Katherine L Lee

发表

Blockade of cytosolic phospholipase A2α prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses

M. Leach, Takao Shimizu, J. D. Clark, 2008, Journal of Neuroimmunology.

Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors.

J. D. Clark, J. McKew, E. A. Murphy, 2008, Analytical biochemistry.

Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.

David R. Anderson, S. Wright, V. Rao, 2017, Journal of medicinal chemistry.

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists

P. Cohen, N. Gray, Tinghu Zhang, 2017, The Biochemical journal.

Cytosolic Phospholipase A2α Blockade Abrogates Disease during the Tissue-Damage Effector Phase of Experimental Autoimmune Encephalomyelitis by Its Action on APCs

V. Kuchroo, M. Leach, J. D. Clark, 2011, The Journal of Immunology.

This information is current as Encephalomyelitis by Its Action on APCs Effector Phase of Experimental Autoimmune Abrogates Disease during the Tissue-Damage Blockade α 2 Cytosolic Phospholipase

V. Kuchroo, M. Leach, J. D. Clark, 2011 .

Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.

J. D. Clark, M. Hegen, J. McKew, 2008, Journal of medicinal chemistry.

The cPLA2α inhibitor efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid

J. D. Clark, J. McKew, W. Duan, 2011, Neuropharmacology.

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy.

J. D. Clark, J. McKew, W. Abraham, 2008, Bioorganic & medicinal chemistry.

Blockade of cytosolic phospholipase A2α prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses

M. Leach, Takao Shimizu, J. D. Clark, 2008, Journal of Neuroimmunology.

Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors.

R. Kurumbail, D. Hepworth, J. Guzova, 2017, European journal of medicinal chemistry.

Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α2α

S. Khor, J. D. Clark, J. McKew, 2007 .

Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists.

F. Vajdos, M. Schnute, M. Vazquez, 2023, ACS medicinal chemistry letters.

Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice

P. Cohen, V. Rao, J. Arthur, 2019, Life Science Alliance.

IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes

V. Rao, R. Hawtin, Lih-Ling Lin, 2017, The Journal of Biological Chemistry.