M. Moserová

发表

carcinogen benzo [ a ] pyrene : effects in Trp 53 ( + / + ) , Trp 53 ( + /-) and Trp 53 (-/-) mice

Radek, V. Arlt, D. Phillips, 2015 .

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice

V. Arlt, D. Phillips, K. Kopka, 2015, Archives of Toxicology.

Effect of dihydromyricetin on benzo[a]pyrene activation in rats.

J. Hudeček, P. Pávek, E. Frei, 2014, Neuro endocrinology letters.

The Anticancer Drug Ellipticine Activated with Cytochrome

V. Arlt, E. Frei, M. Stiborová, 2015 .

The Anticancer Drug Ellipticine Activated with Cytochrome P450 Mediates DNA Damage Determining Its Pharmacological Efficiencies: Studies with Rats, Hepatic Cytochrome P450 Reductase Null (HRN™) Mice and Pure Enzymes

V. Arlt, E. Frei, M. Stiborová, 2014, International journal of molecular sciences.

The effect of benzo[a]pyrene on metabolic activation of anticancer drug ellipticine in mice.

V. Arlt, E. Frei, M. Stiborová, 2013, Neuro endocrinology letters.

Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney.

Barbora Mrázová, E. Frei, M. Stiborová, 2010, Neuro endocrinology letters.

Modulation of xenobiotic conjugation enzymes by dihydromyricetin in rats

P. Pávek, M. Stiborová, P. Hodek, 2017, Monatshefte für Chemie - Chemical Monthly.

Role of dihydromyricetin in cytochrome P450-mediated metabolism and carcinogen activation.

P. Pávek, M. Stiborová, P. Hodek, 2015, Neuro endocrinology letters.

Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study.

E. Frei, M. Stiborová, M. Sulc, 2013, Neuro endocrinology letters.

Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy.

J. Hudeček, Barbora Mrázová, Václav Martínek, 2011, Biochemical pharmacology.

Analysis of benzo[a]pyrene metabolites formed by rat hepatic microsomes using high pressure liquid chromatography: optimization of the method

E. Frei, M. Stiborová, M. Sulc, 2009, Interdisciplinary toxicology.

NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.

V. Arlt, D. Phillips, D. Nebert, 2012, Toxicology and applied pharmacology.

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

V. Arlt, D. Phillips, C. Wolf, 2019, Toxicology and applied pharmacology.

The Anticancer Drug Ellipticine Activated with Cytochrome 3 P450 Mediates DNA Damage that Determines its 4 Pharmacological Efficiencies: Studies with Knockout Mouse 5 Models and Pure Enzymes

V. Arlt, E. Frei, M. Stiborová, 2015 .

Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling.

V. Arlt, D. Phillips, C. Wolf, 2012, Toxicology letters.

Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.

V. Arlt, D. Phillips, C. Wolf, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2

V. Arlt, E. Frei, M. Stiborová, 2008, Interdisciplinary toxicology.

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.

V. Arlt, D. Phillips, C. Wolf, 2008, Toxicology and applied pharmacology.

Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma.

R. Kizek, E. Frei, M. Stiborová, 2011, Neuro endocrinology letters.

Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O-acetyltransferases.

R. Kizek, Václav Martínek, E. Frei, 2012, Chemical research in toxicology.

Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo

V. Arlt, K. Kopka, E. Frei, 2016, Toxicology.

Induced expression of microsomal cytochrome b5 determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I)

V. Adam, R. Kizek, V. Arlt, 2016, Monatshefte für Chemie - Chemical Monthly.

The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers

P. White, V. Arlt, E. Frei, 2016, Environmental and molecular mutagenesis.

NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1

V. Arlt, E. Frei, M. Stiborová, 2016, Monatshefte für Chemie - Chemical Monthly.

Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice

V. Arlt, D. Phillips, K. Kopka, 2018, Archives of Toxicology.

NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene

V. Arlt, K. Kopka, E. Frei, 2016, Chemical research in toxicology.

Heterologous expression of human cytochrome P450 2S1 in Escherichia coli and investigation of its role in metabolism of benzo[a]pyrene and ellipticine

R. Kizek, V. Arlt, M. Stiborová, 2016, Monatshefte für Chemie - Chemical Monthly.

Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems

V. Arlt, K. Kopka, E. Frei, 2017, Monatshefte für Chemie - Chemical Monthly.

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.

V. Arlt, D. Phillips, C. Wolf, 2014, Toxicology.

Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5.

V. Adam, R. Kizek, V. Arlt, 2014, Neuro endocrinology letters.

Ellipticine and benzo ( a ) pyrene increase their own metabolic activation and detoxication via modulation of expression and enzymatic activity of cytochromes P 450 1 A 1 and 1 A 2 : a comparative study

E. Frei, M. Stiborová, M. Arlt, 2013 .

Activation and detoxification metabolism of urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone by rat and mouse hepatic microsomes.

V. Arlt, E. Frei, M. Stiborová, 2012, Neuro endocrinology letters.

Isolation and partial characterization of the adduct formed by 13-hydroxyellipticine with deoxyguanosine in DNA.

J. Hudeček, E. Frei, M. Stiborová, 2008, Neuro endocrinology letters.

The Anticancer Drug Ellipticine Induces Cytochromes P450 1A1, 1A2 and 3A, Cytochrome b5 and NADPH:Cytochrome P450 Oxidoreductase in Rat Liver, Kidney and Lung

R. Kizek, E. Frei, M. Stiborová, 2013 .

Chicken immunoglobulins for prophylaxis: Effect of inhaled antibodies on inflammatory parameters in rat airways

V. Mandys, M. Stiborová, I. Stříž, 2015 .