S. Leung

发表

Generation of Anti-Idiotype scFv for Pharmacokinetic Measurement in Lymphoma Patients Treated with Chimera Anti-CD22 Antibody SM03

Qi Zhao, S. Lee, Jun-zhi Wang, 2014, PloS one.

The effects of domain deletion, glycosylation, and long IgG3 hinge on the biodistribution and serum stability properties of a humanized IgG1 immunoglobulin, hLL2, and its fragments.

D. Goldenberg, R. Sharkey, H. Hansen, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Pharmacokinetics, Pharmacodynamics and Preliminary Observations for Clinical Activity and Safety of Multiple Doses of Human Mouse Chimeric Anti-CD22 Monoclonal Antibody (SM03) in Chinese Patients with Systemic Lupus Erythematosus

Xia Chen, Ji Jiang, P. Hu, 2016, Clinical Drug Investigation.

A single-chain immunotoxin against carcinoembryonic antigen that suppresses growth of colorectal carcinoma cells.

J. C. Murphy, K. F. Nolan, R. Kreitman, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Surrogate target cells expressing surface anti-idiotype antibody for the clinical evaluation of an internalizing CD22-specific antibody

Qi Zhao, Kai Gao, S. Leung, 2015, mAbs.

Co-secretion of two distinct kappa light chains by the mu-9 hybridoma.

D. Goldenberg, H. Hansen, D. Gold, 1999, Hybridoma.

Chimerization of mu‐9

D. Goldenberg, H. Hansen, M. Losman, 1997, Cancer.

Treatment of non-Hodgkin's lymphoma with radiolabeled murine, chimeric, or humanized LL2, an anti-CD22 monoclonal antibody.

M. Juweid, R. Sharkey, H. Hansen, 1995, Cancer research.

SM03, an Anti-CD22 Antibody, Converts Cis-to-Trans Ligand Binding of CD22 against α2,6-Linked Sialic Acid Glycans and Immunomodulates Systemic Autoimmune Diseases

Nan Song, S. Leung, Zhengdong Li, 2022, The Journal of Immunology.

PRECLINICAL AND CLINICAL EVALUATION OF A CDR-GRAFTED (HUMANIZED) ANTI-CARCINOEMBRYONIC ANTIGEN (CEA) MONOCLONAL ANTIBODY (MAb)

M. Juweid, G. Griffiths, D. Goldenberg, 1994 .

Interleukins 4 and 21 Protect Anti-IgM Induced Cell Death in Ramos B Cells: Implication for Autoimmune Diseases

C. Hui, S. Leung, Wai Chung Wu, 2022, Frontiers in Immunology.

Bacterial expression of a kemptide fusion protein facilitates 32P labeling of a humanized, anti-carcinoembryonic antigen (hMN-14) antibody fragment.

G. Griffiths, D. Goldenberg, H. Hansen, 1995, Cancer research.

Transcriptional and translational analysis of the human theta globin gene.

N. Proudfoot, E. Whitelaw, S. Leung, 1989, Nucleic acids research.

Structure determination of N-linked oligosaccharides engineered at the CH1 domain of humanized LL2.

D. Goldenberg, R. Sharkey, H. Hansen, 1997, Glycobiology.

Construction and characterization of a humanized, internalizing, B-cell (CD22)-specific, leukemia/lymphoma antibody, LL2.

A S Dion, D. Goldenberg, H. Hansen, 1995, Molecular immunology.

Generation and monitoring of cell lines producing humanized antibodies.

D. Goldenberg, H. Hansen, M. Losman, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Humanization of Immu31, an alpha-fetoprotein-specific antibody.

D. Goldenberg, H. Hansen, M. Losman, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Engineering a unique glycosylation site for site-specific conjugation of haptens to antibody fragments.

G. Griffiths, D. Goldenberg, H. Hansen, 1995, Journal of immunology.

The gene for \[thetas]-globin is transcribed in human fetal erythroid tissues

N. Proudfoot, E. Whitelaw, S. Leung, 1987, Nature.

The immunomodulatory and antitumor activities of trichosanthin-an abortifacient protein isolated from tian-hua-fen (Trichosanthes kirilowii).

H. Yeung, K. Leung, S. Leung, 1986, Asian Pacific journal of allergy and immunology.

The immunosuppressive activities of two abortifacient proteins isolated from the seeds of bitter melon (Momordica charantia).

H. Yeung, K. Leung, S. Leung, 1987, Immunopharmacology.

Bypassing immunization: optimized design of "designer T cells" against carcinoembryonic antigen (CEA)-expressing tumors, and lack of suppression by soluble CEA.

C. Yun, J. C. Murphy, E. Beecham, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Effect of VK framework‐1 glycosylation on the binding affinity of lymphoma‐specific murine and chimeric LL2 antibodies and its potential use as a novel conjugation site

D. Goldenberg, H. Hansen, A. Dion, 1995, International journal of cancer.

Generation of a high‐producing clone of a humanized anti‐B‐cell lymphoma monoclonal antibody (hLL2)

D. Goldenberg, H. Hansen, M. Losman, 1997, Cancer.

Chimerization of LL2, a rapidly internalizing antibody specific for B cell lymphoma.

D. Goldenberg, H. Hansen, A. Dion, 1994, Hybridoma.

SM03, an anti-human CD22 monoclonal antibody, for active rheumatoid arthritis: a phase II randomized, double-blind, placebo-controlled study.

Fengchun Zhang, Mengtao Li, Jiaxin Zhou, 2021, Rheumatology.

Carbohydrates engineered at antibody constant domains can be used for site-specific conjugation of drugs and chelates.

D. Goldenberg, R. Sharkey, H. Hansen, 1998, Journal of immunological methods.

Anticorps glycosyles et fragments d'anticorps presentant des groupes cetoniques reactifs

W. Mcbride, S. Leung, Z. Qu, 1998 .

Site-specific modifications of light chain glycosylated antilymphoma (LL2) and anti-carcinoembryonic antigen (hImmu-14-N) antibody divalent f1agments.

G. Griffiths, D. Goldenberg, H. Hansen, 1995, Cancer Research.

Development and evaluation of the specificity of a rat monoclonal anti-idiotype antibody, WN, to an anti-B-cell lymphoma monoclonal antibody, LL2.

D. Goldenberg, H. Hansen, R. Shukla, 1995, Cancer research.

Evaluation of a complementarity-determining region-grafted (humanized) anti-carcinoembryonic antigen monoclonal antibody in preclinical and clinical studies.

M. Juweid, G. Griffiths, D. Goldenberg, 1995, Cancer research.