J. Falkenburg

发表

Donor T-cell responses and disease progression patterns of multiple myeloma

H. Putter, H. Veelken, J. Schetelig, 2017, Bone Marrow Transplantation.

Multi-state analysis illustrates treatment success after stem cell transplantation for acute myeloid leukemia followed by donor lymphocyte infusion

H. Putter, H. Veelken, P. A. von dem Borne, 2016, Haematologica.

Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy.

M. Kester, J. Jansen, L. Gattinoni, 2014, Blood.

Addition of 10-Day Decitabine to Fludarabine/Total Body Irradiation Conditioning is Feasible and Induces Tumor-Associated Antigen-Specific T Cell Responses.

M. Kester, J. Jansen, G. Huls, 2016, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

PRAME-Specific Allo-HLA–Restricted T Cells with Potent Antitumor Reactivity Useful for Therapeutic T-Cell Receptor Gene Transfer

A. Amir, M. V. van Loenen, R. Hagedoorn, 2011, Clinical Cancer Research.

PrimaryAllogeneic T-Cell Responses againstMantle Cell Lymphoma Antigen-Presenting Cells forAdoptive Immunotherapy after StemCellTransplantation

R. Willemze, I. Jedema, M. Hoogendoorn, 2005 .

Combined CD8+ and CD4+ adenovirus hexon-specific T cells associated with viral clearance after stem cell transplantation as treatment for adenovirus infection

M. Schilham, H. Guchelaar, M. Kester, 2010, Haematologica.

Ex vivo AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8+ T cells for adoptive immunotherapy

M. Kester, J. Jansen, L. Gattinoni, 2018, Oncoimmunology.

Intentional donor lymphocyte-induced limited acute graft-versus-host disease is essential for long-term survival of relapsed acute myeloid leukemia after allogeneic stem cell transplantation

H. Veelken, P. A. von dem Borne, S. Kersting, 2014, Haematologica.

Molecular persistence of chronic myeloid leukemia caused by donor T cells specific for lineage-restricted maturation antigens not recognizing immature progenitor-cells

M. Heemskerk, R. Willemze, A. Mulder, 2006, Leukemia.

Identification of HLA class II-restricted H-Y-specific T-helper epitope evoking CD4+ T-helper cells in H-Y-mismatched transplantation

T. Mutis, E. Goulmy, E. Spierings, 2003, The Lancet.

Tetrameric HLA class I–minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease

P. Moss, T. Mutis, G. Gillespie, 1999, Nature Medicine.

Generation of B-cell chronic lymphocytic leukemia (B-CLL)-reactive T-cell lines and clones from HLA class I-matched donors using modified B-CLL cells as stimulators: implications for adoptive immunotherapy

R. Willemze, R. Barge, J. O. Wolbers, 2004, Leukemia.

Development of a coordinated allo T cell and auto B cell response against autosomal PTK2B after allogeneic hematopoietic stem cell transplantation

P. Nilsson, J. Schwenk, M. Griffioen, 2014, Haematologica.

Hematopoietic stem cell-derived myeloid and plasmacytoid DC-based vaccines are highly potent inducers of tumor-reactive T cell and NK cell responses ex vivo

M. Kester, J. Jansen, H. Dolstra, 2017, Oncoimmunology.

Identification of a novel RAS GTPase‐activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia

E. Schuuring, P. Kluin, A. Groot, 2004, Genes, chromosomes & cancer.

TRANSPLANTATION HLA class II upregulation during viral infection leads to HLA-DP – directed graft-versus-host disease after CD4 1 donor lymphocyte infusion

F. Claas, M. Griffioen, A. Kruisselbrink, 2013 .

HLA class I-minor histocompatibility antigen tetramers select cytotoxic T cells with high avidity to the natural ligand.

P. Moss, T. Mutis, G. Gillespie, 2000, The hematology journal : the official journal of the European Haematology Association.

Early Detection and Rapid Isolation of Leukemia-Reactive Donor T Cells for Adoptive Transfer Using the IFN-γ Secretion Assay

R. Willemze, S. V. van Luxemburg-Heijs, I. Jedema, 2007, Clinical Cancer Research.

Artificial antigen-presenting constructs efficiently stimulate minor histocompatibility antigen-specific cytotoxic T lymphocytes.

