G. Dou

发表

Phase I study of chidamide (CS055/HBI-8000), a novel histone deacetylase inhibitor, in patients with advanced solid tumors and lymphomas.

M. J. Newman, Z. Ning, X. Lu, 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Phase I study of chidamide (CS055/HBI-8000), a new histone deacetylase inhibitor, in patients with advanced solid tumors and lymphomas

P. Xing, Yuankai Shi, Z. Ning, 2012, Cancer Chemotherapy and Pharmacology.

In vitro and in vivo safety studies indicate that R15, a synthetic polyarginine peptide, could safely reverse the effects of unfractionated heparin

Zhuo-na Wu, Xiaoxia Zhu, Su-Eun Han, 2021, FEBS open bio.

The performance of a fly-larva shell-derived chitosan sponge as an absorbable surgical hemostatic agent.

Xiaoxiao Zhu, Qingzi Tang, Zhuo-na Wu, 2010, Biomaterials.

Characterization and Hemostatic Potential of Two Kaolins from Southern China

Donggen Wang, Zhuo-na Wu, Jinglin Wang, 2019, Molecules.

Time-Course Investigation of Small Molecule Metabolites in MAP-Stored Red Blood Cells Using UPLC-QTOF-MS

Zhuo-na Wu, Xiaoxia Zhu, Ruo-lan Gu, 2018, Molecules.

Pharmacokinetics of sifuvirtide, a novel anti-HIV-1 peptide, in monkeys and its inhibitory concentration in vitro

Yong-tang Zheng, Liu-meng Yang, Qing Liang, 2005, Acta Pharmacologica Sinica.

Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection

Fan Wang, Zhuo-na Wu, Xiaoxia Zhu, 2022, Molecules.

Rapid intestinal glucuronidation and hepatic glucuronide recycling contributes significantly to the enterohepatic circulation of icaritin and its glucuronides in vivo

Yifan Tu, Y. Rong, Taijun Yin, 2020, Archives of Toxicology.

Preclinical pharmacokinetics of M10 after intragastrical administration of M10-H and M10-Na in Wistar rats.

Zhuo-na Wu, Xiaoxia Zhu, Suxiang Feng, 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

METABOLIC PROFILE OF 1,5-DICAFFEOYLQUINIC ACID IN RATS, AN IN VIVO AND IN VITRO STUDY

Junxing Dong, L. Zou, G. Dou, 2005, Drug Metabolism and Disposition.

Application of ultra high‐performance liquid chromatography tandem mass spectrometry to investigate the regioselective glucuronidation of icaritin in vitro

Xinyu Wang, Zhuo-na Wu, Y. Rong, 2018, Journal of pharmaceutical and biomedical analysis.

Pharmacokinetics and metabolism of 1,5-dicaffeoylquinic acid in rats following a single intravenous administration.

L. Zou, G. Dou, Z. Meng, 2006, Journal of pharmaceutical and biomedical analysis.

Characterization of metabolites and cytochrome P450 isoforms involved in the microsomal metabolism of aconitine.

Yuguang Wang, Yue Gao, G. Dou, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A LC-MS/MS method to monitor the concentration of HYD-PEP06, a RGD-modified Endostar mimetic peptide in rat blood.

Zhuo-na Wu, Xiaoxia Zhu, Xiaona Dong, 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Hemostatic Efficacy and Biocompatibility Evaluation of a Novel Absorbable Porous Starch Hemostat

Zhuo-na Wu, Xiaoxia Zhu, Ruo-lan Gu, 2021, Surgical innovation.

In vivo and in vitro metabolism of lefucoxib in rats.

X. Bi, Xiaoxia Zhu, G. Dou, 2008, Journal of pharmaceutical and biomedical analysis.

Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases

Yang Xiao, Y. Zhan, Miao Yu, 2021, Science Immunology.

Pharmacokinetics and pharmacodynamics of SCT800, a new recombinant FVIII, in hemophilia A mice

Zhuo-na Wu, Liangzhi Xie, Ruo-lan Gu, 2016, Acta Pharmacologica Sinica.

An optimized LC-MS/MS method for determination of HYNIC-3PRGD2, a new promising imaging agent for tumor targeting, in rat plasma and its application.

Fan Wang, Xinyu Wang, Bing Jia, 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Quantitative determination of beta,beta-dimethylacrylshikonin (DASK) in rat whole blood by liquid chromatography-tandem mass spectrometry with pre-column derivation and its pharmacokinetic application.

