B. Schalke

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The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes.

A. Marx, A. Melms, P. Ströbel, 2013, Autoimmunity reviews.

Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial

A. Marx, S. Muley, R. Conwit, 2019, The Lancet Neurology.

Abbreviations used: AD,

F. Cetani, T. Battelino, L. Tserel, 2022 .

Cytoreductive surgery and hyperthermic intrathoracic chemotherapy perfusion for malignant pleural tumours: perioperative management and clinical experience.

Y. Zausig, M. Ried, C. Diez, 2013, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Evaluation of prognostic features in thymic epithelial tumors.

H. Müller-Hermelink, T. Kirchner, A. Marx, 1989, Thymus.

Well-Differentiated Thymic Carcinoma: An Organotypical Low-Grade Carcinoma with Relationship to Cortical Thymoma

H. Müller-Hermelink, A. Marx, T. Kirchner, 1992, The American journal of surgical pathology.

The Autoimmune Regulator AIRE in Thymoma Biology: Autoimmunity and Beyond

A. Marx, P. Schnabel, R. Gold, 2010, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Neurofilament is an autoantigenic determinant in myasthenia gravis

H. Müller-Hermelink, A. Marx, R. Gold, 1999, Annals of neurology.

Late-onset myasthenia gravis - CTLA4(low) genotype association and low-for-age thymic output of naïve T cells.

H. Müller-Hermelink, A. Marx, P. Bugert, 2014, Journal of autoimmunity.

The PTPN22gain-of-function+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis

H. Müller-Hermelink, A. Marx, R. Gold, 2009, Genes and Immunity.

A CTLA4high genotype is associated with myasthenia gravis in thymoma patients

H. Müller-Hermelink, A. Marx, R. Gold, 2005, Annals of neurology.

Thymoma Associated Myasthenia Gravis (TAMG): Differential Expression of Functional Pathways in Relation to MG Status in Different Thymoma Histotypes

A. Marx, C. Sticht, C. Weis, 2020, Frontiers in Immunology.

Pathogenesis of myasthenia gravis. Acetylcholine receptor-related antigenic determinants in tumor-free thymuses and thymic epithelial tumors.

H. Müller-Hermelink, F. Hoppe, H. Wekerle, 1988, The American journal of pathology.

Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS‐1)

A. Rosenwald, H. Müller-Hermelink, A. Marx, 2007, The Journal of pathology.

cFLIP overexpression in T cells in thymoma-associated myasthenia gravis

G. Ott, A. Marx, R. Gold, 2015, Annals of clinical and translational neurology.

A. Marx, C. Weis, P. Ströbel, 2015, Experimental Neurology.

Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4(+) T cells in thymomas.

H. Müller-Hermelink, A. Marx, S. Lewin, 2002, Blood.

Anti-Apoptotic Signature in Thymic Squamous Cell Carcinomas – Functional Relevance of Anti-Apoptotic BIRC3 Expression in the Thymic Carcinoma Cell Line 1889c

A. Rosenwald, H. Müller-Hermelink, G. Ott, 2013, Front. Oncol..

Proteins with epitopes of the acetylcholine receptor in epithelial cell cultures of thymomas in myasthenia gravis.

H. Müller-Hermelink, A. Marx, F. Hoppe, 1989, The American journal of pathology.

Microenvironment of thymic myoid cells in myasthenia gravis

H. Müller-Hermelink, F. Hoppe, T. Kirchner, 1987, Virchows Archiv. B, Cell pathology including molecular pathology.

Risk and course of COVID-19 in immunosuppressed patients with myasthenia gravis

H. Wiendl, P. Urban, M. Pawlitzki, 2022, Journal of Neurology.

WNT4 overexpression and secretion in thymic epithelial tumors drive an autocrine loop in tumor cells in vitro

G. Ott, M. Kriegsmann, K. Kvell, 2022, Frontiers in Oncology.

Molecular pathology of thymomas: implications for diagnosis and therapy

A. Marx, S. Schölch, C. Weis, 2021, Virchows Archiv.

Autoimmune associations and autoantibody screening show focused recognition in patient subgroups with generalized myasthenia gravis.

A. Marx, P. Ströbel, R. Klein, 2013, Human immunology.

Expression of neurofilaments and of a titin epitope in thymic epithelial tumors. Implications for the pathogenesis of myasthenia gravis.

