Stephen Neidle

发表

Stephen Neidle, S. Neidle, 2007 .

PHYSICAL METHODS .3. X-RAY CRYSTALLOGRAPHY

Stephen Neidle, Mb Hursthouse, 1975 .

Molecular Dynamics Studies of the STAT3 Homodimer: DNA Complex: Relationships between STAT3 Mutations and Protein-DNA Recognition

Stephen Neidle, David E. Thurston, Jarmila Husby, 2012, J. Chem. Inf. Model..

INOR 151-Stabilization of quadruplex DNA and inhibition of telomerase by square planar metal complexes

Stephen Neidle, A Arola, Julie E Reed, 2007 .

Assessment of single agent activity of BRACO19 and combination studies with cytotoxic drugs in a human tumor model with short telomeres.

Stephen Neidle, Angelika M. Burger, Smith, 2003 .

Rational design and evaluation of substituted acridones and acridines as telomerase inhibitors.

Stephen Neidle, Michael Moore, Christoph Schultes, 2003 .

The structure of drug-deoxydinucleoside phosphate complex; generalized conformational behavior of intercalation complexes with RNA and DNA fragments

Helen M. Berman, Stephen Neidle, H. S. Shieh, 1980, Nucleic Acids Res..

Molecular modeling of drug-DNA interactions: Facts and fantasies

Stephen Neidle, John O. Trent, S. Neidle, 1996 .

PHYSICAL METHODS AND TECHNIQUES .2. X-RAY CRYSTALLOGRAPHY

Stephen Neidle, Mb Hursthouse, 1977 .

DNA minor groove recognition of a non-self-complementary AT-rich sequence by a tris-benzimidazole ligand

Stephen Neidle, Juan Aymami, Christine M. Nunn, 1999, Nucleic Acids Res..

Molecular Structural Approaches to the Rational Design of New Anticancer Agents

Stephen Neidle, 1995 .

Metal-containing stabilisers of G-quadruplex DNA as telomerase inhibitors.

Stephen Neidle, Julie E Reed, Ramon Vilar, 2005 .

A new class of non-covalent sequence-selective DNA groove-binders with potential antitumour activity

Stephen Neidle, G. B. Jones, David E. Thurston, 1989 .

An Integrated Sequence-Structure Database incorporating matching mRNA sequence, amino acid sequence and protein three-dimensional structure data

Stephen Neidle, Ivan A. Adzhubei, Alexei A. Adzhubei, 1998, Nucleic Acids Res..

Structural Bioinformatics in Cancer

Stephen Neidle, 2006 .

Cancer drug design and discovery

Stephen Neidle, S. Neidle, 2008 .

The design of G-quadruplex ligands as telomerase inhibitors.

Stephen Neidle, Javier Cuesta, S. Neidle, 2003, Mini reviews in medicinal chemistry.

A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene.

Stephen Neidle, Shankar Balasubramanian, Ashok R Venkitaraman, 2006, Biochemistry.

Selectivity in ligand recognition of G-quadruplex loops.

Stephen Neidle, Gary N Parkinson, G. Parkinson, 2009, Biochemistry.

Highly structured water network in crystals of a deoxydinucleoside–drug complex

Helen M. Berman, Stephen Neidle, H. Berman, 1980, Nature.

Putative DNA quadruplex formation within the human c-kit oncogene.

Stephen Neidle, Mire Zloh, Alan K Todd, 2005, Journal of the American Chemical Society.

ANALYSIS OF VAN-DER-WAALS AND ELECTROSTATIC CONTRIBUTIONS IN THE INTERACTIONS OF MINOR-GROOVE BINDING BENZIMIDAZOLES WITH DNA

Min Zhao, Stephen Neidle, Christine M. Nunn, 1995 .

Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates.

Stephen Neidle, Shankar Balasubramanian, S. Balasubramanian, 2009, Organic & biomolecular chemistry.

Synthesis of distamycin A polyamides targeting G-quadruplex DNA.

Stephen Neidle, Mark Searcey, S. Neidle, 2006, Organic & biomolecular chemistry.

Chemical approaches to the discovery and development of cancer therapies

Stephen Neidle, David E. Thurston, S. Neidle, 2005, Nature Reviews Cancer.

Quadruplex DNA crystal structures and drug design.

Stephen Neidle, Gary N Parkinson, G. Parkinson, 2008, Biochimie.

Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein.

Stephen Neidle, Shankar Balasubramanian, S. Balasubramanian, 2006, Biochemistry.

Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA.

Stephen Neidle, David O'Hagan, N. Campbell, 2011, Organic & biomolecular chemistry.

Structure of a G-quadruplex-ligand complex.

Stephen Neidle, Gary N Parkinson, G. Parkinson, 2003, Journal of molecular biology.

Virtual screening of DNA minor groove binders.

Stephen Neidle, S. Neidle, David A Evans, 2006, Journal of medicinal chemistry.

Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands.

Stephen Neidle, Shozeb Haider, Mekala Gunaratnam, 2008, Molecular bioSystems.

Crystal structure of the potassium form of an Oxytricha nova G-quadruplex.

Stephen Neidle, Shozeb Haider, Gary N Parkinson, 2002, Journal of molecular biology.

Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition.

Gianni Chessari, Stephen Neidle, John Mann, 2003, Nucleic Acids Research.

Human telomeric G‐quadruplex: The current status of telomeric G‐quadruplexes as therapeutic targets in human cancer

Stephen Neidle, S. Neidle, 2010, The FEBS journal.

