Y. Higashi

发表

ASP2409, A Next‐Generation CTLA4‐Ig, Versus Belatacept in Renal Allograft Survival in Cynomolgus Monkeys

Y. Hu, A. Ma, P. Daloze, 2017, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor.

K. Nakai, Ayako Moritomo, Takayuki Inoue, 2018, Bioorganic & medicinal chemistry.

Discovery of 3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2(1H)-one derivatives as novel JAK inhibitors.

A. Tanaka, Ayako Moritomo, Takayuki Inoue, 2015, Bioorganic & medicinal chemistry.

Anti-inflammatory effect and selectivity profile of AS1940477, a novel and potent p38 mitogen-activated protein kinase inhibitor.

H. Yamazaki, M. Terajima, H. Mizuhara, 2013, European journal of pharmacology.

Effect of novel PKCθ selective inhibitor AS2521780 on acute rejection in rat and non-human primate models of transplantation.

S. Tsujimoto, J. Hirose, Koji Nakamura, 2015, International immunopharmacology.

A Comparison of Protocols Used to Generate Insulin‐Producing Cell Clusters from Mouse Embryonic Stem Cells

K. Wood, Douglas C. Wu, Y. Higashi, 2008, Stem cells.

Role of JAK-STAT signaling in the pathogenic behavior of fibroblast-like synoviocytes in rheumatoid arthritis: Effect of the novel JAK inhibitor peficitinib.

S. Narumiya, Hiromu Ito, M. Hashimoto, 2020, European journal of pharmacology.

Benefits of a loading dose of tacrolimus on graft survival of kidney transplants in nonhuman primates

S. Tsujimoto, J. Hirose, Koji Nakamura, 2019, Transplant Immunology.

Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.

T. Ono, N. Inamura, Y. Higashi, 1997, European journal of pharmacology.

A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model.

Takayuki Inoue, M. Inami, M. Kuno, 2017, Journal of pharmacological sciences.

Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3.

A. Tanaka, K. Nakai, Ayako Moritomo, 2015, Bioorganic & medicinal chemistry.

Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids).

S. Sakuma, T. Goto, Y. Ohkubo, 2001, International immunopharmacology.

FK506 suppresses neutrophil chemoattractant production by peripheral blood mononuclear cells.

S. Sakuma, T. Goto, Y. Higashi, 2000, European journal of pharmacology.

Effective suppression of donor specific antibody production by Cathepsin S inhibitors in a mouse transplantation model

M. Inami, Yutaka Nakajima, Koji Nakamura, 2018, European journal of pharmacology.

Immunosuppressive effect of ASP2408, a novel CD86-selective variant of CTLA4-Ig, in rats and cynomolgus monkeys.

B. Devens, F. Takamura, H. Mizuhara, 2016, International immunopharmacology.

Efficacy of oral treatment with tacrolimus in the renal transplant model in cynomolgus monkeys.

N. Seki, J. Hirose, M. Maeda, 2008, Journal of pharmacological sciences.

Impacts of dosing and drug withdrawal period on tacrolimus-based triple therapy in a non-human primate renal transplantation model.

Koji Nakamura, M. Maeda, T. Morokata, 2022, Transplant immunology.

A chronic renal rejection model with a fully MHC-mismatched rat strain combination under immunosuppressive therapy.

A. Fujikawa, S. Miyoshi, J. Hirose, 2016, Transplant immunology.

Role of Inhibition of Penicillin Binding Proteins and Cell Wall Cross-Linking by Beta-Lactam Antibiotics in Low- and High-Level Methicillin Resistance of Staphylococcus aureus

A. Ohno, Y. Matsumoto, Y. Higashi, 1999, Chemotherapy.

Topical Application of FK506 (Tacrolimus) Ointment Inhibits Mite Antigen-Induced Dermatitis by Local Action in NC/Nga Mice

S. Sakuma, S. Mutoh, Y. Ohkubo, 2004, International Archives of Allergy and Immunology.

Release mechanisms of tacrolimus-loaded PLGA and PLA microspheres and immunosuppressive effects of the microspheres in a rat heart transplantation model.

N. Oku, M. Maeda, R. Kojima, 2015, International journal of pharmaceutics.

Transplanting stem cells: potential targets for immune attack. Modulating the immune response against embryonic stem cell transplantation.

K. Wood, Y. Higashi, A. Boyd, 2005, Advanced drug delivery reviews.

Atopic Dermatitis-Like Skin Lesions Induced by Topical Application of Mite Antigens in NC/Nga Mice

H. Matsuda, T. Goto, Y. Ohkubo, 2001, International Archives of Allergy and Immunology.

Discovery of tricyclic dipyrrolopyridine derivatives as novel JAK inhibitors.

Ayako Moritomo, Takayuki Inoue, M. Inami, 2017, Bioorganic & medicinal chemistry.

FK1706, a novel non-immunosuppressive immunophilin: neurotrophic activity and mechanism of action.

T. Yanagihara, T. Yamaji, B. Gold, 2005, European journal of pharmacology.

The Effect of ASP2409, a Novel CD86-Selective Variant of CTLA4-Ig, on Renal Allograft Rejection in Nonhuman Primates

B. Devens, S. Tsujimoto, J. Hirose, 2016, Transplantation.

ASP2408 and ASP2409, novel CTLA4-Ig variants with CD86-selective ligand binding activity and improved immunosuppressive potency, created by directed evolution.

S. Bass, M. Whitlow, Qian Zhang, 2016, Protein engineering, design & selection : PEDS.

Inhibition of c-Rel DNA binding is critical for the anti-inflammatory effects of novel PIKfyve inhibitor.

M. Terajima, H. Mizuhara, M. Hiramoto, 2016, European journal of pharmacology.

THU0101 ASP015K: A Novel Jak Inhibitor Demonstrated Potent Efficacy in Adjuvant-Induced Arthritis Model in Rats

N. Seki, M. Inami, M. Ito, 2013 .

Effect of AS2521780, a novel PKCθ selective inhibitor, on T cell-mediated immunity.

A. Tanaka, Keiko Suzuki, M. Maeda, 2014, European journal of pharmacology.