R. Millet

发表

4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands: structural insights into the design of a novel inverse agonist series.

P. Chavatte, P. Desreumaux, M. Djouina, 2010, Journal of medicinal chemistry.

Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.

E. Davioud‐Charvet, C. Sergheraert, L. Maes, 2002, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of substituted dioxodibenzothiazepines and dibenzocycloheptanes as farnesyltransferase inhibitors.

A. Lemoine, G. Laconde, A. Farce, 2007, Bioorganic & medicinal chemistry letters.

On the synthesis and biological properties of isocombretastatins: a case of ketone homologation during Wittig reaction attempts

A. Farce, P. Gautret, C. Waterlot, 2013 .

Synthesis of Bioorganometallic Nanomolar-Potent CB2 Agonists Containing a Ferrocene Unit

S. Coles, G. Tizzard, J. Spencer, 2016 .

Probing BRD Inhibition Substituent Effects in Bulky Analogues of (+)‐JQ1

Hannah J. Maple, T. Chevassut, G. Gasser, 2021, Helvetica Chimica Acta.

Synthesis and biological evaluation of ferrocene-based cannabinoid receptor 2 ligands.

A. Farce, S. Coles, G. Tizzard, 2018, Future medicinal chemistry.

Development of novel oxazolo[5,4-d]pyrimidines as competitive CB2 neutral antagonists based on scaffold hopping.

P. Chavatte, J. Spencer, X. Dezitter, 2018, European journal of medicinal chemistry.

Novel potent substance P and neurokinin A receptor antagonists. Conception, synthesis and biological evaluation of indolizine derivatives.

J. Goossens, L. Goossens, R. Houssin, 2002, Bioorganic & medicinal chemistry.

Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines.

A. Bridoux, N. Pommery, J. Pommery, 2010, Bioorganic & medicinal chemistry.

Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: consequences in receptor affinity and functionality.

P. Depreux, J. Poupaert, J. Goossens, 2007, Journal of medicinal chemistry.

Synthesis and biological evaluation of tripeptide derivatives of Cbz-Gly-Leu-Trp-OBzl(CF3)2 as NK1/NK2 ligands

J. Goossens, R. Houssin, J. Hénichart, 1999, Letters in Peptide Science.

Scaffold hopping strategy toward original pyrazolines as selective CB₂ receptor ligands.

P. Chavatte, V. Levacher, R. Millet, 2012, European journal of medicinal chemistry.

New substance P receptor antagonists. Conception, synthesis and biological evaluation of spirolactam derivatives and their tripeptide Cbz-Pro-Leu-Trp-OBzl(CF3)2 and lactam pseudopeptide derivatives

J. Goossens, L. Goossens, R. Houssin, 2000, Letters in Peptide Science.

A flexible approach to the design of new potent substance P receptor ligands

J. Goossens, L. Goossens, R. Houssin, 2001, The Journal of pharmacy and pharmacology.

Conformation of the tripeptide Cbz‐Pro‐Leu‐Trp‐OBzl(CF3)2 deduced from two‐dimensional 1H‐NMR and conformational energy calculations is related to its affinity for NK1‐receptor

P. Chavatte, J. Goossens, L. Goossens, 2001, Journal of peptide science : an official publication of the European Peptide Society.

Flow cytometry: An accurate tool for screening P2RX7 modulators

T. Idziorek, S. Adriouch, N. Renault, 2020, Cytometry Part A.

Switching cannabinoid response from CB(2) agonists to FAAH inhibitors.

P. Chavatte, P. Desreumaux, M. Djouina, 2014, Bioorganic & medicinal chemistry letters.

3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.

P. Chavatte, A. Lemoine, P. Desreumaux, 2013, Bioorganic & medicinal chemistry.

4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis.

P. Chavatte, P. Desreumaux, M. Djouina, 2012, Journal of medicinal chemistry.

Switching invariant natural killer T (iNKT) cell response from anticancerous to anti-inflammatory effect: molecular bases.

P. Chavatte, B. Bertin, P. Desreumaux, 2014, Journal of medicinal chemistry.

New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis.

P. Chavatte, P. Desreumaux, M. Djouina, 2011, Bioorganic & medicinal chemistry.

From dicarbonylallene to 1-aryl-3,6-dimethyl-4-aminoaryl-2-pyridones: a one-pot versatile and uncatalyzed synthesis

J. Hénichart, B. Rigo, R. Millet, 2007 .

Benzo[d]thiazol-2(3H)-ones as new potent selective CB2 agonists with anti-inflammatory properties.

