A. Janoff

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The fifth component of complement (C5) is necessary for maximal pulmonary leukocytosis in mice chronically exposed to cigarette smoke.

B. Ghebrehiwet, R. Kew, A. Janoff, 1987, Clinical immunology and immunopathology.

Mediators of inflammation in leukocyte lysosomes. IX. Elastinolytic activity in granules of human polymorphonuclear leukocytes.

A. Janoff, J. Scherer, 1968 .

Elastase in tissue injury.

A. Janoff, 1985, Annual review of medicine.

Proteases, antiproteases, and oxidants: pathways of tissue injury during inflammation.

H. Carp, A. Janoff, 1982, Monographs in pathology.

Cigarette smoke blocks cross-linking of elastin in vitro.

H. Kagan, P. Laurent, A. Janoff, 1983, The American review of respiratory disease.

Characterization of the third component of complement (C3) after activation by cigarette smoke.

B. Ghebrehiwet, R. Kew, A. Janoff, 1987, Clinical immunology and immunopathology.

INACTIVATION OF BACTERIAL EXOTOXINS AND ENDOTOXIN BY IRON

B. Zweifach, A. Janoff, 1960, The Journal of experimental medicine.

Pathogenesis of experimental shock. IV. Studies on lysosomes in normal and tolerant animals subjected to lethal trauma and endotoxemia.

B. Zweifach, G. Weissmann, A. Janoff, 1962 .

Urinary excretion of desmosine (elastin cross-links) in subjects with PiZZ alpha-1-antitrypsin deficiency, a phenotype associated with hereditary predisposition to pulmonary emphysema.

A. Buist, R. Crystal, M. Wewers, 1985, The American review of respiratory disease.

Evaluation of the urinary desmosine radioimmunoassay as a monitor of lung injury after endobronchial elastase instillation in sheep.

H. Susskind, D. Joel, P. Laurent, 1983, The American review of respiratory disease.

Cigarette smoke can activate the alternative pathway of complement in vitro by modifying the third component of complement.

B. Ghebrehiwet, R. Kew, A. Janoff, 1985, The Journal of clinical investigation.

Vascular Injury and Lysis of Basement Membrane in vitro by Neutral Protease of Human Leukocytes

J. Zeligs, A. Janoff, 1968, Science.

Interactions of human mast cell tryptase with biological protease inhibitors.

L. Schwartz, J. Kramps, A. Janoff, 1990, Archives of biochemistry and biophysics.

Urinary excretion of desmosine in patients with severe burns.

S. Y. Yu, A. Janoff, S. Harel, 1981, Metabolism: clinical and experimental.

Possible Mechanisms Of Emphysema in Smokers

H. Carp, A. Janoff, 2015 .

Elevated histamine and tryptase levels in smokers' bronchoalveolar lavage fluid. Do lung mast cells contribute to smokers' emphysema?

L. Schwartz, R. Kalenderian, A. Janoff, 1988, Chest.

Cigarette smoke blocks cross-linking of elastin in vitro.

H. Kagan, P. Laurent, A. Janoff, 1983, Chest.

Experimental emphysema induced with purified human neutrophil elastase: tissue localization of the instilled protease.

R. Sandhaus, P. Kimbel, G. Weinbaum, 2015, The American review of respiratory disease.

The role of complement in cigarette smoke-induced chemotactic activity of lung fluids.

B. Ghebrehiwet, R. Kew, A. Janoff, 1986, The American review of respiratory disease.

Possible mechanisms of emphysema in smokers: cigarette smoke condensate suppresses protease inhibition in vitro.

H. Carp, A. Janoff, 1977, The American review of respiratory disease.

The role of oxidative processes in emphysema.

H. Carp, P. Laurent, A. Janoff, 1983, The American review of respiratory disease.

Elastin-Lysine Derived Cross-Links Structure, Biosthesis, and Relation to Lung Emphysema Pathogenesis

H. Kagan, P. Laurent, A. Janoff, 1984 .

Inactivation of alpha 1-proteinase inhibitor and bronchial mucous proteinase inhibitor by cigarette smoke in vitro and in vivo.