T. Mutis, J. Curtsinger, M. Mescher, 2004, Blood.

Characterization of graft-versus-leukemia responses in patients treated for advanced chronic lymphocytic leukemia with donor lymphocyte infusions after in vitro T-cell depleted allogeneic stem cell transplantation following reduced-intensity conditioning

R. Willemze, S. Luxemburg-Heijs, E. Marijt, 2007, Leukemia.

B and T Lymphocyte Attenuator Mediates Inhibition of Tumor-Reactive CD8+ T Cells in Patients After Allogeneic Stem Cell Transplantation

D. Olive, A. Korman, H. Dolstra, 2012, The Journal of Immunology.

Monocyte‐derived dendritic cells can induce autoreactive CD4+ T cells showing myeloid lineage directed reactivity in healthy individuals

I. Jedema, J. Falkenburg, M. Meent, 2015, European journal of immunology.

High Mutation Frequency of the PIGA Gene in T Cells Results in Reconstitution of GPI Anchor−/CD52− T Cells That Can Give Early Immune Protection after Alemtuzumab-Based T Cell–Depleted Allogeneic Stem Cell Transplantation

H. Veelken, P. A. von dem Borne, I. Jedema, 2018, The Journal of Immunology.

SARS-CoV-2-specific CD4+ and CD8+ T cell responses can originate from cross-reactive CMV-specific T cells

S. Gras, R. Hagedoorn, M. Heemskerk, 2022, bioRxiv.

Efficient induction of minor histocompatibility antigen HA-1-specific cytotoxic T-cells using dendritic cells retrovirally transduced with HA-1-coding cDNA.

M. Heemskerk, M. Wilke, K. Ghoreschi, 2002, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

The allogeneic HLA-DP-restricted T-cell repertoire provoked by allogeneic dendritic cells contains T cells that show restricted recognition of hematopoietic cells including primary malignant cells

P. van Balen, I. Jedema, J. Falkenburg, 2018, Haematologica.

A Polymorphism in the Splice Donor Site of ZNF419 Results in the Novel Renal Cell Carcinoma-Associated Minor Histocompatibility Antigen ZAPHIR

M. Kester, M. Griffioen, P. D. De Mulder, 2011, PloS one.

Tissue Damage Caused by Myeloablative, but Not Non-Myeloablative, Conditioning before Allogeneic Stem Cell Transplantation Results in Dermal Macrophage Recruitment without Active T-Cell Interaction

A. Kruisselbrink, K. Szuhai, E. Jordanova, 2018, Front. Immunol..

Long‐term in vitro persistence of magnetic properties after magnetic bead‐based cell separation of T cells

I. Jedema, J. Falkenburg, C. Hoogstraten, 2020, Scandinavian journal of immunology.

Generation and infusion of multi-antigen-specific T cells to prevent complications early after T-cell depleted allogeneic stem cell transplantation—a phase I/II study

H. Einsele, L. Germeroth, J. Zwaginga, 2019, Leukemia.

PD-1/PD-L1 interactions contribute to functional T-cell impairment in patients who relapse with cancer after allogeneic stem cell transplantation.

A. Korman, M. Kester, M. Quigley, 2011, Cancer research.

PD-1 signaling impairs MiHA-specific CD8+ T cells

Kester, A. Korman, Robbert, 2011 .

PD-1 / PD-L 1 interactions contribute to functional T cell impairment in patients that relapse with cancer after allogeneic stem cell transplantation

Kester, A. Korman, Robbert, 2011 .

Microenvironment and Immunology PD-1 / PD-L 1 Interactions Contribute to Functional T-Cell Impairment in Patients Who Relapse with Cancer After Allogeneic Stem Cell Transplantation

A. Korman, M. Kester, M. Quigley, 2011 .

Myeloablative T cell-depleted alloSCT with early sequential prophylactic donor lymphocyte infusion is an efficient and safe post-remission treatment for adult ALL

R. Willemze, H. Veelken, S. Kersting, 2014, Bone Marrow Transplantation.

WT1-specific TCRs directed against newly identified peptides install antitumor reactivity against acute myeloid leukemia and ovarian carcinoma

