N. Okino

发表

Ergosteryl-β-glucosidase (Egh1) involved in sterylglucoside catabolism and vacuole formation in Saccharomyces cerevisiae.

M. Tani, Makoto Ito, Takashi Watanabe, 2015, Glycobiology.

Purification, molecular cloning, and application of a novel sphingomyelin-binding protein (clamlysin) from the brackishwater clam, Corbicula japonica.

A. Omori, S. Ichinose, Makoto Ito, 2011, Biochimica et biophysica acta.

Loss-of-Function Mutation in Bi-Functional Marine Bacterial Sialyltransferase

Takeshi Yamamoto, Y. Kakuta, Makoto Ito, 2012, Bioscience, biotechnology, and biochemistry.

Inhibition of GM3 Synthase Attenuates Neuropathology of Niemann-Pick Disease Type C by Affecting Sphingolipid Metabolism

Y. Bae, E. Schuchman, H. Jin, 2014, Molecules and cells.

Purification, crystallization and preliminary crystallographic characterization of the α2,6-sialyltransferase from Photobacterium sp. JT-ISH-224

Takeshi Yamamoto, Y. Kakuta, Masako Ichikawa, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Expression, purification, and characterization of highly active endo-α-N-acetylgalactosaminidases expressed by silkworm-baculovirus expression system

J. M. Lee, H. Mon, T. Kusakabe, 2019, Journal of Asia-Pacific Entomology.

Two Fatty Acid Elongases Possessing C18-Δ6/C18-Δ9/C20-Δ5 or C16-Δ9 Elongase Activity in Thraustochytrium sp. ATCC 26185

Yuji Okita, K. Sakaguchi, Makoto Ito, 2013, Marine Biotechnology.

Regulation of TG accumulation and lipid droplet morphology by the novel TLDP1 in Aurantiochytrium limacinum F26-b[S]

M. Hayashi, Makoto Ito, K. Nomura, 2017, Journal of Lipid Research.

Transglycosylation-based fluorescent labeling of 6-gala series glycolipids by endogalactosylceramidase.

M. Kiso, R. Geyer, H. Ishida, 2009, Glycobiology.

A novel fucosyl glycosphingolipid of brine shrimp that is highly sensitive to endoglycoceramidase.

Y. Horibata, M. Inagaki, K. Sakaguchi, 2009, Glycobiology.

Fucosyl-GM1a, an endoglycoceramidase-resistant ganglioside of porcine brain.

Kuniko Yamaguchi, M. Inagaki, K. Sakaguchi, 2006, Journal of biochemistry.

The glycosphingolipid receptor for Vibrio trachuri in the red sea bream intestine is a GM4 ganglioside which contains 2-hydroxy fatty acids.

Y. Horibata, N. Furuya, M. Inagaki, 2005, Biochemical and biophysical research communications.

Purification, characterization, and cDNA cloning of alpha-N-acetylgalactosamine-specific lectin from starfish, Asterina pectinifera.

S. Kawabata, A. Omori, Kuniko Yamaguchi, 2002, Glycobiology.

Crystal structure of the covalent intermediate of human cytosolic beta-glucosidase.

M. Kimura, Y. Hayashi, J. Noguchi, 2008, Biochemical and biophysical research communications.

Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide.

M. Tani, M. Ito, S. Mitsutake, 1999, Journal of biochemistry.

Two bacterial glycosphingolipid synthases responsible for the synthesis of glucuronosylceramide and α-galactosylceramide

Y. Hayashi, M. Matsumoto, Makoto Ito, 2020, The Journal of Biological Chemistry.

Ceramidase Enhances Phospholipase C-induced Hemolysis by Pseudomonas aeruginosa*

Makoto Ito, N. Okino, 2007, Journal of Biological Chemistry.

Molecular Cloning of the Full-length cDNA Encoding Mouse Neutral Ceramidase

K. Mori, M. Tani, H. Izu, 2000, The Journal of Biological Chemistry.

cDNA Cloning, Tissue Distribution, and Subcellular Localization of Horseshoe Crab Big Defensin

Y. Toh, T. Saito, S. Kawabata, 1997, Biological chemistry.

Identification of Perfluorooctane Sulfonate Binding Protein in Plasma of Rat

Y. Shimasaki, Y. Oshima, Masato Honda, 2014 .

Zebrafish and Mouse α2,3-Sialyltransferases Responsible for Synthesizing GM4 Ganglioside*

