Meire C D Bremer

发表

Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.

Adam R. Johnson, C. Eigenbrot, J. Lubach, 2016, Bioorganic & medicinal chemistry letters.

The Minimal Essential Core of a Cysteine-based Protein-tyrosine Phosphatase Revealed by a Novel 16-kDa VH1-like Phosphatase, VHZ*

Joanna M. Sasin, A. Godzik, A. Alonso, 2004, Journal of Biological Chemistry.

Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.

Adam R. Johnson, Z. Modrušan, J. DeVoss, 2017, JCI insight.

Development of a multi‐matrix LC–MS/MS method for urea quantitation and its application in human respiratory disease studies

Fang Cai, X. Ding, Jianshuang Wang, 2017, Journal of pharmaceutical and biomedical analysis.

Safety, Pharmacokinetics, and Pharmacodynamics in Healthy Volunteers Treated With GDC‐0853, a Selective Reversible Bruton's Tyrosine Kinase Inhibitor

L. Chinn, H. Winter, A. Serone, 2018, Clinical pharmacology and therapeutics.

Dose‐dependent inactivation of airway tryptase with a novel dissociating anti‐tryptase antibody (MTPS9579A) in healthy participants: A randomized trial

J. Galanter, S. Sukumaran, P. Belloni, 2021, Clinical and translational science.

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton’s Tyrosine Kinase with Improved Druglike Properties

Adam R. Johnson, C. Eigenbrot, J. Lubach, 2017, ACS medicinal chemistry letters.

The oxidative mechanism of action of ortho-quinone inhibitors of protein-tyrosine phosphatase alpha is mediated by hydrogen peroxide.

Stefan Vasile, Terence Hui, Gerald McMahon, 2004, Archives of biochemistry and biophysics.

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

B. Yaspan, J. Hackney, Lawren C. Wu, 2019, Cell.

Preclinical safety profile of a depleting antibody against CRTh2 for asthma: Well tolerated despite unexpected CRTh2 expression on vascular pericytes in the central nervous system and gastric mucosa

D. Danilenko, L. Rangell, R. Carano, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

VHY, a Novel Myristoylated Testis-restricted Dual Specificity Protein Phosphatase Related to VHX*

A. Alonso, T. Mustelin, H. Huynh, 2004, Journal of Biological Chemistry.

In vitro selection of peptides acting at a new site of NMDA glutamate receptors

E. Whitehorn, E. Tate, Min Li, 1996, Nature Biotechnology.

Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.

S. Hymowitz, J. Lubach, K. Reif, 2015, Bioorganic & medicinal chemistry letters.