R. Hagedoorn, M. Heemskerk, M. Griffioen, 2022, Journal for ImmunoTherapy of Cancer.

HLA Class II Restricted T-Cell Reactivity to a Developmentally Regulated Antigen Shared by Leukemic Cells and CD34+ Early Progenitor Cells

C. Melief, T. Mutis, E. Schrama, 1997 .

Amino acids at position 5 in the peptide/MHC binding region of a public virus‐specific TCR are completely inter‐changeable without loss of function

D. Amsen, I. Jedema, J. Falkenburg, 2022, European journal of immunology.

Delayed Transfer of Immune Cells or the Art of Donor Lymphocyte Infusion

F. Locatelli, H. Kolb, J. Kuball, 2018, The EBMT Handbook.

Identification of 4 novel HLA-B*40:01 restricted minor histocompatibility antigens and their potential as targets for graft-versus-leukemia reactivity

M. Kester, M. Griffioen, E. Lurvink, 2012, Haematologica.

Detection and Functional Analysis of CD8+ T Cells Specific for PRAME: a Target for T-Cell Therapy

S. H. van der Burg, C. Melief, J. Falkenburg, 2006, Clinical Cancer Research.

Induction of A. fumigatus-specific CD4-positive T cells in patients recovering from invasive aspergillosis

E. Lagendijk, R. Hagedoorn, M. Heemskerk, 2014, Haematologica.

A library of cancer testis specific T cell receptors for T cell receptor gene therapy

R. Hagedoorn, M. Heemskerk, P. V. van Veelen, 2022, Molecular therapy oncolytics.

Human iPSC-derived preclinical models to identify toxicity of tumor-specific T cells with clinical potential

R. Hagedoorn, M. Heemskerk, C. Freund, 2023, Molecular therapy. Methods & clinical development.

ANTIGENS ARE DIFFERENTIALLY EXPRESSED ON HUMAN HEMATOPOIETIC PROGENITOR CELLS

W. Fibbe, E. Goulmy, J. Rood, 2003 .

Minor Histocompatibility Antigen (mHag)-specific And B-cell Chronic Lymphocytic Leukemia (CLL)- reactive T Cells Can Be Derived From Matched Sibling Donors Using Transformed CLL Cells As Stimulator Cells

A. Mulder, R. Barge, S. Luxemburg-Heijs, 2007 .

BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells.

T. Chambers, H. M. Goselink, I. Jedema, 2015, Cancer research.

Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

J. Falkenburg, M. Griffioen, P. Dellabona, 2019, Nature Communications.

Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8+ T Cells During Relapse after Allogeneic Stem Cell Transplantation.

M. Kester, J. Jansen, H. Dolstra, 2017, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

1 BH 3 inhibitor sensitivity and Bcl-2 dependence in primary acute lymphoblastic leukemia cells

T. Chambers, I. Jedema, J. Eichhorn, 2015 .

Feasibility, safety, and efficacy of early prophylactic donor lymphocyte infusion after T cell-depleted allogeneic stem cell transplantation in acute leukemia patients

H. Veelken, P. A. von dem Borne, W. Marijt, 2023, Annals of Hematology.

Mismatched transplants for refractory lymphoma?

H. Kluin-Nelemans, J. Falkenburg, 1999, The Lancet.

Myeloablative T cell-depleted alloSCT with early sequential prophylactic donor lymphocyte infusion is an efficient and safe post-remission treatment for adult ALL

R. Willemze, H. Veelken, S. Kersting, 2014, Bone Marrow Transplantation.

Quantification of the HA-1 gene product at the RNA level; relevance for immunotherapy of hematological malignancies.

E. Schuuring, F. Brasseur, M. Wilke, 2003, The hematology journal : the official journal of the European Haematology Association.

Competitive repopulation and allo-immunological pressure determine chimerism kinetics after T-cell depleted allogeneic stem cell transplantation and donor lymphocyte infusions.

H. Veelken, P. A. von dem Borne, L. D. de Wreede, 2022, Transplantation and cellular therapy.

Impact of alemtuzumab pharmacokinetics on T-cell dynamics, graft-versus-host disease and viral reactivation in patients receiving allogeneic stem cell transplantation with an alemtuzumab-based T-cell-depleted graft.

