D. Toader

发表

Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.

V. Oza, P. Lyne, J. Janetka, 2008, Bioorganic & medicinal chemistry letters.

Antibody–Drug Conjugates

D. Toader, 2017 .

Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4

E. Hurt, M. Rebelatto, R. Hollingsworth, 2017, Molecular Cancer Therapeutics.

Straightforward Glycoengineering Approach to Site-Specific Antibody-Pyrrolobenzodiazepine Conjugates.

Herren Wu, P. Thompson, Changshou Gao, 2016, ACS medicinal chemistry letters.

The Development and Scale-Up of an Antibody Drug Conjugate Tubulysin Payload

David W. Anderson, Beatrice A. Maltman, J. Parker, 2017 .

PERFORMANCE FLUIDS AS AN INERT MEDIUM FOR THE PREPARATION OF BENZOTRIAZOLE DERIVATIVES

A. Katritzky, D. Toader, Jinlong Jiang, 1995 .

Structure-Cytotoxicity Relationships of Analogues of N14-Desacetoxytubulysin H.

V. Bedian, Fengjiang Wang, A. Kamal, 2016, Journal of medicinal chemistry.

First General Synthesis of (p-Nitroaryl)diarylmethanes via Vicarious Nucleophilic Substitution of Hydrogen

A. Katritzky, D. Toader, 1997 .

A Four-Carbon Unit Reagent for the Regiospecific Synthesis of 2-Alkyl-Substituted 1,3-Butadienes.

A. Katritzky, Xiaojing Wang, D. Toader, 1999, The Journal of organic chemistry.

NOVEL AND EFFICIENT ENTRY TO GAMMA -ARYL-SUBSTITUTED GAMMA , DELTA -UNSATURATED KETONES, AMIDES, NITRILES, AND SULFONES BY CONJUGATE ADDITIONS OF 2-BE NZOTRIAZOLYLETHYLSILANES

A. Katritzky, M. Voronkov, D. Toader, 1998 .

NOVEL SYNTHESES OF 1,2-DIARYLPROP-2-EN-1-ONES

A. Katritzky, C. Chassaing, D. Toader, 1998 .

Efficient Syntheses of Secondary and Tertiary 2-Aryl- and 2-Heteroaryl-allyl Alcohols

A. Katritzky, Xiaojing Wang, D. Toader, 1998 .

Mechanistic studies of fluoride-promoted silicon elimination in β-benzotriazolyl-β-aryl-γ-ketosilanes

A. Katritzky, M. Voronkov, D. Toader, 1998 .

Masked α-Arylalkenyllithium Reagents for Efficient Syntheses of Functionalized Monosubstituted and 1,1-Disubstituted Ethylenes

A. Katritzky, D. Toader, 1997 .

General and Efficient Insertions of Carbons Carrying Aryl and Heteroaryl Groups: Synthesis of alpha-Aryl- and alpha-Heteroaryl-Substituted Ketones.

A. Katritzky, D. Toader, Linghong Xie, 1996, The Journal of organic chemistry.

General and Efficient Carbon Insertion Route to One-Carbon-Homologated .alpha.-Aryl, .alpha.-Alkenyl, .alpha.-Alkoxy, and .alpha.-Phenylthio Alkyl Ketones

A. Katritzky, D. Toader, Linghong Xie, 1995 .

Syntheses of 2-alkylamino- and 2-dialkylamino-4,6-diarylpyridines and 2,4,6-trisubstituted pyrimidines using solid-phase-bound chalcones.

B. Forood, C. Chassaing, X. Wang, 2000, Journal of combinatorial chemistry.

New synthesis of SASRIN™ resin

J. Kiely, K. Watson, D. Toader, 1997 .

Efficient Transformations of Aldehydes and Ketones into One‐Carbon Homologated Carboxylic Acids.

A. Katritzky, D. Toader, Linghong Xie, 1997 .

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol.

Jon Read, Zhongwu Lai, Francoise Powell, 2013, ACS chemical biology.

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy.

M. Rebelatto, J. Osbourn, Herren Wu, 2016, Cancer cell.

Structure-based design of protein tyrosine phosphatase-1B inhibitors.

