L. Almeida

发表

Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.

V. Oza, P. Lyne, J. Janetka, 2008, Bioorganic & medicinal chemistry letters.

Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.

David A. Scott, S. Kazmirski, A. Ferguson, 2015, Bioorganic & medicinal chemistry letters.

Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology.

S. Kazmirski, Nancy Su, D. Ogg, 2015, ACS medicinal chemistry letters.

In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors.

David A. Scott, M. Lamb, Hai‐Jun Zhang, 2011, Bioorganic & medicinal chemistry letters.

Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.

Jon Read, Mei Su, Minwei Ye, 2011, Journal of medicinal chemistry.

Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors.

Mei Su, Minwei Ye, C. Chuaqui, 2014, Journal of medicinal chemistry.

Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.

J. Breed, V. Oza, P. Lyne, 2012, Journal of medicinal chemistry.

Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.

M. Lamb, Audrey M Davies, M. Zinda, 2009, Bioorganic & medicinal chemistry letters.

Replacement of pyrazol-3-yl amine hinge binder with thiazol-2-yl amine: Discovery of potent and selective JAK2 inhibitors.

M. Lamb, Stephanos Ioannidis, Michelle L Lamb, 2010, Bioorganic & medicinal chemistry letters.

Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.

P. Lyne, J. Janetka, S. Ashwell, 2008, Bioorganic & medicinal chemistry letters.