H. Veelken, P. A. von dem Borne, D. Moes, 2019, Transplant immunology.

CMV seronegative donors: Effect on clinical severity of CMV infection and reconstitution of CMV-specific immunity.

W. Marijt, L. D. de Wreede, I. Jedema, 2018, Transplant immunology.

Integrated Whole Genome and Transcriptome Analysis Identified a Therapeutic Minor Histocompatibility Antigen in a Splice Variant of ITGB2

M. Vermaat, P. Hoen, M. Kester, 2016, Clinical Cancer Research.

Allo‐reactive T cells for the treatment of hematological malignancies

I. Jedema, J. Falkenburg, 2015, Molecular oncology.

Primary Allogeneic T-Cell Responses against Mantle Cell Lymphoma Antigen-Presenting Cells for Adoptive Immunotherapy after Stem Cell Transplantation

R. Willemze, R. Barge, I. Jedema, 2005, Clinical Cancer Research.

Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

R. Hagedoorn, M. Heemskerk, J. Leusen, 2022, Oncoimmunology.

BH 3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells

T. Chambers, H. M. Goselink, I. Jedema, 2015 .

Promiscuity of Peptides Presented in HLA-DP Molecules from Different Immunogenicity Groups Is Associated With T-Cell Cross-Reactivity

P. V. van Veelen, A. D. de Ru, Arnoud H de Ru, 2022, Frontiers in Immunology.

The DBY gene codes for an HLA-DQ5-restricted human male-specific minor histocompatibility antigen involved in graft-versus-host disease.

J. Drijfhout, M. Kester, R. Willemze, 2002, Blood.

T Cells Specific for an Unconventional Natural Antigen Fail to Recognize Leukemic Cells

M. Griffioen, R. Spaapen, M. Jongsma, 2019, Cancer Immunology Research.

Identification of Biological Relevant Minor Histocompatibility Antigens within the B-lymphocyte–Derived HLA-Ligandome Using a Reverse Immunology Approach

M. Heemskerk, M. Griffioen, C. Hassan, 2015, Clinical Cancer Research.

A phase I/II minor histocompatibility antigen-loaded dendritic cell vaccination trial to safely improve the efficacy of donor lymphocyte infusions in myeloma

M. Kersten, M. Kester, I. Slaper-Cortenbach, 2017, Bone Marrow Transplantation.

Early detection and rapid isolation of leukemia-reactive donor T cells for adoptive transfer using the IFN-gamma secretion assay.

R. Willemze, S. V. van Luxemburg-Heijs, I. Jedema, 2007, Clinical cancer research : an official journal of the American Association for Cancer Research.

Successful generation of primary virus-specific and anti-tumor T-cell responses from the naïve donor T-cell repertoire is determined by the balance between antigen-specific precursor T cells and regulatory T cells

M. Kester, I. Jedema, M. T. van der Beek, 2011, Haematologica.

Simultaneous Isolation of CD8+ and CD4+ T Cells Specific for Multiple Viruses for Broad Antiviral Immune Reconstitution After Allogeneic Stem Cell Transplantation

H. Guchelaar, M. Kester, S. Kruithof, 2011, Journal of immunotherapy.

LB-ARHGDIB-1R as a novel minor histocompatibility antigen for therapeutic application

M. Kester, M. Griffioen, C. V. van Bergen, 2015, Haematologica.

HA-1H T-Cell Receptor Gene Transfer to Redirect Virus-Specific T Cells for Treatment of Hematological Malignancies After Allogeneic Stem Cell Transplantation: A Phase 1 Clinical Study

M. V. van Loenen, R. Hagedoorn, R. de Boer, 2020, Frontiers in Immunology.

Rapid Re-expression of Retrovirally Introduced VersusEndogenous TCRs in Engineered T cells AfterAntigen-specific Stimulation

M. V. van Loenen, R. Hagedoorn, R. de Boer, 2011, Journal of immunotherapy.

Magnitude of Off-Target Allo-HLA Reactivity by Third-Party Donor-Derived Virus-Specific T Cells Is Dictated by HLA-Restriction

D. Amsen, I. Jedema, J. Falkenburg, 2021, Frontiers in Immunology.

Co-ordinated isolation of CD8(+) and CD4(+) T cells recognizing a broad repertoire of cytomegalovirus pp65 and IE1 epitopes for highly specific adoptive immunotherapy.

