H. Appel

发表

Structural Basis of T-Cell Receptor Specificity and Cross-Reactivity: Implications for Pathogenesis of Human Autoimmune Diseases

K. Wucherpfennig, H. Appel, 2000 .

IL-17A Expression Is Localised to Both Mononuclear and Polymorphonuclear Synovial Cell Infiltrates

D. Veale, U. Fearon, J. Sieper, 2011, PloS one.

Investigation of involved tissue in axial spondyloarthritis--what have we learnt from immunohistochemical studies?

J. Sieper, D. Poddubnyy, H. Appel, 2010, Best practice & research. Clinical rheumatology.

In vitro observations of T cell responsiveness to recall antigens during tumor necrosis factor-alpha-blocking therapy in patients with ankylosing spondylitis.

A. Thiel, H. Haibel, M. Rudwaleit, 2007, The Journal of rheumatology.

Efficiency of treatment with non-steroidal anti-inflammatory drugs according to current recommendations in patients with radiographic and non-radiographic axial spondyloarthritis

S. Peters, J. Braun, U. Kiltz, 2017, Rheumatology.

Analysis of the CD8+ T cell response to the G1 domain of aggrecan in ankylosing spondylitis

A. Thiel, J. Sieper, M. Rudwaleit, 2004, Annals of the rheumatic diseases.

Granulation Tissue Eroding the Subchondral Bone Also Promotes New Bone Formation in Ankylosing Spondylitis

U. Syrbe, J. Sieper, A. Hempfing, 2016, Arthritis & rheumatology.

Histomorphologic and Histomorphometric Characteristics of Zygapophyseal Joint Remodeling in Ankylosing Spondylitis

U. Syrbe, J. Sieper, A. Hempfing, 2014, Arthritis & rheumatology.

HLA-B27-restricted antigen presentation by human chondrocytes to CD8+ T cells: potential contribution to local immunopathologic processes in ankylosing spondylitis.

G. Schulze-Tanzil, A. Radbruch, T. John, 2009, Arthritis and rheumatism.

Synovial and Peripheral Blood CD4+FoxP3+ T Cells in Spondyloarthritis

Andreas Radbruch, A. Thiel, U. Syrbe, 2011, The Journal of Rheumatology.

Frontline: Self‐peptides that bind with low affinity to the diabetes‐associated I‐Ag7 molecule readily induce T cell tolerance in non‐obese diabetic mice

J. Cazareth, N. Glaichenhaus, K. Wucherpfennig, 2004 .

Use of HLA-B27 tetramers to identify low-frequency antigen-specific T cells in Chlamydia-triggered reactive arthritis

A. Thiel, P. Bowness, J. Sieper, 2004, Arthritis research & therapy.

Anergy Induction by Dimeric TCR Ligands

L. Gauthier, Nilufer P. Seth, N. Seth, 2001 .

Self-peptides that bind with low affinity to the diabetes-associated I-A(g7) molecule readily induce T cell tolerance in non-obese diabetic mice.

J. Cazareth, N. Glaichenhaus, K. Wucherpfennig, 2004, European journal of immunology.

An elevated level of IL-10- and TGFβ-secreting T cells, B cells and macrophages in the synovial membrane of patients with reactive arthritis compared to rheumatoid arthritis

J. Braun, J. Sieper, M. Rudwaleit, 2004, Clinical Rheumatology.

Characterization of the synovial T cell response to various recombinant Yersinia antigens in Yersinia enterocolitica-triggered reactive arthritis. Heat-shock protein 60 drives a major immune response.

S. Batsford, P. Wu, J. Braun, 1998, Arthritis and rheumatism.

Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment

J. Listing, J. Sieper, M. Rudwaleit, 2008, Arthritis research & therapy.

Immunohistochemical analysis of hip arthritis in ankylosing spondylitis: evaluation of the bone-cartilage interface and subchondral bone marrow.

H. Stein, C. Loddenkemper, J. Sieper, 2006, Arthritis and rheumatism.

Robust hepatitis B vaccine-reactive T cell responses in failed humoral immunity

U. Stervbo, N. Babel, Anna-Barbara Stittrich, 2021, Molecular therapy. Methods & clinical development.

Oligodendrocyte Glycoprotein System Tissue Recognize Myelin Antibodies from Inflamed Central Nervous

D. Hafler, K. Wucherpfennig, M. Call, 2005 .

Cartilage in facet joints of patients with ankylosing spondylitis (AS) shows signs of cartilage degeneration rather than chondrocyte hypertrophy: implications for joint remodeling in AS

U. Syrbe, J. Sieper, A. Hempfing, 2015, Arthritis Research & Therapy.

In situ analysis of interleukin-6 expression at different sites of zygapophyseal joints from patients with ankylosing spondylitis in comparison to controls