K. Ikeda, R. Taguchi, Y. Yoshimura, 2009, The Journal of Biological Chemistry.

M. Tani, H. Narimatsu, Y. Hayashi, 2007, Journal of Biological Chemistry.

Purification, Characterization, Molecular Cloning, and Subcellular Distribution of Neutral Ceramidase of Rat Kidney*

K. Mori, M. Tani, A. Omori, 2001, The Journal of Biological Chemistry.

PUFA synthase-independent DHA synthesis pathway in Parietichytrium sp. and its modification to produce EPA and n-3DPA

M. Hayashi, K. Tashiro, D. Honda, 2021, Communications Biology.

Quality Control of Fungus-specific Glucosylceramide in Cryptococcus neoformans by Endoglycoceramidase-related Protein 1 (EGCrP1)*

K. Ikeda, R. Taguchi, K. Sakaguchi, 2011, The Journal of Biological Chemistry.

A sensitive and reproducible assay to measure the activity of glucosylceramide synthase and lactosylceramide synthase using HPLC and fluorescent substrates.

Y. Hayashi, Y. Horibata, K. Sakaguchi, 2005, Analytical biochemistry.

Sterylglucoside Catabolism in Cryptococcus neoformans with Endoglycoceramidase-related Protein 2 (EGCrP2), the First Steryl-β-glucosidase Identified in Fungi*

K. Ikeda, R. Taguchi, T. Miyamoto, 2014, The Journal of Biological Chemistry.

Versatile Transformation System That Is Applicable to both Multiple Transgene Expression and Gene Targeting for Thraustochytrids

M. Hayashi, S. Sugimoto, D. Honda, 2012, Applied and Environmental Microbiology.

Determination of globotriaosylceramide analogs in the organs of a mouse model of Fabry disease

S. Ishii, Makoto Ito, H. Maruyama, 2020, The Journal of Biological Chemistry.

Pseudomonas-Derived Ceramidase Induces Production of Inflammatory Mediators from Human Keratinocytes via Sphingosine-1-Phosphate

K. Iwabuchi, K. Takamori, Y. Suga, 2014, PloS one.

Proline-rich Cell Surface Antigens of Horseshoe Crab Hemocytes Are Substrates for Protein Cross-linking with a Clotting Protein Coagulin*

S. Kawabata, S. Iwanaga, F. Tokunaga, 2002, The Journal of Biological Chemistry.

N-oleoyl-D-erythro-sphingosine-based analysis of ceramide by high performance liquid chromatography and its application to determination in diverse biological samples

Y. Yun, J. Hong, Tack-Joong Kim, 2018 .

Purification and Characterization of a Novel Ceramidase fromPseudomonas aeruginosa *

M. Tani, S. Imayama, N. Okino, 1998, The Journal of Biological Chemistry.

Lipid rafts enriched in monosialylGb5Cer carrying the stage-specific embryonic antigen-4 epitope are involved in development of mouse preimplantation embryos at cleavage stage

N. Kiyokawa, Y. Katagiri, J. Fujimoto, 2011, BMC Developmental Biology.

Purification, Characterization, and cDNA Cloning of a Novel Acidic Endoglycoceramidase from the Jellyfish, Cyanea nozakii *

M. Ito, A. Omori, Y. Horibata, 2000, The Journal of Biological Chemistry.

The Glu residue in the conserved Asn-Glu-Pro sequence of endoglycoceramidase is essential for enzymatic activity.

M. Ito, H. Izu, K. Sakaguchi, 1999, Biochemical and biophysical research communications.

A sensitive and reproducible fluorescent-based HPLC assay to measure the activity of acid as well as neutral beta-glucocerebrosidases.

Y. Hayashi, K. Ohno, Makoto Ito, 2008, Analytical biochemistry.

A novel ether-linked phytol-containing digalactosylglycerolipid in the marine green alga, Ulva pertusa.

T. Miyamoto, Kuniko Yamaguchi, Makoto Ito, 2014, Biochemical and biophysical research communications.

Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons

H. Kim, J. Bae, Y. Okada, 2014, Nature Communications.

Expression, Purification, and Characterization of a Recombinant Neutral Ceramidase from Mycobacterium tuberculosis

Makoto Ito, N. Okino, Rie Ikeda, 2010, Bioscience, biotechnology, and biochemistry.

Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice

H. Otani, K. Furukawa, T. Hatta, 2018, PLoS genetics.

A neutral ceramidase homologue from Dictyostelium discoideum exhibits an acidic pH optimum.

