Y. Ikeura

发表

Synthesis and Structure Activity Relationship Studies of Benzothieno[3,2- b ]furan Derivatives as a Novel Class of IKKβ Inhibitors

H. Oki, Toshimasa Tanaka, T. Kawamoto, 2007 .

Effects of TAK-637, a novel neurokinin-1 receptor antagonist, on colonic function in vivo.

H. Natsugari, Y. Ikeura, N. Inatomi, 2001, The Journal of pharmacology and experimental therapeutics.

Effects of TAK-637, a tachykinin receptor antagonist, on the micturition reflex in guinea pigs.

I. Kamo, H. Natsugari, S. Okanishi, 2000, European journal of pharmacology.

Amide-based atropisomers in tachykinin NK1-receptor antagonists: synthesis and antagonistic activity of axially chiral N-benzylcarboxamide derivatives of 2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocin-6-one

Y. Ishichi, H. Natsugari, Y. Ikeura, 2004 .

Axially chiral 1,7-naphthyridine-6-carboxamide derivatives as orally active tachykinin NK(1) receptor antagonists: synthesis, antagonistic activity, and effects on bladder functions.

A. Fujishima, T. Doi, M. Kawada, 1999, Journal of medicinal chemistry.

Axially chiral N-benzyl-N,7-dimethyl-5-phenyl-1, 7-naphthyridine-6-carboxamide derivatives as tachykinin NK1 receptor antagonists: determination of the absolute stereochemical requirements.

A. Fujishima, T. Doi, M. Kawada, 1998, Journal of medicinal chemistry.

ENANTIOSELECTIVE SYNTHESIS OF AN AXIALLY CHIRAL 1,7-NAPHTHYRIDINE-6-CARBOXAMIDE DERIVATIVE HAVING POTENT ANTAGONIST ACTIVITY AT THE NK1 RECEPTOR

A. Fujishima, T. Doi, H. Natsugari, 1998 .

Novel, potent, and orally active substance P antagonists: synthesis and antagonist activity of N-benzylcarboxamide derivatives of pyrido[3,4-b]pyridine.

T. Doi, I. Kamo, Y. Ishichi, 1995, Journal of medicinal chemistry.

Microbial synthesis of three metabolites of a tachykinin receptor antagonist, TAK-637.

H. Natsugari, Y. Ikeura, K. Nakahama, 2001, Journal of bioscience and bioengineering.

Effects of tachykinin NK1 receptor antagonists on the viscerosensory response caused by colorectal distention in rabbits.

Y. Ikeura, N. Inatomi, S. Okano, 2002, The Journal of pharmacology and experimental therapeutics.

Microbial synthesis of a deuterium-labelled metabolite of an NK1 receptor antagonist, TAK-637

H. Natsugari, Y. Ikeura, K. Nakahama, 2001 .

Effects of TAK-637, a tachykinin receptor antagonist, on lower urinary tract function in the guinea pig.

I. Kamo, H. Natsugari, S. Okanishi, 1999, European journal of pharmacology.

Synthesis and Structure Activity Relationship Studies of Benzothieno[3,2‐b]furan Derivatives as a Novel Class of IKKβ Inhibitors.

H. Oki, Toshimasa Tanaka, T. Kawamoto, 2007 .

Synthesis and structure activity relationship studies of benzothieno[3,2-b]furan derivatives as a novel class of IKKbeta inhibitors.

H. Oki, Toshimasa Tanaka, T. Kawamoto, 2007, Chemical and pharmaceutical bulletin.

Potent NK1 receptor antagonists: synthesis and antagonistic activity of various heterocycles with an N-[3,5-bis(trifluoromethyl)benzyl]-N-methylcarbamoyl substituent.

T. Doi, S. Morimoto, M. Ogino, 1997, Chemical & pharmaceutical bulletin.

Novel 3-phenylpiperidine-4-carboxamides as highly potent and orally long-acting neurokinin-1 receptor antagonists with reduced CYP3A induction.

S. Morimoto, I. Kamo, Hironobu Maezaki, 2012, Bioorganic & medicinal chemistry.

Design, structure-activity relationship, and highly efficient asymmetric synthesis of 3-phenyl-4-benzylaminopiperidine derivatives as novel neurokinin-1 receptor antagonists.

M. Yamashita, I. Kamo, Tadatoshi Hashimoto, 2011, Bioorganic & medicinal chemistry.

3-benzhydryl-4-piperidones as novel neurokinin-1 receptor antagonists and their efficient synthesis.

E. Imamiya, Tadatoshi Hashimoto, Minoru Nakamura, 2011, Bioorganic & medicinal chemistry.