J. Kozelka

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Ortho-(methylsulfanyl)phenylphosphonates and derivatives: Synthesis and applications as mono- or bidentate ligands for the preparation of platinum complexes

M. Hamel, M. Gulea, Mathieu Lecinq, 2013 .

High-salt and low-salt models for kinked adducts of cis-diamminedichloroplatinum(II) with oligonucleotide duplexes

G. Petsko, G. Quigley, S. Lippard, 1986 .

Cisplatin adducts on a GGG sequence within a DNA duplex studied by NMR spectroscopy and molecular dynamics simulations.

E. Sletten, T. Skauge, S. Téletchéa, 2009, Chemistry.

Quantum chemical topology study of the water-platinum(II) interaction.

J. Bergès, J. Pilmé, I. Fourré, 2013, Inorganic chemistry.

Hydration and `inverse hydration' of platinum(II) complexes: an analysis using the density functionals PW91 and BLYP

J. Langlet, J. Caillet, J. Kozelka, 2001 .

Influence of dT20 and [d(AT)10]2 on cisplatin hydrolysis studied by two-dimensional [1H,15N] HMQC NMR spectroscopy.

E. Sletten, J. Kozelka, J. Vinje, 2005, Chemistry.

cis-Diamminediaquaplatinum(II) selectivity for GpG: influence of the adjacent base on the first platination step

A. Laoui, J. Kozelka, J. Chottard, 1988 .

A pyrazolato-bridged dinuclear platinum(II) complex induces only minor distortions upon DNA-binding.

J. Reedijk, S. Téletchéa, J. Kozelka, 2006, Chemistry.

Agostic and Hydrogen-Bonding X–H…M Interactions Involving a d8 Metal Center: Recent Advances Towards Their Understanding

J. Kozelka, 2015 .

Kinetic aspects of interactions between DNA and platinum complexes

J. Kozelka, J. Chottard, F. Legendre, 1999 .

Isolation of cis-[PtCl(NH3)2(H2O)](ClO4), the monohydrated form of the anti-tumour drug cisplatin, using cation-exchange high-performance liquid chromatography

F. Gonnet, J. Kozelka, J. Chottard, 1993 .

Regional Biophysics Conference (RBC2016) BOOK OF ABSTRACTS 25-28 August 2016, Trieste (Italy) http://rbc2016.sibpa.it

J. Novotný, S. Bazzi, R. Marek, 2016 .

Molecular Modeling of Platinum Complexes with Oligonucleotides: Methodological Lessons and Structural Insights

F. Allain, J. Bergès, F. Gonnet, 1997 .

How does cisplatin alter DNA structure? A molecular mechanics study on double-stranded oligonucleotides.

J. Kozelka, J. Chottard, 1990, Biophysical chemistry.

High-Salt and Low-Salt Models for Kinked Adducts of cis-Diamminedichloroplatinum(II) with Oligonucleotide Duplexes.

G. Petsko, G. Quigley, S. Lippard, 1986 .

Kinetic study of azole-bridged dinuclear platinum(II) complexes reacting with a hairpin-stabilized double-stranded oligonucleotide.

S. Bombard, J. Reedijk, S. Perrier, 2003, Journal of inorganic biochemistry.

GA and AG sequences of DNA react with cisplatin at comparable rates.

S. Bombard, J. Kozelka, J. Chottard, 2003, Chemistry.

Platinum(II) and Palladium(II) Complexes with N-Aminoguanidine

A. Gautier, S. Rizzato, G. Morgant, 2007 .

Reactions of the Double‐Stranded Oligonucleotide d(TTGGCCAA)2 with cis‐[Pt(NH3)2(H2O)2]2+ and [Pt(NH3)3(H2O)]2+

F. Gonnet, J. Kozelka, J. Chottard, 1996 .

O−H⋅⋅⋅PtII: Hydrogen Bond with a Strong Dispersion Component

J. Bergès, R. Attias, J. Kozelka, 2000 .

Hydrolysis of chlorido complexes of d8 metals: Old models, new facts

J. Kozelka, 2019, Inorganica Chimica Acta.

The TpG chelate of cis(diammineplatinum) forms two head-to-head rotamers in H2O solution

