P. D. De Clercq

发表

Previtamin D3 with a trans-Fused Decalin CD-ring Has Pronounced Genomic Activity*

R. Bouillon, Keiko Yamamoto, G. Eelen, 2003, Journal of Biological Chemistry.

Synthesis, biological activity, and conformational analysis of four seco-D-15,19-bisnor-1alpha,25-dihydroxyvitamin D analogues, diastereomeric at C17 and C20.

R. Bouillon, A. Verstuyf, G. Zhu, 1999, Journal of medicinal chemistry.

Synthesis of 1α,25-Dihydroxyvitamin D Analogues Featuring a S2-symmetric CD-ring Core

L. Verlinden, A. Verstuyf, P. D. De Clercq, 2009, Molecules.

Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor.

D. Moras, Yoshiteru Sato, N. Rochel, 2008, Chemistry & biology.

The Biological Activity of Nonsteroidal Vitamin D Hormone Analogs Lacking Both the C‐ and D‐Rings

R. Bouillon, L. Verlinden, A. Verstuyf, 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Interaction of Two Novel 14‐Epivitamin D3 Analogs with Vitamin D3 Receptor‐Retinoid X Receptor Heterodimers on Vitamin D3 Responsive Elements

C. Carlberg, R. Bouillon, L. Verlinden, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Mechanism and potential of the growth-inhibitory actions of vitamin D and ana-logs.

C. Mathieu, R. Bouillon, C. Gysemans, 2007, Current medicinal chemistry.

1,25-Dihydroxyvitamin D3 and Its Analog TX527 Promote a Stable Regulatory T Cell Phenotype in T Cells from Type 1 Diabetes Patients

C. Mathieu, C. Gysemans, T. V. Van Belle, 2014, PloS one.

1,25-Dihydroxyvitamin D3 and analogues protect primary human keratinocytes against UVB-induced DNA damage.

H. Degreef, M. Garmyn, R. Bouillon, 2005, Journal of photochemistry and photobiology. B, Biology.

Synthesis and affinity studies of himbacine derived muscarinic receptor antagonists.

M. Milanesio, Ling-Jie Gao, D. Viterbo, 2002, Bioorganic & medicinal chemistry letters.

Antiproliferative and calcemic actions of trans-decalin CD-ring analogs of 1,25-dihydroxyvitamin D3.

C. Mathieu, R. Bouillon, J. Laureys, 2009, Anticancer research.

Biologic activity of dihydroxylated 19‐nor‐(pre)vitamin D3

R. Bouillon, L. Sarandeses, A. Mouriño, 1993 .

Two novel 14-Epi-analogues of 1,25-dihydroxyvitamin D3 inhibit the growth of human breast cancer cells in vitro and in vivo.

R. Bouillon, L. Verlinden, A. Verstuyf, 2000, Cancer research.

Synthesis of spiro[4.5]decane CF-ring analogues of 1 alpha,25-dihydroxyvitamin D3.

R. Bouillon, A. Verstuyf, D. Van Haver, 2006, Organic letters.

Asymmetric synthesis of (7aS)-7a-methyl-4,5,7,7a-tetrahydro-1H-indene-2,6-dione and useful derivatives thereof.

D. Van Haver, P. D. De Clercq, Samuël Demin, 2006, Molecules.

Microarray analysis of MCF-7 breast cancer cells treated with 1,25-dihydroxyvitamin D3 or a 17-methyl-D-ring analog.

B. De Moor, K. Marchal, K. Engelen, 2009, Anticancer research.

Vitamin D(3): synthesis of seco-C-9,11-bisnor-17-methyl-1 alpha,25-dihydroxyvitamin D(3) analogues.

Yusheng Wu, R. Bouillon, A. Verstuyf, 2002, Bioorganic & medicinal chemistry letters.

WY 1048, a 17-methyl 19-nor D-ring analog of vitamin D3, in combination with risedronate restores bone mass in a mouse model of postmenopausal osteoporosis

R. Bouillon, L. Verlinden, A. Verstuyf, 2019, The Journal of Steroid Biochemistry and Molecular Biology.

Structure function analysis of vitamin D analogs with C-ring modifications.