M. Tani, M. Maeda, Makoto Ito, 2003, The Biochemical journal.

Reverse hydrolysis reaction of a recombinant alkaline ceramidase of Pseudomonas aeruginosa.

M. Ito, N. Okino, K. Kita, 2000, Biochimica et biophysica acta.

Enhancing the sialylation of recombinant EPO produced in CHO cells via the inhibition of glycosphingolipid biosynthesis

Seung-Yeol Park, Jung Hoe Kim, Makoto Ito, 2017, Scientific Reports.

M. Tani, H. Narimatsu, Y. Hayashi, 2007, The Journal of biological chemistry.

Molecular Cloning and Expression of Mn2+-Dependent Sphingomyelinase/Hemolysin of an Aquatic Bacterium, Pseudomonas sp. Strain TK4

Takashi Nakamura, K. Sakaguchi, Makoto Ito, 2002, Journal of bacteriology.

Analysis of Δ12-fatty acid desaturase function revealed that two distinct pathways are active for the synthesis of PUFAs in T. aureum ATCC 34304

M. Hayashi, S. Sugimoto, D. Honda, 2012, Journal of Lipid Research.

Nucleotide sequence of the cDNA encoding the proenzyme of phenol oxidase A1 of Drosophila melanogaster.

S. Kawabata, S. Iwanaga, K. Fujimoto, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Purification, Characterization, and cDNA Cloning of a 27-kDa Lectin (L10) from Horseshoe Crab Hemocytes (*)

S. Kawabata, M. Hirata, S. Iwanaga, 1995, The Journal of Biological Chemistry.

A thraustochytrid-specific lipase/phospholipase with unique positional specificity contributes to microbial competition and fatty acid acquisition from the environment

M. Hayashi, Yohei Ishibashi, N. Okino, 2019, Scientific Reports.

Purification, characterization, and cDNA cloning of α - N -acetylgalactosamine-specific lectin from starfish, Asterina pectinifera

S. Kawabata, A. Omori, Kuniko Yamaguchi, 2002 .

[14C]ceramide synthesis by sphingolipid ceramide N-deacylase: new assay for ceramidase activity detection.

M. Ito, S. Mitsutake, N. Okino, 1997, Analytical biochemistry.

Simultaneous quantification of glucosylceramide and galactosylceramide by normal-phase HPLC using O-phtalaldehyde derivatives prepared with sphingolipid ceramide N-deacylase.

Y. Hirabayashi, Y. Hayashi, S. Ito, 2009, Glycobiology.

New insight into the structure, reaction mechanism, and biological functions of neutral ceramidase.

M. Tani, Makoto Ito, N. Okino, 2014, Biochimica et biophysica acta.

Purification and Characterization of a Neutral Ceramidase from Mouse Liver

M. Tani, N. Okino, M. Ito, 2000, The Journal of Biological Chemistry.

Molecular cloning, expression, and characterization of a novel endo-alpha-N-acetylgalactosaminidase from Enterococcus faecalis.

Hiromi Ito, H. Narimatsu, Makoto Ito, 2008, Biochemical and biophysical research communications.

Molecular Cloning and Characterization of Sphingolipid CeramideN-Deacylase from a Marine Bacterium, Shewanella alga G8*

A. Omori, S. Mitsutake, S. Ichinose, 2002, The Journal of Biological Chemistry.

Subcellular localization of human neutral ceramidase expressed in HEK293 cells.

M. Tani, Makoto Ito, Young-ha Hwang, 2005, Biochemical and biophysical research communications.

Purification and Characterization of Recombinant, Human Acid Ceramidase

E. Schuchman, K. Sandhoff, S. Gatt, 2003, Journal of Biological Chemistry.

The Reverse Activity of Human Acid Ceramidase*

E. Schuchman, K. Sandhoff, S. Gatt, 2003, Journal of Biological Chemistry.

Molecular Evolution of Neutral Ceramidase: From Bacteria to Mammals

M. Tani, S. Mitsutake, N. Okino, 2002 .

Molecular Cloning, Sequencing, and Expression of the Gene Encoding Alkaline Ceramidase from Pseudomonas aeruginosa

A. Omori, S. Imayama, Takashi Nakamura, 1999, The Journal of Biological Chemistry.

Enzymatic remodeling of fatty acid molecules by SCDase demonstrated that fucosyl GM1a possessing a polyunsaturated fatty acid induces apoptosis in HL60 human promyelocyte leukemia cells

M. Inagaki, Makoto Ito, N. Okino, 2009 .

Synthesis of fluorescent glycosphingolipids and neoglycoconjugates which contain 6-gala oligosaccharides using the transglycosylation reaction of a novel endoglycoceramidase (EGALC).