F. Gonnet, J. Girault, J. Kozelka, 1998, JBIC Journal of Biological Inorganic Chemistry.

The Phosphodiester Groups of d(TpT)− and d(TpG)‐ Coordinate to Platinum(II) in N,N‐Dimethylformamide

J. Kozelka, G. Barre, 1997 .

Model of the Second Most Abundant Cisplatin-DNA Cross-Link: X-ray Crystal Structure and Conformational Analysis of cis-[(NH(3))(2)Pt(9-MeA-N7)(9-EtGH-N7)](NO(3)).2H(2)O (9-MeA = 9-Methyladenine; 9-EtGH = 9-Ethylguanine).

M. Sabat, B. Lippert, J. Kozelka, 1996, Inorganic chemistry.

Cisplatin GG-crosslinks within single-stranded DNA: origin of the preference for left-handed helicity.

J. Monnet, J. Kozelka, 2012, Journal of inorganic biochemistry.

Effect of platinum N7-binding to deoxyguanosine and deoxyadenosine on the H8 and H2 chemical shifts. A quantitative analysis

J. Kozelka, M. Fouchet, D. Lemaire, 1994 .

Synthetic route to dinuclear platinum(II) complexes [{trans-PtCl(NH3)2}2(mu-L)]2+ (L = aliphatic or heterocyclic diamine) as potential antitumor agents, exploiting the mutual activation of hydroxido ligands and ammonium groups.

S. Rizzato, C. Lenoir, A. Albinati, 2008, Inorganic chemistry.

Reaction between the diaqua form of cisplatin and 2-methylsulfanylphenylphosphonic acid yields a dinuclear phosphonato-bridged complex via NH3 elimination

A. Albinati, J. Kozelka, C. Mauger, 2000 .

Platinum(II) complexes with four ligating Phosphorus atoms crystal and molecular structure of [Pt(PEt3)4](ClO4)2. Discussion of electronic spectra of planar and tetrahedrally distorted PtP4 chromophores

H. Lüthi, R. Kunz, J. Kozelka, 1984 .

Lone-pair-π interactions: analysis of the physical origin and biological implications.

S. Bazzi, J. Novotný, R. Marek, 2016, Physical chemistry chemical physics : PCCP.

Anion-π Interactions in Flavoproteins Involve a Substantial Charge-Transfer Component.

S. Bazzi, R. Marek, Yevgen P Yurenko, 2017, Chemistry.

Dispersion-driven hydrogen bonding: predicted hydrogen bond between water and platinum(II) identified by neutron diffraction.

J. Bergès, S. Rizzato, A. Albinati, 2010, Angewandte Chemie.

Study of intramolecular competition between carboxylate and phosphonate for Pt(II) with the aid of a novel tridentate carboxylato-thioether-phosphonato ligand.

S. Rizzato, M. Hamel, A. Albinati, 2007, Chemistry.

Fixing the conformations of diamineplatinum(II)-GpG chelates: NMR and CD signatures of individual rotamers

G. Bertho, J. Kozelka, M. Elizondo-Riojas, 2006, JBIC Journal of Biological Inorganic Chemistry.

Asymmetrical complexes [Pt(N,N-dmen)(dGuo)L](2)+ (N,N-dmen=N,N-dimethylethylenediamine; L=H2O, Cl−, dGuo): H8 nuclei experience an orientation-dependent deshielding effect attributable to the paramagnetic anisotropy of the platinum atom

J. Kozelka, M. Elizondo-Riojas, 2000 .

H8 chemical shifts in oligonucleotide cross-linked at a GpG sequence by cis-Pt(NH3)2(2+): a clue to the adduct structure.

