J. Bishop

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Distinct Conformational Changes Induced by 20-epi Analogues of 1,25-Dihydroxyvitamin D Are Associated with Enhanced Activation of the Vitamin D Receptor (*)

A. Norman, S. Peleg, M. Sastry, 1995, The Journal of Biological Chemistry.

1,25-Dihydroxyvitamin D and three low-calcemic analogs decrease UV-induced DNA damage via the rapid response pathway

R. Mason, A. Norman, G. Halliday, 2004, Journal of Steroid Biochemistry and Molecular Biology.

Molecular tools for study of genomic and rapid signal transduction responses initiated by 1α,25(OH)2-vitamin D3

A. Norman, W. Okamura, H. Ishida, 2002, Steroids.

Conservative mutageneic perturbations of amino acids connecting helix 12 in the 1α,25(OH)2-D3 receptor (VDR) to the ligand cause significant transactivational effects

A. Norman, C. Bula, J. Bishop, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

A perspective on how the Vitamin D sterol/Vitamin D receptor (VDR) conformational ensemble model can potentially be used to understand the structure–function results of A-ring modified Vitamin D sterols

A. Norman, Mathew T. Mizwicki, M. Mizwicki, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Effect of 25-hydroxyl group orientation on biological activity and binding to the 1α,25-dihydroxy vitamin D3 receptor

A. Norman, W. Okamura, C. Bula, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

25-Dehydro-1alpha-hydroxyvitamin D3-26,23S-lactone antagonizes the nuclear vitamin D receptor by mediating a unique noncovalent conformational change.

A. Norman, C. Bula, S. Ishizuka, 2000, Molecular endocrinology.

Comparison of 6-s-cis- and 6-s-trans-locked analogs of 1alpha,25-dihydroxyvitamin D3 indicates that the 6-s-cis conformation is preferred for rapid nongenomic biological responses and that neither 6-s-cis- nor 6-s-trans-locked analogs are preferred for genomic biological responses.

R. Bouillon, A. Norman, M. Farach-Carson, 1997, Molecular endocrinology.

Hypocalcemia and hypercalcemia in patients with rhabdomyolysis with and without acute renal failure.

S. Massry, A. Norman, M. Akmal, 1986, The Journal of clinical endocrinology and metabolism.

1,25(OH)2-vitamin D3, a steroid hormone that produces biologic effects via both genomic and nongenomic pathways

A. C. Maiyar, A. Norman, M. Farach-Carson, 1992, The Journal of Steroid Biochemistry and Molecular Biology.

A specific binding protein/receptor for 1alpha,25-dihydroxyvitamin D(3) is present in an intestinal caveolae membrane fraction.

A. Norman, J. Bishop, Christopher J. Olivera, 2002, Biochemical and biophysical research communications.

Production of 1alpha,25-dihydroxy-3-epi-vitamin D3 in two rat osteosarcoma cell lines (UMR 106 and ROS 17/2.8): existence of the C-3 epimerization pathway in ROS 17/2.8 cells in which the C-24 oxidation pathway is not expressed.

M. Uskoković, A. Norman, P. Vouros, 1999, Bone.

1,25-Dihydroxyvitamin D3 receptor RNA: expression in hematopoietic cells.

H. Koeffler, A. Karmakar, M. Kizaki, 1991, Blood.

Vitamin D metabolism in hypoparathyroidism.

A. Norman, O. H. Sørensen, B. Lund, 1980, The Journal of clinical endocrinology and metabolism.

Skin cancer prevention: A possible role of 1,25dihydroxyvitamin D3 and its analogs

R. Mason, M. Slater, A. Norman, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

gamma-Interferon stimulates production of 1,25-dihydroxyvitamin D3 by normal human macrophages.

H. Koeffler, A. Norman, H. Reichel, 1985, Biochemical and biophysical research communications.

THE VITAMIN D ENDOCRINE SYSTEM: PLEIOTROPIC INTERACTIONS WHICH CONTRIBUTE TO CALCIUM HOMEOSTASIS

A. Norman, H. Reichel, I. Nemere, 1987 .

23,25-Dihydroxy-24-oxovitamin D3: a metabolite of vitamin D3 made in the kidney.

A. Norman, R. Chandraratna, W. Okamura, 1983, Biochemistry.

Evidence for multiple molecular weight forms of the chick intestinal 1,25-dihydroxyvitamin D3 receptor.

A. Norman, W. Hunziker, J. Bishop, 1982, Biochemical and biophysical research communications.

Effect of vitamin D status on the equilibrium between occupied and unoccupied 1,25-dihydroxyvitamin D intestinal receptors in the chick.

A. Norman, M. Walters, W. Hunziker, 1982, The Journal of clinical investigation.

25-Phosphorus analogs of vitamin D3

W. G. Dauben, A. Norman, J. Bishop, 1991 .

Demonstration that 1 beta,25-dihydroxyvitamin D3 is an antagonist of the nongenomic but not genomic biological responses and biological profile of the three A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D3.