M. Djouina, M. Body-Malapel, N. Renault, 2019, European journal of medicinal chemistry.

Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction.

C. Bailly, G. Vergoten, X. Thuru, 2022, European journal of medicinal chemistry.

Synthesis of an azabicycloalkane amino acid scaffold as potential rigid dipeptide mimetic

R. Houssin, J. Hénichart, B. Rigo, 2002 .

Discovery of highly functionalized scaffolds: Pyrroloimidazolediones as P2X7 receptor antagonists

X. Dezitter, Alina Ghinet, B. Rigo, 2017 .

Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library

J. Deadman, P. Chavatte, Jahangir Amin, 2012 .

Conformationally constrained dipeptides. Obtention of enantiomerically pure 6‐acetamido‐5‐oxo‐1,2,3,5,6,7‐hexahydro‐3‐indolizine carboxylic acid

L. Goossens, R. Houssin, J. Hénichart, 2000 .

Novel potent substance P and neurokinin A receptor antagonists. Conception, synthesis and biological evaluation of indolizine derivatives.

J. Goossens, L. Goossens, R. Houssin, 2002, Bioorganic & medicinal chemistry.

Synthesis of a novel conformationally restricted Val‐Phe dipeptidomimetic

A. Farce, R. Houssin, J. Hénichart, 2006, Journal of peptide science : an official publication of the European Peptide Society.

A rapid route for the preparation of pyrimido[5,4-d]- and pyrido[3,2-d]oxazoles

J. Spencer, R. Millet, A. Abdul-Sada, 2015 .

A new scaffold for dipeptide β‐turn mimetics: Expeditious synthesis of an unsaturated 6,5‐fused bicyclic lactam

R. Houssin, J. Hénichart, B. Rigo, 1999 .

Antagonists of the P2X7 receptor: Mechanism of enantioselective recognition using highly sulfated and sulfobutylether cyclodextrins by capillary electrokinetic chromatography

C. Vaccher, P. Gautret, X. Dezitter, 2014, Electrophoresis.

NMR studies of interactions of new CB2 cannabinoid receptor ligands with cyclodextrins hosts. Correlation with micellar electrokinetic chromatography and reversed phase high performance liquid chromatography

P. Chavatte, A. Farce, C. Vaccher, 2014, Journal of Inclusion Phenomena and Macrocyclic Chemistry.

Potent and selective farnesyl transferase inhibitors.

P. Chavatte, J. Goossens, N. Pommery, 2004, Journal of medicinal chemistry.

Antiproliferative Activities of Methanolic Extracts from a Neotropical Ganoderma Species (Aphyllophoromycetideae): Identification and Characterization of a Novel Ganoderic Acid

A. Lemoine, R. Courtecuisse, S. Welti, 2010 .

Exploring chiral separation of 3-carboxamido-5-aryl isoxazole derivatives by supercritical fluid chromatography on amylose and cellulose tris dimethyl- and chloromethyl phenylcarbamate polysaccharide based stationary phases.

P. Chavatte, C. Vaccher, Alina Ghinet, 2016, Journal of chromatography. A.

Small scale separation of isoxazole structurally related analogues by chiral supercritical fluid chromatography.

E. Lipka, R. Millet, Lucas Lemaire, 2017, Journal of chromatography. A.

Synthesis of 1,4-diazepin-5-ones under microwave irradiation and their reduction products

R. Houssin, J. Hénichart, R. Millet, 2007 .

Synthesis and biological evaluation of conformationally restricted derivatives of tryptophan as NK1/NK2 ligands

P. Chavatte, J. Goossens, R. Houssin, 1999, Letters in Peptide Science.

Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer.

P. Chavatte, A. Lemoine, A. Farce, 2011, Journal of medicinal chemistry.

Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds.

P. Chavatte, A. Lemoine, A. Farce, 2006, European journal of medicinal chemistry.

Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

Philippe Chavatte, Pierre Desreumaux, Nicolas Renault, 2012, Journal of medicinal chemistry.

Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling.

Philippe Chavatte, Amaury Farce, P. Depreux, 2006, Journal of medicinal chemistry.

In vitro and in vivo evaluation of two rational-designed nonpeptidic farnesyltransferase inhibitors on HT29 human colon cancer cell lines.

