G. Arad

发表

Bacterial superantigen toxins induce a lethal cytokine storm by enhancing B7-2/CD28 costimulatory receptor engagement, a critical immune checkpoint.

R. Kaempfer, Andrey Popugailo, Ziv Rotfogel, 2017, Receptors & clinical investigation.

Superantigens hyperinduce inflammatory cytokines by enhancing the B7-2/CD28 costimulatory receptor interaction

F. Osman, R. Kaempfer, Andrey Popugailo, 2016, Proceedings of the National Academy of Sciences.

Correction: Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock

R. Kaempfer, U. Barash, Tomer Shpilka, 2015, PLoS biology.

CD28: Direct and Critical Receptor for Superantigen Toxins

R. Kaempfer, Ziv Rotfogel, D. Hillman, 2013, Toxins.

Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock

R. Kaempfer, U. Barash, Tomer Shpilka, 2011, PLoS biology.

A peptide antagonist of CD28 signaling attenuates toxic shock and necrotizing soft-tissue infection induced by Streptococcus pyogenes.

S. Opal, A. Cross, G. Ramachandran, 2013, The Journal of infectious diseases.

Post-transcriptional Regulation of Human Interleukin-2 Gene Expression at Processing of Precursor Transcripts (*)

S. Efrat, R. Kaempfer, L. Gerez, 1995, The Journal of Biological Chemistry.

Regulation of Human Interleukin‐2 and Interferon‐Gamma Gene Expression by Suppressor T Lymphocytes

E. Deutsch, S. Efrat, R. Kaempfer, 1991, Scandinavian journal of immunology.

Regulation of interleukin-2 and interferon-γ gene expression in renal failure

R. Kaempfer, B. Kristal, T. Shkolnik, 1991 .

Aberrant regulation of interleukin-2 but not of interferon-gamma gene expression in Down syndrome (trisomy 21).

R. Kaempfer, T. Sharav, L. Gerez, 1991, Clinical immunology and immunopathology.

Hyperinducible expression of the interferon‐gamma (IFN‐γ) gene and its suppression in systemic lupus erythematosus (SLE)

R. Kaempfer, T. Shkolnik, L. Gerez, 1997, Clinical and experimental immunology.

Interleukin-2 induces an early step in the activation of interferon-γ gene expression

R. Kaempfer, G. Arad, R. Nussinovich, 1995 .

Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation

R. Kaempfer, D. Hillman, R. Levy, 2000, Nature Medicine.

Transient expression of human interleukin-2 and interferon-gamma genes is regulated by interaction between distinct cell subsets.

E. Deutsch, R. Kaempfer, L. Gerez, 1995, Cellular immunology.

Linomide, an immunomodulator that inhibits Th1 cytokine gene expression.

R. Kaempfer, S. Slavin, R. Levy, 1996, International immunology.

Broad-Spectrum Peptide Antagonists of Superantigen Toxins

R. Kaempfer, D. Hillman, R. Levy, 2007 .

Broad-spectrum immunity against superantigens is elicited in mice protected from lethal shock by a superantigen antagonist peptide.

R. Kaempfer, D. Hillman, R. Levy, 2004, Immunology letters.

Defense against biologic warfare with superantigen toxins.

R. Kaempfer, D. Hillman, R. Levy, 2002, The Israel Medical Association journal : IMAJ.

Development of anti-human FSH antibody in a patient with isolated FSH deficiency.

I. Spitz, J. Bell, D. Rabinowitz, 1973, The Journal of clinical endocrinology and metabolism.

Down-regulation of human tumor necrosis factor-beta gene expression by cells with suppressive activity.

F. Osman, R. Kaempfer, D. Aframian, 1996, Immunology letters.

The potential to express or suppress human interleukin-2 and interferon-gamma genes is not restricted to distinct cell subsets.

R. Kaempfer, L. Gerez, A. Reshef, 1990, Molecular immunology.

Effects of glutamine, methionine sulfone and dexamethasone on rates of synthesis of glutamine synthetase in cultured hepatoma cells.

R. G. Kulka, G. Arad, 1978, Biochimica et biophysica acta.

Glutamine-stimulated modification and degradation of glutamine synthetase in hepatoma tissue culture cells

R. G. Kulka, G. Arad, A. Freikopf, 1976, Cell.

Superantigen concomitantly induces Th1 cytokine genes and the ability to shut off their expression on re-exposure to superantigen.

R. Kaempfer, R. Levy, G. Arad, 2002, Immunology letters.

CD28 homodimer interface mimetic peptide acts as a preventive and therapeutic agent in models of severe bacterial sepsis and gram-negative bacterial peritonitis.

W. Blackwelder, A. Chahin, S. Opal, 2015, The Journal of infectious diseases.

Dual control of human interleukin-2 and interferon-gamma gene expression by histamine: activation and suppression.

R. Kaempfer, G. Arad, M. Na’amad, 1996, Cellular immunology.

Superantigen antagonist blocks Th1 cytokine gene induction and lethal shock

R. Kaempfer, D. Hillman, R. Levy, 2001, Journal of leukocyte biology.

Activation of ribonuclease F by the two isomers (2'–5') oligoadenylate and (3'–5') oligoadenylate

A. Panet, G. Arad, S. Rappoport, 1982, FEBS letters.

The homodimer interfaces of costimulatory receptors B7 and CD28 control their engagement and pro-inflammatory signaling

R. Kaempfer, Tomer Shpilka, Andrey Popugailo, 2023, Journal of Biomedical Science.

Regulation of interleukin-2 and interferon-gamma gene expression in renal failure.

B. Kristal, T. Shkolnik, S. Shasha, 1991, Kidney international.