J. Kozelka, J. Chottard, M. Fouchet, 1992, European journal of biochemistry.

Reversible hydrolysis of [PtCl(dien)]+ and [PtCl(NH3)3]+. Determination of the rate constants using UV spectrophotometry

G. H. Hoa, J. Kozelka, Niklaus Marti, 1998 .

Molecular origin of the sequence-dependent kinetics of reactions between cisplatin derivatives and DNA

J. Kozelka, 2009 .

From the Modelization of DNA Platination to the Conception of New Drugs

E. Ségal-Bendirdjian, A. Jacquemin-Sablon, A. Yeung, 1991 .

GG versus AG Platination: A Kinetic Study on Hairpin-Stabilized Duplex Oligonucleotides.

J. Kozelka, J. Chottard, F. Legendre, 1998, Inorganic chemistry.

Kinetic Analysis of the Reactions between GG-Containing Oligonucleotides and Platinum Complexes. 1. Reactions of Single-Stranded Oligonucleotides with cis-[Pt(NH(3))(2)(H(2)O)(2)](2+) and [Pt(NH(3))(3)(H(2)O)](2+).

F. Gonnet, J. Kozelka, J. Chottard, 1996, Inorganic chemistry.

Platinum-DNA interstrand crosslinks: molecular determinants of bending and unwinding of the double helix.

V. Brabec, J. Kašpárková, K. Kubícek, 2012, Journal of inorganic biochemistry.

Lone-pair – p interactions : analysis of the physical origin and biological implications †

S. Bazzi, J. Novotný, R. Marek, 2016 .

LEF-1 recognition of platinated GG sequences within double-stranded DNA. Influence of flanking bases.

M. Sari, K. Chválová, S. Bombard, 2008, Journal of inorganic biochemistry.

Unrestrained 5 ns molecular dynamics simulation of a cisplatin-DNA 1,2-GG adduct provides a rationale for the NMR features and reveals increased conformational flexibility at the platinum binding site.

J. Kozelka, M. Elizondo-Riojas, 2001, Journal of molecular biology.

Very short oligonucleotides migrate on 20% polyacrylamide gels with an apparent friction coefficient proportional to molecular mass.

S. Bombard, A. Favre, J. Kozelka, 1998, Analytical biochemistry.

Discrimination Between BI and BII Conformational Substates of B-DNA Based on Sugar-base Interproton Distances

B. Hartmann, S. Téletchéa, J. Kozelka, 2004, Journal of biomolecular structure & dynamics.

A d(GpG)-platinated decanucleotide duplex is kinked. An extended NMR and molecular mechanics study.

E. Guittet, T. Huynh-Dinh, J. Lallemand, 1990, European journal of biochemistry.

Protein environment affects the water-tryptophan binding mode. MD, QM/MM, and NMR studies of engrailed homeodomain mutants.

N. Špačková, L. Žídek, Milan Zachrdla, 2018, Physical chemistry chemical physics : PCCP.

Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent.

V. Brabec, O. Delalande, J. Malina, 2005, Biophysical journal.

Force field for platinum binding to adenine

Richard Lavery, Jirí Kozelka, Roger Savinelli, 1993, J. Comput. Chem..

Molecular mechanics modeling of oligonucleotide adducts of the antitumor drug cis‐diamminedichloroplatinum(II)

G. Petsko, G. Quigley, S. Lippard, 1987, Biopolymers.

Molecular mechanics calculations on cis ([Pt(NH3)2{d(GpG)}] adducts in two oligonucleotide duplexes

G. Petsko, G. Quigley, S. Lippard, 1985 .

On the non-classical contribution in lone-pair-π interaction: IQA perspective.

R. Marek, Zahra Badri, C. Foroutan‐Nejad, 2015, Physical chemistry chemical physics : PCCP.

Lone pair–π interactions in biological systems: occurrence, function, and physical origin

J. Kozelka, 2017, European Biophysics Journal.

A complete kinetic study of GG versus AG plantination suggests that the doubly aquated derivatives of cisplatin are the actual DNA binding species.

