J. Marcinkiewicz

发表

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.

N. Seidah, S. Benjannet, M. Chrétien, 2003, The Journal of clinical investigation.

Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.

N. Seidah, R. A. Murphy, M. Marcinkiewicz, 1999, Proceedings of the National Academy of Sciences of the United States of America.

In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate

A. Prat, N. Seidah, A. Chamberland, 2008, Proceedings of the National Academy of Sciences.

The Subtilisin/Kexin Family of Precursor Convertases: Emphasis on PC1, PC2/7B2, POMC and the Novel Enzyme SKI‐1

N. Seidah, M. Marcinkiewicz, S. Benjannet, 1999, Annals of the New York Academy of Sciences.

Gene Inactivation of PCSK9 Reduces Atherosclerosis in Mice

A. Prat, C. Lazure, A. Zaid, 2012 .

Deletion of the Gene Encoding Proprotein Convertase 5/6 Causes Early Embryonic Lethality in the Mouse

A. Prat, N. Seidah, A. Chamberland, 2006, Molecular and Cellular Biology.

Nerve growth factor and proprotein convertases furin and PC7 in transected sciatic nerves and in nerve segments cultured in conditioned media: Their presence in Schwann cells, macrophages, and smooth muscle cells

M. Marcinkiewicz, M. Chrétien, J. Marcinkiewicz, 1999, The Journal of comparative neurology.

PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice[S]

A. Prat, N. Seidah, A. Chamberland, 2015, Journal of Lipid Research.

Circulating Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Regulates VLDLR Protein and Triglyceride Accumulation in Visceral Adipose Tissue

A. Prat, K. Cianflone, A. Chamberland, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Reducing Vascular Calcification by Anti-IL-1β Monoclonal Antibody in a Mouse Model of Familial Hypercholesterolemia

N. Seidah, H. Gram, Z. Awan, 2016, Angiology.

The pro-protein convertase PC1 is induced in the transected sciatic nerve and is present in cultured Schwann cells: comparison with PC5, furin and PC7, implication in pro-BDNF processing.

M. Marcinkiewicz, D. Savaria, J. Marcinkiewicz, 1998, Brain research. Molecular brain research.

Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other*

A. Prat, N. Seidah, Y. Jacob, 2015, The Journal of Biological Chemistry.

PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol.

A. Prat, M. Koschinsky, A. Chamberland, 2022, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Expression of a tetracycline-controlled transactivator (Tet-On/Off system) in beta cells reduces insulin expression and secretion in mice

T. Alquier, J. Estall, C. Baldwin, 2021, bioRxiv.

Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor).

N. Seidah, B. Coulombe, M. Gauthier, 2019, Arteriosclerosis, thrombosis, and vascular biology.

The Proprotein Convertase PCSK9 Induces the Degradation of Low Density Lipoprotein Receptor (LDLR) and Its Closest Family Members VLDLR and ApoER2*

A. Prat, N. Seidah, S. Benjannet, 2008, Journal of Biological Chemistry.

Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7

N. Seidah, M. Chrétien, A. Basak, 2008, Gut.

Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte‐specific low‐density lipoprotein receptor degradation and critical role in mouse liver regeneration

Annik Prat, A. Prat, N. Seidah, 2008, Hepatology.

A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice

A. Prat, N. Seidah, A. Chamberland, 2018, Biological chemistry.

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation

A. Prat, N. Seidah, S. Benjannet, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice

A. Prat, N. Seidah, C. Lazure, 2012, Circulation.

PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke[S]

M. Hatten, A. Prat, N. Seidah, 2011, Journal of Lipid Research.

Brain‐derived neurotrophic factor superinduction parallels anti‐epileptic−neuroprotective treatment in the pilocarpine epilepsy model

M. Avoli, M. Marcinkiewicz, G. Biagini, 2001, Journal of neurochemistry.

Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice

R. Rodriguiz, A. Prat, N. Seidah, 2013, Proceedings of the National Academy of Sciences.

Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin

N. Seidah, R. Essalmani, Delia Susan-Resiga, 2021, The Journal of biological chemistry.

Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR that is shed by Furin

N. Seidah, R. Essalmani, Delia Susan-Resiga, 2021, bioRxiv.

Selective Expression of the Proprotein Convertases Furin, PC5, and PC7 in Proliferating Vascular Smooth Muscle Cells of the Rat Aorta In Vitro

E. Fleck, N. Seidah, M. Marcinkiewicz, 2001, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

The Proprotein Convertase 7 Regulates Triglyceride Levels via Enhanced ApoA5 Degradation

A. Prat, N. Seidah, J. Hamelin, 2018, Atherosclerosis Supplements.