K. Kuwabara

发表

Development of a new knock-in mouse model and evaluation of pharmacological activities of lusutrombopag, a novel, nonpeptidyl small-molecule agonist of the human thrombopoietin receptor c-Mpl.

H. Yoshida, K. Dohi, Y. Gahara, 2017, Experimental hematology.

Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.

Y. Sugiyama, T. Asaki, K. Kuwabara, 2007, Bioorganic & medicinal chemistry.

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)

K. Kosugi, A. Hashino, K. Kuwabara, 2008, Journal of Pharmacology and Experimental Therapeutics.

Structure–activity studies on 1,3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor α (PPARα) agonists

Y. Sugiyama, T. Asaki, K. Kuwabara, 2008 .

Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.

Y. Sugiyama, T. Asaki, K. Kuwabara, 2008, Bioorganic & medicinal chemistry letters.

Antibody-Induced Arthritis Matrix Metalloproteinase-9 in The Role of Matrix Metalloproteinase-2 and Kuwabara

S. Itohara, T. Itoh, K. Kuwabara, 2002 .

Relevance of anti-reactive oxygen species activity to anti-inflammatory activity of components of eviprostat, a phytotherapeutic agent for benign prostatic hyperplasia.

K. Kuwabara, N. Inoue, K. Noda, 2007, Phytomedicine : international journal of phytotherapy and phytopharmacology.

ACETYL CoA CARBOXYLASE INHIBITORS FROM THE FUNGUS GONGRONELLA BUTRELI

H. Takeshima, K. Kuwabara, Akirae Ndo, 1985 .

Acetyl CoA carboxylase inhibitors from the fungus Gongronella butleri.

H. Takeshima, A. Endo, K. Kuwabara, 1985, The Journal of antibiotics.

Effects of leukotriene B4 receptor antagonist, LY293111Na, on antigen-induced bronchial hyperresponsiveness and leukocyte infiltration in sensitized guinea pigs

J. Fleisch, A. Arimura, K. Kuwabara, 2001, Inflammation Research.

Long-Acting Prostacyclin Receptor Agonist Prodrug

A. Hashino, T. Asaki, K. Kuwabara, 2007 .

Therapeutic time-window of a group IIA phospholipase A2 inhibitor in rabbit acute lung injury: Correlation with lung surfactant protection

A. Matsukawa, M. Yoshinaga, H. Obara, 2001, Critical care medicine.

Crucial role of group IIA phospholipase A(2) in oleic acid-induced acute lung injury in rabbits.

A. Matsukawa, M. Yoshinaga, N. Maekawa, 1999, American journal of respiratory and critical care medicine.

2- -N-(methylsulfonyl)acetamide (NS-304), an Orally Available and Long-Acting Prostacyclin Receptor Agonist Prodrug

K. Kuwano, A. Hashino, K. Okubo, 2007 .

Inhibition of antigen-induced arthritis in guinea pigs by a selective LTB4 receptor antagonist LY293111Na

J. Fleisch, K. Kuwabara, Y. Hori, 2002, Inflammation Research.

Effects of the second-generation leukotriene B(4) receptor antagonist, LY293111Na, on leukocyte infiltration and collagen-induced arthritis in mice.

T. Maruyama, J. Fleisch, K. Kuwabara, 2000, European journal of pharmacology.

Novel synthetic retinoic acid inhibits rat collagen arthritis and differentially affects serum immunoglobulin subclass levels

K. Kuwabara, Y. Hori, K. Shudo, 1996, FEBS letters.

Anti-inflammatory properties of zinc protoporphyrin disodium (Zn−PP−2Na)

H. Nagai, A. Koda, K. Kuwabara, 1992, Agents and Actions.

Cytosolic phospholipase A2 alpha inhibitor, pyrroxyphene, displays anti-arthritic and anti-bone destructive action in a murine arthritis model

Y. Gahara, K. Kuwabara, T. Ono, 2009, Inflammation Research.

Effect of methylprednisolone on phospholipase A(2) activity and lung surfactant degradation in acute lung injury in rabbits.

A. Matsukawa, M. Yoshinaga, H. Obara, 2001, European journal of pharmacology.

The Role of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Antibody-Induced Arthritis

Shigeyoshi Itohara, S. Itohara, R. Suzuki, 2002, The Journal of Immunology.

NON-PRODUCTIVITY OF AFLATOXIN BY JAPANESE INDUSTRIAL STRAINS OF ASPERGILLUS

K. Kuwabara, H. Murakami, S. Takase, 1968 .

Galactose-modified cationic liposomes as a liver-targeting delivery system for small interfering RNA.

J. Yano, T. Ueda, S. Sonoke, 2011, Biological & pharmaceutical bulletin.

Increased activity of group II phospholipase A2 in plasma in rat sodium deoxycholate induced acute pancreatitis

K. Kuwabara, K. Tanaka, M. Yamamoto, 1997, Gut.

Effect of a selective inhibitor of secretory phospholipase A2, S-5920/LY315920Na, on experimental acute pancreatitis in rats.

Katsutoshi Yamada, T. Ajiki, T. Maruyama, 2004, Journal of pharmacological sciences.

A Novel Selective Peroxisome Proliferator-Activated Receptor α Agonist, 2-Methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), Potently Decreases Plasma Triglyceride and Glucose Levels and Modifies Lipoprotein Profiles in KK-Ay Mice

J. Yano, M. Murai, T. Asaki, 2004, Journal of Pharmacology and Experimental Therapeutics.

2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), an Orally Available and Long-Acting Prostacyclin Receptor Agonist Prodrug

Tetsuhiro Yamada, Asami Hashino, Kenji Kuwabara, 2007, Journal of Pharmacology and Experimental Therapeutics.

Role of group IIA phospholipase A2 in rat colitis induced by dextran sulfate sodium.

I. Okayasu, Katsutoshi Yamada, H. Arita, 2003, European journal of pharmacology.