R. Bouillon, A. Norman, M. Farach-Carson, 1993, The Journal of biological chemistry.

Biological activity assessment of the vitamin D metabolites 1,25-dihydroxy-24-oxo-vitamin D3 and 1,23,25-trihydroxy-24-oxo-vitamin D3.

A. Norman, J. Bishop, N. Ohnuma, 1983, Archives of biochemistry and biophysics.

Profile of ligand specificity of the vitamin D binding protein for 1α,25‐dihydroxyvitamin d3 and its analogs

A. Norman, E. D. Collins, J. Bishop, 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Differing shapes of 1α,25-dihydroxyvitamin D3 function as ligands for the D-binding protein, nuclear receptor and membrane receptor: A status report

S. Zanello, R. Bouillon, A. Norman, 1996, The Journal of Steroid Biochemistry and Molecular Biology.

Nonnuclear effects of the steroid hormone 1 alpha,25(OH)2-vitamin D3: analogs are able to functionally differentiate between nuclear and membrane receptors.

A. Norman, I. Nemere, W. Okamura, 1994, Biochemical and biophysical research communications.

In vivo relevance for photoprotection by the vitamin D rapid response pathway

R. Mason, A. Norman, G. Halliday, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

Novel Gemini analogs of 1α,25-dihydroxyvitamin D3 with enhanced transcriptional activity

P. Dhawan, M. Uskoković, G. P. Studzinski, 2004 .

Stimulation of Phosphorylation of Mitogen-Activated Protein Kinase by 1α,25-Dihydroxyvitamin D3 in Promyelocytic NB4 Leukemia Cells: A Structure-Function Study.

A. Norman, W. Okamura, J. Bishop, 1998, Endocrinology.

Characterization of five 19-nor-analogs of 1α,25(OH)2-Vitamin D3 with 20-cyclopropyl-modified side-chains: implications for ligand binding and calcemic properties

M. Uskoković, L. Adorini, A. Norman, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

Presence of a truncated form of the vitamin D receptor (VDR) in a strain of VDR-knockout mice.

A. Norman, H. Henry, C. Bula, 2005, Endocrinology.

Characterization of a novel analogue of 1alpha,25(OH)(2)-vitamin D(3) with two side chains: interaction with its nuclear receptor and cellular actions.

H. Koeffler, M. Uskoković, J. Hisatake, 2000, Journal of medicinal chemistry.

Acute effects of parathyroid hormone on vitamin D metabolism in patients with the bone loss of aging.

L. Mosekilde, F. Melsen, A. Norman, 1982, The Journal of clinical endocrinology and metabolism.

Studies on 24R,25-dihydroxyvitamin D3: evidence for a nonnuclear membrane receptor in the chick tibial fracture-healing callus.

T. Einhorn, A. Norman, J. Bishop, 1998, Bone.

1,25-Dihydroxyvitamin D3 in the Atlantic cod: plasma levels, a plasma binding component, and organ distribution of a high affinity receptor.

B. Björnsson, A. Norman, K. Sundell, 1992, Endocrinology.

The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1 alpha,25(OH)2-vitamin D3 in vivo and in vitro.

A. Norman, J. Bishop, J. Huhtakangas, 2004, Molecular endocrinology.

Regulation of vitamin D metabolism in normal human pregnancy.

A. Norman, D. Goltzman, G. Reddy, 1983, The Journal of clinical endocrinology and metabolism.

Studies on the mode of action of vitamin D XXXVII 1α-hydroxyvitamin D3: A long-acting 1,25-dihydroxyvitamin D3 analog

A. Norman, M. Walters, W. Hunziker, 1983, Calcified Tissue International.

Stimulation of 1,25-dihydroxyvitamin D production by parathyroid hormone and hypocalcemia in man.

A. Norman, O. H. Sørensen, B. Lund, 1980, The Journal of clinical endocrinology and metabolism.

25-Hydroxyvitamin D3 metabolism by lipopolysaccharide-stimulated normal human macrophages.

H. Koeffler, A. Norman, H. Reichel, 1987, The Journal of clinical endocrinology and metabolism.

Isolation and identification of 1,25-dihydroxy-24-oxo-vitamin D3 and 1,23,25-trihydroxy-24-oxo-vitamin D3. New metabolites of vitamin D3 produced by a C-24 oxidation pathway of metabolism for 1,25-dihydroxyvitamin D3 present in intestine and kidney.

A. Norman, R. Chandraratna, W. Okamura, 1983, The Journal of biological chemistry.

25-Dehydro-1alpha-hydroxyvitamin D3-26,23S-lactone antagonizes the nuclear vitamin D receptor by mediating a unique noncovalent conformational change.

A. Norman, C. Bula, S. Ishizuka, 2000, Molecular endocrinology.

Evidence for a 1 alpha,25-dihydroxyvitamin D3 receptor/binding protein in a membrane fraction isolated from a chick tibial fracture-healing callus.

A. Norman, J. Bishop, A. Kato, 1996, Biochemical and biophysical research communications.

Selective biological response by target organs (intestine, kidney, and bone) to 1,25-dihydroxyvitamin D3 and two analogues.