H. Müller-Hermelink, A. Marx, K. Toyka, 1996, The American journal of pathology.

A Striational Muscle Antigen and Myasthenia Gravis-Associated Thymomas Share an Acetylcholine-Receptor Epitope

H. Müller-Hermelink, A. Marx, T. Kirchner, 1992, Developmental immunology.

Thymoma and paraneoplastic myasthenia gravis

A. Marx, W. Chuang, P. Ströbel, 2010, Autoimmunity.

Increased cFLIP expression in thymic epithelial tumors blocks autophagy via NF-κB signalling.

G. Ott, A. Marx, P. Hohenberger, 2017, Oncotarget.

Tumor recurrence and survival in patients treated for thymomas and thymic squamous cell carcinomas: a retrospective analysis.

H. Müller-Hermelink, A. Marx, M. Semik, 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Abnormal thymocyte development and generation of autoreactive T cells in mixed and cortical thymomas.

H. Müller-Hermelink, A. Marx, R. Nenninger, 1998, Laboratory investigation; a journal of technical methods and pathology.

Corticomedullary differentiation and maturational arrest in thymomas

A. Rosenwald, G. Ott, A. Marx, 2014, Histopathology.

Selective loss of regulatory T cells in thymomas

A. Rosenwald, H. Müller-Hermelink, A. Marx, 2004, Annals of neurology.

Octreotide LAR and Prednisone as Neoadjuvant Treatment in Patients with Primary or Locally Recurrent Unresectable Thymic Tumors: A Phase II Study

A. Marx, U. Bogdahn, G. Schuierer, 2016, PloS one.

Immunohistological patterns of non-neoplastic changes in the thymus in Myasthenia gravis

H. Müller-Hermelink, T. Kirchner, A. Melms, 1986, Virchows Archiv. B, Cell pathology including molecular pathology.

Increased cFLIP expression in thymic epithelial tumors blocks autophagy via NF-κB signalling

G. Ott, A. Marx, P. Hohenberger, 2017, Oncotarget.

Impact of Surgical Evaluation of Additional Cine Magnetic Resonance Imaging for Advanced Thymoma with Infiltration of Adjacent Structures: The Thoracic Surgeon's View

O. Hamer, M. Ried, H. Hofmann, 2016, The Thoracic and Cardiovascular Surgeon.

Evaluation of Surgical Therapy in Advanced Thymic Tumors

A. Marx, M. Ried, H. Hofmann, 2021, Cancers.

Abnormal T Lymphocyte Development in Myasthenia Gravis-Associated Thymomas

H. Müller-Hermelink, A. Marx, R. Nenninger, 1997 .

State of the art: diagnostic tools and innovative therapies for treatment of advanced thymoma and thymic carcinoma.

A. Marx, O. Hamer, M. Ried, 2016, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Radical surgical resection of advanced thymoma and thymic carcinoma infiltrating the heart or great vessels with cardiopulmonary bypass support

M. Ried, Z. Sziklavári, H. Hofmann, 2015, Journal of Cardiothoracic Surgery.

Characterization of a protein with an acetylcholine receptor epitope from myasthenia gravis-associated thymomas.

H. Müller-Hermelink, A. Marx, F. Hoppe, 1990, Laboratory investigation; a journal of technical methods and pathology.

Association of acetylcholine receptor α-subunit gene expression in mixed thymoma with myasthenia gravis

H. Müller-Hermelink, A. Marx, S. Tzartos, 1999, Neurology.

Metabolic Profiling of Thymic Epithelial Tumors Hints to a Strong Warburg Effect, Glutaminolysis and Precarious Redox Homeostasis as Potential Therapeutic Targets

G. Ott, S. Schölch, C. Sticht, 2022, Cancers.

Thymus and autoimmunity

A. Marx, C. Weis, P. Ströbel, 2021, Seminars in Immunopathology.

Thymomas alter the T-cell subset composition in the blood: a potential mechanism for thymoma-associated autoimmune disease.

H. Müller-Hermelink, A. Marx, R. Gold, 2000, Blood.

[Radical pleurectomy and hyperthermic intrathoracic chemotherapy for treatment of thymoma with pleural spread].