H. Guchelaar, R. Willemze, I. Jedema, 2010, Cytotherapy.

Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application

R. Hagedoorn, M. A. van der Hoorn, M. Kester, 2008, Haematologica.

Public T-Cell Receptors (TCRs) Revisited by Analysis of the Magnitude of Identical and Highly-Similar TCRs in Virus-Specific T-Cell Repertoires of Healthy Individuals

G. Efimov, D. Amsen, I. Jedema, 2021, bioRxiv.

Effective Treatment of Refractory CMV Reactivation After Allogeneic Stem Cell Transplantation With In Vitro-generated CMV pp65-specific CD8+ T-cell Lines

A. Lankester, P. A. von dem Borne, S. Kruithof, 2012, Journal of immunotherapy.

Efficiency and Mechanism of Antigen-specific CD8+ T-cell Activation Using Synthetic Long Peptides

H. Guchelaar, M. Griffioen, P. V. van Veelen, 2012, Journal of immunotherapy.

T cell receptor engineering of primary NK cells to therapeutically target tumors and tumor immune evasion

M. V. van Loenen, M. Heemskerk, D. Remst, 2022, Journal for ImmunoTherapy of Cancer.

Detailed Analysis of IFNg Response Upon Activation Permits Efficient Isolation of Cytomegalovirus-specific CD8+ T Cells for Adoptive Immunotherapy

H. Guchelaar, R. Willemze, I. Jedema, 2009, Journal of immunotherapy.

A Good Manufacturing Practice procedure to engineer donor virus-specific T cells into potent anti-leukemic effector cells

Inge Jedema, Pauline Meij, M. V. van Loenen, 2014, Haematologica.

Long-term risk of cancer development in adult patients with idiopathic aplastic anemia after treatment with anti-thymocyte globulin

H. Veelken, A. Brand, L. D. de Wreede, 2017, Haematologica.

Mismatched HLA-DRB3 Can Induce a Potent Immune Response After HLA 10/10 Matched Stem Cell Transplantation

C. V. van Bergen, S. V. van Luxemburg-Heijs, P. van Balen, 2017, Transplantation.

Clinically applicable CD34+-derived blood dendritic cell subsets exhibit key subset-specific features and potently boost anti-tumor T and NK cell responses

M. Kester, M. Heemskerk, J. Borst, 2021, Cancer Immunology, Immunotherapy.

Complement-dependent cytotoxicity induced by therapeutic antibodies in B-cell acute lymphoblastic leukemia is dictated by target antigen expression levels and augmented by loss of membrane-bound complement inhibitors

I. Jedema, C. Halkes, J. Falkenburg, 2017, Leukemia & lymphoma.

Tracking the progeny of adoptively transferred virus-specific T cells in patients posttransplant using TCR sequencing

H. Einsele, L. Germeroth, C. V. van Bergen, 2022, Blood advances.

PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy

Karoly Szuhai, Marco W Schilham, M. Schilham, 2018, Oncoimmunology.

Double Umbilical Cord Blood Transplantation in High-Risk Hematological Patients: A Phase II Study Focusing on the Mechanism of Graft Predominance

B. van der Holt, C. Lamers, C. V. van Bergen, 2019, HemaSphere.

A broad and systematic approach to identify B-cell malignancy targeting TCRs for multi-antigen based T-cell therapy.

R. Hagedoorn, M. Kester, M. Heemskerk, 2021, Molecular therapy : the journal of the American Society of Gene Therapy.

Indications for allo- and auto-SCT for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2015

A. Gennery, N. Kröger, A. Nagler, 2015, Bone Marrow Transplantation.

Simultaneous Deletion of Endogenous TCRαβ for TCR Gene Therapy Creates an Improved and Safe Cellular Therapeutic.

J. Falkenburg, M. Heemskerk, R. Reijmers, 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia

R. Hagedoorn, M. Kester, J. Falkenburg, 2019, The Journal of clinical investigation.

Durable Remission of Renal Cell Carcinoma in Conjuncture with Graft versus Host Disease following Allogeneic Stem Cell Transplantation and Donor Lymphocyte Infusion: Rule or Exception?