The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

Stephen Neidle, S. Neidle, J. Double, 2005, Cancer research.

Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors

Stephen Neidle, W. David Wilson, S. Neidle, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Loop-length-dependent folding of G-quadruplexes.

Stephen Neidle, Shankar Balasubramanian, S. Balasubramanian, 2004, Journal of the American Chemical Society.

The crystal structure of a-D-glucose monohydrate

Stephen Neidle, E. Hough, Donald Rogers, 1973 .

Bioactive pyridine-N-oxide disulfides from Allium stipitatum.

Stephen Neidle, Simon Gibbons, Mekala Gunaratnam, 2009, Journal of natural products.

A molecular model for the enzyme cytochrome P45017α, a major target for the chemotherapy of prostatic cancer

Stephen Neidle, C. A. Laughton, M. Sternberg, 1990 .

Extended molecular dynamics of a c-kit promoter quadruplex

Stephen Neidle, Jaroslav Koca, Shozeb Haider, 2015, Nucleic acids research.

Structural basis of DNA quadruplex recognition by an acridine drug.

Stephen Neidle, Gary N Parkinson, G. Parkinson, 2008, Journal of the American Chemical Society.

Characterization of a novel DNA minor-groove complex.

Binh Nguyen, Stephen Neidle, Donald Hamelberg, 2004, Biophysical journal.

Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation.

Stephen Neidle, Javier Cuesta, Mekala Gunaratnam, 2006, Journal of medicinal chemistry.

An evaluation cascade for G-quadruplex telomere targeting agents in human cancer cells.

Stephen Neidle, Mekala Gunaratnam, S. Neidle, 2010, Methods in molecular biology.

Non‐random usage of ‘degenerate’ codons is related to protein three‐dimensional structure

Stephen Neidle, S. Neidle, A. Adzhubei, 1996, FEBS letters.

Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands.

Stephen Neidle, Gary N Parkinson, Gavin W Collie, 2012, Journal of the American Chemical Society.

Mechanism of acridine-based telomerase inhibition and telomere shortening.

Stephen Neidle, Hamid Morjani, Mekala Gunaratnam, 2007, Biochemical pharmacology.

Small-molecule quadruplex-targeted drug discovery.

Stephen Neidle, Stephan A. Ohnmacht, S. Neidle, 2014, Bioorganic & medicinal chemistry letters.

Crystallographic insights into DNA minor groove recognition by drugs

Stephen Neidle, S. Neidle, 1997 .

Protein and drug interactions in the minor groove of DNA.

Stephen Neidle, Zdenek Morávek, B. Schneider, 2002, Nucleic acids research.

Thiophene-based diamidine forms a "super" at binding minor groove agent.

Stephen Neidle, Christian Bailly, C. Bailly, 2004, Journal of the American Chemical Society.

Telomere maintenance as a target for anticancer drug discovery

Gary Parkinson, Stephen Neidle, G. Parkinson, 2002, Nature Reviews Drug Discovery.

Molecular modeling and simulation of G-quadruplexes and quadruplex-ligand complexes.

Stephen Neidle, Shozeb Haider, S. Neidle, 2010, Methods in molecular biology.

Quadruplex nucleic acids.

Stephen Neidle, Shankar Balasubramanian, S. Balasubramanian, 2006 .

Crystal structure of parallel quadruplexes from human telomeric DNA

Stephen Neidle, G. Parkinson, S. Neidle, 2002, Nature.

Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy.

Stephen Neidle, S. Neidle, S. Haider, 2010, Journal of molecular biology.

Comparative structural studies of [3.1.0]-fused 2',3'-modified β-D-nucleosides by X-ray crystallography, NMR spectroscopy, and molecular mechanics calculations

Stephen Neidle, Weimin Tong, Jyoti Chattopadhyaya, 1991 .

Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells.

Stephen Neidle, B. Guyen, S. Neidle, 2009, Bioorganic & medicinal chemistry letters.

Molecular dynamics and principal components analysis of human telomeric quadruplex multimers.

Stephen Neidle, Shozeb Haider, Gary N Parkinson, 2008, Biophysical journal.

Molecular foundations of drug—receptor interaction

Stephen Neidle, S. Neidle, 1988 .

A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells.

Stephen Neidle, S. Neidle, L. Kèlland, 2004, Molecular cancer therapeutics.

Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes.

Stephen Neidle, Mekala Gunaratnam, Silvia Sparapani, 2010, Journal of the American Chemical Society.

Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex.

Stephen Neidle, Christian Bailly, Yang Liu, 2007, Journal of the American Chemical Society.

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

Stephen Neidle, Laurence H. Hurley, Shankar Balasubramanian, 2011, Nature Reviews Drug Discovery.

Hitting the target

Stephen Neidle, S. Neidle, 1999, Nature.

Quadruplex nucleic acids as targets for anticancer therapeutics

Stephen Neidle, S. Neidle, 2017 .

Can We Execute Reliable MM-PBSA Free Energy Computations of Relative Stabilities of Different Guanine Quadruplex Folds?

Stephen Neidle, Shozeb Haider, Barira Islam, 2016, The journal of physical chemistry. B.

Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells.

Stephen Neidle, Mekala Gunaratnam, Stephan A. Ohnmacht, 2013, Journal of medicinal chemistry.

Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs.

Stephen Neidle, Mekala Gunaratnam, Gary N Parkinson, 2008, Journal of medicinal chemistry.

The structures of quadruplex nucleic acids and their drug complexes.

Stephen Neidle, S. Neidle, 2009, Current opinion in structural biology.