M. Ried, Z. Sziklavári, H. Hofmann, 2013, Zentralblatt fur Chirurgie.

Local and systemic exposure of cisplatin during hyperthermic intrathoracic chemotherapy perfusion after pleurectomy and decortication for treatment of pleural malignancies

M. Ried, C. Diez, T. Potzger, 2013, Journal of surgical oncology.

Extended Surgical Resections of Advanced Thymoma Masaoka Stages III and IVa Facilitate Outcome

M. Ried, C. Diez, T. Potzger, 2013, Thoracic and Cardiovascular Surgeon.

Surgical Resection of Thymoma Still Represents the First Choice of Treatment

M. Ried, C. Diez, T. Potzger, 2011, Thoracic and Cardiovascular Surgeon.

Cytoreductive surgery and hyperthermic intrathoracic chemotherapy perfusion for malignant pleural tumors: perioperative management and early clinical experience

F. Schettler, M. Ried, C. Diez, 2012 .

Pathogenetic Significance of Fetal-Type Acetylcholine Receptors on Thymic Myoid Cells in Myasthenia Gravis

H. Müller-Hermelink, A. Marx, K. Toyka, 1992, Developmental immunology.

ACETYLCHOLINE RECEPTOR EPITOPES ON EPITHELIAL CELLS OF THYMOMA IN MYASTHENIA GRAVIS

H. Müller-Hermelink, F. Hoppe, T. Kirchner, 1987, The Lancet.

The ageing and myasthenic thymus: A morphometric study validating a standard procedure in the histological workup of thymic specimens

H. Müller-Hermelink, A. Marx, R. Gold, 2008, Journal of Neuroimmunology.

Titin Epitope in Thymoma

A. Marx, A. Jung, T. Kirchner, 1997 .

Challenging the current model of early‐onset myasthenia gravis pathogenesis in the light of the MGTX trial and histological heterogeneity of thymectomy specimens

A. Marx, C. Weis, P. Ströbel, 2018, Annals of the New York Academy of Sciences.

Expression of the Acetylcholine Receptor α-Subunit Gene is Associated with Paraneoplastic Myasthenia Gravis in Mixed Thymoma

H. Müller-Hermelink, A. Marx, S. Tzartos, 2000 .

Genomic organization and lack of transcription of the nicotinic acetylcholine receptor subunit genes in myasthenia gravis-associated thymoma.

H. Müller-Hermelink, A. Marx, T. Kirchner, 1992, Laboratory investigation; a journal of technical methods and pathology.

Common Cellular and Diverse Genetic Basis of Thymoma‐associated Myasthenia Gravis

H. Müller-Hermelink, A. Marx, R. Gold, 2008, Annals of the New York Academy of Sciences.

CD40-Expression in Thymoma

A. Marx, R. Nenninger, A. Greiner, 1997 .

Intrathymic pathogenesis of myasthenia gravis: AChR specific T ylmphocytes and AChR expression in the myasthenic thymus

H. Müller-Hermelink, H. Wekerle, T. Kirchner, 1987, Journal of Neuroimmunology.

Thymus pathology observed in the MGTX trial

A. Marx, P. Ströbel, W. Nix, 2012, Annals of the New York Academy of Sciences.

Low Levels of Acetylcholine Receptor Delta-Subunit Message and Protein in Human Thymus Suggests the Occurrence of ‘Triplet Receptors’ in Thymic Myoid Cells

A. Marx, S. Tzartos, C. Schneider, 2000 .

Long-Term Prognosis of Patients with Thymoma-Associated Myasthenia Gravis

A. Marx, K. Toyka, B. Schalke, 1997 .

Monoclonal Antibodies as Probes for Acetylcholine Receptor Epitopes in Thymuses and Thymic Epithelial Tumors of Patients with Myasthenia Gravis and Nonmyasthenic Controls

F. Hoppe, H. Wekerle, T. Kirchner, 1988, Annals of the New York Academy of Sciences.

LONG-TERM TREATMENT WITH AZATHIOPRINE ABOLISHES THYMIC LYMPHOID FOLLICULAR HYPERPLASIA IN MYASTHENIA GRAVIS

T. Kirchner, H. Mertens, B. Schalke, 1987, The Lancet.

Myasthenia Gravis‐Associated Thymic Epithelial Tumors Express Neurofilaments and Are Associated with Antiaxonal Autoimmunity

T. Kirchner, A. Marx, A. Greiner, 1993, Annals of the New York Academy of Sciences.

Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th 17-associated cytokines

F. Cetani, T. Battelino, L. Tserel, 2010 .

Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines

F. Cetani, T. Battelino, L. Tserel, 2010, The Journal of experimental medicine.

Somatostatin receptor scintigraphy in thymoma imaging method and clinical application.

U. Bogdahn, J. Marienhagen, P. Held, 1999, Pathology, research and practice.

A. Marx, P. Ströbel, S. Porubský, 2015, Experimental Neurology.

Reprints Available Directly from the Publisher Photocopying Permitted by License Only a Striational Muscle Antigen and Myasthenia Gravis- Associated Thymomas Share an Acetylcholine-receptor Epitope

A. Marx, S. Tzartos, M. Osborn, 2022 .