J. Kozelka, J. Chottard, F. Legendre, 2000, Chemistry.

cis-[Pt(NH3)2(9-MeA-N7)(9-EtGH-N7)](PF6)2·1.5H2O (9-MeA = 9-Methyladenine; 9-EtGH = 9-Ethylguanine): A Right-Handed Helicoidal Model Compound for the Intrastrand A,G Cross-Link in Duplex DNA

M. Sabat, B. Lippert, I. Baxter, 1997 .

Water-Tryptophan Interactions: Lone-pair⋅⋅⋅π or O-H⋅⋅⋅π? Molecular Dynamics Simulations of β-Galactosidase Suggest that Both Modes Can Co-exist.

R. Marek, J. Kozelka, Matúš Durec, 2018, Chemistry.

Platin(II)‐Chromophore mit σ‐gebundenen Ligatoratomen

J. Kozelka, W. Ludwig, 1983 .

A dinuclear platinum(II) complex with hydrazine and chloro bridges: (NPrn4)[PtCl2(μ-Cl)(μ-N2H4)PtCl2]

J. Kozelka, Y. Montet, 1999 .

Recognition of DNA interstrand cross-link of antitumor cisplatin by HMGB1 protein.

V. Brabec, J. Kašpárková, O. Delalande, 2003, Biochemistry.

Crosslinking of Adjacent Guanine Residues in an Oligonucleotide by cis‐[Pt(NH3)2(H2O)2]2+: Kinetic Analysis of the Two‐Step Reaction

F. Gonnet, J. Kozelka, J. Chottard, 1992 .

Cytotoxic activity of platinum (II) complexes with tri-n-butylphosphine. Crystal structure of the dinuclear hydrazine-bridged complex, cis,cis-[PtCl(PBu3n)2(mu-N2H4)PtCl(PBu3n) 2] (ClO4)2.2CHCl3.

C. Bois, J. Kozelka, E. Segal, 1992, Journal of inorganic biochemistry.

Reaction between ethylenediamine and acetone on a platinum(II) complex. Crystal structure of chloro(ethylenediamine)(tributylphosphine)platinum(1+) chloro(N-isopropylideneethylenediamine)(tributylphosphine)platinum(1+) dichloride.acetone

C. Bois, J. Kozelka, 1988 .

A combined effect of molecular electrostatic potential and N7 accessibility explains sequence-dependent binding of cis-[Pt(NH3)2(H2O)2]2+ to DNA duplexes.

J. Kozelka, M. Elizondo-Riojas, J. Chottard, 2002, Angewandte Chemie.

Reaction Between Ethylenediamine and Acetone on a Platinum(II) Complex. Crystal Structure of (PtCl(en)(PBu3)) (PtCl(ien)(PBu3))Cl2·CH3COCH3.

C. Bois, J. Kozelka, 1989 .

Fast interstrand cross-linking of cisplatin-DNA monoadducts compared with intrastrand chelation: a kinetic study using hairpin-stabilized duplex oligonucleotides.

J. Kozelka, J. Chottard, Véronique Monjardet-Bas, 2002, Chemistry.

Probing the mechanism of an Mn2+-dependent ribozyme by means of platinum complexes.

S. Bombard, A. Favre, J. Kozelka, 1998, European Journal of Biochemistry.

Unusual interstrand Pt(S,S-diaminocyclohexane)-GG crosslink formed by rearrangement of a classical intrastrand crosslink within a DNA duplex.

G. Natile, J. Monnet, F. Arnesano, 2010, Chemistry, an Asian journal.

Recognition Complex Between the HMG Domain of LEF-1 and its Cognate DNA Studied by Molecular Dynamics Simulations with Explicit Solvation

J. Kozelka, M. Drumm, Stéphane Téletchéa, 2005, Journal of biomolecular structure & dynamics.

Evaluation of dissociation constants from competition binding experiments based on the relative binding ratio.

J. Kozelka, 2011, Analytical biochemistry.