H. Carp, A. Janoff, D. Lee, 1980, Bulletin europeen de physiopathologie respiratoire.

Cigarette smoke inhalation decreases alpha 1-antitrypsin activity in rat lung.

R. T. Drew, H. Carp, A. Janoff, 1979, Science.

Lung injury induced by leukocytic proteases.

H. Carp, A. Janoff, R. White, 1979, The American journal of pathology.

HUMAN NEUTROPHIL ELASTASE AND THE PROTEASE-PATHOGENESIS MODEL OF PULMONARY EMPHYSEMA

A. Janoff, 1978 .

Levels of elastase activity in bronchoalveolar lavage fluids of healthy smokers and nonsmokers.

A. Janoff, R. Dearing, L. Raju, 2015, The American review of respiratory disease.

Effects of cigarette smoke on elastase secretion by murine macrophages.

J. White, A. Janoff, R. White, 1979, The Journal of laboratory and clinical medicine.

Desmosine radioimmunoassay for measuring elastin degradation in vivo.

E. Bergofsky, A. Hurewitz, S. Y. Yu, 2015, The American review of respiratory disease.

In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.

H. Carp, A. Janoff, 1979, The Journal of clinical investigation.

Partial purification and characterization of mouse peritoneal exudative macrophage elastase.

A. Janoff, R. White, R. Dearing, 1980, Biochimica et biophysica acta.

Elastase-Like, Esteroprotease Activity in Human and Rabbit Alveolar Macrophage Granules 1

A. Janoff, M. Galdston, R. Rosenberg, 1971, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Secretion of Alpha1 -Proteinase Inhibitor by Cultured Rat Alveolar Macrophages1–3

G. Habicht, A. Janoff, Richard H. White, 2015 .

Identification of neutral proteases in human neutrophil granules that degrade articular cartilage proteoglycan.

C. Malemud, A. Janoff, Aaron Janoff, 1975, Arthritis and rheumatism.

Secretion of elastase and alpha-2-macroglobulin by cultured murine peritoneal macrophages: studies on their interaction.

H. Godfrey, G. Habicht, A. Janoff, 1981, The Journal of laboratory and clinical medicine.

Prevention of elastase-induced experimental emphysema by oral administration of a synthetic elastase inhibitor.

A. Janoff, R. Dearing, 2015, The American review of respiratory disease.

A genetically engineered, mutant human alpha-1-proteinase inhibitor is more resistant than the normal inhibitor to oxidative inactivation by chemicals, enzymes, cells, and cigarette smoke.

S. Rosenberg, A. Janoff, C. George-Nascimento, 1986, The American review of respiratory disease.

Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity.

J. Hoidal, H. Carp, Frederick Miller, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Proteases and lung injury. A state-of-the-art minireview.

A. Janoff, Aaron Janoff, 1983, Chest.

Characterization of Two Distinct Transglutaminases of Murine Bone Marrow‐Derived Macrophages: Effects of Exposure of Viable Cells to Cigarette Smoke on Enzyme Activity

S. I. Chung, H. Fleit, A. Janoff, 1987, Journal of leukocyte biology.

Degradation of Human aI-Antitrypsin by Hepatocyte Acid Cathepsins Possible Role in Clinical aI-Antitrypsin Deficiency!' 2

R. Sandhaus, A. Janoff, 1974 .

Inactivation of bronchial mucous proteinase inhibitor by cigarette smoke and phagocyte-derived oxidants.

H. Carp, A. Janoff, 1980, Experimental lung research.

Inhibition of human granulocyte elastase by serum alpha-1-antitrypsin.

A. Janoff, 1972, The American review of respiratory disease.

Potential mediator of inflammation. Phagocyte-derived oxidants suppress the elastase-inhibitory capacity of alpha 1-proteinase inhibitor in vitro.

H. Carp, A. Janoff, 1980, The Journal of clinical investigation.

NHLBI workshop summary. Effects of tobacco smoke components on cellular and biochemical processes in the lung.

A. Janoff, W. A. Pryor, Z. Bengali, 1987, The American review of respiratory disease.

Investigations into the biochemical mechanisms of pulmonary emphysema: effects of cigarette smoke on enzymes and anti-enzymes in the lung.