A. Lemoine, J. Goossens, N. Pommery, 2006, Oncology research.

Enantioseparation of pyroglutamide derivatives on polysaccharide based chiral stationary phases by high-performance liquid chromatography and supercritical fluid chromatography: a comparative study.

Philippe Chavatte, P. Chavatte, C. Vaccher, 2014, Journal of chromatography. A.

Involvement of the P2X7 purinergic receptor in inflammation: an update of antagonists series since 2009 and their promising therapeutic potential.

Alina Ghinet, E. Lipka, Davy Baudelet, 2015, Current medicinal chemistry.

Pyroglutamide-Based P2X7 Receptor Antagonists Targeting Inflammatory Bowel Disease.

A. Farce, S. Adriouch, B. Sendid, 2020, Journal of medicinal chemistry.

ZrCl4 as a new catalyst for ester amidation: an efficient synthesis of h-P2X7R antagonists

X. Dezitter, Alina Ghinet, Pierrick Dufrénoy, 2016 .

Evaluation and comparison of three different separation techniques for analysis of retroamide enantiomers and their biological evaluation against h-P2X7 receptor.

C. Vaccher, P. Gautret, S. Adriouch, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy

B. Ryffel, J. Kanellopoulos, J. Benzaquen, 2021, Nature Communications.

Synthesis of 2,3 and 4,5-Dihydro-hydroxy-isoxazoles and Isoxazoles Under Different pH Conditions

P. Chavatte, C. Vaccher, J. Bonte, 2010 .

Small-molecule P2RX7 activator sensitizes tumor to immunotherapy and vaccinates mouse against tumor re-challenge

B. Ryffel, J. Kanellopoulos, J. Benzaquen, 2020, bioRxiv.

Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.

P. Chavatte, J. Spencer, Supojjanee Sansook, 2017, Journal of medicinal chemistry.

Therapeutical potential of CB₂ receptors in immune-related diseases.

P. Chavatte, P. Desreumaux, R. Millet, 2013, Current molecular pharmacology.

Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis.

P. Chavatte, P. Desreumaux, M. Djouina, 2015, ACS medicinal chemistry letters.

Virtual Screening of CB2 Receptor Agonists from Bayesian Network and High‐Throughput Docking: Structural Insights into Agonist‐Modulated GPCR Features

Philippe Chavatte, Pierre Desreumaux, Xavier Laurent, 2013, Chemical biology & drug design.

Design, synthesis and biological evaluation of potent FAAH inhibitors.

P. Chavatte, N. Renault, R. Millet, 2016, Bioorganic & medicinal chemistry letters.

A versatile and efficient synthesis of 3-aroyl-1,4-dihydroquinolin-4-ones

P. Depreux, J. Hénichart, E. Stern, 2004 .

A Versatile and Efficient Synthesis of 3‐Aroyl‐1,4‐dihydroquinolin‐4‐ones.

P. Depreux, J. Hénichart, E. Stern, 2005 .

Novel PD-L1-Targeted Phenyl-Pyrazolone Derivatives with Antioxidant Properties

C. Bailly, X. Thuru, H. Vezin, 2023, Molecules.

Novel N-(4-Piperidinyl)benzamide antimalarials with mammalian protein farnesyltransferase inhibitory activity.

C. Sergheraert, A. Lemoine, N. Pommery, 2005, Chemical & pharmaceutical bulletin.

Recent advances in the development of selective CB(2) agonists as promising anti-inflammatory agents.

P. Chavatte, P. Desreumaux, M. Body-Malapel, 2012, Current medicinal chemistry.

Synthesis of 5-nitro-2-furancarbohydrazides and their cis-diamminedichloroplatinum complexes as bitopic and irreversible human thioredoxin reductase inhibitors.

K. Becker, E. Davioud‐Charvet, S. Gromer, 2005, Journal of medicinal chemistry.

Antioxidant Properties and Aldehyde Reactivity of PD-L1 Targeted Aryl-Pyrazolone Anticancer Agents

C. Bailly, X. Thuru, H. Vezin, 2022, Molecules.

Flow cytometry: An accurate tool for screening P2RX7 modulators

T. Idziorek, S. Adriouch, N. Renault, 2020, Cytometry Part A.

Hypercalcaemia and parathyroid hyperplasia associated with renal adenocarcinoma

R. Millet, R. Walton, A. Jung, 1976, Postgraduate medical journal.