Jason Thresher

发表

Mechanism of Action for Respiratory Syncytial Virus Inhibitor RSV604

Olga Yuzhakov, Andrew D. Scott, Sreerupa Challa, 2014, Antimicrobial Agents and Chemotherapy.

ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii

D. Ehmann, S. McLeod, Camilo Velez-Vega, 2017, Nature Microbiology.

Fluorescence anisotropy-based measurement of Pseudomonas aeruginosa penicillin-binding protein 2 transpeptidase inhibitor acylation rate constants.

A. Shapiro, Ning Gao, Jason Thresher, 2014, Analytical biochemistry.

Overexpression of Pseudomonas aeruginosa LpxC with its inhibitors in an acrB-deficient Escherichia coli strain.

S. McLeod, P. Ross, F. Reck, 2014, Protein expression and purification.

Target-Based Resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a Novel Bacterial Type II Topoisomerase Inhibitor

T. Dougherty, D. Ehmann, F. Reck, 2014, Antimicrobial Agents and Chemotherapy.

Continuous fluorescence anisotropy-based assay of BOCILLIN FL penicillin reaction with penicillin binding protein 3.

A. Shapiro, Ning Gao, Jason Thresher, 2013, Analytical biochemistry.

A Homogeneous, High-Throughput-Compatible, Fluorescence Intensity–Based Assay for UDP-N-Acetylenolpyruvylglucosamine Reductase (MurB) with Nanomolar Product Detection

James D. Whiteaker, Jian Huang, A. Shapiro, 2012, Journal of biomolecular screening.

Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC.

R. Alm, R. Mclaughlin, James D. Whiteaker, 2015, The Journal of antimicrobial chemotherapy.

Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.

Matthew D. Miller, P. Ross, Michael R. Hale, 2014, ACS medicinal chemistry letters.

Exploring the UDP pocket of LpxC through amino acid analogs.

Matthew D. Miller, Wei Yang, P. Ross, 2013, Bioorganic & medicinal chemistry letters.

Selective inhibitors of bacterial t-RNA-(N(1)G37) methyltransferase (TrmD) that demonstrate novel ordering of the lid domain.

Ning Gao, T. Grebe, Jian Huang, 2013, Journal of medicinal chemistry.

Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases

D. Ehmann, P. Ross, S. Fisher, 2013, The Journal of Biological Chemistry.

Mode Of Inhibition of a novel DNA gyrase inhibitor with activity against Neisseria gonorrhoeae Inhibition of Neisseria gonorrhoeae type II Topoisomerases by the Novel Spiropyrimidinetrione AZD 0914 * #

D. Ehmann, P. Doig, S. D. Mills, 2015 .

Antibacterial Therapy (PPAT) To Validate PPAT as a Target for -Phosphopantetheine Adenylyltransferase ' Discovery of Inhibitors of 4

M. Johnstone, Ning Gao, Jason Thresher, 2014 .

Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy

H. Ni, M. Johnstone, S. Lahiri, 2013, Antimicrobial Agents and Chemotherapy.

Molecular Mechanisms of Sulbactam Antibacterial Activity and Resistance Determinants in Acinetobacter baumannii

D. Ehmann, M. Huband, R. Giacobbe, 2015, Antimicrobial Agents and Chemotherapy.

Quantitative investigation of the affinity of human respiratory syncytial virus phosphoprotein C-terminus binding to nucleocapsid protein

G. Sproat, R. Overman, A. Shapiro, 2014, Virology Journal.

A Homogeneous, High-Throughput Fluorescence Anisotropy-Based DNA Supercoiling Assay

D. Ehmann, S. Prasad, A. Shapiro, 2010, Journal of biomolecular screening.

A Homogeneous, High-Thr oughput Fluor escence Anisotropy-Based DNA Super coiling Assay

S. Prasad, A. Shapiro, Ning Gao, 2010 .

Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914*

D. Ehmann, G. Basarab, P. Doig, 2015, The Journal of Biological Chemistry.

The kinetic mechanism of S. pneumoniae DNA ligase and inhibition by adenosine-based antibacterial compounds.

D. Ehmann, Ce-Feng Liu, Hongming Wang, 2012, Biochemical pharmacology.

Target-Based Resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 1 5463 , a Novel Bacterial Type II Topoisomerase Inhibitor 2 3 4 5

T. Dougherty, D. Ehmann, B. Shapiro, 2014 .

Discovery of ATP-Competitive Inhibitors of tRNAIle Lysidine Synthetase (TilS) by High-Throughput Screening

S. Tentarelli, H. Plant, Jarrod Walsh, 2014, Journal of biomolecular screening.

A High-Throughput–Compatible Fluorescence Anisotropy-Based Assay for Competitive Inhibitors of Escherichia coli UDP-N-Acetylglucosamine Acyltransferase (LpxA)

Wei Yang, P. Ross, A. Shapiro, 2013, Journal of biomolecular screening.

A High-Throughput Absorbance-Based Assay for Methionine Produced by Methionine Aminopeptidase Using S-Adenosyl-L-Methionine Synthetase

James D. Whiteaker, A. Shapiro, G. Walkup, 2011, Journal of biomolecular screening.

Fluorescence anisotropy-based measurement of Pseudomonas aeruginosa penicillin-binding protein 2 transpeptidase inhibitor acylation rate constants.

A. Shapiro, Ning Gao, Jason Thresher, 2014, Analytical biochemistry.