A. Janoff, 1986, Respiration; international review of thoracic diseases.

The specificity of macrophage elastase on the insulin B-chain.

E. Shaw, C. Kettner, A. Janoff, 1981, The Biochemical journal.

MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES

A. Janoff, W. Seegers, 1966, The Journal of experimental medicine.

PRODUCTION OF INFLAMMATORY CHANGES IN THE MICROCIRCULATION BY CATIONIC PROTEINS EXTRACTED FROM LYSOSOMES

B. Zweifach, A. Janoff, 1964, The Journal of experimental medicine.

Adhesion and Emigration of Leukocytes Produced by Cationic Proteins of Lysosomes

B. Zweifach, A. Janoff, 1964, Science.

MEDIATORS OF I N F L A M M A T I O N I N LEUKOCYTE LYSOSOMES

A. Janoff, P. D, W. Seegers, 2003 .

Human granulocyte elastase. Further delineation of its role in connective tissue damage.

A. Janoff, 1972, The American journal of pathology.

Prevention of elastase-induced experimental emphysema by a synthetic elastase inhibitor administered orally.

A. Janoff, R. Dearing, 1980, Bulletin europeen de physiopathologie respiratoire.

Neutrophil proteases in inflammation.

A. Janoff, 1972, Annual review of medicine.

Measurement of elastin degradation in vivo by desmosine radioimmunoassay.

E. Bergofsky, A. Hurewitz, S. Y. Yu, 1980, Bulletin europeen de physiopathologie respiratoire.

Tumorigenesis in Mouse Skin: Inhibition by Synthetic Inhibitors of Proteases

W. Troll, A. Janoff, Arnold Klassen, 1970, Science.

Human methionine sulfoxide-peptide reductase, an enzyme capable of reactivating oxidized alpha-1-proteinase inhibitor in vitro.

N. Brot, H. Weissbach, R. T. Drew, 2015, The American review of respiratory disease.

Macrophage transglutaminases: characterization of molecular species and measurement of enzymatic modification by cigarette smoke components.

S. I. Chung, A. Janoff, L. Raju, 1988, Advances in experimental medicine and biology.

Inactivation of Alveolar Macrophage Transglutaminase by Oxidants in Cigarette Smoke

S. I. Chung, A. Janoff, W. Roth, 1986, Journal of leukocyte biology.

The course and nature of acinar cell death following pancreatic ligation in the guinea pig.

J. Zeligs, A. Janoff, A. Dumont, 1975, The American journal of pathology.

Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants.

H. Carp, A. Janoff, 1978, The American review of respiratory disease.

Letter: Familial variation of leukocyte lysosomal protease and serum alpha 1-antitrypsin as determinants in chronic obstructive pulmonary disease.

A. Janoff, A. Davis, M. Galdston, 1973, The American review of respiratory disease.

Mediators of inflammation in leukocyte lysosomes. VII. Observations on mast cell-rupturing agents in different species.

A. Janoff, J. Scherer, 1968, Laboratory investigation; a journal of technical methods and pathology.

MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES

A. Janoff, M. Bean, J. Scherer, 1965, The Journal of experimental medicine.

SECOND (COl]NELL) MEDICAL DIVISION

A. Janoff, M. Bean, J. Scherer, 2003 .

Characterization of sheep alpha-1-proteinase inhibitor. Important differences from the human protein.

U. Sinha, S. Sinha, A. Janoff, 1988, The American review of respiratory disease.

Mediators of Acute Inflammation in Leucocyte Lysosomes

A. Janoff, S. Schaefer, 1967, Nature.

Editorial: Timely appraisal: Induction of α1-Antitrypsin; A prophylactic treatment for pulmonary emphysema?

A. Janoff, 1977, Agents and Actions.

PATHOGENESIS OF EXPERIMENTAL SHOCK

B. Zweifach, G. Weissmann, A. Janoff, 1962, The Journal of experimental medicine.

Digestion of Lung Proteins by Human Leukocyte Granules in Vitro 1

R. Sandhaus, A. Janoff, V. Hospelhorn, 1972, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES

A. Janoff, J. Scherer, 1968, The Journal of experimental medicine.

Mediators of inflammation in leukocyte lysosomes. 3. Studies on lysosomes of rabbit peritoneal macrophages.