U. Syrbe, J. Sieper, J. Bleil, 2015, Scandinavian journal of rheumatology.

Analysis of Bone Samples from Patients with Spondyloarthritides—Identifying Causes of New Bone Formation in Axial Spondyloarthritis

J. Sieper, H. Appel, 2015, The Journal of Rheumatology.

Synovitis in Spondyloarthritides

J. Braun, H. Appel, 2011, The open rheumatology journal.

Immunohistochemical Analysis of Osteoblasts in Zygapophyseal Joints of Patients with Ankylosing Spondylitis Reveal Repair Mechanisms Similar to Osteoarthritis

C. Loddenkemper, J. Sieper, A. Hempfing, 2010, The Journal of Rheumatology.

Spondyloarthritis at the crossroads of imaging, pathology, and structural damage in the era of biologics

J. Sieper, H. Appel, 2008, Current rheumatology reports.

Antibodies from Inflamed Central Nervous System Tissue Recognize Myelin Oligodendrocyte Glycoprotein1

D. Hafler, K. Wucherpfennig, M. Call, 2005, The Journal of Immunology.

Impact of renal disease and comorbidities on mortality in hemodialysis patients with COVID-19: a multicenter experience from Germany

N. Babel, T. Westhoff, J. Hörstrup, 2020, Journal of Nephrology.

Critical appraisal of assessment of structural damage in ankylosing spondylitis: implications for treatment outcomes.

J. Braun, J. Sieper, M. Rudwaleit, 2008, Arthritis and rheumatism.

Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis

H. Stein, C. Loddenkemper, M. Dreimann, 2006, Arthritis research & therapy.

New onset of Crohn's disease during treatment of active ankylosing spondylitis with etanercept.

C. Loddenkemper, J. Braun, H. Haibel, 2008, The Journal of rheumatology.

Different response to rituximab in tumor necrosis factor blocker-naive patients with active ankylosing spondylitis and in patients in whom tumor necrosis factor blockers have failed: a twenty-four-week clinical trial.

J. Braun, J. Listing, J. Sieper, 2010, Arthritis and rheumatism.

Inhibition of cell growth by N-(phosphonacetyl)-L-aspartate in human and murine cells in vitro.

J. Lankelma, H. Pinedo, A. Leyva, 1981, Cancer letters.

Purine modulation of thymidine activity in L1210 leukemia cells in vitro.

H. Pinedo, A. Leyva, H. Appel, 1982, Leukemia research.

In situ analysis of interleukin-23- and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis.

C. Loddenkemper, U. Syrbe, J. Sieper, 2013, Arthritis and rheumatism.

Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers.

B. Walker, P. Klenerman, G. Lauer, 2003, The Journal of clinical investigation.

Elevated serum level of the vascular endothelial growth factor predicts radiographic spinal progression in patients with axial spondyloarthritis

U. Syrbe, J. Braun, J. Sieper, 2013, Annals of the rheumatic diseases.

Differential metabolism of thymidine in human lymphoid and melanoma cells in vitro.

H. Pinedo, A. Leyva, H. Appel, 1984, Anticancer research.

The Evolutionarily Conserved Ribosomal Protein L23 and the Cationic Urease β-Subunit of Yersinia enterocolitica O:3 Belong to the Immunodominant Antigens in Yersinia-Triggered Reactive Arthritis: Implications for Autoimmunity

M. Skurnik, K. Wiesmüller, J. Braun, 1994, Molecular medicine.

Chronic but not inflammatory changes at the Achilles’ tendon differentiate patients with peripheral spondyloarthritis from other diagnoses – Results from a prospective clinical trial

J. Braun, U. Kiltz, X. Baraliakos, 2017, RMD Open.

Proteome with Possible Relevance to Chlamydia trachomatis Peptides from the Identification of HLA-B27-Restricted

H. Holzhütter, A. Thiel, P. Bowness, 2015 .

HLA-B27-restricted CD8+ T cell response to cartilage-derived self peptides in ankylosing spondylitis.

P. Kloetzel, A. Thiel, J. Sieper, 2005, Arthritis and rheumatism.

Identification of HLA-B27-Restricted Peptides from the Chlamydia trachomatis Proteome with Possible Relevance to HLA-B27-Associated Diseases1

P. Kloetzel, H. Holzhütter, Andreas Radbruch, 2001, The Journal of Immunology.

HLA-B 27-Associated Diseases Proteome with Possible Relevance to Chlamydia trachomatis Peptides from the Identification of HLA-B 27-Restricted Kloetzel and

P. Kloetzel, H. Holzhütter, A. Thiel, 2001 .

Anergy Induction by Dimeric TCR Ligands1

K. Wucherpfennig, L. Gauthier, Nilufer P. Seth, 2001, The Journal of Immunology.

Associated with Spondyloarthropathy Cell Epitopes in HLA-B27 Transgenic Mice Identification of Novel Human Aggrecan T

D. Busch, J. Sieper, E. Weiss, 2013 .

Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major.

