P. Hewawasam

发表

3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction.

V. Gribkoff, S. Dworetzky, Joanne Natale, 2004, Bioorganic & medicinal chemistry letters.

Radiochemical synthesis and biodistribution of a novel maxi-K potassium channel opener.

V. Gribkoff, J. Starrett, D. Kiesewetter, 2002, Nuclear medicine and biology.

The Synthesis and Structure—Activity Relationships of 1,3‐Diaryl 1,2,4‐(4H)‐Triazol‐5‐ones: A New Class of Calcium‐Dependent, Large Conductance, Potassium (Maxi‐K) Channel Opener Targeted for Urge Urinary Incontinence.

V. Gribkoff, N. Meanwell, C. Boissard, 2002 .

3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction.

V. Gribkoff, S. Dworetzky, Joanne Natale, 2004, Bioorganic & medicinal chemistry letters.

4-Aryl-3-(mercapto)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle.

V. Gribkoff, C. Boissard, N. Lodge, 2004, Bioorganic & medicinal chemistry letters.

Synthesis of water-soluble prodrugs of BMS-191011: a maxi-K channel opener targeted for post-stroke neuroprotection.

Astrid A. Ortiz, V. Gribkoff, J. Knipe, 2003, Bioorganic & medicinal chemistry letters.

The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection.

V. Gribkoff, C. Boissard, J. Knipe, 2002, Bioorganic & medicinal chemistry letters.

The synthesis and structure-activity relationships of 3-amino-4-benzylquinolin-2-ones; discovery of novel KCNQ2 channel openers.

V. Gribkoff, S. Dworetzky, Joanne Natale, 2004, Bioorganic & medicinal chemistry letters.

A practical and efficient synthesis of 6-carboalkoxy-13-cycloalkyl-5H-indolo[2,1-a][2]benzazepine-10-carboxylic acid derivatives

N. Meanwell, J. Kadow, Yong Tu, 2014 .

Synthesis and structure-activity relationships of 3-aryloxindoles: a new class of calcium-dependent, large conductance potassium (maxi-K) channel openers with neuroprotective properties.

V. Gribkoff, Stella Huang, N. Meanwell, 2002, Journal of medicinal chemistry.

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

A. Good, H. Klei, A. Cocuzza, 2014, Journal of medicinal chemistry.

4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction.

V. Gribkoff, S. Dworetzky, C. Boissard, 2003, Journal of medicinal chemistry.

DISCOVERY OF A NOVEL CLASS OF BK CHANNEL OPENERS: ENANTIOSPECIFIC SYNTHESIS AND BK CHANNEL OPENING ACTIVITY OF 3-(5-CHLORO-2-HYDROXYPHENYL)-1,3-DIHYDRO-3-HYDROXY-6-(TRIFLUOROMETHYL)-2H-INDOL-2-ONE

V. Gribkoff, N. Meanwell, S. Dworetzky, 1997 .

The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.

Qi Gao, Huabin Sun, Hong Shi, 2014, Journal of medicinal chemistry.

Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.

Chong-Hwan Chang, M. Witmer, B. Beno, 2014, Journal of medicinal chemistry.

The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels.

V. Gribkoff, R. Perrone, N. Meanwell, 2002, Bioorganic & medicinal chemistry letters.

Stereospecific syntheses of (E)-1,3-disubstituted dienes

F. Hauser, P. Hewawasam, Y. Rho, 1988 .

Regio- and stereospecific construction of anthracyclinones: total syntheses of (.+-.)-.gamma.-citromycinone, (.+-.)-dimethyl-6-deoxydaunomycinone, and (.+-.)-dimethyl-6-deoxyadriamycinone

F. Hauser, D. Mal, P. Hewawasam, 1988 .

1(4H)-Naphthalenones in anthracyclinone synthesis: a new route for the total synthesis of (.+-.)-aklavinone

F. Hauser, P. Hewawasam, Y. Rho, 1989 .

A general method for the synthesis of isatins: Preparation of regiospecifically functionalized isatins from anilines

N. Meanwell, P. Hewawasam, 1994 .

Synthesis and excitatory amino acid pharmacology of some novel quinoxalinediones

V. Gribkoff, N. Meanwell, D. Post‐Munson, 1993 .

Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels

Astrid A. Ortiz, P. Molinoff, V. Gribkoff, 2001, Nature Medicine.

The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel opener targeted for urge urinary incontinence.

V. Gribkoff, N. Meanwell, C. Boissard, 2002, Bioorganic & medicinal chemistry letters.

Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase.

N. Meanwell, J. Lemm, J. Kadow, 2016, Bioorganic & medicinal chemistry letters.

Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore

R. Bindra, J. Herrington, R. Sundaram, 2021, Oncotarget.

Regiospecific preparation of the benz[b]xanthen-12-one ring system: total synthesis of bikaverin

F. Hauser, P. Hewawasam, V. M. Baghdanov, 1988 .

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A

Min Gao, Nicholas A. Meanwell, Yong Tu, 2015, Nature.

Regio- and stereospecific syntheses of 4-deoxyadriamycinone and 4,6-dideoxyadriamycinone from a common intermediate

F. Hauser, P. Hewawasam, 1988 .

Inhibitors of blood platelet cAMP phosphodiesterase. 4. Structural variation of the side-chain terminus of water-soluble 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives.

N. Meanwell, J. A. Thomas, J. Russell, 1993, Journal of Medicinal Chemistry.

Inhibitors of Blood Platelet cAMP Phosphodiesterase. Part 4. Structural Variation of the Side-Chain Terminus of Water-Soluble 1,3- Dihydro-2H-imidazo(4,5-b)quinolin-2-one Derivatives.

N. Meanwell, J. A. Thomas, J. Russell, 1994 .

Effect of 4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a Novel Opener of Large Conductance Ca2+-Activated K+ (Maxi-K) Channels on Normal and Stress-Aggravated Colonic Motility and Visceral Nociception

N. Lodge, M. Plym, Laura J. Signor, 2005, Journal of Pharmacology and Experimental Therapeutics.

Synergistic Activity of Combined NS5A Inhibitors

N. Meanwell, M. Cockett, M. Gao, 2015, Antimicrobial Agents and Chemotherapy.

Discovery of a Novel Class of BK Channel Openers: Enantiospecific Synthesis and BK Channel Opening Activity of 3-(5-Chloro-2- hydroxyphenyl)-1,3-dihydro-3-hydroxy-6-trifluoromethyl-2H-indol-2-one.

V. Gribkoff, N. Meanwell, S. Dworetzky, 1997 .

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A

N. Meanwell, D. Langley, J. Lemm, 2015, Nature.

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

A. Good, H. Klei, A. Cocuzza, 2014, Journal of medicinal chemistry.