenic Stroke Organization and the Hellenic Atherosclerosis Society

C. Pitsavos, H. Milionis, K. Vemmos, 2020, International journal of stroke : official journal of the International Stroke Society.

Site-specific effects of apolipoprotein E expression on diet-induced obesity and white adipose tissue metabolic activation.

C. Kalogeropoulou, C. Constantinou, Kyriakos E Kypreos, 2018, Biochimica et biophysica acta. Molecular basis of disease.

The aminoterminal 1-185 domain of human apolipoprotein E suffices for the de novo biogenesis of apoE-containing HDL-like particles in apoA-I deficient mice.

D. Gantz, Yanan Wang, P. Rensen, 2011, Atherosclerosis.

Domains of Apolipoprotein E Contributing to Triglyceride and Cholesterol Homeostasis in Vivo

K. V. van Dijk, L. Havekes, V. Zannis, 2001, The Journal of Biological Chemistry.

Adenovirus-mediated gene transfer.

K. V. van Dijk, J. Hageman, Kyriakos E Kypreos, 2011, Methods in molecular biology.

Andenovirus-Mediated Gene Transfer

K. W. Dijk, C. d’Oliveira, Kyriakos E Kypreos, 2003 .

Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain Published, JLR Papers in Press, October 16, 2002. DOI 10.1194/jlr.M200313-JLR200

B. Teusink, K. V. van Dijk, L. Havekes, 2003, Journal of Lipid Research.

M De Spirito, G. Maulucci, G. Pani, 2016, Free radical research.

A-myb is expressed in bovine vascular smooth muscle cells during the late G1-to-S phase transition and cooperates with c-myc to mediate progression to S phase

M. Arsura, G. Sonenshein, Kyriakos E Kypreos, 1997, Molecular and cellular biology.

F. Gonzalez, M. Konstandi, K. Krausz, 2019, The FEBS journal.

Pharmacological Management of Dyslipidemia in Atherosclerosis: Limitations, Challenges, and New Therapeutic Opportunities

C. Constantinou, G. Panayiotakopoulos, R. Bitzur, 2018, Angiology.

B-Myb represses trans-activation of the Col5A2 collagen promoter indirectly via inhibition of binding of factors interacting with positive elements within the first exon.

G. Sonenshein, Kyriakos E Kypreos, D. J. Marhamati, 1999, Matrix biology : journal of the International Society for Matrix Biology.

Basic fibroblast growth factor-induced decrease in type I collagen gene transcription is mediated by B-myb.

M. Nugent, G. Sonenshein, Kyriakos E Kypreos, 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

High-density lipoprotein (HDL) metabolism and bone mass.

H. Blair, D. Papachristou, Kyriakos E Kypreos, 2017, The Journal of endocrinology.

The Lipoprotein Transport System in the Pathogenesis of Multiple Myeloma: Advances and Challenges

A. Symeonidis, Kyriakos E Kypreos, A. Hatziri, 2021, Frontiers in Oncology.

Τhe Antioxidant Function of HDL in Atherosclerosis

C. Kalogeropoulou, Kyriakos E Kypreos, E. Zvintzou, 2020, Angiology.

Tissue-specific Functional Interaction Between Apolipoproteins A1 and E in Cold-Induced Adipose Organ Mitochondrial Energy Metabolism.

Kyriakos E Kypreos, E. Zvintzou, E. Xepapadaki, 2020, Biochimica et biophysica acta. Molecular and cell biology of lipids.

HDL quality and functionality: what can proteins and genes predict?

C. Constantinou, Kyriakos E Kypreos, E. Zvintzou, 2014, Expert review of cardiovascular therapy.

Type V collagen regulates the assembly of collagen fibrils in cultures of bovine vascular smooth muscle cells

D. Hartmann, V. Trinkaus-Randall, G. Sonenshein, 2000, Journal of Cellular Biochemistry.

Basic fibroblast growth factor decreases type V/XI collagen expression in cultured bovine aortic smooth muscle cells

G. Sonenshein, Kyriakos E Kypreos, 1998, Journal of cellular biochemistry.

Increased CUG Triplet Repeat-binding Protein-1 Predisposes to Impaired Adipogenesis with Aging*

T. Lash, S. Farmer, J. Kirkland, 2006, Journal of Biological Chemistry.

Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity

Elisavet H. Fotiadou, Smaragda M. Giakoumi, E. Tsompanidi, 2009, The FEBS journal.