N. Glaichenhaus, V. Julia, K. Wucherpfennig, 2000, Immunity.

Analysis of IL-17+ cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response

C. Loddenkemper, Andreas Radbruch, A. Thiel, 2011, Arthritis research & therapy.

Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis.

J. Zwerina, G. Schett, M. Herrmann, 2009, Arthritis and rheumatism.

Whole-body MRI as a new screening tool for detecting axial and peripheral manifestations of spondyloarthritis

B. Hamm, J. Sieper, I. Eshed, 2007, Annals of the rheumatic diseases.

Immunohistologic analysis of zygapophyseal joints in patients with ankylosing spondylitis.

H. Stein, C. Loddenkemper, M. Dreimann, 2006, Arthritis and rheumatism.

High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis

J. Zwerina, G. Schett, J. Listing, 2011, Annals of the rheumatic diseases.

inflammatory lesions in a patient with ankylosing spondylitis before and after Whole-body magnetic resonance imaging evaluation of widespread

K. Hermann, H. Appel, 2014 .

The Solvent-Inaccessible Cys67 Residue of HLA-B27 Contributes to T Cell Recognition of HLA-B27/Peptide Complexes1

M. Zeitz, K. Wucherpfennig, P. Bowness, 2004, The Journal of Immunology.

HLA-B 27 / Peptide Complexes HLA-B 27 Contributes to T Cell Recognition Residue of 67 The Solvent-Inaccessible

M. Zeitz, K. Wucherpfennig, P. Bowness, 2004 .

Kinetics of T-cell Receptor Binding by Bivalent HLA-DR·Peptide Complexes That Activate Antigen-specific Human T-cells*

L Gauthier, K. Wucherpfennig, J. Pyrdol, 2000, The Journal of Biological Chemistry.

Synovial T cell proliferation to the Yersinia enterocolitica 19 kDa antigen differentiates yersinia triggered reactive arthritis (ReA) from ReA triggered by other enterobacteria

P. Wu, J. Sieper, M. Rudwaleit, 2002, Annals of the rheumatic diseases.

Congenital Absence of the Portal Vein with Splenomegaly and Hypersplenism in a Young Woman

P. Schirmacher, C. Loddenkemper, M. Zeitz, 2003, Digestion.

One-year follow-up of ankylosing spondylitis patients responding to rituximab treatment and re-treated in case of a flare

J. Braun, J. Listing, J. Sieper, 2012, Annals of the rheumatic diseases.

Relevance of osteoproliferation as an outcome parameter in ankylosing spondylitis

J. Sieper, M. Rudwaleit, H. Appel, 2008, Nature Clinical Practice Rheumatology.

Whole-body magnetic resonance imaging evaluation of widespread inflammatory lesions in a patient with ankylosing spondylitis before and after 1 year of treatment with infliximab.

J. Sieper, K. Hermann, M. Rudwaleit, 2007, The Journal of rheumatology.

CHARACTERIZATION OF THE SYNOVIAL T CELL RESPONSE TO VARIOUS RECOMBINANT YERSINH ANTIGENS IN YERSINIA ENTEROCOLITICA-TRIGGERED REACTIVE ARTHRITIS

J. Braun, R. Lauster, Z. Yin, 1998 .

Identification of Novel Human Aggrecan T Cell Epitopes in HLA-B27 Transgenic Mice Associated with Spondyloarthropathy1

D. Busch, J. Sieper, E. Weiss, 2004, The Journal of Immunology.

[Biomarkers in rheumatology. Biomarkers and imaging for the diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the ArthroMark network funded by the Federal Ministry of Education and Research].

G. Burmester, B. Hoppe, T. Häupl, 2012, Zeitschrift fur Rheumatologie.

Rheumatoid arthritis and ankylosing spondylitis - pathology of acute inflammation.

C. Loddenkemper, P. Miossec, H. Appel, 2009, Clinical and experimental rheumatology.

The 19 kDa protein of Yersinia enterocolitica O:3 is recognized on the cellular and humoral level by patients with Yersinia induced reactive arthritis.

J. Braun, J. Sieper, A. Distler, 1999, The Journal of rheumatology.

SARS-CoV-2–reactive cellular and humoral immunity in hemodialysis population

U. Stervbo, N. Babel, T. Westhoff, 2021, Kidney International.