Haihong Huang

发表

The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119.

Z. Shen, Yang Lu, Y. Li, 2019, European journal of medicinal chemistry.

Synthesis and in vitro antitumor activities of novel benzyl urea analogues of sorafenib.

Y. Li, Ke Tang, D. Yin, 2013, Yao xue xue bao = Acta pharmaceutica Sinica.

Design, synthesis and in vitro antitumor evaluation of novel diaryl urea derivatives bearing sulfonamide moiety

Y. Li, Xiaoguang Chen, Ke Tang, 2013, Science China Chemistry.

Design, synthesis and biological evaluation of diamino substituted cyclobut-3-ene-1,2-dione derivatives for the treatment of drug-resistant tuberculosis.

P. Li, Yu Lu, L. Fu, 2020, European journal of medicinal chemistry.

In Vitro and In Vivo Activity of Oxazolidinone Candidate OTB-658 against Mycobacterium tuberculosis

Yu Lu, L. Fu, Bin Wang, 2021, Antimicrobial agents and chemotherapy.

Discovery of Fluorine-Containing Benzoxazinyl-oxazolidinones for the Treatment of Multidrug Resistant Tuberculosis.

Bin Wang, Z. Yuan, Yan Li, 2017, ACS medicinal chemistry letters.

The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo

QUAN LIU, Shuainan Liu, Quan Liu, 2017, Scientific Reports.

Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant tuberculosis.

G. Besra, Yu Lu, L. Fu, 2022, European journal of medicinal chemistry.

Discovery of Novel Thiophene-arylamide Derivatives as DprE1 Inhibitors with Potent Antimycobacterial Activities

G. Besra, Yu Lu, L. Fu, 2021, Journal of medicinal chemistry.

Identification of novel benzothiopyranone compounds against Mycobacterium tuberculosis through scaffold morphing from benzothiazinones.

G. Besra, P. Li, Peng Li, 2018, European journal of medicinal chemistry.

Discovery of a Candidate Containing an (S)-3,3-Difluoro-1-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-inden Scaffold as a Highly Potent Pan-Inhibitor of the BCR-ABL Kinase Including the T315I-Resistant Mutant for the Treatment of Chronic Myeloid Leukemia.

Huanjie Shao, Chunrong Yu, Yang Lu, 2021, Journal of medicinal chemistry.

Identifying Regimens Containing TBI-166, a New Drug Candidate against Mycobacterium tuberculosis In Vitro and In Vivo

Yu Lu, L. Fu, Tian J. Yang, 2019, Antimicrobial Agents and Chemotherapy.

Design, Synthesis, and Biological Evaluation of Pyrrole-2-carboxamide Derivatives as Mycobacterial Membrane Protein Large 3 Inhibitors for Treating Drug-Resistant Tuberculosis.

M. Jackson, L. Sheng, Yu Lu, 2022, Journal of medicinal chemistry.

An efficient and concise access to 2-amino-4H-benzothiopyran-4-one derivatives

P. Li, Gang Li, Chen Ma, 2019, Beilstein journal of organic chemistry.

A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide

Haihong Huang, Dongfeng Zhang, Zi-yun Lin, 2020 .

An Efficient Synthesis of Aryl-Substituted Pyrroles by the Suzuki–Miyaura Coupling Reaction of SEM-Protected Pyrroles

Hong Yan, Haihong Huang, Dongfeng Zhang, 2019, Molecules.

Design, synthesis and primary activity of thiomorpholine derivatives as DPP-IV inhibitors

Z. Shen, Yi Huan, D. Yin, 2012 .

Mild, metal-free synthesis of 2-substituted quinazolinones from imidates and methyl 2-aminobenzoates or 2-aminobenzamides

Haihong Huang, Dongfeng Zhang, Hongyi Zhao, 2022, Tetrahedron.

DMAP-Catalyzed One-Pot Synthesis of Quinazoline-2,4-diones from 2-Aminobenzamides and Di-tert-butyl Dicarbonate

Hong Yan, P. Li, Gang Li, 2020, ACS omega.