D. Yuan, Dongxiao Sun, G. Dou, 2009, Biomedical chromatography : BMC.

The improved efficacy of Sifuvirtide compared with enfuvirtide might be related to its selectivity for the rigid biomembrane, as determined through surface plasmon resonance

P. Cao, Yuanguo Cheng, J. Che, 2017, PloS one.

Pharmacokinetics and bioavailability of tuftsin-derived T peptide, a promising antitumor agent, in beagles.

Zhuo-na Wu, Xiaoxia Zhu, Su-Eun Han, 2016, Drug metabolism and pharmacokinetics.

A sharp, robust, and quantitative method by liquid chromatography tandem mass spectrometry for the measurement of EAD for acute radiation syndrome and its application.

Zhuo-na Wu, Xiaoxia Zhu, Ruo-lan Gu, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography-tandem mass spectrometry for pharmacokinetic studies.

Guoxiang Sun, G. Dou, Z. Meng, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pharmacokinetics of topically applied recombinant human keratinocyte growth factor-2 in alkali-burned and intact rabbit eye.

Xiaokun Li, Wencan Wu, Long Zheng, 2015, Experimental eye research.

Determination of lefucoxib in rat plasma, urine, and feces by high-performance liquid chromatography with fluorescence detection: application in pharmacokinetic studies.

X. Bi, G. Dou, Z. Meng, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Simultaneous quantitation of E0703, a novel radioprotective agent and its oxidative metabolite M1 in human plasma by UPLC-MS/MS, and application to clinical pharmacokinetics.

Zhuo-na Wu, Yue Gao, Ruo-lan Gu, 2019, Journal of pharmaceutical and biomedical analysis.

Evaluation of Novel Tranexamic Acid/Montmorillonite Intercalation Composite, as a New Type of Hemostatic Material

Fei Li, Peng Han, Zhuo-na Wu, 2022, BioMed research international.

Predicting the metabolic characteristics of neorudin, a novel anticoagulant fusion protein, in patients with deep vein thrombosis.

Xiaoxia Zhu, Ruo-lan Gu, G. Dou, 2020, Thrombosis research.

Quantification of sifuvirtide in monkey plasma by an on-line solid-phase extraction procedure combined with liquid chromatography/electrospray ionization tandem mass spectrometry.

Shujia Dai, X. Qian, Haifeng Song, 2005, Rapid communications in mass spectrometry : RCM.

Simultaneous determination of lidamycin enediyne chromophore (LDC) and its aromatized derivative (LDCA) using puerarin as internal standard in rat plasma by LC-MS/MS.

Zhuo-na Wu, Xiaoxia Zhu, Ruo-lan Gu, 2011, Biomedical chromatography : BMC.

The pharmacokinetics and pharmacodynamics of a novel recombinant activated human factor VII, GEN-0828, in hemophilia B mice.

Zhuo-na Wu, Ruo-lan Gu, Yanqing Gao, 2022, Journal of Pharmacy and Science.

Quantitative and qualitative analysis of the novel antitumor 1,3,4-oxadiazole derivative (GLB) and its metabolites using HPLC-UV and UPLC-QTOF-MS

Chuang Lu, Guo-liang Zhang, Jian Li, 2015, Scientific Reports.

High performance liquid chromatographic determination of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]-ethane (BBSKE), a novel organoselenium compound, in dog plasma using pre-column derivatization and its application in pharmacokinetic study.

Guo-liang Zhang, Y. Lou, G. Dou, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pharmacokinetic Properties of Arsenic Species after Intravenous and Intragastrical Administration of Arsenic Trioxide Solution in Cynomolgus Macaques Using HPLC-ICP-MS

Zhuo-na Wu, Qiaoli Shi, Xiaoxia Zhu, 2019, Molecules.

[LC-MSn analysis of metabolites of 1,2-[bis (1,2-benzisoselenazolone-3(2H)-ketone)]-ethane, a novel anti-cancer agent in rat].

Guo-liang Zhang, Y. Lou, G. Dou, 2010, Yao xue xue bao = Acta pharmaceutica Sinica.

Pharmacokinetics and metabolism of 3,4-dichlorophenyl-propenoyl-sec.-butylamine in rats by high performance liquid chromatography-ion trap mass spectrometry.

