T. Gero

发表

Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.

V. Oza, P. Lyne, J. Janetka, 2008, Bioorganic & medicinal chemistry letters.

A Mild Efficient Procedure for the Conversion of Carboxylic Acid Esters to Primary Amides Using Formamide/Methanolic Sodium Methoxide

G. E. Jagdmann, H. R. Munson, T. Gero, 1990 .

AWARD NUMBER: W81XWH-16-1-0106 TITLE: Fragment-Based Approaches to Enhance GTP Competitive KRAS G12C Inhibitors PRINCIPAL INVESTIGATOR: Kenneth Westover CONTRACTING ORGANIZATION: University of Texas Southwestern Medical Center

David A. Scott, Kwok-Kin Wong, N. Gray, 2018 .

Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507.

David A. Scott, D. Valle, L. Drew, 2013, Bioorganic & medicinal chemistry letters.

Discovery of a Series of Benzopyrimidodiazepinone TNK2 Inhibitors via Scaffold Morphing.

David A. Scott, N. Gray, F. Féru, 2020, Bioorganic & medicinal chemistry letters.

Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC.

David A. Scott, P. Jänne, N. Gray, 2022, Bioorganic & medicinal chemistry letters.

Benzo- and pyrido-1,4-oxazepin-5-ones and -thiones: synthesis and structure-activity relationships of a new series of H1 antihistamines.

C. A. Leonard, Y. Lo, T. Gero, 1989, Journal of medicinal chemistry.

Halogenation of 2-Hydroxynicotinic Acid

Y. Lo, T. Gero, L. W. Jaques, 1989 .

Benzo- and pyrido-1,4-oxazepin-5-ones and -thiones: synthesis and structure-activity relationships of a new series of H1 antihistamines.

C. A. Leonard, Y. Lo, T. Gero, 1989, Journal of medicinal chemistry.

Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase.

David A. Scott, Audrey M Davies, M. Zinda, 2009, Bioorganic & medicinal chemistry letters.

3-amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor.

David A. Scott, L. Drew, L. Dakin, 2011, Bioorganic & medicinal chemistry letters.

AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Tristan J. Lubinski, E. Hennessy, M. Garnett, 2020, Clinical Cancer Research.

Structure-based design of protein tyrosine phosphatase-1B inhibitors.

Jon Read, Alexander L Breeze, A. Breeze, 2005, Bioorganic & medicinal chemistry letters.

Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.

J. Breed, V. Oza, P. Lyne, 2012, Journal of medicinal chemistry.

Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.

David A. Scott, P. Jänne, Kwok-Kin Wong, 2017, Cell chemical biology.

Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor.

P. Jänne, Kwok-Kin Wong, N. Gray, 2019, Cancer discovery.

An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer

David A. Scott, P. Jänne, N. Gray, 2022, Nature Cancer.

Exploring Targeted Degradation Strategy for Oncogenic KRASG12C.

David A. Scott, P. Jänne, N. Gray, 2019, Cell chemical biology.

Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.

C. Chuaqui, A. Ferguson, P. Lyne, 2018, Journal of medicinal chemistry.

Towards the next generation of dual Bcl-2/Bcl-xL inhibitors.

Kate F. Byth, Prasenjit Mukherjee, J. Saeh, 2014, Bioorganic & medicinal chemistry letters.

Discovery of sterically-hindered phenol compounds with potent cytoprotective activities against ox-LDL-induced retinal pigment epithelial cell death as a potential pharmacotherapy.

David A. Scott, F. Rossato, E. Choi, 2021, Free radical biology & medicine.

3-amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile.

David A. Scott, L. Drew, L. Dakin, 2009, Bioorganic & medicinal chemistry letters.

Infrared Investigation of Acid Activation by PyBOP in Polystyrene/Divinylbenzene Supported Solid-Phase Synthesis

D. Pivonka, T. Gero, D. L. Palmer, 1999 .

Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors.

David A. Scott, P. Jänne, N. Gray, 2019, ACS medicinal chemistry letters.

Benzopyrimidodiazepinone inhibitors of TNK2.

David A. Scott, N. Gray, F. Féru, 2020, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of a cyclic pseudohexapeptide analog of somatostatin.

A. Schally, A. Spatola, T. Gero, 1984, Biochemical and Biophysical Research Communications - BBRC.

Structure‐activity studies of analogs of β, γ‐methylene‐ATP at P2X‐purinoceptors in the rabbit ear central artery

Pauline L. Martin, T. Gero, N. Cusack, 1995 .

Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.

P. Lyne, J. Janetka, S. Ashwell, 2008, Bioorganic & medicinal chemistry letters.

Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase.

David A. Scott, Audrey M Davies, M. Zinda, 2009, Bioorganic & medicinal chemistry letters.