Facile and efficient synthesis of quinazoline-2,4(1H,3H)-diones through sequential hydrogenation condensation

Gang Li, Haihong Huang, Zi-yun Lin, 2018 .

A facile protocol for N-Cbz protection of amines in PEG-600

D. Zhang, Haihong Huang, Zi-yun Lin, 2012 .

Mild synthesis of quinazolines from 2,2,2-trichloroethyl imidates and 2–aminophenyl ketones

Haihong Huang, Dongfeng Zhang, Hongyi Zhao, 2022, Tetrahedron Letters.

Iron-catalyzed one-pot synthesis of benzimidazoles from 2-nitroanilines and benzylic alcohols

Peng Li, Gang Li, Baokun Yuan, 2013 .

An Efficient and Convenient Protocol for the Synthesis of 1,1-Difluoro-6-nitro-2,3-dihydro-1H-indene Derivatives

P. Li, Haihong Huang, Dongfeng Zhang, 2014 .

Efficient and stereoselective one-pot synthesis of benzo[b]oxazolo[3,4-d][1,4]oxazin-1-ones

S-H Cheng, Haihong Huang, Dongfeng Zhang, 2020, RSC advances.

A mild and metal-free synthesis of chiral 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazines

S-H Cheng, Haihong Huang, Dongfeng Zhang, 2021, Tetrahedron.

Synthesis of 2-Aryl-4H-thiochromen-4-one Derivatives via a Cross-Coupling Reaction

Gang Li, Haihong Huang, Shengnan Li, 2021, ACS omega.

Discovery of novel xanthine compounds targeting DPP-IV and GPR119 as anti-diabetic agents.

Z. Shen, Yi Huan, Qian Jiang, 2016, European journal of medicinal chemistry.

Identification of less lipophilic riminophenazine derivatives for the treatment of drug-resistant tuberculosis.

Christopher B. Cooper, Chun Xing Li, C. Cooper, 2012, Journal of medicinal chemistry.

A facile and efficient synthesis of 4H-1,3-benzoxazine-4-one with electron-withdrawing group derivatives

Peng Li, M. Cheng, Gang Li, 2015 .

Clofazimine Analogs with Efficacy against Experimental Tuberculosis and Reduced Potential for Accumulation

P. Li, D. Yin, Yu Lu, 2011, Antimicrobial Agents and Chemotherapy.

and Reduced Potential for Accumulation 2

Peng Li, D. Yin, Yu Lu, 2011 .

Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position

Chun Xing Li, Gang Zhang, D. Yin, 2011, Molecules.

Systematic Evaluation of Structure-Activity Relationships of the Riminophenazine Class and Discovery of a C2 Pyridylamino Series for the Treatment of Multidrug-Resistant Tuberculosis

Bin Wang, Fei Wang, Chun Xing Li, 2012, Molecules.

In Vitro and In Vivo Activities of the Riminophenazine TBI-166 against Mycobacterium tuberculosis

D. Yin, Yu Lu, L. Fu, 2019, Antimicrobial Agents and Chemotherapy.

Synthesis and Biological Evaluation of Novel 2-Methoxypyridylamino-Substituted Riminophenazine Derivatives as Antituberculosis Agents

C. Cooper, D. Yin, Yu Lu, 2014, Molecules.

Synthesis and anti-tubercular activity of novel alkyl substituted riminophenazine derivatives.

D. Yin, Yu Lu, Bin Wang, 2012, Yao xue xue bao = Acta pharmaceutica Sinica.

Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents.

Y. Li, P. Li, Xiaoguang Chen, 2014, European journal of medicinal chemistry.

A facile synthesis of goodyeroside A from (S)-malic acid

D. Yin, Haihong Huang, Jun Wei, 2009 .

A novel total synthesis of kinsenoside and goodyeroside A relying on the efficient reaction of the chiral 2(5H)-furanones

Qingping Chen, Haihong Huang, Xiang Zhang, 2005, Journal of Asian natural products research.

Identification of Novel Tricyclic Benzo[1,3]oxazinyloxazolidinones as Potent Antibacterial Agents with Excellent Pharmacokinetic Profiles against Drug-Resistant Pathogens.

