G. Mak

发表

Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy

A. Faisal, M. Valenti, A. K. de Haven Brandon, 2017, British Journal of Cancer.

Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.

R. V. van Montfort, A. Faisal, N. Cronin, 2016, Journal of medicinal chemistry.

Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.

R. V. van Montfort, P. Workman, A. Faisal, 2015, Cancer research.

CDK5RAP3 Is a Novel Repressor of p14ARF in Hepatocellular Carcinoma Cells

Ming-tao Li, I. Ng, Yuan Zhou, 2012, PloS one.

Title CDK 5 RAP 3 is a novel repressor of p 14 ARF in hepatocellularcarcinoma cells

Ming-tao Li, I. Ng, Yuan Zhou, 2012 .

Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis.

I. Ng, Y. Ching, J. Lee, 2011, Cancer research.

The LIM-only protein FHL2 regulates interleukin-6 expression through p38 MAPK mediated NF-κB pathway in muscle cells.

S. Tsui, C. Wong, G. Mak, 2012, Cytokine.

High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers

R. V. van Montfort, A. Faisal, F. Raynaud, 2019, Molecular Cancer Therapeutics.

Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (BOS172722)

R. V. van Montfort, A. Faisal, N. Cronin, 2018, Journal of medicinal chemistry.

Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3,2-c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Isaac M. Westwood, Julian Blagg, Florence I. Raynaud, 2013, Journal of medicinal chemistry.

Running head: NEUROTICISM AND COPING 1 The Effect of Initial Coping on Subsequent Coping, and the Role of Neuroticism

G. Mak, 2010 .

Green fluorescent protein induces the secretion of inflammatory cytokine interleukin-6 in muscle cells.

S. Tsui, C. Wong, G. Mak, 2007, Analytical biochemistry.

Abstract 5450: Naturally occurring mutations in the MPS1 gene predispose cells to kinase inhibitor drug-resistance

P. Workman, A. Faisal, K. Boxall, 2015 .