Apolipoprotein E predisposes to obesity and related metabolic dysfunctions in mice

A. Tzortzopoulou, P. Voshol, Kyriakos E Kypreos, 2008, The FEBS journal.

Residues Leu261, Trp264, and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of apolipoprotein E-containing high-density lipoprotein.

K. Drosatos, V. Zannis, Kyriakos E Kypreos, 2007, Biochemistry.

A Dominant Negative Form of the Transcription Factor c-Jun Affects Genes That Have Opposing Effects on Lipid Homeostasis in Mice*

D. Kardassis, D. Sanoudou, K. Drosatos, 2007, Journal of Biological Chemistry.

The Expression of the Low-Density Lipoprotein Receptor Modulates the Effects of Hypogonadism on Mitochondrial Activity in Different Brain Domains

Kyriakos E Kypreos, A. Natsos, K. Athanasopoulou, 2021, Androgens: Clinical Research and Therapeutics.

Regulation of Endothelial Nitric Oxide Synthase and High-Density Lipoprotein Quality by Estradiol in Cardiovascular Pathology

E. Isenovic, A. Traish, S. Zafirovic, 2014, Journal of cardiovascular pharmacology and therapeutics.

Cardiovascular Pathology Regulation of Endothelial Nitric Oxide Synthase and High-Density Lipoprotein Quality by Estradiol in

E. Isenovic, A. Traish, S. Zafirovic, 2014 .

Advances in high-density lipoprotein physiology: surprises, overturns, and promises.

C. Kalogeropoulou, C. Constantinou, G. Panayiotakopoulos, 2016, American journal of physiology. Endocrinology and metabolism.

Synchronization of cultured vascular smooth muscle cells following reversal of quiescence induced by treatment with the antioxidant N-acetylcysteine.

G. Sonenshein, J. S. Lee, Kyriakos E Kypreos, 1998, Experimental cell research.

Medicines for Obesity: Appraisal of Clinical Studies with Grading of Recommendations, Assessment, Development, and Evaluation Tool

T. Filippatos, Demosthenes Panagiotakos, Kyriakos E Kypreos, 2023, Nutrients.

Deficiency in apolipoprotein A-I ablates the pharmacological effects of metformin on plasma glucose homeostasis and hepatic lipid deposition.

C. Kalogeropoulou, C. Constantinou, D. Papachristou, 2015, European journal of pharmacology.

Substitutions of glutamate 110 and 111 in the middle helix 4 of human apolipoprotein A-I (apoA-I) by alanine affect the structure and in vitro functions of apoA-I and induce severe hypertriglyceridemia in apoA-I-deficient mice.

V. Zannis, H. Kan, A. Chroni, 2004, Biochemistry.

Qualitative characteristics of HDL in young patients of an acute myocardial infarction.

L. Rallidis, S. Hartwig, S. Lehr, 2012, Atherosclerosis.

HDL quality in atherosclerosis: can ratios between apolipoproteins of HDL be used effectively to indicate risk of premature myocardial infarction?

Kyriakos E Kypreos, 2012 .

Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain.

V. Zannis, E. Zanni, Kyriakos E Kypreos, 2003, Biochemistry.

ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression Published, JLR Papers in Press, May 1, 2005. DOI 10.1194/jlr.M400479-JLR200

L. Havekes, P. Rensen, K. Willems van Dijk, 2005, Journal of Lipid Research.

High-Density Lipoprotein in Metabolic Disorders and Beyond: An Exciting New World Full of Challenges and Opportunities

K. Benabdellah, G. Skroubis, Kyriakos E Kypreos, 2023, Pharmaceuticals.

Adenovirus-mediated gene transfer.

K. V. van Dijk, C. d'Oliveira, Kyriakos E Kypreos, 2003, Methods in molecular biology.

INFLAMMATION AND MITOCHONDRIAL DYSFUNCTION IN AFFECTIVE DISORDERS-NOVEL UNDERSTANDINGS, NOVEL TREATMENTS?

A. Halaris, P. Gourzis, M. Skokou, 2023, Journal of Affective Disorders Reports.

Allele-dependent thermodynamic and structural perturbations in ApoE variants associated with the correction of dyslipidemia and formation of spherical ApoE-containing HDL particles.

K. Drosatos, E. Stratikos, V. Zannis, 2013, Atherosclerosis.

Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype.

K. V. van Dijk, L. Havekes, V. Zannis, 2003, Biochemistry.