C. Weaver

发表

Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells.

Sydney L. Stoops, A. Waterson, C. Lindsley, 2011, ACS chemical biology.

Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide-1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Core.

Anna L. Blobaum, C. Lindsley, Hyekyung P. Cho, 2017, Journal of medicinal chemistry.

Discovery, Synthesis, SAR Development of a Series of N -4-(2,5-dioxopyrrolidin-1-yl)-phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu 4 ) with Oral Efficacy in an anti-Parkinsonian Animal Model

Colleen, Y. Smith, C. Lindsley, 2011 .

Functional impact of allosteric agonist activity of selective positive allosteric modulators of mGlu 5 in regulating CNS function

H. Lavreysen, Z. Xiang, C. Lindsley, 2011 .

Optimization of a small molecule probe that restores e-cadherin expression.

Sydney L. Stoops, A. Waterson, C. Lindsley, 2015, Bioorganic & medicinal chemistry letters.

Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe.

D. Sheffler, C. Lindsley, Hyekyung P. Cho, 2011, Bioorganic & medicinal chemistry letters.

Small molecule/ML327 mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition

Sydney L. Stoops, A. Waterson, C. Lindsley, 2015, Oncotarget.

A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function

C. Lindsley, Joshua A. Bauer, C. Santi, 2023, Proceedings of the National Academy of Sciences of the United States of America.

ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice.

B. Zou, C. Lindsley, G. Sliwoski, 2013, ACS chemical neuroscience.

Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models.

C. Lindsley, C. Hopkins, M. Bubser, 2018, ACS chemical neuroscience.

Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity

P Jeffrey Conn, Craig W Lindsley, Colleen M Niswender, 2010, Molecular Pharmacology.

Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

H. Lavreysen, Z. Xiang, C. Lindsley, 2012, Molecular Pharmacology.

Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Kari A. Johnson, Z. Xiang, C. Lindsley, 2008, Molecular Pharmacology.

Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkins

Anna L. Blobaum, Y. Smith, S. Jadhav, 2011, Journal of medicinal chemistry.

Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold.

C. Lindsley, P. Conn, S. Stauffer, 2011, Bioorganic & medicinal chemistry letters.

Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening

Jens Meiler, C. David Weaver, P. Jeffrey Conn, 2010, ACS chemical neuroscience.

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Kari A. Johnson, Days, C. Lindsley, 2008 .

Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

H. Lavreysen, C. Lindsley, Hyekyung P. Cho, 2012, Molecular Pharmacology.

Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.

Matthew T. Dickerson, Emily L. Days, C. Weaver, 2017, ACS chemical neuroscience.

High-Throughput Screening Reveals a Small-Molecule Inhibitor of the Renal Outer Medullary Potassium Channel and Kir7.1

Brian A. Chauder, C. Lindsley, B. Chauder, 2009, Molecular Pharmacology.

Identification and Characterization of a Compound That Protects Cardiac Tissue from Human Ether-à-go-go-related Gene (hERG)-related Drug-induced Arrhythmias*

J. Balser, C. Lindsley, Beiyan Zou, 2012, The Journal of Biological Chemistry.

Characterization of VU0468554, a New Selective Inhibitor of Cardiac G Protein – Gated Inwardly Rectifying K 1 Channels

C. Hopkins, C. Weaver, E. M. F. D. Velasco, 2021 .

Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels*

Melissa R. Miller, O. McManus, C. Lindsley, 2011, The Journal of Biological Chemistry.

Use of chemical probes to explore the toxicological potential of the K+/Cl- cotransporter (KCC) as a novel insecticide target to control the primary vector of dengue and Zika virus, Aedes aegypti.

C. Lindsley, C. Weaver, Zhilin Li, 2018, Pesticide biochemistry and physiology.

Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels.

M. Poss, Ronald J. Knox, N. Lodge, 2008, Bioorganic & medicinal chemistry letters.

Label-Free Whole Cell Biosensing for High-Throughput Discovery of Activators and Inhibitors Targeting G Protein-Activated Inwardly Rectifying Potassium Channels

Oscar M. Bautista-Aguilera, B. Fleischmann, M. Gütschow, 2018, ACS omega.

Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992

Amanda M. Duran, Anna L. Blobaum, J. Meiler, 2018, Molecular Pharmacology.

Development of a Selective Small-Molecule Inhibitor of Kir1.1, the Renal Outer Medullary Potassium Channel

Brian A. Chauder, J. Meiler, C. Lindsley, 2011, Molecular Pharmacology.