A. Norman, W. Okamura, J. Bishop, 1993, Cancer research.

Studies on calciferol metabolism. Metabolism of 25-hydroxy-vitamin D3 by the chicken embryo.

A. Norman, J. Bishop, 1975, Archives of biochemistry and biophysics.

Enzymic preparation of [3H]1,25-dihydroxyvitamin D3.

A. Norman, J. Bishop, 1980, Methods in enzymology.

Acromegaly and vitamin D metabolism: effect of bromocriptine treatment.

A. Norman, P. Eskildsen, O. H. Sørensen, 1979, The Journal of clinical endocrinology and metabolism.

Inhibitory and stimulatory effects of dexamethasone and 1,25-dihydroxyvitamin D3 on chick intestinal calbindin-D28K and its mRNA

A. Norman, J. Bishop, A. Hall, 1987, Molecular and Cellular Endocrinology.

Evidence for 1,25-dihydroxyvitamin D3 production by cultured porcine alveolar macrophages

H. Koeffler, A. Norman, H. Reichel, 1991, Molecular and Cellular Endocrinology.

Lymphocyte cell lines from vitamin D-dependent rickets type II show functional defects in the 1α,25-dihydroxyvitamin D3 receptor

A. Tobler, H. Koeffler, A. Norman, 1990, Molecular and Cellular Endocrinology.

The Vitamin D Receptor Is Present in Caveolae-Enriched Plasma Membranes and Binds 1α,25(OH)2-Vitamin D3 in Vivo and in Vitro

A. Norman, J. Bishop, J. Huhtakangas, 2004 .

Differential effects of protease inhibitors on 1,25-dihydroxyvitamin D3 receptors.

A. Norman, M. Walters, W. Hunziker, 1983, The Journal of biological chemistry.

The pathogenesis of renal osteodystrophy: role of vitamin D, aluminium, parathyroid hormone, calcium and phosphorus.

A. Norman, C. Dunstan, S. Wong, 1985, The Quarterly journal of medicine.

Metabolism of 25-hydroxycholecalciferol in human promyelocytic leukemia cells (HL-60). Isolation and identification of (5Z)- and (5E)-19-nor-10-oxo-25-hydroxycholecalciferol.

T. Matsui, F. Takaku, H. Reichel, 1986, European journal of biochemistry.

Treatment of hemodialysis bone disease with 24,25-(OH)2D3 and 1,25-(OH)2D3 alone or in combination.

A. Norman, C. Dunstan, S. Wong, 1985, Mineral and electrolyte metabolism.

The effects of aluminum loading on the renal response to parathyroid hormone in the vitamin D-replete rat.

A. Norman, M. Jongen, M. Vaccaro, 1986, Biochemical medicine and metabolic biology.

Evidence that annexin II Is not a putative membrane receptor for 1α,25(OH)2‐vitamin D3

A. Norman, Mathew T. Mizwicki, M. Mizwicki, 2004, Journal of cellular biochemistry.

Update on biological actions of 1α,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3

A. Norman, W. Okamura, H. Henry, 2002, Molecular and Cellular Endocrinology.

Normal egg hatchability requires the simultaneous administration to the hen of 1 alpha,25-dihydroxycholecalciferol and 24R,25-dihydroxycholecalciferol.

A. Norman, V. Leathers, J. Bishop, 1983, The Journal of nutrition.

New insights into Vitamin D sterol-VDR proteolysis, allostery, structure–function from the perspective of a conformational ensemble model

A. Norman, M. Mizwicki, C. Bula, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

Novel Gemini analogs of 1alpha,25-dihydroxyvitamin D(3) with enhanced transcriptional activity.

P. Dhawan, M. Uskoković, G. P. Studzinski, 2004, Biochemical pharmacology.

Local chromatin changes accompany the expression of the calbindin-D28K gene: tissue specificity and effect of vitamin D activation.

A. Norman, H. Ishida, L. Cancela, 1992, Molecular endocrinology.

Unoccupied and in vitro and in vivo occupied 1,25-dihydroxyvitamin D3 intestinal receptors. Multiple biochemical forms and evidence for transformation.

A. Norman, M. Walters, W. Hunziker, 1983, The Journal of biological chemistry.

Applications of the Vitamin D sterol–Vitamin D receptor (VDR) conformational ensemble model

A. Norman, Mathew T. Mizwicki, M. Mizwicki, 2005, Steroids.

Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling.

Dino Moras, D. Moras, J. Wurtz, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Normal myelopoiesis but abnormal T lymphocyte responses in vitamin D receptor knockout mice.

H. Koeffler, J. Hisatake, A. Norman, 2002, The Journal of clinical investigation.

1,25-Dihydroxyvitamin D3 receptor RNA: expression in hematopoietic cells

H. Koeffler, A. Karmakar, J. Bishop, 1991 .

Effect of Dietary Calcium, Phosphate and Vitamin D Deprivation on the Pharmacokinetics of 1,25-Dihydroxyvitamin D3 in the Rat

A. Norman, M. Jongen, C. Cade, 1987, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.