E. Schuller, A. Janoff, M. Bean, 1965, Life sciences.

Cigarette smoke blocks cross-linking of elastin in vitro.

H. Kagan, P. Laurent, A. Janoff, 1983, Chest.

Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis.

A Janoff, A. Janoff, 1985, The American review of respiratory disease.

Alanine p-nitrophenyl esterase activity of human leucocyte granules.

A. Janoff, 1969, The Biochemical journal.

The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin.

C. Malemud, A. Janoff, G. Feinstein, 1976, Biochimica et biophysica acta.

AT LEAST THREE HUMAN NEUTROPHIL LYSOSOMAL PROTEASES ARE CAPABLE OF DEGRADING JOINT CONNECTIVE TISSUES *

A. Janoff, 1975, Annals of the New York Academy of Sciences.

Neutral proteases of human polymorphonuclear leukocytes: Biochemistry, physiology, and clinical significance

K. Havemann, A. Janoff, 1978 .

Acute Response to Elastase in Sheep Lungs

H. Susskind, A. Janoff, A. Brill, 2006 .

Acute response to elastase in sheep lungs measured with Ga-67.

H. Susskind, A. Brill, D. Joel, 1984, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Letter to the editorThe role of iron in macrophages

A. Janoff, 1964 .

Inhibition of the Elastase-Like Esterase in Human Leukocyte Granules by Human Leukocyte Cell Sap 1

A. Janoff, J. Blondin, 1971, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Subcellular localization and further characterization of a new elastase inhibitor from pneumococci

S. Simon, M. Vered, A. Janoff, 1985, Infection and immunity.

Inhibition of human neutrophil elastase by bacterial polyanions.

S. Simon, M. Vered, A. Janoff, 1988, Experimental lung research.

Mediators of tissue damage in human polymorphonuclear neutrophils.

A. Janoff, 1970, Series haematologica.

Effect of Endotoxin-Tolerance, Cortisone, and Thorotrast on Release of Enzymes from Subcellular Particles of Mouse Liver.∗

B. Zweifach, A. Janoff, 1963, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Cigarette smoke contains anticoagulants against fibrin aggregation and factor XIIIa in plasma.

D. Galanakis, P. Laurent, A. Janoff, 1982, Science.

HUMAN POLYMORPHONUCLEAR LEUKOCYTE ELASTASE AND CATHEPSIN G MEDIATE THE DEGRADATION OF LAPINE ARTICULAR CARTILAGE PROTEOGLYCAN *

C. Malemud, A. Janoff, Charles J. Malemud, 1975, Annals of the New York Academy of Sciences.

PATHOGENESIS OF EXPERIMENTAL SHOCK : III. A LETHAL FACTOR IN THE BLOOD OF RABBITS FOLLOWING OCCLUSION OF THE SUPERIOR MESENTERIC ARTERY

B. Zweifach, S. Baez, A. Janoff, 1961 .

PATHOGENESIS OF EXPERIMENTAL SHOCK

B. Zweifach, S. Baez, A. Janoff, 1961, The Journal of experimental medicine.

Biochemical links between cigarette smoking and pulmonary emphysema.

A. Janoff, 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

Detection of Ferritin in the Plasma of Guinea Pigs in Experimental Shock

A. Janoff, A. Nagler, Benjamin W. Zweifach, 1961, Circulation Research.

Familial variation of leukocyte lysosomal protease and serum 1 -antitrypsin as determinants in chronic obstructive pulmonary disease.

A. Janoff, A. Davis, M. Galdston, 1973, The American review of respiratory disease.

In vivo detection of ferritin in the normal guinea pig by passive cutaneous anaphylaxis.

A. Janoff, Z. Óváry, 1961, Journal of immunology.

Levels of plasmabound iron in experimental shock in the rabbit and dog.