Yu Lu, Ning-Xi Sun, Bin Wang, 2021, Journal of medicinal chemistry.

Apigenin Sensitizes Colon Cancer Cells to Antitumor Activity of ABT-263

Huanjie Shao, Chunrong Yu, X. Fang, 2013, Molecular Cancer Therapeutics.

The Study of a Novel Sorafenib Derivative HLC-080 as an Antitumor Agent

Y. Li, Ke Tang, Xiao-guang Chen, 2014, PloS one.

Solubility-driven optimization of benzothiopyranone salts leading to a preclinical candidate with improved pharmacokinetic properties and activity against Mycobacterium tuberculosis.

Yang Lu, Peng Li, Ning-bo Gong, 2023, European journal of medicinal chemistry.

Design, Synthesis and Hepatoprotective Activity of Analogs of the Natural Product Goodyeroside A

D. Yin, Yan Li, Haihong Huang, 2013, Molecules.

Design and synthesis of novel benzimidazole derivatives as anti-tuberculosis agents.

Yan Li, L. Sheng, Dan Li, 2014, Yao xue xue bao = Acta pharmaceutica Sinica.

Anti-tubercular derivatives of rhein require activation by the monoglyceride lipase Rv0183

N. Loman, G. Besra, Katherine A Abrahams, 2020, Cell surface.

Protection of asparagine and glutamine during Nα‐Bpoc‐based solid‐phase peptide synthesis

Haihong Huang, Carey Ri, Wadsworth Jl, 2009 .

Preparation and properties of Nα-Bpoc-amino acid pentafluorophenyl esters

E. Furusjö, Haihong Huang, R. I. Carey, 2009 .

Docking- and pharmacophore-based virtual screening for the identification of novel Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with a thiobarbiturate scaffold.

Yongjun Lu, Yu Lu, Bin Wang, 2019, Bioorganic chemistry.

(2R,3S)-2-Benzyl-3-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyloxy)butanolide

D. Yin, Haihong Huang, J. Zhong, 2010, Acta crystallographica. Section E, Structure reports online.

The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo

QUAN LIU, Shuainan Liu, Z. Shen, 2017, Scientific Reports.

Degradation Characteristics of a Novel PAF Receptor Antagonist, SY0916, in Aqueous Solution

Haihong Huang, Bo Jin, Wanting Yin, 2019, Journal of analytical methods in chemistry.

The optimization and characterization of functionalized sulfonamides derived from sulfaphenazole against Mycobacterium tuberculosis with reduced CYP 2C9 inhibition.

Yu Lu, Bin Wang, Gang Li, 2021, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of 3-substituted-2-thioxothiazolidin-4-one (rhodanine) derivatives as antitubercular agents against Mycobacterium tuberculosis protein tyrosine phosphatase B.

Yu Lu, Jinying Tian, Yi-Hong Zou, 2023, European journal of medicinal chemistry.

Discovery of biphenyls bearing thiobarbiturate fragment by structure-based strategy as Mycobacterium tuberculosis protein tyrosine phosphatase B inhibitors.

Yongjun Lu, Yu Lu, Jinying Tian, 2022, Bioorganic & medicinal chemistry.

Activity of Clofazimine and TBI-166 against Mycobacterium tuberculosis in Different Administration Intervals in Mouse Tuberculosis Models

Yu Lu, L. Fu, Bin Wang, 2021, Antimicrobial Agents and Chemotherapy.

Design, synthesis and biological evaluation of alkynyl-containing maleimide derivatives for the treatment of drug-resistant tuberculosis.

Peng Li, Yu Lu, Bin Wang, 2022, Bioorganic chemistry.

Identification of Piperazinyl-Difluoro-indene Derivatives Containing Pyridyl Groups as Potent FGFR Inhibitors against FGFR Mutant Tumor: Design, Synthesis, and Biological Evaluation.

Haihong Huang, Dongfeng Zhang, Shuting Chen, 2024, Journal of medicinal chemistry.