C. Kirby

The novolactone natural product disrupts the allosteric regulation of Hsp70.

Roman Kityk, M. Mayer, R. Riedl, 2015, Chemistry & biology.

Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer.

F. Lombardo, Alice T. Loo, L. Hamann, 2017, Journal of medicinal chemistry.

Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.

F. Lombardo, L. Hamann, T. Abrams, 2018, Journal of medicinal chemistry.

ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor

Joshua M. Korn, W. Sellers, J. Korn, 2016, eLife.

Identification of Elongation Factor G as the Conserved Cellular Target of Argyrin B

Christopher J. Wilson, J. Tallarico, R. Riedl, 2012, PloS one.

Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor.

D. Chin, B. Lagu, B. Firestone, 2013, Journal of medicinal chemistry.

A capillary-based microfluidic device enables primary high-throughput room-temperature crystallographic screening

A. Cohen, W. Weihofen, R. Chopra, 2021, Journal of applied crystallography.

[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.

D. Chin, W. Shao, Yun Feng, 2012, Journal of medicinal chemistry.

Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases.

D. Chin, W. Shao, Yun Feng, 2013, Journal of medicinal chemistry.

Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.

H J Fromm, H. Fromm, G. Bourenkov, 2000, Journal of molecular biology.

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939.

Atwood K Cheung, M. Shultz, T. Stams, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.