Guo-liang Zhang, Ting Liu, Y. Lou, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Simultaneous determination of 1,5-dicaffeoylquinic acid and its active metabolites in human plasma by liquid chromatography-tandem mass spectrometry for pharmacokinetic studies.

Junxing Dong, Ruo-lan Gu, Jing Wang, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Evaluation of genipin-crosslinked chitosan hydrogels as a potential carrier for silver sulfadiazine nanocrystals.

T. Sun, Zhuo-na Wu, Xiaoxia Zhu, 2016, Colloids and surfaces. B, Biointerfaces.

An improved LC-MS/MS method for simultaneous determination of 1,5-dicaffeoylquinic acid and its active metabolites in human plasma and its application to a pharmacokinetic study in patients.

D. Yuan, Zhuo-na Wu, Xiaona Dong, 2010, Biomedical chromatography : BMC.

Effects of genipin cross-linking of chitosan hydrogels on cellular adhesion and viability.

Ying Zheng, Jian Li, Wenzhong Sun, 2014, Colloids and surfaces. B, Biointerfaces.

Combined Silver Sulfadiazine Nanosuspension with Thermosensitive Hydrogel: An Effective Antibacterial Treatment for Wound Healing in an Animal Model

Xiaoya Liu, Zhuo-na Wu, Xiaoxia Zhu, 2023, International journal of nanomedicine.

Accurate Determination of the Degree of Deacetylation of Chitosan Using UPLC–MS/MS

Fan Wang, Zhuo-na Wu, Ruo-lan Gu, 2022, International journal of molecular sciences.

Development of a mass spectrometry method for the characterization of a series of chitosan.

G. Dou, Z. Meng, Jing-Feng Li, 2019, International journal of biological macromolecules.

Lycium barbarum mitigates radiation injury via regulation of the immune function, gut microbiota, and related metabolites.

Jie Zhang, B. Ma, Xiaoxia Zhu, 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Development, validation, and clinical pharmacokinetic application of ultra-performance liquid chromatography/tandem mass spectrometry method for simultaneously determining a novel recombinant hirudin derivative (Neorudin) and its active metabolite in human serum.

Xiaona Dong, Ruo-lan Gu, G. Dou, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Enhanced oral bioavailability and anti‐tumour effect of paclitaxel by 20(s)‐ginsenoside Rg3 in vivo

Zhuo-na Wu, S. Fu, D. Zhan, 2012, Biopharmaceutics & drug disposition.

[Pharmacodynamics and pharmacokinetics of batroxobin in Beagle dog].

Zhuo-na Wu, Ruo-lan Gu, G. Dou, 2013, Yao xue xue bao = Acta pharmaceutica Sinica.

A novel exendin-4 human serum albumin fusion protein, E2HSA, with an extended half-life and good glucoregulatory effect in healthy rhesus monkeys.

Zhuo-na Wu, Xiaoxia Zhu, Ruo-lan Gu, 2014, Biochemical and biophysical research communications.

Preparation of Chitosan/Clay Composites for Safe and Effective Hemorrhage Control

Zhuo-na Wu, Lei Yang, Xiaoxia Zhu, 2022, Molecules.

Development and validation of a sensitive HPLC-MS/MS method for determination of chidamide (epidaza), a new benzamide class of selective histone deacetylase inhibitor, in human plasma and its clinical application.

Zhuo-na Wu, Xiaoxia Zhu, Ruo-lan Gu, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

An UPLC-MS/MS method to monitor Estriol injection and comparison of pharmacokinetic characteristics after irradiation

Zhuo-na Wu, Xiaoxia Zhu, Ruo-lan Gu, 2021, Radiation Medicine and Protection.

Silver sulfadiazine nanosuspension-loaded thermosensitive hydrogel as a topical antibacterial agent

Wenzhong Sun, Guifang Dou, Xiaoya Liu, 2018, International journal of nanomedicine.

Preclinical Pharmacokinetics, Tissue Distribution, and Primary Safety Evaluation of Indo5, a Novel Selective Inhibitor of c-Met and Trks

Shouguo Zhang, Y. Zhan, K. Zhao, 2021, Frontiers in Pharmacology.

Effects of radon exposure on gut microbiota and its metabolites short-chain fatty acids in mice.

Yunbo Sun, Shuchen Liu, Zhuo-na Wu, 2023, Toxicology.

