Qiansen Zhang

发表

Effects of ion interactions with a cholesterol-rich bilayer.

Hualiang Jiang, Huaiyu Yang, Linlin Yang, 2015, Biochemical and biophysical research communications.

Scaffold Hopping Strategy to Identify Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy.

Wei Wang, Mingyao Liu, Weiqiang Lu, 2022, Journal of medicinal chemistry.

An orally available small molecule BCL6 inhibitor effectively suppresses diffuse large B cell lymphoma cells growth in vitro and in vivo.

Mingyao Liu, Z. Yi, Yihua Chen, 2021, Cancer letters.

‘C-type’ closed state and gating mechanisms of K2P channels revealed by conformational changes of the TREK-1 channel

Juwen Shen, X. Yao, Jie Fu, 2022, Journal of molecular cell biology.

General Pharmacological Activation Mechanism of K+ Channels Bypassing Channel Gates.

Juwen Shen, Huaiyu Yang, Shaoying Zhang, 2022, Journal of medicinal chemistry.

Discovery and Characterization of 1H-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy.

Mingyao Liu, Weiqiang Lu, Peili Wang, 2019, Journal of medicinal chemistry.

Probing the structure and dynamics of caveolin-1 in a caveolae-mimicking asymmetric lipid bilayer model

Hualiang Jiang, Huaiyu Yang, Linlin Yang, 2016, European Biophysics Journal.

A TREK Channel Family Activator with Well-Defined Structure-Activation Relationship for Pain and Neurogenic Inflammation.

Jie Fu, Wei Huang, F. Liu, 2020, Journal of medicinal chemistry.

Chiral implications on Fmoc-dipeptide self-assembly and catalytic kinetics of thermolysin

S. Bai, Honglei Jian, Xin Li, 2023, Colloids and Surfaces A: Physicochemical and Engineering Aspects.

Role of Thermolysin in Catalytic-Controlled Self-Assembly of Fmoc-Dipeptides

S. Bai, Peng Ren, Anhe Wang, 2020 .

Celastrol is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis.

Mingyao Liu, Weiqiang Lu, Xiyun Ye, 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors

Leping Li, Min Huang, Lin-jiang Tong, 2022, Cell Research.

Synthesis and Biological Evaluation of B-Cell Lymphoma 6 Inhibitors of N-phenyl-4-pyrimidinamine Derivatives Bearing Potent Activities against Tumor Growth.

Mingyao Liu, Xiufeng Pang, Z. Yi, 2020, Journal of medicinal chemistry.

Arenobufagin, isolated from toad venom, inhibited epithelial-to-mesenchymal transition and suppressed migration and invasion of lung cancer cells via targeting IKKβ/NFκB signal cascade.

Jiangmin Zhao, Qiansen Zhang, Qingxi Yue, 2019, Journal of ethnopharmacology.

Capn4 promotes colorectal cancer cell proliferation by increasing MAPK7 through activation of the Wnt/&bgr;‐Catenin pathway

Liang Zhu, W. Shen, Qiang Huang, 2018, Experimental cell research.

Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer

R. Nussinov, F. Cheng, Mingyao Liu, 2020, EMBO molecular medicine.

Crystal structure of the extracellular domains of GPR110.

Fang Wang, Huaiyu Yang, Gaojie Song, 2023, Journal of molecular biology.

Selective activation of TWIK-related acid-sensitive K+ 3 subunit–containing channels is analgesic in rodent models

Hualiang Jiang, Weiqiang Lu, Wei-Guang Li, 2019, Science Translational Medicine.

Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse

Longnian Lin, Mingyao Liu, Dali Li, 2020, Proceedings of the National Academy of Sciences.

The Human Ether-A-Go-Go–Related Gene Activator NS1643 Enhances Epilepsy-Associated KCNQ Channels

Hualiang Jiang, Huaiyu Yang, Zhaobing Gao, 2014, The Journal of Pharmacology and Experimental Therapeutics.

From a Designer Drug to the Discovery of Selective Cannabinoid Type 2 Receptor Agonists with Favorable Pharmacokinetic Profiles for the Treatment of Systemic Sclerosis.

Mingyao Liu, Weiqiang Lu, Lifang Yu, 2020, Journal of medicinal chemistry.

Discovery of 2H-Indazole-3-carboxamide Derivatives as Novel Potent Prostanoid EP4 Receptor Antagonists for Colorectal Cancer Immunotherapy.

Wei Wang, Mingyao Liu, Weiqiang Lu, 2023, Journal of medicinal chemistry.

Molecular basis for ligand activation of the human KCNQ2 channel

Jie Fu, S. Ye, Huaiyu Yang, 2020, Cell research.

Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects

Juwen Shen, Huaiyu Yang, Ruotian Jiang, 2022, Cell Research.

Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating

Hualiang Jiang, Zhuxi Chen, Hualiang Jiang, 2013, Proceedings of the National Academy of Sciences.

Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel.

Weiqiang Lu, Xi Cheng, Wei Huang, 2019, Journal of medicinal chemistry.

Selective Activation of TASK-3-containing K+ Channels Reveals Their Therapeutic Potentials in Analgesia

Hualiang Jiang, Weiqiang Lu, Wei-Guang Li, 2019, bioRxiv.

Unconventional Split Aptamers Cleaved at Functionally Essential Sites Preserve Biorecognition Capability.

Xiaohong Zhou, Ruoyu Wang, Han-Chang Shi, 2019, Analytical chemistry.

Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating.

Jie Fu, Huaiyu Yang, Qiansen Zhang, 2020, Journal of medicinal chemistry.

Dynamic States of the Ligand-Free Class A G Protein-Coupled Receptor Extracellular Side.

Hualiang Jiang, Huaiyu Yang, Lifen Zhao, 2018, Biochemistry.

Molecular basis and restoration of function deficiencies of Kv7.4 variants associated with inherited hearing loss

Huaiyu Yang, Juanmei Yang, Y. Shu, 2020, Hearing Research.

Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation

Yang Li, Zhuxi Chen, Hualiang Jiang, 2015, Scientific Reports.

Structural insights into dual-antagonize mechanism of AB928 on adenosine A2 receptors

Mingyao Liu, Yonghui Wang, Weiqiang Lu, 2023, bioRxiv.

Probing the structure and dynamics of caveolin-1 in a caveolae-mimicking asymmetric lipid bilayer model

Hualiang Jiang, Huaiyu Yang, Linlin Yang, 2016, European Biophysics Journal.

Selectively targeting STAT3 using a small molecule inhibitor is a potential therapeutic strategy for pancreatic cancer.

Mingyao Liu, Yihua Chen, Zhenliang Sun, 2022, Clinical cancer research : an official journal of the American Association for Cancer Research.

Effects of HO-/MeO-PBDEs on androgen receptor: in vitro investigation and helix 12-involved MD simulation.

Hualiang Jiang, Xiaowei Zhang, Huaiyu Yang, 2013, Environmental science & technology.

Discovery of the Highly Selective and Potent STAT3 Inhibitor for Pancreatic Cancer Treatment

Qiansen Zhang, Huang Chen, Aiwu Bian, 2024, ACS central science.

Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels

Linlin Yang, T. Jentsch, Heng Liu, 2023, Cell reports.