M. Kiyohara, Makoto Ito, Yohei Ishibashi, 2007, Journal of biochemistry.

Molecular Cloning and Functional Analysis of Zebrafish Neutral Ceramidase*[boxs]

M. Tani, Y. Yoshimura, H. Iida, 2004, Journal of Biological Chemistry.

Conserved Amino Acid Residues in the COOH-terminal Tail Are Indispensable for the Correct Folding and Localization and Enzyme Activity of Neutral Ceramidase*

M. Tani, Makoto Ito, N. Sueyoshi, 2004, Journal of Biological Chemistry.

Activation of bacterial ceramidase by anionic glycerophospholipids: possible involvement in ceramide hydrolysis on atopic skin by Pseudomonas ceramidase.

M. Kiso, H. Ishida, S. Imayama, 2002, The Biochemical journal.

Mechanistic Insights into the Hydrolysis and Synthesis of Ceramide by Neutral Ceramidase*

Y. Kai, H. Okano, M. Tani, 2009, Journal of Biological Chemistry.

Genomic structure and promoter analysis of the mouse neutral ceramidase gene.

Makoto Ito, N. Okino, K. Mori, 2002, Biochemical and biophysical research communications.

Preparation and characterization of EGCase I, applicable to the comprehensive analysis of GSLs, using a rhodococcal expression system

A. Hijikata, K. Sakaguchi, Makoto Ito, 2012, Journal of Lipid Research.

Multiplex analysis of sphingolipids using amine-reactive tags (iTRAQ)

S. Takeoka, Toshihide Kobayashi, Y. Hirabayashi, 2011, Journal of Lipid Research.

C4-monomethylsterol β-glucoside and its synthase in Aurantiochytrium limacinum mh0186.

M. Hayashi, T. Miyamoto, Makoto Ito, 2021, Glycobiology.

Visualization of Endoplasmic Reticulum and Mitochondria in Aurantiochytrium limacinum by the Expression of EGFP with Cell Organelle-Specific Targeting/Retaining Signals

Makoto Ito, Yohei Ishibashi, N. Okino, 2018, Marine Biotechnology.

Two Fatty Acid Elongases Possessing C18-Δ6/C18-Δ9/C20-Δ5 or C16-Δ9 Elongase Activity in Thraustochytrium sp. ATCC 26185

Yuji Okita, K. Sakaguchi, Makoto Ito, 2013, Marine Biotechnology.

Lack of ∆5 Desaturase Activity Impairs EPA and DHA Synthesis in Fish Cells from Red Sea Bream and Japanese Flounder

Y. Hayashi, Makoto Ito, Tatsuki Noda, 2021, Marine Biotechnology.

Novel Lysophospholipid Acyltransferase PLAT1 of Aurantiochytrium limacinum F26-b Responsible for Generation of Palmitate-Docosahexaenoate-Phosphatidylcholine and Phosphatidylethanolamine

M. Hayashi, K. Ikeda, R. Taguchi, 2014, PloS one.

Increase of Eicosapentaenoic Acid in Thraustochytrids through Thraustochytrid Ubiquitin Promoter-Driven Expression of a Fatty Acid Δ5 Desaturase Gene

M. Hayashi, S. Sugimoto, D. Honda, 2011, Applied and Environmental Microbiology.

Tamavidins – novel avidin‐like biotin‐binding proteins from the Tamogitake mushroom

Takeshi Yamamoto, Y. Kakuta, Makoto Ito, 2009, The FEBS journal.

Unique Catabolic Pathway of Glycosphingolipids in a Hydrozoan, Hydra magnipapillata, Involving Endoglycoceramidase*

T. Fujisawa, H. Iida, Y. Horibata, 2004, Journal of Biological Chemistry.

Vibrios adhere to epithelial cells in the intestinal tract of red sea bream, Pagrus major, utilizing GM4 as an attachment site.

Makoto Ito, Shin-ichi Chisada, N. Okino, 2013, FEMS microbiology letters.

Elevated water temperature reduces the acute toxicity of the widely used herbicide diuron to a green alga, Pseudokirchneriella subcapitata

Xuchun Qiu, S. Fukuda, M. Tsuyama, 2013, Environmental Science and Pollution Research.

Vibrio-binding gangliosides in fish intestinal tracts

Shin-ichi Chisada, N. Okino, Makoto Ito, 2023, Glycoconjugate Journal.

