J. Selkirk

发表

5‐HT1A receptor agonist‐antagonist binding affinity difference as a measure of intrinsic activity in recombinant and native tissue systems

C. Scott, G. W. Price, G. Riley, 2000, British journal of pharmacology.

The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.

J. Hagan, D. Middlemiss, G. W. Price, 1998, Journal of medicinal chemistry.

Investigation into MAO B–Mediated Formation of CC112273, a Major Circulating Metabolite of Ozanimod, in Humans and Preclinical Species: Stereospecific Oxidative Deamination of (S)-Enantiomer of Indaneamine (RP101075) by MAO B

V. Shanmugasundaram, D. Dalvie, S. Surapaneni, 2021, Drug Metabolism and Disposition.

Identification of differential melanocortin 4 receptor agonist profiles at natively expressed receptors in rat cortical astrocytes and recombinantly expressed receptors in human embryonic kidney cells

L. Nottebaum, S. Lechner, J. Selkirk, 2007, Neuropharmacology.

Competitive Binding of Ozanimod and Other Sphingosine 1-Phosphate Receptor Modulators at Receptor Subtypes 1 and 5

A. Bortolato, R. Hargreaves, J. Selkirk, 2022, Frontiers in Pharmacology.

SB-236057, a selective 5-HT1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor.

D. Middlemiss, C. Scott, G. W. Price, 1999, European journal of pharmacology.

Manipulation of small-molecule inhibitory kinetics modulates MCH-R1 function

R. Maki, Mingzhu Zhang, J. Grey, 2006, Molecular and Cellular Endocrinology.

A Novel Cell-Based Assay for G-Protein-Coupled Receptor-Mediated Cyclic Adenosine Monophosphate Response Element Binding Protein Phosphorylation

A. Foster, L. Nottebaum, S. Lechner, 2006, Journal of biomolecular screening.

Over‐expression of the human EAAT2 glutamate transporter within neurons of mouse organotypic hippocampal slice cultures leads to increased vulnerability of CA1 pyramidal cells

D. Poulsen, I. Stone, A. Foster, 2005, The European journal of neuroscience.

SHORT COMMUNICATION Over-expression of the human EAAT2 glutamate transporter within neurons of mouse organotypic hippocampal slice cultures leads to increased vulnerability of CA1 pyramidal cells

D. Poulsen, I. Stone, A. Foster, 2005 .

Characterization of an N‐terminal secreted domain  of the type‐1 human metabotropic glutamate receptor  produced by a mammalian cell line

R. Challiss, R. Mcilhinney, J. Selkirk, 2002, Journal of neurochemistry.

Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator

Peijin Zhang, R. Hargreaves, D. Dalvie, 2021, Drug Metabolism and Disposition.

Increase in 15-hydroxyprostaglandin dehydrogenase activity in the ovine placentome at parturition and effect of oestrogen.

D. Howe, R. Kelly, S. Riley, 2000, Journal of reproduction and fertility.

In vitro assessment of the binding and functional reponses of ozanimod and its plasma metabolites across human sphingosine 1-phosphate receptors.

R. Hargreaves, J. Selkirk, Y. Yan, 2022, European journal of pharmacology.

SB‐224289–a novel selective (human) 5‐HT1B receptor antagonist with negative intrinsic activity

D. Middlemiss, C. Scott, G. W. Price, 1998, British journal of pharmacology.

Blockade of excitatory amino acid transporters in the rat hippocampus results in enhanced activation of group I and group III metabotropic glutamate receptors

A. Foster, G. S. Naeve, J. Selkirk, 2003, Neuropharmacology.

Cell type-specific differences in the coupling of recombinant mGlu1α receptors to endogenous G protein sub-populations

G. W. Price, R. Challiss, S. Nahorski, 2001, Neuropharmacology.

Complex involvement of pertussis toxin-sensitive G proteins in the regulation of type 1alpha metabotropic glutamate receptor signaling in baby hamster kidney cells.

R. Challiss, R. Mistry, E. Hermans, 2000, Molecular pharmacology.

Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5

A. Bortolato, R. Hargreaves, D. Dalvie, 2021, The Journal of Pharmacology and Experimental Therapeutics.

Enhanced inducible mGlu1α receptor expression in Chinese hamster ovary cells

Mark S. Nash, Julie V. Selkirk, Caroline E. Gaymer, 2001 .

Role of the GLT‐1 subtype of glutamate transporter in glutamate homeostasis: the GLT‐1‐preferring inhibitor WAY‐855 produces marginal neurotoxicity in the rat hippocampus

A. Foster, J. Dunlop, K. B. Mackay, 2005, The European journal of neuroscience.

Development of Flashplate™ Technology to Measure [35S]GTPyS Binding to Chinese Hamster Ovary Cell Membranes Expressing the Cloned Human 5-HTIB Receptor

A. Brown, J. Selkirk, J. Watson, 1998 .

The selective 5-HT1B receptor inverse agonist SB-224289, potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.

J. Hagan, D. Middlemiss, G. W. Price, 1998, Annals of the New York Academy of Sciences.