J. Falkenburg, M. Griffioen, C. V. van Bergen, 2014, PloS one.

Generation and administration of HA-1-specific T-cell lines for the treatment of patients with relapsed leukemia after allogeneic stem cell transplantation: a pilot study

A. Wafelman, M. A. van der Hoorn, J. Falkenburg, 2012, Haematologica.

UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition.

J. Falkenburg, R. Willemze, E. Goulmy, 2000, Blood.

DFFRY codes for a new human male-specific minor transplantation antigen involved in bone marrow graft rejection.

J. Falkenburg, R. Willemze, J. Falkenburg, 2000, Blood.

Graft versus tumor effects and why people relapse.

J. Falkenburg, I. Jedema, J. Falkenburg, 2017, Hematology. American Society of Hematology. Education Program.

Joint models quantify associations between immune cell kinetics and allo-immunological events after allogeneic stem cell transplantation and subsequent donor lymphocyte infusion

H. Veelken, E. Koster, P. V. Borne, 2023, Frontiers in immunology.

Internalization and cell cycle-dependent killing of leukemic cells by Gemtuzumab Ozogamicin: rationale for efficacy in CD33-negative malignancies with endocytic capacity

J. Falkenburg, R. Willemze, J. Dongen, 2004, Leukemia.

Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase

A. Mackensen, J. Falkenburg, M. Griffioen, 2020, Frontiers in Immunology.

Long-term follow-up of myeloablative allogeneic stem cell transplantation using Campath ‘in the bag’ as T-cell depletion: the Leiden experience

J. Falkenburg, R. Willemze, R. Barge, 2006, Bone Marrow Transplantation.

Therapeutic targeting of the BCR-associated protein CD79b in a TCR-based approach is hampered by aberrant expression of CD79b.

R. Hagedoorn, M. Kester, J. Falkenburg, 2015, Blood.

Rapid Re-expression of Retrovirally Introduced VersusEndogenous TCRs in Engineered T cells AfterAntigen-specific Stimulation

M. V. van Loenen, R. Hagedoorn, R. de Boer, 2011, Journal of immunotherapy.

Kinetic preservation of dual specificity of coprogrammed minor histocompatibility antigen-reactive virus-specific T cells.

M. V. van Loenen, R. Hagedoorn, M. Kester, 2009, Cancer research.

T-cell receptor gene transfer for treatment of leukemia.

M. Heemskerk, M. Griffioen, J. Falkenburg, 2008, Cytotherapy.

Reprogramming of Virus-specific T Cells into Leukemia-reactive T Cells Using T Cell Receptor Gene Transfer

R. Hagedoorn, M. Kester, J. Falkenburg, 2004, The Journal of experimental medicine.

High susceptibility of human leukemic cells to Fas-induced apoptosis is restricted to G1 phase of the cell cycle and can be increased by interferon treatment

J. Falkenburg, R. Willemze, R. Barge, 2003, Leukemia.

Efficient Induction and Isolation of CMV-Specific CD8+ T Cells from CMV Seronegative Donors for the Treatment of CMV Reactivation in CMV Seropositive Patients Transplanted with a CMV Seronegative Donor.

R. Willemze, I. Jedema, P. Meij, 2007 .

NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: Graft-versus-Tumor/Leukemia Reaction.

J. Ritz, M. V. D. van den Brink, A. Barrett, 2010, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Hairy cell leukemia-specific recognition by multiple autologous HLA-DQ or DP-restricted T-cell clones.

J. Falkenburg, R. Willemze, H. Kluin-Nelemans, 1999, Blood.

Characterization of the T-cell-mediated immune response against the Aspergillus fumigatus proteins Crf1 and catalase 1 in healthy individuals.

R. Hagedoorn, J. Falkenburg, F. Claas, 2013, The Journal of infectious diseases.

Human allo-reactive CD4+ T cells as strong mediators of anti-tumor immunity in NOD/scid mice engrafted with human acute lymphoblastic leukemia

J. Falkenburg, R. Willemze, M. Griffioen, 2012, Leukemia.

HLA class II upregulation during viral infection leads to HLA-DP-directed graft-versus-host disease after CD4+ donor lymphocyte infusion.

M. Griffioen, A. Kruisselbrink, C. V. van Bergen, 2013, Blood.

Introduction to the reports from the National Cancer Institute First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.

