I. E. Kopka

发表

The discovery of sulfonylated dipeptides as potent VLA-4 antagonists.

M. Maccoss, S. D. de Laszlo, J. Fenyk-Melody, 2001, Bioorganic & medicinal chemistry letters.

Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists.

M. Maccoss, W. Hagmann, K. Lyons, 2002, Bioorganic & medicinal chemistry letters.

α4β7/α4β1Dual Integrin Antagonists Block α4β7-Dependent Adhesion under Shear Flow

S. E. D. Laszlo, B. Pikounis, P. Detmers, 2002 .

The discovery of acylated beta-amino acids as potent and orally bioavailable VLA-4 antagonists.

M. Maccoss, S. D. de Laszlo, J. Fenyk-Melody, 2002, Bioorganic & medicinal chemistry letters.

Dual Integrin Antagonists Block 4 7-Dependent Adhesion under Shear Flow

S. E. D. Laszlo, B. Pikounis, P. Detmers, 2002 .

Role of HMPT and TMEDA in control of enolate stereochemistry for reactions of lithium amides with 3-pentanone

M. Rathke, I. E. Kopka, Z. A. Fataftah, 1980 .

Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides

K. Chapman, R. Harrison, C. Esser, 1993 .

2,3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis.

F. Baker, D. Macintyre, J. Boger, 1989, Journal of medicinal chemistry.

Inhibition of matrix metalloproteinases by N-carboxyalkyl dipeptides: Enhanced potency and selectivity with substituted P1′ homophenylalanines

M. Maccoss, W. Hagmann, K. Chapman, 1995 .

The inhibition of C5a receptor binding by analogs of L-156,602, a cyclic hexadepsipeptide antibiotic

Sumire V. Kobayashi, W. Hagmann, J. Boger, 1992 .

Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.

W. F. Hoffman, Kenny K. Wong, M. Maccoss, 2000, Bioorganic & medicinal chemistry letters.

Preparation of a series of highly hindered secondary amines, including bis(triethylcarbinyl)amine

M. Rathke, I. E. Kopka, Z. A. Fataftah, 1980 .

A total synthesis of (±)-dihydropalustrine

I. E. Kopka, M. Leadbetter, Harry D. Wasserman, 1984 .

Acylation of ketone silyl enol ethers with acetyl tetrafluoroborate. Synthesis of 1,3-diketones

M. Rathke, I. E. Kopka, 1981 .

Preparation of hindered lithium amide bases and rates of their reaction with ether solvents

M. Rathke, I. E. Kopka, Z. A. Fataftah, 1987 .

A convenient synthesis of 4-tert-butyl-5-benzofuranols and dihydrobenzofuranols

R. Zambias, C. G. Caldwell, M. Hammond, 1988 .

Dehydrohalogenation Reactions Using Hindered Lithium Dialkylamide Bases

M. Rathke, M. Nowak, I. E. Kopka, 1986 .

Selective semisynthetic modification of L-156,602, a novel cyclic hexadepsipeptide antibiotic

I. E. Kopka, 1990 .

Characterization of zinc-binding sites in human stromelysin-1: stoichiometry of the catalytic domain and identification of a cysteine ligand in the proenzyme.

J. Hermes, Catherine K. Smith, C. K. Smith, 1992, Biochemistry.

Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides.

M. Maccoss, J. W. Becker, W. Hagmann, 1997, Journal of medicinal chemistry.

Substituted N-(3,5-dichlorobenzenesulfonyl)-L-prolyl-phenylalanine analogues as potent VLA-4 antagonists.

M. Maccoss, W. Hagmann, K. Lyons, 2002, Bioorganic & medicinal chemistry letters.

Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists.

M. Maccoss, W. Hagmann, K. Lyons, 2002, Bioorganic & Medicinal Chemistry Letters.

Adhesion under Shear Flow

S. E. D. Laszlo, B. Pikounis, P. Detmers, 2002 .

Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant.

L. V. D. van der Ploeg, W. Hagmann, James P. Jewell, 2010, Bioorganic & medicinal chemistry letters.

Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides.

K. Chapman, P L Durette, I E Kopka, 1995, Journal of medicinal chemistry.

N-(arylacetyl)-biphenylalanines as potent VLA-4 antagonists.

Bing Li, M. Maccoss, S. D. de Laszlo, 2002, Bioorganic & medicinal chemistry letters.

A novel one-pot synthesis of substituted 4-t-butyldimethylsilyloxy-thiazoles

I. E. Kopka, 1988 .

Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5- benzofuranol, a potent topical antiinflammatory agent.

R. Zambias, D. Boulton, M. Hammond, 1990, Journal of medicinal chemistry.