Jon Read, Alexander L Breeze, A. Breeze, 2005, Bioorganic & medicinal chemistry letters.

Reactions of 1-(Benzotriazol-1-yl)-1-phenoxyalkane and (Benzotriazol-1-yl)ethoxyphenylmethane Anions with Nitroarenes: a New Approach to Alkyl and Aryl p-Nitroaryl Ketones

A. Katritzky, C. Chassaing, D. Toader, 1999 .

Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.

J. Breed, V. Oza, P. Lyne, 2012, Journal of medicinal chemistry.

Structural approaches to obtain kinase selectivity.

Richard A Norman, A. Ferguson, R. A. Norman, 2012, Trends in pharmacological sciences.

Essential role of TAK1 in regulating mantle cell lymphoma survival.

A. Younes, Kate F. Byth, D. Buglio, 2012, Blood.

Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.

C. Chuaqui, A. Ferguson, P. Lyne, 2018, Journal of medicinal chemistry.

Abstract 2114: Tumor cell-targeted STING-agonist antibody-drug conjugates achieve potent anti-tumor activity by delivering STING agonist specifically to tumor cells andFcγRI-expressing subset of myeloid cells

Jeremy R. Duvall, M. Protopopova, M. Damelin, 2022, Cancer Research.

Abstract 3503: XMT-2056, a HER2-targeted Immunosynthen STING-agonist antibody-drug conjugate, binds a novel epitope of HER2 and shows increased anti-tumor activity in combination with trastuzumab and pertuzumab

Jeremy R. Duvall, M. Protopopova, S. Collins, 2022, Cancer Research.

Abstract 1738: XMT-2056, a well-tolerated, Immunosynthen-based STING-agonist antibody-drug conjugate which induces anti-tumor immune activity

Jeremy R. Duvall, M. Protopopova, S. Collins, 2021, Immunology.

Abstract 6706: Systemic administration of STING agonist antibody-drug conjugates elicit potent anti-tumor immune responses with minimal induction of circulating cytokines

Jeremy R. Duvall, M. Protopopova, S. Collins, 2020 .

Abstract 907: XMT-1660, a B7-H4-targeted Dolasynthen antibody-drug conjugate for the treatment of breast cancer

Steven P. Bradley, S. Collins, Phonphimon Wongthida, 2021, Experimental and Molecular Therapeutics.

Abstract 2687: Dolasynthen–a novel, homogeneous Auristatin F hydroxypropyl amide antibody-drug conjugate platform

S. Collins, M. Damelin, Liuliang Qin, 2019, Experimental and Molecular Therapeutics.

Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.

J. Breed, P. Lyne, J. Janetka, 2018, Journal of Medicinal Chemistry.

EFFICIENT TRANSFORMATIONS OF ALDEHYDES AND KETONES INTO ONE-CARBON HOMOLOGATED CARBOXYLIC ACIDS

A. Katritzky, D. Toader, Linghong Xie, 1996 .

Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors.

Jon Read, Mei Su, J. Breed, 2012, Bioorganic & medicinal chemistry letters.

Discovery of a novel class of triazolones as checkpoint kinase inhibitors--hit to lead exploration.

J. Breed, V. Oza, P. Lyne, 2010, Bioorganic & medicinal chemistry letters.

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy.

M. Rebelatto, J. Osbourn, Herren Wu, 2016, Cancer cell.

Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4

E. Hurt, M. Rebelatto, R. Hollingsworth, 2017, Molecular Cancer Therapeutics.

Synthesis of Pyrylium Salts with Various Anions

A. Balaban, T. Balaban, C. Popescu, 2010 .

Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates

Jeremy R. Duvall, S. Collins, M. Damelin, 2023, Journal of medicinal chemistry.

Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.

P. Lyne, J. Janetka, S. Ashwell, 2008, Bioorganic & medicinal chemistry letters.

Tumor cell-directed STING agonist antibody-drug conjugates induce type III interferons and anti-tumor innate immune responses

M. Damelin, R. Bukhalid, Kalli C Catcott, 2024, Nature communications.