H. Pols, R. Bouillon, J. V. van Leeuwen, 1992, The Journal of biological chemistry.

Removal of C-ring from the CD-ring skeleton of 1alpha,25-dihydroxyvitamin D3 does not alter its target tissue metabolism significantly.

R. Bouillon, P. Vouros, A. Verstuyf, 2007, Archives of biochemistry and biophysics.

Remote-controlled production of [11C]antipyrine.

C. Vandecasteele, D. Van Haver, P. D. De Clercq, 1982, The International journal of applied radiation and isotopes.

A novel short convergent entry into himbacine derivatives.

M. Milanesio, Ling-Jie Gao, D. Viterbo, 2002, Organic letters.

A pentaerythritol-based molecular scaffold for solid-phase combinatorial chemistry.

A. Madder, P. D. De Clercq, N. Hosten, 2001, Organic letters.

Application of the B-alkyl suzuki-miyaura cross-coupling reaction to the stereoselective synthesis of analogues of (3S)-oxidosqualene.

Johan M. Winne, J. D'herde, P. D. De Clercq, 2006, Organic letters.

Possibility of [1,5] sigmatropic shifts in bicyclo[4.2.0]octa-2,4-dienes.

L. Hermosilla, V. Van Speybroeck, M. Waroquier, 2015, The Journal of organic chemistry.

Development of analogues of 1alpha,25-dihydroxyvitamin D3 with biased side chain orientation: methylated des-C,D-homo analogues.

R. Bouillon, A. Verstuyf, D. Van Haver, 2001, Chemistry.

Superagonistic Action of 14-epi-Analogs of 1,25-Dihydroxyvitamin D Explained by Vitamin D Receptor-Coactivator Interaction

D. Moras, F. Claessens, N. Rochel, 2005, Molecular Pharmacology.

Synthesis, biological activity, and conformational analysis of CD-ring modified trans-decalin 1 alpha,25-dihydroxyvitamin D analogs.

R. Bouillon, M. Milanesio, L. Verlinden, 2003, Organic & biomolecular chemistry.

Biological Activity of CD‐Ring Modified 1α,25‐Dihydroxyvitamin D Analogues: C‐Ring and Five‐Membered D‐Ring Analogues

M. Haussler, C. Mathieu, R. Bouillon, 2000 .

Nonenzymic polycyclization of analogues of oxidosqualene with a preformed C-ring.

P. Pattison, M. Milanesio, D. Viterbo, 2008, Organic & biomolecular chemistry.

Conformational analysis of prostaglandins F1 based on proton nuclear magnetic resonance spectral data.

D. Tavernier, D. Van Haver, M. Vandewalle, 1977, The Journal of organic chemistry.

Asymmetric synthesis of the epimeric (3S)-3-((E)-hex-1-enyl)-2-methylcyclohexanones.

P. D. De Clercq, Freek Vrielynck, 2007, Molecules.

Vitamin D analogs and coactivators.

R. Bouillon, G. Eelen, L. Verlinden, 2006, Anticancer research.

Possibility of [1,5] sigmatropic shifts in bicyclo[4.2.0]octa-2,4-dienes.

L. Hermosilla, V. Van Speybroeck, M. Waroquier, 2015, Journal of Organic Chemistry.

The Intramolecular Diels-Alder Reaction with Furan-Diene: A Novel Route to (±)-Gibberellin A5

G. Appendino, P. D. De Clercq, Frank Nuyttens, 1991 .

A novel approach to periplanone-b involving an intramolecular Diels-Alder reaction with furan-diene and allene-dienophile

P. D. Clercq, S. Cauwberghs, P. D. De Clercq, 1988 .

We Need to Talk about Kekulé: The 150 th Anniversary of the Benzene Structure

P. D. De Clercq, 2022, European Journal of Organic Chemistry.