K. Hashimoto

发表

Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes.

M. D. de Andrés, H. Roach, M. Goldring, 2013, Arthritis and rheumatism.

Association of Reduced Type IX Collagen Gene Expression in Human Osteoarthritic Chondrocytes With Epigenetic Silencing by DNA Hypermethylation

E. Itoi, M. D. de Andrés, H. Roach, 2014, Arthritis & rheumatology.

Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation

H. Roach, N. Yamada, K. Hashimoto, 2009, Rheumatology International.

Improved Quantification of DNA Methylation Using Methylation-Sensitive Restriction Enzymes and Real-Time PCR

E. Itoi, H. Roach, S. Kokubun, 2007, Epigenetics.

Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis.

H. Roach, M. Goldring, K. Marcu, 2011, European cells & materials.

The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes--implications for osteoarthritis.

E. Itoi, H. Roach, M. Goldring, 2011, Biochemical and biophysical research communications.

DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes

E. Itoi, M. Goldring, R. Oreffo, 2017, Scientific Reports.

DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes.

H. Roach, M. Goldring, R. Oreffo, 2009, Arthritis and rheumatism.

Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis

E. Itoi, R. Oreffo, R. Oreffo, 2015, Osteoarthritis and cartilage.

Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide.

M. Makuuchi, H. Esumi, A. Weisz, 2000, Blood.

ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by inhibiting SOX9-CBP/p300-driven histone acetyltransferase activity

M. Goldring, K. Culley, M. Otero, 2017, Connective tissue research.

Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites*

H. Roach, M. Goldring, R. Oreffo, 2013, The Journal of Biological Chemistry.

Specific Proximal Promoter CpG Sites Chondrocytes Depends on Methylation of ) Genes in IL1B ( β Interleukin-1 ) and MMP13 Metalloproteinase 13 ( Regulated Transcription of Human Matrix Molecular Bases of Disease:

H. Roach, M. Goldring, R. Oreffo, 2014 .

A whole-genome transcriptome analysis of articular chondrocytes in secondary osteoarthritis of the hip

E. Itoi, K. Hashimoto, Takashi Aki, 2018, PloS one.

Human chondrocyte cultures as models of cartilage-specific gene regulation.

M. Goldring, M. Otero, C. Dragomir, 2012, Methods in molecular biology.

E74-like Factor 3 (ELF3) Impacts on Matrix Metalloproteinase 13 (MMP13) Transcriptional Control in Articular Chondrocytes under Proinflammatory Stress*

Ko Hashimoto, Yefu Li, P. Oettgen, 2011, The Journal of Biological Chemistry.

Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis.

H. Roach, M. Goldring, R. Oreffo, 2011, Biochemical and biophysical research communications.

PCR-based methods to determine DNA methylation status at specific CpG sites using methylation-sensitive restriction enzymes

H. Roach, K. Hashimoto, 2007 .

DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes

E. Itoi, M. Goldring, R. Oreffo, 2017, Scientific Reports.

Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes.

H. Roach, M. Goldring, R. Oreffo, 2013, Arthritis and rheumatism.

Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites*

H. Roach, M. Goldring, R. Oreffo, 2013, The Journal of Biological Chemistry.

Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis

E. Itoi, R. Oreffo, A. Takahashi, 2015, Osteoarthritis and cartilage.