J. Barbosa

发表

Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.

Adam R. Johnson, C. Eigenbrot, J. Lubach, 2016, Bioorganic & medicinal chemistry letters.

Omega-carboxypyridyl substituted ureas as Raf kinase inhibitors: SAR of the amide substituent.

Xiao-Gao Liu, Barbara Hibner, Joel Renick, 2004, Bioorganic & medicinal chemistry letters.

Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis.

Brandon J. Bravo, L. Diehl, S. Hymowitz, 2011, Nature chemical biology.

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton’s Tyrosine Kinase with Improved Druglike Properties

Adam R. Johnson, C. Eigenbrot, J. Lubach, 2017, ACS medicinal chemistry letters.

Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach.

J. S. Johnson, H. Wild, D. Rogers, 2001, Bioorganic & medicinal chemistry letters.

Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.

H. Rong, K. Currie, J. Kropf, 2014, Journal of medicinal chemistry.

Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.

S. Hymowitz, J. Lubach, K. Reif, 2015, Bioorganic & medicinal chemistry letters.

Anti-EPO and anti-NESP antibodies raised against synthetic peptides that reproduce the minimal amino acid sequence differences between EPO and NESP

D. Andreu, B. G. Torre, E. Giménez, 2007, Analytical and bioanalytical chemistry.

Antiarthritis Effect of a Novel Bruton's Tyrosine Kinase (BTK) Inhibitor in Rat Collagen-Induced Arthritis and Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling: Relationships between Inhibition of BTK Phosphorylation and Efficacy

K. Reif, H. Wong, H. Rong, 2011, Journal of Pharmacology and Experimental Therapeutics.

Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.

H. Rong, K. Currie, J. Kropf, 2014, Journal of medicinal chemistry.