P. Bourassa

发表

Improved Method for Tissue Preservation in Murine Atherosclerotic Lesion Tissue

P. Bourassa, R. Aiello, 1998 .

Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors.

V. Paralkar, D. Goldberg, W. Zavadoski, 2016, Bioorganic & medicinal chemistry letters.

The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.

Michael D. Hamilton, J. Pfefferkorn, N. Barucci, 2012, Bioorganic & medicinal chemistry letters.

Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

M. Ammirati, J. Treadway, S. Liras, 2011 .

SAMD1 Distribution Patterns in Mouse Atherosclerosis Models Suggest Roles in LDL Retention, Antigen Presentation, and Cell Phenotype Modulation

B. Campbell, P. Bourassa, R. Aiello, 2021 .

Optimizing glucokinase activator binding kinetics to lower in vivo hypoglycemia risk

T. Rolph, J. Pfefferkorn, K. Borzilleri, 2014 .

Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Models of Pulmonary Hypertension

M. Humbert, V. Paralkar, T. McKinsey, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors.

V. Paralkar, D. Goldberg, W. Zavadoski, 2016, Bioorganic & Medicinal Chemistry Letters.

Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice.

P. Milos, J. Breslow, P. Bourassa, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors.

V. Paralkar, D. Goldberg, W. Zavadoski, 2017, Bioorganic & medicinal chemistry letters.

Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity

D. Engelman, Y. Reshetnyak, O. Andreev, 2021, NAR cancer.

Investigation of SAMD1 ablation in mice

Robert Liefke, S. Engle, T. Ozolins, 2023, Scientific Reports.

Ablation of SAMD1 in Mice Causes Failure of Angiogenesis, Embryonic Lethality

B. Campbell, T. Ozolins, P. Bourassa, 2022, bioRxiv.

Leukotriene B4 Receptor Antagonism Reduces Monocytic Foam Cells in Mice

H. Showell, S. Lindsey, P. Bourassa, 2002, Arteriosclerosis, thrombosis, and vascular biology.

Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice.

B. Rollins, P. Milos, E. Natoli, 1999, Arteriosclerosis, thrombosis, and vascular biology.

Deficient Mice Monocyte Chemoattractant Protein-1 Accelerates Atherosclerosis in Apolipoprotein

B. Rollins, P. Milos, E. Natoli, 1999 .

CCR2 receptor blockade alters blood monocyte subpopulations but does not affect atherosclerotic lesions in apoE(-/-) mice.

A. Kalgutkar, D. Knight, R. Gladue, 2010, Atherosclerosis.

Inhibition of CETP activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in New Zealand White rabbits Published, JLR Papers in Press, February 26, 2007.

F. Zimetti, A. Milici, T. Sand, 2007, Journal of Lipid Research.

Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels.

O. Francone, P. Bourassa, R. Aiello, 2001, The Journal of clinical investigation.

Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

Jing Chen, David B Duignan, Robert Aiello, 2012, Journal of medicinal chemistry.

Increased Atherosclerosis in Hyperlipidemic Mice With Inactivation of ABCA1 in Macrophages

O. Francone, L. Royer, T. Coskran, 2002, Arteriosclerosis, thrombosis, and vascular biology.

2.P.40 Discovery of the squalene synthetase inhibitor CP-340,868

C. Aldinger, H. J. Harwood, S. Petras, 1997 .