Ceramidase Activity in Bacterial Skin Flora as a Possible Cause of Ceramide Deficiency in Atopic Dermatitis

S. Imayama, N. Okino, Makoto Ito, 1999, Clinical Diagnostic Laboratory Immunology.

A Novel Endoglycoceramidase Hydrolyzes Oligogalactosylceramides to Produce Galactooligosaccharides and Ceramides*

A. Hijikata, M. Kiso, A. Omori, 2007, Journal of Biological Chemistry.

Molecular cloning and characterization of a secretory neutral ceramidase of Drosophila melanogaster.

M. Tani, Y. Yoshimura, Makoto Ito, 2002, Journal of biochemistry.

Molecular mechanism for sphingosine-induced Pseudomonas ceramidase expression through the transcriptional regulator SphR

N. Okino, Makoto Ito, 2016, Scientific Reports.

Purification and Characterization of Recombinant, Human Acid Ceramidase: Catalytic Reactions and Interactions With Acid Sphingomyelinase

E. Schuchman, K. Sandhoff, S. Gatt, 2003 .

The glycerol-3-phosphate acyltransferase PLAT2 functions in the generation of DHA-rich glycerolipids in Aurantiochytrium limacinum F26-b

M. Hayashi, Takashi Watanabe, Yohei Ishibashi, 2019, PloS one.

Molecular cloning of a Pinguiochrysis pyriformis oleate-specific microsomal Δ12-fatty acid desaturase and functional analysis in yeasts and thraustochytrids.

N. Kurano, M. Hayashi, S. Sugimoto, 2011, Journal of biochemistry.

Crystal structure of Vibrionaceae Photobacterium sp. JT-ISH-224 alpha2,6-sialyltransferase in a ternary complex with donor product CMP and acceptor substrate lactose: catalytic mechanism and substrate recognition.

Takeshi Yamamoto, Y. Kakuta, Masako Ichikawa, 2007, Glycobiology.

Glycosphingolipid receptors for pathogenic vibrios in intestines of mariculture fish

Makoto Ito, N. Okino, H. Fujioka, 2011, Fisheries Science.

Mechanistic Insights into the Hydrolysis and Synthesis of Ceramide by Neutral Ceramidase*

Y. Kai, H. Okano, M. Tani, 2009, Journal of Biological Chemistry.

A label-free impedance-based whole cell assay revealed a new G protein-coupled receptor ligand for mouse microglial cell migration.

Shigeki Furuya, Makoto Ito, S. Furuya, 2016, Biochemical and biophysical research communications.

Regulation of TG accumulation and lipid droplet morphology by the novel TLDP1 in Aurantiochytrium limacinum F26-b[S]

M. Hayashi, Makoto Ito, K. Nomura, 2017, Journal of Lipid Research.

Novel Lysophospholipid Acyltransferase PLAT1 of Aurantiochytrium limacinum F26-b Responsible for Generation of Palmitate-Docosahexaenoate-Phosphatidylcholine and Phosphatidylethanolamine

M. Hayashi, K. Ikeda, R. Taguchi, 2014, PloS one.

Quality Control of Fungus-specific Glucosylceramide in Cryptococcus neoformans by Endoglycoceramidase-related Protein 1 (EGCrP1)*

K. Ikeda, R. Taguchi, K. Sakaguchi, 2011, The Journal of Biological Chemistry.

Multiplex analysis of sphingolipids using amine-reactive tags (iTRAQ)

S. Takeoka, Toshihide Kobayashi, Y. Hirabayashi, 2011, Journal of Lipid Research.

Crystal structure of α/β‐galactoside α2,3‐sialyltransferase from a luminous marine bacterium, Photobacterium phosphoreum

M. Kimura, Takeshi Yamamoto, Y. Kakuta, 2009, FEBS letters.

Identification of perfluorooctane sulfonate binding protein in the plasma of tiger pufferfish Takifugu rubripes.

K. Kannan, Y. Shimasaki, Y. Oshima, 2014, Ecotoxicology and environmental safety.

Inhibition of GM3 Synthase Attenuates Neuropathology of Niemann-Pick Disease Type C by Affecting Sphingolipid Metabolism

E. Schuchman, H. Jin, J. Bae, 2014, Molecules and cells.

Lysoglycosphingolipids have the ability to induce cell death through direct PI3K inhibition

D. Tsuji, N. Okino, Y. Ohnishi, 2023, Journal of neurochemistry.