N. Kröger, D. Porter, C. June, 2010, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Dissecting Genetic Control of HLA-DPB1 Expression and Its Relation to Structural Mismatch Models in Hematopoietic Stem Cell Transplantation

J. Falkenburg, P. Horn, K. Fleischhauer, 2018, Front. Immunol..

Microarray Gene Expression Analysis to Evaluate Cell Type Specific Expression of Targets Relevant for Immunotherapy of Hematological Malignancies

M J Jager, J. Goeman, R. Vries, 2016, PloS one.

Loss or downregulation of HLA class I expression at the allelic level in acute leukemia is infrequent but functionally relevant, and can be restored by interferon.

J. Falkenburg, F. Claas, R. Willemze, 2002, Human immunology.

An animal model for human cellular immunotherapy: specific eradication of human acute lymphoblastic leukemia by cytotoxic T lymphocytes in NOD/scid mice.

J. Falkenburg, R. Willemze, J. Falkenburg, 2002, Blood.

8-Bromo-cAMP induces a proliferative response in an IL-3 dependent leukemic cell line and activates Erk 1,2 via a Shc-independent pathway.

J. Falkenburg, R. Willemze, J. Maassen, 1997, Biochimica et biophysica acta.

Association of disparities in known minor histocompatibility antigens with relapse-free survival and graft-versus-host disease after allogeneic stem cell transplantation.

M. Kester, J. Falkenburg, J. Jansen, 2013, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Minor histocompatibility antigens as targets of graft-versus-leukemia reactions

J. Falkenburg, M. Heemskerk, R. Willemze, 2002, Current opinion in hematology.

ANTIGENS ARE DIFFERENTIALLY EXPRESSED ON HUMAN HEMATOPOIETIC PROGENITOR CELLS

W. Fibbe, E. Goulmy, J. Rood, 2003 .

National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee.

N. Kröger, D. Porter, C. June, 2011, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Immunopeptidome Analysis of HLA-DPB1 Allelic Variants Reveals New Functional Hierarchies

M. Kester, J. Falkenburg, M. Heemskerk, 2020, The Journal of Immunology.

Extracellular Domains of CD8α and CD8ß Subunits Are Sufficient for HLA Class I Restricted Helper Functions of TCR-Engineered CD4+ T Cells

M. V. van Loenen, R. Hagedoorn, R. de Boer, 2013, PloS one.

Alloreactive effector T cells require the local formation of a proinflammatory environment to allow crosstalk and high avidity interaction with nonhematopoietic tissues to induce GVHD reactivity.

A. Kruisselbrink, P. A. von dem Borne, I. Jedema, 2012, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

HLA-DP as specific target for cellular immunotherapy in HLA class II-expressing B-cell leukemia

J. Falkenburg, M. Heemskerk, R. Willemze, 2008, Leukemia.

Promiscuity of the AlloHLA-A2 restricted T cell repertoire hampers the generation of minor Histocompatibility antigen-specific cytotoxic T cells across HLA barriers.

M. Kester, J. Falkenburg, E. Goulmy, 2007, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Patient HLA-DP-specific CD4+ T cells from HLA-DPB1-mismatched donor lymphocyte infusion can induce graft-versus-leukemia reactivity in the presence or absence of graft-versus-host disease.

J. Falkenburg, M. Griffioen, C. V. van Bergen, 2013, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Graft versus leukemia reactivity after allogeneic stem cell transplantation.

J. Falkenburg, E. Warren, J. Falkenburg, 2011, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

New CFSE-based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population.

J. Falkenburg, R. Willemze, R. Barge, 2004, Blood.

Hematopoietic SCT in Europe: data and trends in 2012 with special consideration of pediatric transplantation

A. Gennery, N. Kröger, J. Falkenburg, 2014, Bone Marrow Transplantation.

VISTA expression on cancer-associated endothelium selectively prevents T-cell extravasation.

M. Heemskerk, R. Koning, J. V. van Buul, 2023, Cancer immunology research.

Generation of leukemia-reactive cytotoxic T lymphocyte clones from the HLA-identical bone marrow donor of a patient with leukemia

J. Falkenburg, R. Willemze, L. Faber, 1992, The Journal of experimental medicine.