G. Nishiguchi

发表

Dual Allosteric Inhibition of SHP2 Phosphatase.

Sarah L. Williams, S. Blacklow, M. Glick, 2018, ACS chemical biology.

Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs.

Jeremy P Hunt, C. Mullighan, M. Fischer, 2022, ACS medicinal chemistry letters.

Preclinical evaluation of proteolytic targeting of LCK as a therapeutic approach in T cell acute lymphoblastic leukemia

C. Pui, D. Teachey, J. Panetta, 2022, Science Translational Medicine.

Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.

Yu Ding, Michelle Mathur, Jiong Lan, 2013, ACS medicinal chemistry letters.

Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2000, Journal of medicinal chemistry.

Diaryl-dialkyl-substituted pyrazoles: regioselective synthesis and binding affinity for the estrogen receptor.

J. Katzenellenbogen, Alice L. Rodriguez, G. Nishiguchi, 2002, Bioorganic & medicinal chemistry letters.

Synthetic Efforts Toward, and Biological Activity of, Thyrsiferol and Structurally-Related Analogues

R. Little, G. Nishiguchi, 2008 .

Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers

Audrey Kauffmann, Jianjun Yu, Yumin Dai, 2014, Clinical Cancer Research.

Remote substituent effects upon the rearrangements of housane cation radicals.

R. Little, D. Tantillo, James B. Gerken, 2005, The Journal of organic chemistry.

Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs.

M. Roussel, Taosheng Chen, A. Shelat, 2021, Angewandte Chemie.

Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design.

Shondra M. Pruett-Miller, R. Heath, Jun J. Yang, 2023, ACS medicinal chemistry letters.

Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators

M. Roussel, C. Mullighan, M. Fischer, 2021, Journal of Medicinal Chemistry.

Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.

Yumin Dai, Yanchen Zhang, Mika K Lindvall, 2015, Journal of medicinal chemistry.

7,11-epi-thyrsiferol: completion of its synthesis, evaluation of its antimitotic properties, and the further development of an SAR model.

R. Little, R. Jacobs, G. Nishiguchi, 2006, The Journal of organic chemistry.

From C-glycosides to pyranopyrans: an approach to thyrsiferol using titanium(III)-promoted redox couplings.

R. Little, G. Nishiguchi, 2005, The Journal of organic chemistry.

Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.

W. Sellers, M. P. Dillon, Y. Mishina, 2020, Journal of medicinal chemistry.

Synthesis and Structure-Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases.

M. Lindvall, Yu Ding, Jiong Lan, 2020, Journal of medicinal chemistry.

Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases.

Mika Lindvall, M. Lindvall, Yu Ding, 2011, Bioorganic & medicinal chemistry letters.

Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold.

M. Lindvall, Jiong Lan, Gordana Atallah, 2016, Bioorganic & medicinal chemistry letters.

Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.

M. P. Dillon, Mallika Singh, E. Lees, 2017, Journal of medicinal chemistry.

Evaluating and evolving a screening library in academia: the St Jude approach.

A. Shelat, Z. Rankovic, Sourav Das, 2021, Drug discovery today.

Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF.

Joshua M. Korn, W. Sellers, F. Shen, 2018, Cancer research.

Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers

M. Lindvall, A. Kauffmann, C. Fanton, 2014, Clinical Cancer Research.

Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.

M. P. Dillon, Mallika Singh, E. Lees, 2017, Journal of medicinal chemistry.