Cepharanthine Ameliorates Pulmonary Fibrosis by Inhibiting the NF-κB/NLRP3 Pathway, Fibroblast-to-Myofibroblast Transition and Inflammation

Peng Han, Zhuo-na Wu, Xiaoxia Zhu, 2023, Molecules.

In Vitro and In Vivo Characterizations of Chiglitazar, a Newly Identified PPAR Pan-Agonist

Z. Shen, Z. Li, B. Ko, 2012, PPAR research.

Calcium ion-exchange cross-linked porous starch microparticles with improved hemostatic properties.

Yunbo Sun, Zhuo-na Wu, Qiaoli Shi, 2019, International journal of biological macromolecules.

A novel sodium polyacrylate–based stasis dressing to treat lethal hemorrhage in a penetrating trauma swine model

Peng Han, Lei Yang, Zhuo-na Wu, 2023, The journal of trauma and acute care surgery.

A phase I, single and continuous dose administration study on the safety, tolerability, and pharmacokinetics of neorudin, a novel recombinant anticoagulant protein, in healthy subjects

Chu-Tse Wu, Xiaona Dong, Lin Zhang, 2021, Pharmacology research & perspectives.

Evaluating prodrug characteristics of a novel anticoagulant fusion protein neorudin, a prodrug targeting release of hirudin variant 2‐Lys47 at the thrombosis site, by means of in vitro pharmacokinetics

Xiaoxia Zhu, Xiaona Dong, Ruo-lan Gu, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Preparation and characterization of a new type of porous starch microspheres (PSM) and effect of physicochemical properties on water uptake rate.

Zhuo-na Wu, Xiaoxia Zhu, Ruo-lan Gu, 2018, International journal of biological macromolecules.

Quantitative determination of acetylshikonin in macaque monkey blood by LC-ESI-MS/MS after precolumn derivatization with 2-mercaptoethanol and its application in pharmacokinetic study

Dongxiao Sun, Zhuo-na Wu, Ruo-lan Gu, 2008, Acta Pharmacologica Sinica.

Preparation and characterization of tranexamic acid modified porous starch and its application as a hemostatic agent

Yongxiu Qi, Yunbo Sun, Zhuo-na Wu, 2022, International Journal of Biological Macromolecules.

[Determination of yogliptin and its metabolite in Wistar rat plasma by liquid chromatography-tandem mass spectrometry].

Li-Ying Yu, J. Dai, Ruo-lan Gu, 2014, Yao xue xue bao = Acta pharmaceutica Sinica.

A phase I trial of an oral subtype-selective histone deacetylase inhibitor, chidamide, in combination with paclitaxel and carboplatin in patients with advanced non-small cell lung cancer

Yuankai Shi, Xiaohong Han, Lin Wang, 2016, Chinese journal of cancer research = Chung-kuo yen cheng yen chiu.

Evaluation of the metabolism of PEP06, an endostatin-RGDRGD 30-amino-acid polypeptide and a promising novel drug for targeting tumor cells

Zhuo-na Wu, Xiaoxia Zhu, Ruo-lan Gu, 2022, Journal of pharmaceutical analysis.

Phase I clinical and pharmacokinetic study of UTD1, a genetically engineered epothilone analog in patients with advanced solid tumors

Bing-he Xu, Li Tang, G. Dou, 2011, Cancer Chemotherapy and Pharmacology.

In vitro and in vivo pharmacokinetic and pharmacodynamic study of MBRI-001, a deuterium-substituted plinabulin derivative as a potent anti-cancer agent.

G. Dou, Ming‐jie Ma, Feng Li, 2018, Bioorganic & medicinal chemistry.

Running title : In vitro and in vivo safety studies on R 15 22 Abbreviations : 23 UFH : Unfractionated heparin 24 PS : Protamine sulfate 25

G. Dou, Su-Min Han, 2021 .

Pharmacological Effects of Astragaloside IV: A Review

Biqiong Chen, Yunbo Sun, Zhuo-na Wu, 2023, Molecules.

Silver sulfadiazine nanosuspension-loaded thermosensitive hydrogel as a topical antibacterial agent

Xiaoya Liu, Zhuo-na Wu, Xiaoxia Zhu, 2018, International journal of nanomedicine.

A novel method to quantify chitosan in aqueous solutions by ultrahigh-performance liquid chromatography–tandem mass spectrometry

Zhuo-na Wu, Xiaoxia Zhu, Ruo-lan Gu, 2024, Carbohydrate Polymers.