B. Zweifach, A. Janoff, L. Shapiro, 1960, The American journal of physiology.

Adsorption of Tetanus Toxin by Sub-cellular Fractions of Rabbit Brain Homogenate

A. Janoff, 1964, Nature.

INACTIVATION OF BACTERIAL EXOTOXINS AND E N D O T O X I N BY IRON IN VITRO STUDIES* BY AARON JANOFF,~ PH.D., AND BENJAMIN W. ZWEIFACH,§ PH.D

B. Zweifach, A. Janoff, 2003 .

BACTERIAL ENDOTOXEMIA.

B. Zweifach, A. Janoff, 1965, Annual review of medicine.

Suppression of rabbit kidney histidine decarboxylase activity by endotoxin.

B. Zweifach, A. Janoff, R. Schayer, 1963, The American journal of physiology.

Elastases and Emphysema

A. Janoff, 2015 .

Secretion of alpha-2-macroglobulin by human alveolar macrophages

H. Godfrey, A. Janoff, R. White, 2007, Lung.

Evidence for in vivo internalization of human leukocyte elastase by alveolar macrophages.

E. Campbell, A. Janoff, R. White, 1982, The American review of respiratory disease.

Secretion of alpha 1-proteinase inhibitor by cultured rat alveolar macrophages.

G. Habicht, A. Janoff, R. White, 1981, The American review of respiratory disease.

Possible mechanisms of emphysema in cigarette smokers. Release of elastase from human polymorphonuclear leukocytes by cigarette smoke condensate in vitro.

M. Blue, A. Janoff, 1978, The American review of respiratory disease.

Elastase-induced emphysema: retention of instilled proteinase in the rat.

R. Sandhaus, A. Janoff, 1982, American Review of Respiratory Disease.

MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES VI. PARTIAL PURIFICATION AND CHARACTERIZATION OF A MAST CELL-RUPTURING COMPONENT

A. Janoff, W. Seegers, 1966 .

An inhibitor in human lung macrophages active against human neutrophil elastase.

A. Janoff, J. Blondin, R. Rosenberg, 2015, The American review of respiratory disease.

Assessment of elastase-induced structural and functional changes in sheep lungs.

H. Susskind, A. Brill, D. Joel, 1985, Bulletin europeen de physiopathologie respiratoire.

PATHOGENESIS OF EXPERIMENTAL SHOCK

B. Zweifach, G. Weissmann, A. Janoff, 1962, The Journal of experimental medicine.

MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES

A. Janoff, W. Seegers, 1966, The Journal of experimental medicine.

MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES

A. Janoff, M. Bean, J. Scherer, 1965, The Journal of experimental medicine.

Degradation of human alpha 1-antitrypsin by hepatocyte acid cathepsins. Possible role in clinical alpha 1-antitrypsin deficiency.

R. Sandhaus, A. Janoff, 1974, The American review of respiratory disease.

Inhibition of human neutrophil elastase by polyguanylic acid and other synthetic polynucleotides.

S. Simon, J. Cheronis, A. Rinehart, 1988, Advances in experimental medicine and biology.

Inhibition of human neutrophil elastase by polyguanylic acid and other synthetic RNA homopolymers.

S. Simon, A. Rinehart, M. Vered, 1988, Experimental lung research.

Enzymatic oxidation of alpha- 1-proteinase inhibitor in abnormal tissue turnover

J. Travis, N. Matheson, A. Janoff, 1982, Molecular and Cellular Biochemistry.

Inactivation of alpha 1-proteinase inhibitor and bronchial mucous proteinase inhibitor by cigarette smoke in vitro and in vivo.

H. Carp, A. Janoff, D. Lee, 1980, Bulletin europeen de physiopathologie respiratoire.

A new elastase inhibitor from Streptococcus pneumoniae protects against acute lung injury induced by neutrophil granules.

M. Vered, A. Janoff, R. Dearing, 1985, The American review of respiratory disease.

Variations in Elastaselike Esterase Activities in Human Leucocytes during Cell Maturation 1

A. Janoff, G. Feinstein, A. Janoff, 1976, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

The Role of Elastase in the Digestion of E. coli Proteins by Human Polymorphonuclear Leukocytes I. Experiments in Vitro 1

A. Janoff, J. Blondin, 1974, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.